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^Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S. The protein kinase complement of the human genome. Science. December 2002, 298 (5600): 1912–34. PMID 12471243. doi:10.1126/science.1075762.
延伸阅读
Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899. 引文格式1维护：显式使用等标签 (link)
Gerhard DS, Wagner L, Feingold EA; et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504. 引文格式1维护：显式使用等标签 (link)
Clayburgh DR, Rosen S, Witkowski ED; et al. A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability.. J. Biol. Chem. 2005, 279 (53): 55506–13. PMC 1237105. PMID 15507455. doi:10.1074/jbc.M408822200. 引文格式1维护：显式使用等标签 (link)
Wang F, Graham WV, Wang Y; et al. Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression.. Am. J. Pathol. 2005, 166 (2): 409–19. PMC 1237049. PMID 15681825. doi:10.1016/S0002-9440(10)62264-X. 引文格式1维护：显式使用等标签 (link)
Russo JM, Florian P, Shen L; et al. Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure.. Gastroenterology. 2005, 128 (4): 987–1001. PMC 1237051. PMID 15825080. doi:10.1053/j.gastro.2005.01.004. 引文格式1维护：显式使用等标签 (link)
Shimizu S, Yoshida T, Wakamori M; et al. Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells.. J. Physiol. (Lond.). 2006, 570 (Pt 2): 219–35. PMC 1464317. PMID 16284075. doi:10.1113/jphysiol.2005.097998. 引文格式1维护：显式使用等标签 (link)
Kim MT, Kim BJ, Lee JH; et al. Involvement of calmodulin and myosin light chain kinase in activation of mTRPC5 expressed in HEK cells.. Am. J. Physiol., Cell Physiol. 2006, 290 (4): C1031–40. PMID 16306123. doi:10.1152/ajpcell.00602.2004. 引文格式1维护：显式使用等标签 (link)
Kimura K, Wakamatsu A, Suzuki Y; et al. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.. Genome Res. 2006, 16 (1): 55–65. PMC 1356129. PMID 16344560. doi:10.1101/gr.4039406. 引文格式1维护：显式使用等标签 (link)
Connell LE, Helfman DM. Myosin light chain kinase plays a role in the regulation of epithelial cell survival.. J. Cell. Sci. 2007, 119 (Pt 11): 2269–81. PMID 16723733. doi:10.1242/jcs.02926.
Seguchi O, Takashima S, Yamazaki S; et al. A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart.. J. Clin. Invest. 2007, 117 (10): 2812–24. PMC 1978424. PMID 17885681. doi:10.1172/JCI30804. 引文格式1维护：显式使用等标签 (link)
肌球蛋白轻链激酶, 英語, myosin, light, chain, kinase, mylk, mlck, 是一类丝氨酸, 苏氨酸特异性蛋白激酶, 通过磷酸化来调节ii型肌球蛋白的轻链, 肌球蛋白輕多肽激酶, 平滑肌識別符號, mylkentrez, 4638hugo, 7590omim, 600922refseq, 053025uniprot, q15746其他資料ec編號, 18基因座, qcen, q21myosin, light, chain, kinase, skeletal, musclecryst. 肌球蛋白轻链激酶 英語 Myosin light chain kinase MYLK 或 MLCK 是一类丝氨酸 苏氨酸特异性蛋白激酶 通过磷酸化来调节II型肌球蛋白的轻链 3 肌球蛋白輕多肽激酶 平滑肌識別符號 MYLKEntrez 4638HUGO 7590OMIM 600922RefSeq NM 053025UniProt Q15746其他資料EC編號 2 7 11 18基因座 3 qcen q21myosin light chain kinase 2 skeletal muscleCrystal structure of the S dubia centrin human skeletal muscle myosin light chain complex 1 識別符號 MYLK2Entrez 85366HUGO 16243OMIM 606566RefSeq NM 033118UniProt Q9H1R3其他資料基因座 20 q13 31myosin light chain kinase 3 cardiac識別符號 MYLK3Entrez 91807HUGO 29826OMIM 612147RefSeq NM 182493UniProt Q32MK0其他資料基因座 16 q11 2人類肌球蛋白輕鏈激酶The Crystal Structure of the Human Myosin Light Chain Kinase Loc340156 2 識別符號 MYLK4Entrez 340156HUGO 27972RefSeq NM 001012418UniProt Q86YV6其他資料 目录 1 亚型 2 功能 3 另见 4 参考文献 5 延伸阅读 6 外部链接亚型 编辑现存四种MLCK亚型 4 主要分布于不同肌细胞 MYLK 