^PDB 2ddu; Nogi T, Yasui N, Hattori M, Iwasaki K, Takagi J. Structure of a signaling-competent reelin fragment revealed by X-ray crystallography and electron tomography. EMBO J. August 2006, 25 (15): 3675–83. PMC 1538547. PMID 16858396. doi:10.1038/sj.emboj.7601240.
The book: Fatemi, S. Hossein. Reelin Glycoprotein: Structure, Biology and Roles in Health and Disease. Berlin: Springer. 2008: 444 pages. ISBN 978-0-387-76760-4.
A review: Förster E, Jossin Y, Zhao S, Chai X, Frotscher M, Goffinet AM. Recent progress in understanding the role of Reelin in radial neuronal migration, with specific emphasis on the dentate gyrus. Eur. J. Neurosci. February 2006, 23 (4): 901–9. PMID 16519655. doi:10.1111/j.1460-9568.2006.04612.x.
. Rutgers University. [2008-08-23]. （原始内容存档于2008-07-25）. the scientist who discovered the reelin gene and protein
Figures and images编辑
Reelin gene expression in mice. Brain Gene Expression Map. St. Jude Children’s Research Hospital. [2008-08-23]. （原始内容存档于2005-01-23）.
Schematic representation of signaling through the LDLR family members apoER2 and VLDL receptor. [2008-08-23].[永久失效連結] – A figure from Beffert U, Stolt PC, Herz J. Functions of lipoprotein receptors in neurons. J. Lipid Res. March 2004, 45 (3): 403–9. PMID 14657206. doi:10.1194/jlr.R300017-JLR200.
Proposed mechanism by which mouse RELN promoter regulate reelin gene expression. Proc. Natl. Acad. Sci. USA. [2008-08-23]. （原始内容于2007-12-25）. – A figure from Dong E, Agis-Balboa RC, Simonini MV, Grayson DR, Costa E, Guidotti A. Reelin and glutamic acid decarboxylase67 promoter remodeling in an epigenetic methionine-induced mouse model of schizophrenia. Proc. Natl. Acad. Sci. U.S.A. August 2005, 102 (35): 12578–83. PMC 1194936. PMID 16113080. doi:10.1073/pnas.0505394102.
. [2008-08-23]. （原始内容存档于2007-12-24）. Pictorial rendition of the difference that the lack of reelin brings to the cortical structure – A figure from Magdaleno SM, Curran T. Brain development: integrins and the Reelin pathway. Curr. Biol. December 2001, 11 (24): R1032–5. PMID 11747842. doi:10.1016/S0960-9822(01)00618-2.
Effects of human and naturally occurring mouse RELN mutations on the predicted protein. Nature Genetics. [2008-08-23]. （原始内容于2007-12-15）. A figure from Hong SE; Shugart YY; Huang DT; et al. Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutations. Nat. Genet. September 2000, 26 (1): 93–6. PMID 10973257. doi:10.1038/79246.已忽略未知参数|author-separator= (帮助)
MRI analysis of chromosome 7q22-linked lissencephaly with cerebellar hypoplasia. Nature Genetics. [2008-08-23]. （原始内容于2007-12-15）. – A figure from Hong et al.
十二月 12, 2023
络丝蛋白, 英語, reelin, 是一种分泌于细胞外基质的大型糖蛋白, 用于在大脑的发育中通过细胞, 细胞相互作用调控神经元的迁移和定位, reelin第三重复域的晶体结构, 有效结构pdb, 直系同源检索, pdbe, rcsbpdb查询代码列表2ddu, 2e26标识代号reln, lis2, pro1598, rl扩展标识遗传学, 600514, 鼠基因, 103022, 同源基因, 3699, genecards, reln, geneec編號3, 基因本体论描述分子功能, protein, serine. 络丝蛋白 英語 Reelin 是一种分泌于细胞外基质的大型糖蛋白 用于在大脑的发育中通过细胞 细胞相互作用调控神经元的迁移和定位 Reelin络丝蛋白第三重复域的晶体结构 1 有效结构PDB 直系同源检索 PDBe RCSBPDB查询代码列表2ddu 2e26标识代号RELN LIS2 PRO1598 RL扩展标识遗传学 600514 鼠基因 103022 同源基因 3699 GeneCards RELN GeneEC編號3 4 21 基因本体论描述分子功能 protein serine threonine tyrosine kinase activity serine type peptidase activity metal ion binding lipoprotein particle receptor binding very low density lipoprotein particle receptor binding细胞成分 proteinaceous extracellular matrix extracellular space cytoplasm dendrite生物过程 cell morphogenesis involved in differentiation neuron migration proteolysis cell adhesion axon guidance central nervous system development brain development long term memory associative learning glial cell differentiation positive regulation of neuron projection development positive regulation of phosphatidylinositol 3 kinase cascade dendrite development peptidyl tyrosine phosphorylation spinal cord patterning ventral spinal cord development hippocampus development cerebral cortex tangential migration positive regulation of TOR signaling cascade positive regulation of CREB transcription factor