^ 3.03.13.2GRCh38: Ensembl release 89: ENSG00000282608 - Ensembl, May 2017
^ 4.04.14.2GRCm38: Ensembl release 89: ENSMUSG00000000562 - Ensembl, May 2017
^Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
延伸閱讀编辑
Klotz KN. Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch. Pharmacol. 2001, 362 (4–5): 382–91. PMID 11111832. S2CID 12938732. doi:10.1007/s002100000315.
Monitto CL, Levitt RC, DiSilvestre D, Holroyd KJ. Localization of the A3 adenosine receptor gene (ADORA3) to human chromosome 1p. Genomics. 1995, 26 (3): 637–8. PMID 7607699. doi:10.1016/0888-7543(95)80194-Q.
Salvatore CA, Jacobson MA, Taylor HE, et al. Molecular cloning and characterization of the human A3 adenosine receptor. Proc. Natl. Acad. Sci. U.S.A. 1993, 90 (21): 10365–9. PMC 47775. PMID 8234299. doi:10.1073/pnas.90.21.10365.
Sajjadi FG, Firestein GS. cDNA cloning and sequence analysis of the human A3 adenosine receptor. Biochim. Biophys. Acta. 1993, 1179 (1): 105–7. PMID 8399349. doi:10.1016/0167-4889(93)90077-3.
Murrison EM, Goodson SJ, Edbrooke MR, Harris CA. Cloning and characterisation of the human adenosine A3 receptor gene. FEBS Lett. 1996, 384 (3): 243–6. PMID 8617363. S2CID 3170758. doi:10.1016/0014-5793(96)00324-9.
Bonaldo MF, Lennon G, Soares MB. Normalization and subtraction: two approaches to facilitate gene discovery. Genome Res. 1997, 6 (9): 791–806. PMID 8889548. doi:10.1101/gr.6.9.791.
Bouma MG, Jeunhomme TM, Boyle DL, et al. Adenosine inhibits neutrophil degranulation in activated human whole blood: involvement of adenosine A2 and A3 receptors. J. Immunol. 1997, 158 (11): 5400–8. PMID 9164961.
Atkinson MR, Townsend-Nicholson A, Nicholl JK, et al. Cloning, characterisation and chromosomal assignment of the human adenosine A3 receptor (ADORA3) gene. Neurosci. Res. 1998, 29 (1): 73–9. PMID 9293494. S2CID 36060683. doi:10.1016/S0168-0102(97)00073-4.
Palmer TM, Harris CA, Coote J, Stiles GL. Induction of multiple effects on adenylyl cyclase regulation by chronic activation of the human A3 adenosine receptor. Mol. Pharmacol. 1997, 52 (4): 632–40. PMID 9380026. doi:10.1124/mol.52.4.632.
Liang BT, Jacobson KA. A physiological role of the adenosine A3 receptor: Sustained cardioprotection. Proc. Natl. Acad. Sci. U.S.A. 1998, 95 (12): 6995–9. PMC 22715. PMID 9618527. doi:10.1073/pnas.95.12.6995.
Dougherty C, Barucha J, Schofield PR, et al. Cardiac myocytes rendered ischemia resistant by expressing the human adenosine A1 or A3 receptor. FASEB J. 1999, 12 (15): 1785–92. PMC 5550893. PMID 9837869. doi:10.1096/fasebj.12.15.1785.
Murphy WJ, Eizirik E, Johnson WE, et al. Molecular phylogenetics and the origins of placental mammals. Nature. 2001, 409 (6820): 614–8. PMID 11214319. S2CID 4373847. doi:10.1038/35054550.
Gao ZG, Chen A, Barak D, et al. Identification by site-directed mutagenesis of residues involved in ligand recognition and activation of the human A3 adenosine receptor. J. Biol. Chem. 2002, 277 (21): 19056–63. PMC 5602557. PMID 11891221. doi:10.1074/jbc.M110960200.
Broussas M, Cornillet-Lefèbvre P, Potron G, Nguyên P. Adenosine inhibits tissue factor expression by LPS-stimulated human monocytes: involvement of the A3 adenosine receptor. Thromb. Haemost. 2003, 88 (1): 123–30. PMID 12152652. doi:10.1055/s-0037-1613164.
Merighi S, Mirandola P, Milani D, et al. Adenosine receptors as mediators of both cell proliferation and cell death of cultured human melanoma cells. J. Invest. Dermatol. 2002, 119 (4): 923–33. PMID 12406340. doi:10.1046/j.1523-1747.2002.00111.x.
Trincavelli ML, Tuscano D, Marroni M, et al. A3 adenosine receptors in human astrocytoma cells: agonist-mediated desensitization, internalization, and down-regulation. Mol. Pharmacol. 2002, 62 (6): 1373–84. PMC 4806643. PMID 12435805. doi:10.1124/mol.62.6.1373.
Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899.
