Huang Y, Wang KK. The calpain family and human disease. Trends in Molecular Medicine. 2001, 7 (8): 355–362. PMID 11516996. doi:10.1016/S1471-4914(01)02049-4.
Suzuki K, Sorimachi H, Yoshizawa T, et al. Calpain: novel family members, activation, and physiologic function. Biol. Chem. Hoppe-Seyler. 1996, 376 (9): 523–9. PMID 8561910. doi:10.1515/bchm3.1995.376.9.523.
Davis TL, Walker JR, Finerty PJ, et al. The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition. J. Mol. Biol. 2007, 366 (1): 216–229. PMID 17157313. doi:10.1016/j.jmb.2006.11.037.
Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899.
Lee HJ, Tomioka S, Kinbara K, et al. Characterization of a human digestive tract-specific calpain, nCL-4, expressed in the baculovirus system. Arch. Biochem. Biophys. 1999, 362 (1): 22–31. PMID 9917325. doi:10.1006/abbi.1998.1021.
外部链接编辑
Human CAPN9 genome location and CAPN9 gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）.
The MEROPS online database for peptidases and their inhibitors: C02.006
钙蛋白酶9, 英语, calpain, 是一种在人类中由capn9基因编码的蛋白质, 已知的結構pdb直系同源搜索, pdbe, rcsbpdbid列表1ziv, 2p0r識別號别名capn9, gc36, calpain, 9外部idomim, 606401, 1920897, homologene, 38208, genecards, capn9相關疾病近視, 基因位置, 人类, 染色体1號染色體, 基因座1q42, 2起始230, 终止230, 基因位置, 小鼠, 染色体小鼠8号染色体, 基因座8, e2起始. 钙蛋白酶9 英语 Calpain 9 是一种在人类中由CAPN9基因编码的蛋白质 6 7 8 钙蛋白酶9已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表1ZIV 2P0R識別號别名CAPN9 GC36 nCL 4 calpain 9外部IDOMIM 606401 MGI 1920897 HomoloGene 38208 GeneCards CAPN9相關疾病近視 1 基因位置 人类 染色体1號染色體 2 基因座1q42 2起始230 747 384 bp 2 终止230 802 003 bp 2 基因位置 小鼠 染色体小鼠8号染色体 3 基因座8 8 E2起始125 302 850 bp 3 终止125 345 470 bp 3 RNA表达模式查阅更多表达数据基因本體分子功能 calcium ion binding 肽酶活性 半胱氨酸型肽酶活性 水解酶活性 金屬離子結合 calcium dependent cysteine type endopeptidase activity細胞組分 胞內 細胞質 细胞组件生物學過程 消化作用 蛋白酶解 sarcomere organizationSources Amigo QuickGO直系同源物種人類小鼠Entrez1075373647EnsemblENSG00000135773ENSMUSG00000031981UniProtO14815Q9D805mRNA 序列 NM 006615 NM 016452 NM 001319676NM 023709蛋白序列NP 001306605 NP 006606 NP 057536NP 076198基因位置 UCSC Chr 1 230 75 230 8 MbChr 8 125 3 125 35 MbPubMed 查找 4 5 維基數據檢視 編輯人類檢視 編輯小鼠钙蛋白酶是普遍存在的 保守的钙依赖性半胱氨酸蛋白酶家族 钙蛋白酶是由不变的小亚基和可变的大亚基组成的异二聚体 大亚基具有半胱氨酸蛋白酶结构域 而两个亚基都具有钙结合结构域 钙蛋白酶与神经退行性过程有关 因为它们的激活可以由钙流入和氧化应激触发 由该基因编码的蛋白质主要在胃和小肠中表达 并可能在消化道中具有特殊功能 该基因被认为与胃癌有关 该基因可编码不同亚型的多个可变剪接转录物变体 8 参考资料 编辑 與钙蛋白酶9相關的疾病 在維基數據上查看 編輯參考 2 0 2 1 2 2 GRCh38 Ensembl release 89 ENSG00000135773 Ensembl May 2017 3 0 3 1 3 2 GRCm38 Ensembl release 89 ENSMUSG00000031981 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Lee HJ Sorimachi H Jeong SY Ishiura S Suzuki K Molecular cloning and characterization of a novel tissue specific calpain predominantly expressed in the digestive tract Biol Chem May 1998 379 2 175 184 PMID 9524069 S2CID 37483841 doi 10 1515 bchm 1998 379 2 175 Yoshikawa Y Mukai H Hino F Asada K Kato I Isolation of two novel genes down regulated in gastric cancer Jpn J Cancer Res Jul 2000 91 5 459 63 PMC 5926377 nbsp PMID 10835488 doi 10 1111 j 1349 7006 2000 tb00967 x 8 0 8 1 Entrez Gene CAPN9 calpain 9 2023 01 28 原始内容存档于2010 12 05 延伸阅读 编辑Huang Y Wang KK The calpain family and human disease Trends in Molecular Medicine 2001 7 8 355 362 PMID 11516996 doi 10 1016 S1471 4914 01 02049 4 Suzuki K Sorimachi H Yoshizawa T et al Calpain novel family members activation and physiologic function Biol Chem Hoppe Seyler 1996 376 9 523 9 PMID 8561910 doi 10 1515 bchm3 1995 376 9 523 Davis TL Walker JR Finerty PJ et al The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto inhibition J Mol Biol 2007 366 1 216 229 PMID 17157313 doi 10 1016 j jmb 2006 11 037 Strausberg RL Feingold EA Grouse LH et al Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 2003 99 26 16899 16903 Bibcode 2002PNAS 9916899M PMC 139241 nbsp PMID 12477932 doi 10 1073 pnas 242603899 nbsp Lee HJ Tomioka S Kinbara K et al Characterization of a human digestive tract specific calpain nCL 4 expressed in the baculovirus system Arch Biochem Biophys 1999 362 1 22 31 PMID 9917325 doi 10 1006 abbi 1998 1021 外部链接 编辑Human CAPN9 genome location and CAPN9 gene details page in the UCSC Genome Browser 英语 UCSC Genome Browser The MEROPS online database for peptidases and their inhibitors C02 006 PDB中UniProt可用的所有結構信息之概述 O14815 Human Calpain 9 CAPN9 在PDBe KB 英语 PDBe KB 取自 https zh wikipedia org w index php title 钙蛋白酶9 amp oldid 79353245, 维基百科，wiki，书籍，书籍，图书馆，
