^Rimokh R, Gadoux M, Bertheas MF, Berger F, Garoscio M, Deleage G, Germain D, Magaud JP. FVT-1, a novel human transcription unit affected by variant translocation t(2;18)(p11;q21) of follicular lymphoma. Blood. Feb 1993, 81 (1): 136–42. PMID 8417785.
^Kihara A, Igarashi Y. FVT-1 is a mammalian 3-ketodihydrosphingosine reductase with an active site that faces the cytosolic side of the endoplasmic reticulum membrane. J Biol Chem. Nov 2004, 279 (47): 49243–50. PMID 15328338. doi:10.1074/jbc.M405915200.
^Krebs S, Medugorac I, Rother S, Strasser K, Forster M. A missense mutation in the 3-ketodihydrosphingosine reductase FVT1 as candidate causal mutation for bovine spinal muscular atrophy. Proc Natl Acad Sci U S A. Apr 2007, 104 (16): 6746–51. PMC 1868895. PMID 17420465. doi:10.1073/pnas.0607721104.
^Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U. The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative. Chem Biol Interact. Feb 2009, 178 (1–3): 94–8. PMC 2896744. PMID 19027726. doi:10.1016/j.cbi.2008.10.040.
Stoffel W, LeKim D, Sticht G. Biosynthesis of dihydrosphingosine in vitro. Hoppe. Seylers. Z. Physiol. Chem. 1968, 349: 664–670. PMID 4386961.
Stoffel W, LeKim D, Sticht G. Metabolism of sphingosine bases. 8. Distribution, isolation and properties of D-3-oxosphinganine reductase. Stereospecificity of the NADPH-dependent reaction of 3-oxodihydrospingosine (2-amino-1-hydroxyoctadecane-3-one). Hoppe. Seylers. Z. Physiol. Chem. 1968, 349: 1637–1644. PMID 4387676. doi:10.1515/bchm2.1968.349.2.1637.
扩展阅读编辑
Quintero-Ramos A; Valdez-Vélázquez LL; Hernández G; et al. Assessment of five thrombophilic genetic polymorphisms among couples with habitual abortion. Gaceta médica de México. 2006, 142 (2): 95–8. PMID 16711541.
Gerhard DS; Wagner L; Feingold EA; et al. The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC). Genome Res. 2004, 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504.
Ota T; Suzuki Y; Nishikawa T; et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. 2004, 36 (1): 40–45. PMID 14702039. doi:10.1038/ng1285.
Wang J; Blakey GL; Zhang L; et al. Uterine tumor resembling ovarian sex cord tumor: report of a case with t(X;6)(p22.3;q23.1) and t(4;18)(q21.1;q21.3). Diagn. Mol. Pathol. 2004, 12 (3): 174–80. PMID 12960700.
Strausberg RL; Feingold EA; Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899.
Nacheva E; Dyer MJ; Metivier C; et al. B-cell non-Hodgkin's lymphoma cell line (Karpas 1106) with complex translocation involving 18q21.3 but lacking BCL2 rearrangement and expression. Blood. 1994, 84 (10): 3422–8. PMID 7949096.
一月 01, 1970
脱氢鞘氨酸还原酶, 英語, dehydrosphinganine, reductase, 页面存档备份, 存于互联网档案馆, 也称为, 滤泡变异易位蛋白1, 是一种以nad, 或nadp, 为受体, 作用于供体ch, oh基团上的氧化还原酶, 这种酶能催化以下酶促反应, 命名, 系统命名, erythro, dihydrosphingosine, nadp, oxidoreductase, 缩写, kdsr, fvt1, 别名, dehydrosphinganine, reductase, oxosphingani. 3 脱氢鞘氨酸还原酶 英語 3 dehydrosphinganine reductase EC 1 1 1 102 页面存档备份 存于互联网档案馆 也称为 滤泡变异易位蛋白1 是一种以NAD 或NADP 为受体 作用于供体CH OH基团上的氧化还原酶 这种酶能催化以下酶促反应 3 脱氢鞘氨酸还原酶 命名 系统命名 D erythro dihydrosphingosine NADP 3 oxidoreductase 缩写 KDSR FVT1 别名 D 3 dehydrosphinganine reductase D 3 oxosphinganine reductase DSR 3 oxosphinganine reductase 3 oxosphinganine NADPH oxidoreductase D 3 oxosphinganine B NADPH oxidoreductase follicular variant translocation protein 1 识别码 EC編號 1 1 1 102 CAS号 37250 36 5 数据库 IntEnz IntEnz浏览 BRENDA 英语 BRENDA BRENDA入口 ExPASy 英语 ExPASy NiceZyme浏览 KEGG KEGG入口 MetaCyc 英语 MetaCyc 代谢路径 PRIAM 英语 PRIAM enzyme specific profiles 概述 PDB RCSB PDB PDBj PDBe PDBsum 基因本体 AmiGO EGO 搜索 PMC 相关文献 PubMed 相关文献 3 脱氢鞘氨酸还原酶标识代号KDSR DHSR FVT1 SDR35C1扩展标识遗传学 136440 鼠基因 