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维基百科

A20 (基因)

四月 01, 2023

A20基因（或称为：肿瘤坏死因子α诱导蛋白3，英語：Tumor necrosis factor, alpha-induced protein 3，缩写TNFAIP3）是人类六号染色体上的基因[6][7]，可由肿瘤坏死因子α（TNF-α）诱导表达，是一种去泛素化酶和锌指蛋白，可抑制NF-κB激活和TNF介导的细胞凋亡。A20是一种非常古老的蛋白，在刺胞動物門（水母）中也有带有同源结构域的蛋白[8]。

A20
已知的結構
PDB直系同源搜索: PDBe RCSB
識別號
别名TNFAIP3；, A20, OTUD7C, TNFA1P2, AISBL, TNF alpha induced protein 3, AIFBL1
外部IDOMIM：191163 MGI：1196377 HomoloGene：4582 GeneCards：TNFAIP3
相關疾病
紅斑性狼瘡、​銀屑病[1]
基因位置（人类）
染色体6號染色體[2]
基因座6q23.3起始137,867,214 bp[2]
终止137,883,312 bp[2]
RNA表达模式


查阅更多表达数据
直系同源
物種人類小鼠
Entrez

7128

21929

Ensembl

ENSG00000118503

ENSMUSG00000019850

UniProt

P21580

Q60769

mRNA​序列

​NM_001270507
​NM_001270508
​NM_006290

NM_001166402
​NM_009397

蛋白序列

NP_001257436
​NP_001257437
​NP_006281

NP_001159874
​NP_033423

基因位置​（UCSC）Chr 6: 137.87 – 137.88 MbChr 10: 18.88 – 18.89 Mb
PubMed​查找[4][5]
維基數據
檢視/編輯人類檢視/編輯小鼠

蛋白质的相互作用

A20蛋白与下列蛋白質进行互作：TNIP1[9]、TRAF1[10][11]、TRAF2[10]、IKBKG[12]、TAX1BP1[13]、YWHAB[14]、YWHAZ[14][15]、TRAF6[11][16]和YWHAH[14][15]。

参考文献

  1. ^ 與A20相關的疾病；在維基數據上查看/編輯參考. 
  2. ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000118503 - Ensembl, May 2017
  3. ^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000019850 - Ensembl, May 2017
  4. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  6. ^ Opipari AW Jr; Boguski MS; Dixit VM. The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein. J Biol Chem. October 1990, 265 (25): 14705–8. PMID 2118515. 
  7. ^ Entrez Gene: TNFAIP3 tumor necrosis factor, alpha-induced protein 3. （原始内容于2010-12-05）. 
  8. ^ Staal J, Driege Y, Haegman M, Borghi A, Hulpiau P, Lievens L, et al. Ancient Origin of the CARD-Coiled Coil/Bcl10/MALT1-Like Paracaspase Signaling Complex Indicates Unknown Critical Functions. Frontiers in Immunology. 2018, 9: 1136. PMC 5978004  . PMID 29881386. doi:10.3389/fimmu.2018.01136. 
  9. ^ Heyninck, K; De Valck D; Vanden Berghe W; Van Criekinge W; Contreras R; Fiers W; Haegeman G; Beyaert R. The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN. J. Cell Biol. (UNITED STATES). June 1999, 145 (7): 1471–82. ISSN 0021-9525. PMC 2133159  . PMID 10385526. doi:10.1083/jcb.145.7.1471. 
  10. ^ 10.0 10.1 Song, H Y; Rothe M; Goeddel D V. The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES). June 1996, 93 (13): 6721–5. Bibcode:1996PNAS...93.6721S. ISSN 0027-8424. PMC 39093  . PMID 8692885. doi:10.1073/pnas.93.13.6721. 
  11. ^ 11.0 11.1 Heyninck, K; Beyaert R. The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6. FEBS Lett. (NETHERLANDS). January 1999, 442 (2–3): 147–50. ISSN 0014-5793. PMID 9928991. S2CID 19072203. doi:10.1016/S0014-5793(98)01645-7. 
  12. ^ Zhang, S Q; Kovalenko A; Cantarella G; Wallach D. Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation. Immunity (UNITED STATES). March 2000, 12 (3): 301–11. ISSN 1074-7613. PMID 10755617. doi:10.1016/S1074-7613(00)80183-1. 
  13. ^ De Valck, D; Jin D Y; Heyninck K; Van de Craen M; Contreras R; Fiers W; Jeang K T; Beyaert R. The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. Oncogene (ENGLAND). July 1999, 18 (29): 4182–90. ISSN 0950-9232. PMID 10435631. doi:10.1038/sj.onc.1202787  . 
  14. ^ 14.0 14.1 14.2 Vincenz, C; Dixit V M. 14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules. J. Biol. Chem. (UNITED STATES). August 1996, 271 (33): 20029–34. ISSN 0021-9258. PMID 8702721. doi:10.1074/jbc.271.33.20029  . 
  15. ^ 15.0 15.1 De Valck, D; Heyninck K; Van Criekinge W; Vandenabeele P; Fiers W; Beyaert R. A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins. Biochem. Biophys. Res. Commun. (UNITED STATES). September 1997, 238 (2): 590–4. ISSN 0006-291X. PMID 9299557. doi:10.1006/bbrc.1997.7343. 
  16. ^ Evans, P C; Taylor E R; Coadwell J; Heyninck K; Beyaert R; Kilshaw P J. Isolation and characterization of two novel A20-like proteins. Biochem. J. (England). August 2001, 357 (Pt 3): 617–23. ISSN 0264-6021. PMC 1221992  . PMID 11463333. doi:10.1042/0264-6021:3570617. 

