· extracellular region · cytoplasmic membrane-bounded vesicle
生物过程
· ureteric bud development
· anti-apoptosis · nervous system development · negative regulation of neuroblast proliferation · axon guidance · axon target recognition · learning or memory · feeding behavior · neuron recognition · glutamate secretion · dendrite development · regulation of metabolic process · nerve development · mechanoreceptor differentiation · response to drug · fear response · negative regulation of neuron apoptosis · positive regulation of neuron differentiation · regulation of retinal cell programmed cell death · regulation of synaptic plasticity
^Girotra P, Behl T, Sehgal A, Singh S, Bungau S. Investigation of the Molecular Role of Brain-Derived Neurotrophic Factor in Alzheimer's Disease. J Mol Neurosci. 2022 Feb;72(2):173-186. doi: 10.1007/s12031-021-01824-8. Epub 2021 Aug 23. PMID 34424488.
延伸閱讀
Fawzi MH, Kira IA, Fawzi MM, Mohamed HE, Fawzi MM. Trauma profile in Egyptian adolescents with first-episode schizophrenia: relation to psychopathology and plasma brain-derived neurotrophic factor. J. Nerv. Ment. Dis. January 2013, 201 (1): 23–9. PMID 23274291. doi:10.1097/NMD.0b013e31827ab268.
Vaynman S, Gomez-Pinilla F. Revenge of the "sit": how lifestyle impacts neuronal and cognitive health through molecular systems that interface energy metabolism with neuronal plasticity. J. Neurosci. Res. September 2006, 84 (4): 699–715. PMID 16862541. doi:10.1002/jnr.20979.
van Praag H, Christie BR, Sejnowski TJ, Gage FH. Running enhances neurogenesis, learning, and long-term potentiation in mice. Proc. Natl. Acad. Sci. U.S.A. November 1999, 96 (23): 13427–31. PMC 23964. PMID 10557337.
Gómez-Pinilla F, Ying Z, Roy RR, Molteni R, Edgerton VR. Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity. J. Neurophysiol. November 2002, 88 (5): 2187–95. PMID 12424260. doi:10.1152/jn.00152.2002.
Meerwijk, Esther L., Judith M. Ford, and Sandra J. Weiss. Brain regions associated with psychological pain: implications for a neural network and its relationship to physical pain. Brain imaging and behavior. 2013, 7 (1): 1–14. PMID 12424260. doi:10.1007/s11682-012-9179-y.
外部連結
Cotman CW, Berchtold NC. . Alzforum: Live Discussions. Alzheimer Research Forum. 2004-01-28 [2008-08-21]. （原始内容存档于2008-10-11）.
Patten-Hitt E. . Sciencexpress. The HDLighthouse, Huntingtons Disease: Information and Community. 2001-06-14 [2008-08-21]. （原始内容存档于2008-07-25）.
脑源性神经营养因子, brain, derived, neurotrophic, factor, bdnf, abrineurin, 是人脑中的一种蛋白质, 由基因生成, 是神经营养因子中的一种, 这种因子存在于人的神经系统中, rendering, based, 1bnd, 有效结构pdb, 直系同源检索, pdbe, rcsbpdb查询代码列表1b8m, 1bnd标识代号bdnf, mgc34632扩展标识遗传学, 113505, 鼠基因, 88145, 同源基因, 7245, genecards, bdnf,. 