Feoktistov I, Ryzhov S, Goldstein AE, Biaggioni I. Mast cell-mediated stimulation of angiogenesis: cooperative interaction between A2B and A3 adenosine receptors. Circ. Res. 2003, 92 (5): 485–92. PMID 12600879. doi:10.1161/01.RES.0000061572.10929.2D.
Gao ZG, Kim SK, Gross AS, et al. Identification of essential residues involved in the allosteric modulation of the human A(3) adenosine receptor. Mol. Pharmacol. 2003, 63 (5): 1021–31. PMC 4367541. PMID 12695530. doi:10.1124/mol.63.5.1021.
外部連結编辑
Adenosine Receptors: A3. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. （原始内容于2020-11-30）.
Human ADORA3 genome location and ADORA3 gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）.
十月 19, 2023
腺苷a, 受體, 此條目目前正依照en, adenosine, receptor上的内容进行翻译, 2020年11月1日, 如果您擅长翻译, 並清楚本條目的領域, 欢迎协助翻譯, 改善或校对本條目, 此外, 长期闲置, 未翻譯或影響閱讀的内容可能会被移除, 此條目可参照英語維基百科相應條目来扩充, 若您熟悉来源语言和主题, 请协助参考外语维基百科扩充条目, 请勿直接提交机械翻译, 也不要翻译不可靠, 低品质内容, 依版权协议, 译文需在编辑摘要注明来源, 或于讨论页顶部标记, href, template, tra. 此條目目前正依照en Adenosine A3 receptor上的内容进行翻译 2020年11月1日 如果您擅长翻译 並清楚本條目的領域 欢迎协助翻譯 改善或校对本條目 此外 长期闲置 未翻譯或影響閱讀的内容可能会被移除 此條目可参照英語維基百科相應條目来扩充 若您熟悉来源语言和主题 请协助参考外语维基百科扩充条目 请勿直接提交机械翻译 也不要翻译不可靠 低品质内容 依版权协议 译文需在编辑摘要注明来源 或于讨论页顶部标记 a href Template Translated page html title Template Translated page Translated page a 标签 腺苷A3受體 Adenosine A3 receptor 也稱為ADORA3 是一種腺苷受體 也表示編碼它的人類基因 腺苷A3受體已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表1OEA 1R7N識別號别名ADORA3 A3AR AD026 bA552M11 5 adenosine A3 receptor外部IDOMIM 600445 MGI 104847 HomoloGene 550 GeneCards ADORA3相關疾病肥胖症 1 為以下藥物的標靶腺苷 BAY 60 6583 Regadenoson CCPA CGS 21680 cyclopentyladenosine 咖啡因 CGS 15943 8 cyclopentyl 1 3 dipropylxanthine flavone 高良姜素 istradefylline 尼卡地平 瑞德南特 rolofylline sakuranetin sch 442416 sch 58261 茶碱 ZM 241385 腺苷 cf 102 2 基因位置 人类 染色体1號染色體 3 基因座1p13 2起始111 499 429 bp 3 终止111 503 633 bp 3 基因位置 小鼠 染色体小鼠3号染色体 4 基因座3 F2 2 3 46 45 cM起始105 778 174 bp 4 终止105 816 242 bp 4 RNA表达模式查阅更多表达数据基因本體分子功能 G protein coupled adenosine receptor activity G protein coupled receptor activity signal transducer activity細胞組分 integral component of membrane 细胞膜 膜 integral component of plasma membrane生物學過程 G protein coupled adenosine receptor signaling pathway inflammatory response 訊息傳遞 activation of adenylate cyclase activity regulation of heart contraction response to wounding negative regulation of cell population proliferation negative regulation of cell migration negative regulation of NF kappaB transcription factor activity G protein coupled receptor signaling pathwaySources Amigo QuickGO直系同源物種人類小鼠Entrez14011542EnsemblENSG00000282608ENSMUSG00000000562UniProtP0DMS8Q61618 Q3U4C5mRNA 序列NM 001302679 NM 000677 NM 001302678NM 009631蛋白序列NP 000668 NP 001289607 NP 001289608NP 033761基因位置 UCSC Chr 1 111 5 111 5 MbChr 3 105 78 105 82 MbPubMed 查找 5 6 維基數據檢視 編輯人類檢視 編輯小鼠參考資料 编辑 與腺苷A3受體相關的疾病 在維基數據上查看 編輯參考 對Adenosine A3 receptor起作用的藥物 在維基數據上查看 編輯參考 3 0 3 1 3 2 GRCh38 Ensembl release 89 ENSG00000282608 Ensembl May 2017 4 0 4 1 4 2 GRCm38 Ensembl release 89 ENSMUSG00000000562 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine 延伸閱讀 编辑Klotz KN Adenosine receptors and their ligands Naunyn Schmiedebergs Arch Pharmacol 2001 362 4 5 382 91 PMID 11111832 S2CID 12938732 doi 10 1007 s002100000315 Monitto CL Levitt RC DiSilvestre D Holroyd KJ Localization of the A3 adenosine receptor gene ADORA3 to human chromosome 1p Genomics 1995 26 3 637 8 PMID 7607699 doi 10 1016 0888 7543 95 80194 Q Salvatore CA Jacobson MA Taylor HE et al Molecular cloning and characterization of the human A3 adenosine receptor Proc Natl Acad Sci U S A 1993 90 21 10365 9 PMC 47775 nbsp PMID 8234299 doi 10 1073 pnas 90 21 10365 Sajjadi FG Firestein GS cDNA cloning and sequence analysis of the human A3 adenosine