平滑肌 MYLK2 骨骼肌 MYLK3 心肌 MYLK4 未知功能 编辑另见 编辑蛋白激酶A参考文献 编辑 RCSB Protein Data Bank Structure Summary for 3KF9 Crystal structure of the SdCen skMLCK complex 原始内容存档于2017 06 30 RCSB Protein Data Bank Structure Summary for 2X4F The Crystal Structure of the Human Myosin Light Chain Kinase Loc340156 原始内容存档于2017 06 30 Gao Y Ye LH Kishi H Okagaki T Samizo K Nakamura A Kohama K Myosin light chain kinase as a multifunctional regulatory protein of smooth muscle contraction IUBMB Life June 2001 51 6 337 44 PMID 11758800 doi 10 1080 152165401753366087 Manning G Whyte DB Martinez R Hunter T Sudarsanam S The protein kinase complement of the human genome Science December 2002 298 5600 1912 34 PMID 12471243 doi 10 1126 science 1075762 延伸阅读 编辑Strausberg RL Feingold EA Grouse LH et al Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 2003 99 26 16899 903 PMC 139241 PMID 12477932 doi 10 1073 pnas 242603899 引文格式1维护 显式使用等标签 link Gerhard DS Wagner L Feingold EA et al The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 2004 14 10B 2121 7 PMC 528928 PMID 15489334 doi 10 1101 gr 2596504 引文格式1维护 显式使用等标签 link Clayburgh DR Rosen S Witkowski ED et al A differentiation dependent splice variant of myosin light chain kinase MLCK1 regulates epithelial tight junction permeability J Biol Chem 2005 279 53 55506 13 PMC 1237105 PMID 15507455 doi 10 1074 jbc M408822200 引文格式1维护 显式使用等标签 link Wang F Graham WV Wang Y et al Interferon gamma and tumor necrosis factor alpha synergize to induce intestinal epithelial barrier dysfunction by up regulating myosin light chain kinase expression Am J Pathol 2005 166 2 409 19 PMC 1237049 PMID 15681825 doi 10 1016 S0002 9440 10 62264 X 引文格式1维护 显式使用等标签 link Russo JM Florian P Shen L et al Distinct temporal spatial roles for rho kinase and myosin light chain kinase in epithelial purse string wound closure Gastroenterology 2005 128 4 987 1001 PMC 1237051 PMID 15825080 doi 10 1053 j gastro 2005 01 004 引文格式1维护 显式使用等标签 link Shimizu S Yoshida T Wakamori M et al Ca2 calmodulin dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells J Physiol Lond 2006 570 Pt 2 219 35 PMC 1464317 PMID 16284075 doi 10 1113 jphysiol 2005 097998 引文格式1维护 显式使用等标签 link Kim MT Kim BJ Lee JH et al Involvement of calmodulin and myosin light chain kinase in activation of mTRPC5 expressed in HEK cells Am J Physiol Cell Physiol 2006 290 4 C1031 40 PMID 16306123 doi 10 1152 ajpcell 00602 2004 引文格式1维护 显式使用等标签 link Kimura K Wakamatsu A Suzuki Y et al Diversification of transcriptional modulation large scale identification and characterization of putative alternative promoters of human genes Genome Res 2006 16 1 55 65 PMC 1356129 PMID 16344560 doi 10 1101 gr 4039406 引文格式1维护 显式使用等标签 link Connell LE Helfman DM Myosin light chain kinase plays a role in the regulation of epithelial cell survival J Cell Sci 2007 119 Pt 11 2269 81 PMID 16723733 doi 10 1242 jcs 02926 Seguchi O Takashima S Yamazaki S et al A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart J Clin Invest 2007 117 10 2812 24 PMC 1978424 PMID 17885681 doi 10 1172 JCI30804 引文格式1维护 显式使用等标签 link 外部链接 编辑醫學主題詞表 MeSH MYLK protein human 醫學主題詞表 MeSH Myosin Light Chain Kinase肌球蛋白轻链激酶引用了美国国家医学图书馆提供的資料 这些資料属于公共领域 取自 https zh wikipedia org w index php title 肌球蛋白轻链激酶 amp oldid 72696551, 维基百科，wiki，书籍，书籍，图书馆，