activity reelin mediated signaling pathway positive regulation of protein kinase activity response to pain positive regulation of peptidyl tyrosine phosphorylation regulation of behavior regulation of synaptic transmission positive regulation of small GTPase mediated signal transduction positive regulation of synaptic transmission glutamatergic positive regulation of dendritic spine morphogenesis positive regulation of protein tyrosine kinase activity positive regulation of synapse maturation N methyl D aspartate receptor clustering postsynaptic density protein 95 clustering receptor localization to synapse positive regulation of long term synaptic potentiation regulation of N methyl D aspartate selective glutamate receptor activity positive regulation of excitatory postsynaptic membrane potential positive regulation of alpha amino 3 hydroxy 5 methyl 4 isoxazole propionate selective glutamate receptor activitySources Amigo QuickGORNA表达模式更多表达数据直系同源体物种人类小鼠Entrez564919699EnsemblENSG00000189056ENSMUSG00000042453UniProtP78509Q60841mRNA序列NM 005045NM 011261蛋白序列NP 005036NP 035391基因位置Chr 7 103 11 103 63 MbChr 5 21 88 22 34 MbPubMed查询 1 2 查论编 目录 1 参考文献 2 Recommended reading 3 外部链接 3 1 Articles publications webpages 3 2 Figures and images参考文献 编辑 PDB 2ddu Nogi T Yasui N Hattori M Iwasaki K Takagi J Structure of a signaling competent reelin fragment revealed by X ray crystallography and electron tomography EMBO J August 2006 25 15 3675 83 PMC 1538547 nbsp PMID 16858396 doi 10 1038 sj emboj 7601240 Recommended reading 编辑维基共享资源中相关的多媒体资源 络丝蛋白The book Fatemi S Hossein Reelin Glycoprotein Structure Biology and Roles in Health and Disease Berlin Springer 2008 444 pages ISBN 978 0 387 76760 4 A review Forster E Jossin Y Zhao S Chai X Frotscher M Goffinet AM Recent progress in understanding the role of Reelin in radial neuronal migration with specific emphasis on the dentate gyrus Eur J Neurosci February 2006 23 4 901 9 PMID 16519655 doi 10 1111 j 1460 9568 2006 04612 x 外部链接 编辑查看维基词典中的词条 络丝蛋白 Articles publications webpages 编辑 Gabriella D Arcangelo Rutgers University 2008 08 23 原始内容存档于2008 07 25 the scientist who discovered the reelin gene and protein Human RELN at WikiGenesFigures and images 编辑 Reelin gene expression in mice Brain Gene Expression Map St Jude Children s Research Hospital 2008 08 23 原始内容存档于2005 01 23 Schematic representation of signaling through the LDLR family members apoER2 and VLDL receptor 2008 08 23 永久失效連結 A figure from Beffert U Stolt PC Herz J Functions of lipoprotein receptors in neurons J Lipid Res March 2004 45 3 403 9 PMID 14657206 doi 10 1194 jlr R300017 JLR200 Proposed mechanism by which mouse RELN promoter regulate reelin gene expression Proc Natl Acad Sci USA 2008 08 23 原始内容存档于2007 12 25 A figure from Dong E Agis Balboa RC Simonini MV Grayson DR Costa E Guidotti A Reelin and glutamic acid decarboxylase67 promoter remodeling in an epigenetic methionine induced mouse model of schizophrenia Proc Natl Acad Sci U S A August 2005 102 35 12578 83 PMC 1194936 nbsp PMID 16113080 doi 10 1073 pnas 0505394102 Corticogenesis in wild type reeler mutant and b1 deficient mice 2008 08 23 原始内容存档于2007 12 24 Pictorial rendition of the difference that the lack of reelin brings to the cortical structure A figure from Magdaleno SM Curran T Brain development integrins and the Reelin pathway Curr Biol December 2001 11 24 R1032 5 PMID 11747842 doi 10 1016 S0960 9822 01 00618 2 Effects of human and naturally occurring mouse RELN mutations on the predicted protein Nature Genetics 2008 08 23 原始内容存档于2007 12 15 A figure from Hong SE Shugart YY Huang DT et al Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutations Nat Genet September 2000 26 1 93 6 PMID 10973257 doi 10 1038 79246 已忽略未知参数 author separator 帮助 MRI analysis of chromosome 7q22 linked lissencephaly with cerebellar hypoplasia Nature Genetics 2008 08 23 原始内容存档于2007 12 15 A figure from Hong et al 取自 https zh wikipedia org w index php title 络丝蛋白 amp oldid 78991732, 维基百科，wiki，书籍，书籍，图书馆，