1918000 同源基因 1539 GeneCards KDSR GeneEC編號1 1 1 102基因本体论描述 分子功能 nucleotide binding 3 dehydrosphinganine reductase activity 细胞成分 extracellular space endoplasmic reticulum endoplasmic reticulum membrane integral to membrane 生物过程 sphingolipid metabolic process 3 keto sphinganine metabolic process sphingolipid biosynthetic process small molecule metabolic process Sources Amigo QuickGORNA表达模式更多表达数据直系同源体物种人类小鼠Entrez253170750EnsemblENSG00000119537ENSMUSG00000009905UniProtQ06136Q6GV12mRNA序列NM 002035 2NM 027534 2蛋白序列NP 002026 1NP 081810 1基因位置Chr 18 60 99 61 03 MbChr 1 108 62 108 66 MbPubMed查询 1 2 查论编 鞘氨酸 NADP displaystyle rightleftharpoons 3 脱氢鞘氨酸 NADPH H 3 脱氢鞘氨酸还原酶主要参与鞘脂 sphingolipid 的代谢过程 人类的3 脱氢鞘氨酸还原酶由18号染色体上的基因KDSR编码 1 2 3 4 5 这种蛋白仅在血细胞生成 haematopoiesis 组织中少量表达 参考文献 编辑 Rimokh R Gadoux M Bertheas MF Berger F Garoscio M Deleage G Germain D Magaud JP FVT 1 a novel human transcription unit affected by variant translocation t 2 18 p11 q21 of follicular lymphoma Blood Feb 1993 81 1 136 42 PMID 8417785 Kihara A Igarashi Y FVT 1 is a mammalian 3 ketodihydrosphingosine reductase with an active site that faces the cytosolic side of the endoplasmic reticulum membrane J Biol Chem Nov 2004 279 47 49243 50 PMID 15328338 doi 10 1074 jbc M405915200 Krebs S Medugorac I Rother S Strasser K Forster M A missense mutation in the 3 ketodihydrosphingosine reductase FVT1 as candidate causal mutation for bovine spinal muscular atrophy Proc Natl Acad Sci U S A Apr 2007 104 16 6746 51 PMC 1868895 nbsp PMID 17420465 doi 10 1073 pnas 0607721104 Persson B Kallberg Y Bray JE Bruford E Dellaporta SL Favia AD Duarte RG Jornvall H Kavanagh KL Kedishvili N Kisiela M Maser E Mindnich R Orchard S Penning TM Thornton JM Adamski J Oppermann U The SDR Short Chain Dehydrogenase Reductase and Related Enzymes Nomenclature Initiative Chem Biol Interact Feb 2009 178 1 3 94 8 PMC 2896744 nbsp PMID 19027726 doi 10 1016 j cbi 2008 10 040 Entrez Gene FVT1 follicular lymphoma variant translocation 1 Stoffel W LeKim D Sticht G Biosynthesis of dihydrosphingosine in vitro Hoppe Seylers Z Physiol Chem 1968 349 664 670 PMID 4386961 Stoffel W LeKim D Sticht G Metabolism of sphingosine bases 8 Distribution isolation and properties of D 3 oxosphinganine reductase Stereospecificity of the NADPH dependent reaction of 3 oxodihydrospingosine 2 amino 1 hydroxyoctadecane 3 one Hoppe Seylers Z Physiol Chem 1968 349 1637 1644 PMID 4387676 doi 10 1515 bchm2 1968 349 2 1637 扩展阅读 编辑Quintero Ramos A Valdez Velazquez LL Hernandez G et al Assessment of five thrombophilic genetic polymorphisms among couples with habitual abortion Gaceta medica de Mexico 2006 142 2 95 8 PMID 16711541 Gerhard DS Wagner L Feingold EA et al The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 2004 14 10B 2121 7 PMC 528928 nbsp PMID 15489334 doi 10 1101 gr 2596504 Ota T Suzuki Y Nishikawa T et al Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 2004 36 1 40 45 PMID 14702039 doi 10 1038 ng1285 Wang J Blakey GL Zhang L et al Uterine tumor resembling ovarian sex cord tumor report of a case with t X 6 p22 3 q23 1 and t 4 18 q21 1 q21 3 Diagn Mol Pathol 2004 12 3 174 80 PMID 12960700 Strausberg RL Feingold EA Grouse LH et al Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 2003 99 26 16899 903 PMC 139241 nbsp PMID 12477932 doi 10 1073 pnas 242603899 Nacheva E Dyer MJ Metivier C et al B cell non Hodgkin s lymphoma cell line Karpas 1106 with complex translocation involving 18q21 3 but lacking BCL2 rearrangement and expression Blood 1994 84 10 3422 8 PMID 7949096 取自 https zh wikipedia org w index php title 3 脱氢鞘氨酸还原酶 amp oldid 81162287, 维基百科，wiki，书籍，书籍，图书馆，