外部链接

  • PDB中UniProt可用的所有結構信息之概述：P21580 (Tumor necrosis factor alpha-induced protein 3) 在PDBe-KB（英语：PDBe-KB）。

四月 01, 2023
基因, a20基因, 或称为, 肿瘤坏死因子α诱导蛋白3, 英語, tumor, necrosis, factor, alpha, induced, protein, 缩写tnfaip3, 是人类六号染色体上的基因, 可由肿瘤坏死因子α, 诱导表达, 是一种去泛素化酶和锌指蛋白, 可抑制nf, κb激活和tnf介导的细胞凋亡, a20是一种非常古老的蛋白, 在刺胞動物門, 水母, 中也有带有同源结构域的蛋白, a20已知的結構pdb直系同源搜索, pdbe, rcsbpdbid列表2eqf, 2eqg, 2vfj,. A20基因 或称为 肿瘤坏死因子a诱导蛋白3 英語 Tumor necrosis factor alpha induced protein 3 缩写TNFAIP3 是人类六号染色体上的基因 6 7 可由肿瘤坏死因子a TNF a 诱导表达 是一种去泛素化酶和锌指蛋白 可抑制NF kB激活和TNF介导的细胞凋亡 A20是一种非常古老的蛋白 在刺胞動物門 水母 中也有带有同源结构域的蛋白 8 A20已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表2EQF 2EQG 2VFJ 3DKB 3OJ3 3OJ4 3VUW 3VUX 3VUY 3ZJD 3ZJE 3ZJF 3ZJG 4ZRH 4ZS5識別號别名TNFAIP3 A20 OTUD7C TNFA1P2 AISBL TNF alpha induced protein 3 AIFBL1外部IDOMIM 191163 MGI 1196377 HomoloGene 4582 GeneCards TNFAIP3相關疾病紅斑性狼瘡 銀屑病 1 基因位置 人类 染色体6號染色體 2 基因座6q23 3起始137 867 214 bp 2 终止137 883 312 bp 2 基因位置 小鼠 染色体小鼠10号染色体 3 基因座10 A3 10 8 08 cM起始18 876 658 bp 3 终止18 891 405 bp 3 RNA表达模式查阅更多表达数据基因本體分子功能 DNA结合 半胱氨酸型肽酶活性 鋅離子結合 金屬離子結合 泛素蛋白轉移酶活性 蛋白酶結合 蛋白質自締合 肽酶活性 连接酶活性 激酶结合 K63连接的多聚泛素修饰依赖性蛋白结合 泛素结合 血浆蛋白结合 催化活性 巯基依赖性泛素特异性蛋白酶活性 水解酶活性 相同蛋白质结合 Lys63特异性去泛素酶活性 轉移酶活性細胞組分 細胞質 细胞质基质 溶酶体 外排體 细胞核 細胞內膜結合細胞器生物學過程 生发中心形成的调控 肝细胞增殖的正调控 內皮細胞凋亡過程的負調控 白细胞介素 1b产生的负调控 平滑肌細胞增殖的負調控 血管创伤愈合的调控 B 1 B細胞穩態 protein K48 linked deubiquitination positive regulation of protein catabolic process negative regulation of cyclin dependent protein serine threonine kinase activity 宿主对病毒防御反应的调控 泛素依赖性蛋白质分解代谢过程中的蛋白质去蛋白化 negative regulation of toll like receptor 2 signaling pathway negative regulation of nucleotide binding oligomerization domain containing 2 signaling pathway 肿瘤坏死因子介导的信号通路的调控 negative regulation of interleukin 6 production negative regulation of B cell activation negative regulation of toll like receptor 5 signaling pathway tolerance induction to lipopolysaccharide response to muramyl dipeptide negative regulation of chronic inflammatory response negative regulation of cell death negative regulation of I kappaB kinase NF kappaB signaling 蛋白酶解 establishment of protein localization to vacuole protein deubiquitination negative regulation of protein ubiquitination protein K48 linked ubiquitination protein K63 linked deubiquitination negative regulation of CD40 signaling pathway 死亡域受体对外源性凋亡信号通路的负调控 protein complex oligomerization