脑源性神经营养因子 brain derived neurotrophic factor BDNF abrineurin 1 是人脑中的一种蛋白质 由脑源性神经营养因子基因生成 脑源性神经营养因子是神经营养因子中的一种 这种因子存在于人的神经系统中 脑源性神经营养因子PDB rendering based on 1bnd 有效结构PDB 直系同源检索 PDBe RCSBPDB查询代码列表1B8M 1BND标识代号BDNF MGC34632扩展标识遗传学 113505 鼠基因 88145 同源基因 7245 GeneCards BDNF Gene基因本体论描述分子功能 protein binding growth factor activity细胞成分 extracellular region cytoplasmic membrane bounded vesicle生物过程 ureteric bud development anti apoptosis nervous system development negative regulation of neuroblast proliferation axon guidance axon target recognition learning or memory feeding behavior neuron recognition glutamate secretion dendrite development regulation of metabolic process nerve development mechanoreceptor differentiation response to drug fear response negative regulation of neuron apoptosis positive regulation of neuron differentiation regulation of retinal cell programmed cell death regulation of synaptic plasticity inner ear developmentSources Amigo QuickGORNA表达模式更多表达数据直系同源体物种人类小鼠Entrez62712064EnsemblENSG00000176697ENSMUSG00000048482UniProtP23560Q541P3mRNA序列NM 001143805 1NM 001048139蛋白序列NP 001137277 1NP 001041604基因位置Chr 11 27 68 27 74 MbChr 2 109 51 109 57 MbPubMed查询 1 2 查论编BDNF是大腦中含量最豐富的蛋白質 在腦部可以促進神經元 神經細胞 的生長 也促進大腦神經細胞突觸的成形 簡單來說 就是大腦非常需要的營養蛋白質 研究顯示 在大腦中掌管記憶的海馬迴中含有特別豐富的 BDNF 對於突觸的生長以及長期記憶也非常重要 已經有許多國際研究顯示 缺乏 BDNF 將可能造成一些認知功能障礙 例如阿茲海默症 此為常見的退化性失智症之一 另外 若長期處於壓力大或憂鬱的狀態 也可能會抑制大腦 BDNF 的分泌 影響記憶及認知功能 甚至於導致自律神經失調或海馬迴萎縮等更嚴重的問題 註釋 编辑 Girotra P Behl T Sehgal A Singh S Bungau S Investigation of the Molecular Role of Brain Derived Neurotrophic Factor in Alzheimer s Disease J Mol Neurosci 2022 Feb 72 2 173 186 doi 10 1007 s12031 021 01824 8 Epub 2021 Aug 23 PMID 34424488 延伸閱讀 编辑Fawzi MH Kira IA Fawzi MM Mohamed HE Fawzi MM Trauma profile in Egyptian adolescents with first episode schizophrenia relation to psychopathology and plasma brain derived neurotrophic factor J Nerv Ment Dis January 2013 201 1 23 9 PMID 23274291 doi 10 1097 NMD 0b013e31827ab268 Vaynman S Gomez Pinilla F Revenge of the sit how lifestyle impacts neuronal and cognitive health through molecular systems that interface energy metabolism with neuronal plasticity J Neurosci Res September 2006 84 4 699 715 PMID 16862541 doi 10 1002 jnr 20979 van Praag H Christie BR Sejnowski TJ Gage FH Running enhances neurogenesis learning and long term potentiation in mice Proc Natl Acad Sci U S A November 1999 96 23 13427 31 PMC 23964 PMID 10557337 Gomez Pinilla F Ying Z Roy RR Molteni R Edgerton VR Voluntary exercise induces a BDNF mediated mechanism that promotes neuroplasticity J Neurophysiol November 2002 88 5 2187 95 PMID 12424260 doi 10 1152 jn 00152 2002 Meerwijk Esther L Judith M Ford and Sandra J Weiss Brain regions associated with psychological pain implications for a neural network and its relationship to physical pain Brain imaging and behavior 2013 7 1 1 14 PMID 12424260 doi 10 1007 s11682 012 9179 y 外部連結 编辑Cotman CW Berchtold NC BDNF and Alzheimer s Disease What s the Connection Alzforum Live Discussions Alzheimer Research Forum 2004 01 28 2008 08 21 原始内容存档于2008 10 11 Patten Hitt E Brain Derived Neurotrophic Factor BDNF Sciencexpress The HDLighthouse Huntingtons Disease Information and Community 2001 06 14 2008 08 21 原始内容存档于2008 07 25 Highfield R Brain scans could reveal mental strength Science Telegraph co uk 2007 10 18 2008 08 21 原始内容存档于2008 05 31 Low BDNF activity promotes resilience Template Nerve growth factor family 取自 https zh wikipedia org w index php title 脑源性神经营养因子 amp oldid 74827925, 维基百科，wiki，书籍，书籍，图书馆，
