尿調理素屬於多醣磷脂肌醇錨定物（英语：glycophosphatidylinositol）醣蛋白，在哺乳動物中主要由腎臟的亨耳氏套粗上升支（英语：thick ascending limb of the loop of Henle）產生。尿調理素的單體約為85 kDa，在尿液中則常聚合成數百萬 Da 的大分子[8]。該蛋白在低pH值時會形成膠狀型態，為正常人類尿液中最主要的蛋白質[9]。尿調理素為尿液管型的主要成分。
功能编辑
尿調理素被轉譯完成後，會藉由外結構域（英语：ectodomain）中的醣磷脂肌醇（英语：glycophosphatidylinositol）鍵與膜相接，剩下的部分會暴露於亨耳氏套（英语：loop of Henle）的管腔中。當醣磷脂肌醇鍵被打斷後，尿調理素便會進入尿液中。尿調理素可能可以抑制尿鈣造成結石，或是防止細菌造成的泌尿道感染[7]。
^ 2.02.12.2GRCh38: Ensembl release 89: ENSG00000169344 - Ensembl, May 2017
^ 3.03.13.2GRCm38: Ensembl release 89: ENSMUSG00000030963 - Ensembl, May 2017
^Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Jeanpierre C, Whitmore SA, Austruy E, Cohen-Salmon M, Callen DF, Junien C. Chromosomal assignment of the uromodulin gene (UMOD) to 16p13.11. Cytogenet Cell Genet. Mar 1993, 62 (4): 185–7. PMID 8382593. doi:10.1159/000133470.
^ 8.08.18.28.3Lau WH, Leong WS, Ismail Z, Gam LH. Qualification and application of an ELISA for the determination of Tamm Horsfall protein (THP) in human urine and its use for screening of kidney stone disease. Int. J. Biol. Sci. 2008, 4 (4): 215–22. PMC 2500153. PMID 18695745. doi:10.7150/ijbs.4.215.
^Nagaraj N, Mann M. Quantitative analysis of the intra- and inter-individual variability of the normal urinary proteome. J. Proteome Res. February 2011, 10 (2): 637–45. PMID 21126025. doi:10.1021/pr100835s.
^Bachmann S, Mutig K, Bates J, Welker P, Geist B, Gross V, Luft FC, Alenina N, Bader M, Thiele BJ, Prasadan K, Raffi HS, Kumar S. Renal effects of Tamm-Horsfall protein (uromodulin) deficiency in mice. Am. J. Physiol. Renal Physiol. 2005, 288 (3): F559–67. PMID 15522986. doi:10.1152/ajprenal.00143.2004.
^El-Achkar TM, Wu XR, Rauchman M, McCracken R, Kiefer S, Dagher PC. Tamm-Horsfall protein protects the kidney from ischemic injury by decreasing inflammation and altering TLR4 expression. Am J Physiol Renal Physiol. 2008 Aug;295(2):F534-44. doi: 10.1152/ajprenal.00083.2008. Epub 2008 May 21. PMID 18495803
延伸閱讀编辑
Scolari F, Viola BF, Ghiggeri GM, et al. Towards the identification of (a) gene(s) for autosomal dominant medullary cystic kidney disease.. J. Nephrol. 2003, 16 (3): 321–8. PMID 12832729.
Rindler MJ, Naik SS, Li N, et al. Uromodulin (Tamm-Horsfall glycoprotein/uromucoid) is a phosphatidylinositol-linked membrane protein.. J. Biol. Chem. 1991, 265 (34): 20784–9. PMID 2249987.
Muchmore AV, Decker JM. Uromodulin: a unique 85-kilodalton immunosuppressive glycoprotein isolated from urine of pregnant women.. Science. 1985, 229 (4712): 479–81. PMID 2409603. doi:10.1126/science.2409603.
Pennica D, Kohr WJ, Kuang WJ, et al. Identification of human uromodulin as the Tamm-Horsfall urinary glycoprotein.. Science. 1987, 236 (4797): 83–8. PMID 3453112. doi:10.1126/science.3453112.
Hession C, Decker JM, Sherblom AP, et al. Uromodulin (Tamm-Horsfall glycoprotein): a renal ligand for lymphokines.. Science. 1987, 237 (4821): 1479–84. PMID 3498215. doi:10.1126/science.3498215.
Prasadan K, Bates J, Badgett A, et al. Nucleotide sequence and peptide motifs of mouse uromodulin (Tamm-Horsfall protein)--the most abundant protein in mammalian urine.. Biochim. Biophys. Acta. 1995, 1260 (3): 328–32. PMID 7873609. doi:10.1016/0167-4781(94)00240-4.
Huang ZQ, Kirk KA, Connelly KG, Sanders PW. Bence Jones proteins bind to a common peptide segment of Tamm-Horsfall glycoprotein to promote heterotypic aggregation.. J. Clin. Invest. 1994, 92 (6): 2975–83. PMC 288501. PMID 8254051. doi:10.1172/JCI116920.