protein K11 linked deubiquitination regulation of inflammatory response 含有1信號通路的核苷酸結合寡聚結構域的負調控 negative regulation of innate immune response negative regulation of osteoclast proliferation 腫瘤壞死因子產生的負調控 negative regulation of type I interferon production 代謝 inflammatory response response to molecule of bacterial origin negative regulation of NF kappaB transcription factor activity negative regulation of interleukin 2 production negative regulation of inflammatory response negative regulation of toll like receptor 3 signaling pathway 含有信号通路的核苷酸结合寡聚结构域 cellular response to lipopolysaccharide negative regulation of toll like receptor 4 signaling pathway negative regulation of bone resorption cellular response to hydrogen peroxide 细胞凋亡 protein ubiquitination 细胞骨架组织 细胞迁移 positive regulation of Wnt signaling pathway protein K29 linked deubiquitination protein K33 linked deubiquitinationSources Amigo QuickGO直系同源物種人類小鼠Entrez712821929EnsemblENSG00000118503ENSMUSG00000019850UniProtP21580Q60769mRNA 序列 NM 001270507 NM 001270508 NM 006290NM 001166402 NM 009397蛋白序列NP 001257436 NP 001257437 NP 006281NP 001159874 NP 033423基因位置 UCSC Chr 6 137 87 137 88 MbChr 10 18 88 18 89 MbPubMed 查找 4 5 維基數據檢視 編輯人類檢視 編輯小鼠蛋白质的相互作用 编辑A20蛋白与下列蛋白質进行互作 TNIP1 9 TRAF1 10 11 TRAF2 10 IKBKG 12 TAX1BP1 13 YWHAB 14 YWHAZ 14 15 TRAF6 11 16 和YWHAH 14 15 参考文献 编辑 與A20相關的疾病 在維基數據上查看 編輯參考 2 0 2 1 2 2 GRCh38 Ensembl release 89 ENSG00000118503 Ensembl May 2017 3 0 3 1 3 2 GRCm38 Ensembl release 89 ENSMUSG00000019850 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Opipari AW Jr Boguski MS Dixit VM The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein J Biol Chem October 1990 265 25 14705 8 PMID 2118515 Entrez Gene TNFAIP3 tumor necrosis factor alpha induced protein 3 原始内容存档于2010 12 05 Staal J Driege Y Haegman M Borghi A Hulpiau P Lievens L et al Ancient Origin of the CARD Coiled Coil Bcl10 MALT1 Like Paracaspase Signaling Complex Indicates Unknown Critical Functions Frontiers in Immunology 2018 9 1136 PMC 5978004 PMID 29881386 doi 10 3389 fimmu 2018 01136 Heyninck K De Valck D Vanden Berghe W Van Criekinge W Contreras R Fiers W Haegeman G Beyaert R The zinc finger protein A20 inhibits TNF induced NF kappaB dependent gene expression by interfering with an RIP or TRAF2 mediated transactivation signal and directly binds to a novel NF