receptor Biochim Biophys Acta 1993 1179 1 105 7 PMID 8399349 doi 10 1016 0167 4889 93 90077 3 Murrison EM Goodson SJ Edbrooke MR Harris CA Cloning and characterisation of the human adenosine A3 receptor gene FEBS Lett 1996 384 3 243 6 PMID 8617363 S2CID 3170758 doi 10 1016 0014 5793 96 00324 9 Bonaldo MF Lennon G Soares MB Normalization and subtraction two approaches to facilitate gene discovery Genome Res 1997 6 9 791 806 PMID 8889548 doi 10 1101 gr 6 9 791 nbsp Bouma MG Jeunhomme TM Boyle DL et al Adenosine inhibits neutrophil degranulation in activated human whole blood involvement of adenosine A2 and A3 receptors J Immunol 1997 158 11 5400 8 PMID 9164961 Atkinson MR Townsend Nicholson A Nicholl JK et al Cloning characterisation and chromosomal assignment of the human adenosine A3 receptor ADORA3 gene Neurosci Res 1998 29 1 73 9 PMID 9293494 S2CID 36060683 doi 10 1016 S0168 0102 97 00073 4 Palmer TM Harris CA Coote J Stiles GL Induction of multiple effects on adenylyl cyclase regulation by chronic activation of the human A3 adenosine receptor Mol Pharmacol 1997 52 4 632 40 PMID 9380026 doi 10 1124 mol 52 4 632 Liang BT Jacobson KA A physiological role of the adenosine A3 receptor Sustained cardioprotection Proc Natl Acad Sci U S A 1998 95 12 6995 9 PMC 22715 nbsp PMID 9618527 doi 10 1073 pnas 95 12 6995 Dougherty C Barucha J Schofield PR et al Cardiac myocytes rendered ischemia resistant by expressing the human adenosine A1 or A3 receptor FASEB J 1999 12 15 1785 92 PMC 5550893 nbsp PMID 9837869 doi 10 1096 fasebj 12 15 1785 Murphy WJ Eizirik E Johnson WE et al Molecular phylogenetics and the origins of placental mammals Nature 2001 409 6820 614 8 PMID 11214319 S2CID 4373847 doi 10 1038 35054550 Gao ZG Chen A Barak D et al Identification by site directed mutagenesis of residues involved in ligand recognition and activation of the human A3 adenosine receptor J Biol Chem 2002 277 21 19056 63 PMC 5602557 nbsp PMID 11891221 doi 10 1074 jbc M110960200 Broussas M Cornillet Lefebvre P Potron G Nguyen P Adenosine inhibits tissue factor expression by LPS stimulated human monocytes involvement of the A3 adenosine receptor Thromb Haemost 2003 88 1 123 30 PMID 12152652 doi 10 1055 s 0037 1613164 Merighi S Mirandola P Milani D et al Adenosine receptors as mediators of both cell proliferation and cell death of cultured human melanoma cells J Invest Dermatol 2002 119 4 923 33 PMID 12406340 doi 10 1046 j 1523 1747 2002 00111 x Trincavelli ML Tuscano D Marroni M et al A3 adenosine receptors in human astrocytoma cells agonist mediated desensitization internalization and down regulation Mol Pharmacol 2002 62 6 1373 84 PMC 4806643 nbsp PMID 12435805 doi 10 1124 mol 62 6 1373 Strausberg RL Feingold EA Grouse LH et al Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 2003 99 26 16899 903 PMC 139241 nbsp PMID 12477932 doi 10 1073 pnas 242603899 Feoktistov I Ryzhov S Goldstein AE Biaggioni I Mast cell mediated stimulation of angiogenesis cooperative interaction between A2B and A3 adenosine receptors Circ Res 2003 92 5 485 92 PMID 12600879 doi 10 1161 01 RES 0000061572 10929 2D nbsp Gao ZG Kim SK Gross AS et al Identification of essential residues involved in the allosteric modulation of the human A 3 adenosine receptor Mol Pharmacol 2003 63 5 1021 31 PMC 4367541 nbsp PMID 12695530 doi 10 1124 mol 63 5 1021 外部連結 编辑Adenosine Receptors A3 IUPHAR Database of Receptors and Ion Channels International Union of Basic and Clinical Pharmacology 原始内容存档于2020 11 30 Human ADORA3 genome location and ADORA3 gene details page in the UCSC Genome Browser 英语 UCSC Genome Browser 取自 https zh wikipedia org w index php title 腺苷A3受體 amp oldid 74980631, 维基百科，wiki，书籍，书籍，图书馆，