Fukushima K, Watanabe H, Takeo K, et al. N-linked sugar chain structure of recombinant human lymphotoxin produced by CHO cells: the functional role of carbohydrate as to its lectin-like character and clearance velocity.. Arch. Biochem. Biophys. 1993, 304 (1): 144–53. PMID 8323280. doi:10.1006/abbi.1993.1332.
Thomas DB, Davies M, Peters JR, Williams JD. Tamm Horsfall protein binds to a single class of carbohydrate specific receptors on human neutrophils.. Kidney Int. 1993, 44 (2): 423–9. PMID 8397318. doi:10.1038/ki.1993.260.
Badgett A, Kumar S. Phylogeny of Tamm-Horsfall protein.. Urol. Int. 1999, 61 (2): 72–5. PMID 9873244. doi:10.1159/000030292.
van Rooijen JJ, Voskamp AF, Kamerling JP, Vliegenthart JF. Glycosylation sites and site-specific glycosylation in human Tamm-Horsfall glycoprotein.. Glycobiology. 1999, 9 (1): 21–30. PMID 9884403. doi:10.1093/glycob/9.1.21.
Scolari F, Puzzer D, Amoroso A, et al. Identification of a new locus for medullary cystic disease, on chromosome 16p12.. Am. J. Hum. Genet. 1999, 64 (6): 1655–60. PMC 1377908. PMID 10330352. doi:10.1086/302414.
Kamatani N, Moritani M, Yamanaka H, et al. Localization of a gene for familial juvenile hyperuricemic nephropathy causing underexcretion-type gout to 16p12 by genome-wide linkage analysis of a large family.. Arthritis Rheum. 2000, 43 (4): 925–9. PMID 10765940. doi:10.1002/1529-0131(200004)43:4<925::AID-ANR26>3.0.CO;2-B.
Pirulli D, Puzzer D, De Fusco M, et al. Molecular analysis of uromodulin and SAH genes, positional candidates for autosomal dominant medullary cystic kidney disease linked to 16p12.. J. Nephrol. 2002, 14 (5): 392–6. PMID 11730273.
Menozzi FD, Debrie AS, Tissier JP, et al. Interaction of human Tamm-Horsfall glycoprotein with Bordetella pertussis toxin.. Microbiology (Reading, Engl.). 2002, 148 (Pt 4): 1193–201. PMID 11932463. doi:10.1099/00221287-148-4-1193.
Zbikowska HM, Soukhareva N, Behnam R, et al. Uromodulin promoter directs high-level expression of biologically active human alpha1-antitrypsin into mouse urine.. Biochem. J. 2002, 365 (Pt 1): 7–11. PMC 1222653. PMID 11982485. doi:10.1042/BJ20020643.
Hart TC, Gorry MC, Hart PS, et al. Mutations of the UMOD gene are responsible for medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathy.. J. Med. Genet. 2003, 39 (12): 882–92. PMC 1757206. PMID 12471200. doi:10.1136/jmg.39.12.882.
Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899.
Tamm–Horsfall protein deposition Archive.is的存檔，存档日期2007-06-24
九月 25, 2023
尿調理素, uromodulin, 又稱tamm, horsfall蛋白, tamm, horsfall, glycoprotein, 為一種醣蛋白, 該蛋白由, umod, 基因轉譯而成, 為人類正常尿液中最主要的蛋白質, 家族性少年高血尿酸癥腎病已知的結構pdb直系同源搜索, pdbe, rcsbpdbid列表4wrn識別號别名umod, admckd2, fjhn, hnfj, hnfj1, mckd2, thgp, uromodulin, adtkd1外部idomim, 191845, 102674, ho. 