kappaB inhibiting protein ABIN J Cell Biol UNITED STATES June 1999 145 7 1471 82 ISSN 0021 9525 PMC 2133159 PMID 10385526 doi 10 1083 jcb 145 7 1471 10 0 10 1 Song H Y Rothe M Goeddel D V The tumor necrosis factor inducible zinc finger protein A20 interacts with TRAF1 TRAF2 and inhibits NF kappaB activation Proc Natl Acad Sci U S A UNITED STATES June 1996 93 13 6721 5 Bibcode 1996PNAS 93 6721S ISSN 0027 8424 PMC 39093 PMID 8692885 doi 10 1073 pnas 93 13 6721 11 0 11 1 Heyninck K Beyaert R The cytokine inducible zinc finger protein A20 inhibits IL 1 induced NF kappaB activation at the level of TRAF6 FEBS Lett NETHERLANDS January 1999 442 2 3 147 50 ISSN 0014 5793 PMID 9928991 S2CID 19072203 doi 10 1016 S0014 5793 98 01645 7 Zhang S Q Kovalenko A Cantarella G Wallach D Recruitment of the IKK signalosome to the p55 TNF receptor RIP and A20 bind to NEMO IKKgamma upon receptor stimulation Immunity UNITED STATES March 2000 12 3 301 11 ISSN 1074 7613 PMID 10755617 doi 10 1016 S1074 7613 00 80183 1 De Valck D Jin D Y Heyninck K Van de Craen M Contreras R Fiers W Jeang K T Beyaert R The zinc finger protein A20 interacts with a novel anti apoptotic protein which is cleaved by specific caspases Oncogene ENGLAND July 1999 18 29 4182 90 ISSN 0950 9232 PMID 10435631 doi 10 1038 sj onc 1202787 14 0 14 1 14 2 Vincenz C Dixit V M 14 3 3 proteins associate with A20 in an isoform specific manner and function both as chaperone and adapter molecules J Biol Chem UNITED STATES August 1996 271 33 20029 34 ISSN 0021 9258 PMID 8702721 doi 10 1074 jbc 271 33 20029 15 0 15 1 De Valck D Heyninck K Van Criekinge W Vandenabeele P Fiers W Beyaert R A20 inhibits NF kappaB activation independently of binding to 14 3 3 proteins Biochem Biophys Res Commun UNITED STATES September 1997 238 2 590 4 ISSN 0006 291X PMID 9299557 doi 10 1006 bbrc 1997 7343 Evans P C Taylor E R Coadwell J Heyninck K Beyaert R Kilshaw P J Isolation and characterization of two novel A20 like proteins Biochem J England August 2001 357 Pt 3 617 23 ISSN 0264 6021 PMC 1221992 PMID 11463333 doi 10 1042 0264 6021 3570617 外部链接 编辑PDB中UniProt可用的所有結構信息之概述 P21580 Tumor necrosis factor alpha induced protein 3 在PDBe KB 英语 PDBe KB 取自 https zh wikipedia org w index php title A20 基因 amp oldid 63101430, 维基百科，wiki，书籍，书籍，图书馆，

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