尿調理素 uromodulin 又稱Tamm Horsfall蛋白 Tamm Horsfall glycoprotein THP 為一種醣蛋白 該蛋白由 UMOD 基因轉譯而成 6 7 尿調理素為人類正常尿液中最主要的蛋白質 8 家族性少年高血尿酸癥腎病已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表4WRN識別號别名UMOD ADMCKD2 FJHN HNFJ HNFJ1 MCKD2 THGP THP uromodulin ADTKD1外部IDOMIM 191845 MGI 102674 HomoloGene 2522 GeneCards UMOD相關疾病高血壓 腎病變 autosomal dominant medullary cystic kidney disease with hyperuricemia 1 基因位置 人类 染色体16號染色體 2 基因座16p12 3起始20 333 051 bp 2 终止20 356 301 bp 2 基因位置 小鼠 染色体小鼠7号染色体 3 基因座7 F2 7 63 88 cM起始119 061 934 bp 3 终止119 078 505 bp 3 RNA表达模式查阅更多表达数据基因本體分子功能 calcium ion binding IgG binding細胞組分 cell projection spindle pole 膜 细胞膜 細胞外區域 basolateral plasma membrane apical plasma membrane ciliary membrane anchored component of membrane 外排體 extrinsic component of membrane Golgi lumen 纖毛生物學過程 leukocyte cell cell adhesion chemical homeostasis heterophilic cell cell adhesion via plasma membrane cell adhesion molecules 排泄作用 metanephric distal convoluted tubule development metanephric ascending thin limb development cellular defense response neutrophil migration metanephric thick ascending limb development negative regulation of cell population proliferation protein N linked glycosylation via asparagine ion homeostasisSources Amigo QuickGO直系同源物種人類小鼠Entrez736922242EnsemblENSG00000169344ENSMUSG00000030963UniProtP07911Q91X17mRNA 序列NM 001008389 NM 001278614 NM 003361 NM 001378232 NM 001378233 NM 001378234 NM 001378235 NM 001378237NM 001278605 NM 009470蛋白序列NP 001008390 NP 001265543 NP 003352 NP 001365161 NP 001365162 NP 001365163 NP 001365164 NP 001365166NP 001265534 NP 033496基因位置 UCSC Chr 16 20 33 20 36 MbChr 7 119 06 119 08 MbPubMed 查找 4 5 維基數據檢視 編輯人類檢視 編輯小鼠 目录 1 基因 2 蛋白質 3 功能 4 臨床意義 5 歷史 6 參考文獻 7 延伸閱讀 8 外部連結基因 编辑人類的 UMOD 基因位於第16對染色體 該基因可能存在許多不同種變異 但目前已報導的全蛋白序列僅有兩種 大多數人屬於這兩種蛋白 7 蛋白質 编辑尿調理素屬於多醣磷脂肌醇錨定物 英语 glycophosphatidylinositol 醣蛋白 在哺乳動物中主要由腎臟的亨耳氏套粗上升支 英语 thick ascending limb of the loop of Henle 產生 尿調理素的單體約為85 kDa 在尿液中則常聚合成數百萬 Da 的大分子 8 該蛋白在低pH值時會形成膠狀型態 為正常人類尿液中最主要的蛋白質 9 尿調理素為尿液管型的主要成分 功能 编辑尿調理素被轉譯完成後 會藉由外結構域 英语 ectodomain 中的醣磷脂肌醇 英语 glycophosphatidylinositol 鍵與膜相接 剩下的部分會暴露於亨耳氏套 英语 loop of Henle 的管腔中 當醣磷脂肌醇鍵被打斷後 尿調理素便會進入尿液中 尿調理素可能可以抑制尿鈣造成結石 或是防止細菌造成的泌尿道感染 7 目前有關尿調理素的功能尚不清楚 有研究發現 尿調理素可能扮演運輸的角色 10 另外一份研究則顯示該蛋白可能具有抗菌的功能 大腸桿菌的MS 性菌毛或菌毛對於甘露糖相當敏感 而尿調理素側鏈中的甘露糖結構則可以抓住大腸桿菌的菌毛 8 該蛋白也可能在急性腎損傷時具有抑制發炎的功能 11 臨床意義 编辑尿調理素 尿橋蛋白 英语 Uropontin 以及腎鈣蛋白為目前已知三種可能影響腎鈣結石的醣蛋白 尿調理素雖然為腎結石的成分之一 但其對於腎結石的角色目前仍未有定論 但目前已知尿調理素過低是預測腎結石的良好指標 8 歷史 编辑參考文獻 编辑 與家族性少年高血尿酸癥腎病相關的疾病 在維基數據上查看 編輯參考 2 0 2 1 2 2 GRCh38 Ensembl release 89 ENSG00000169344 Ensembl May 2017 3 0 3 1 3 2 GRCm38 Ensembl release 89 ENSMUSG00000030963 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Jeanpierre C Whitmore SA Austruy E Cohen Salmon M Callen DF Junien C Chromosomal assignment of the uromodulin gene UMOD to 16p13 11 Cytogenet Cell Genet Mar 1993 62 4 185 7 PMID 8382593 doi 10 1159 000133470 7 0 7 1 7 2 Entrez Gene UMOD uromodulin uromucoid Tamm Horsfall glycoprotein 2016 12 20 原始内容存档于2010 03 07 8 0 8 1 8 2 8 3 Lau WH Leong WS Ismail Z Gam LH Qualification and application of an ELISA for the determination of Tamm Horsfall protein THP in human urine and its use for screening of kidney stone disease Int J Biol Sci 2008 4 4 215 22 PMC 2500153 nbsp PMID 18695745 doi 10 7150 ijbs 4 215 Nagaraj N Mann M Quantitative analysis of the intra and inter individual variability of the normal urinary proteome J Proteome Res February 2011 10 2 637 45 PMID 21126025 doi 10 1021 pr100835s Bachmann S Mutig K Bates J Welker P Geist B Gross V Luft FC Alenina N Bader M Thiele BJ Prasadan K Raffi HS Kumar S Renal effects of Tamm Horsfall protein uromodulin deficiency in mice Am J Physiol Renal Physiol 2005 288 3 F559 67 PMID 15522986 doi 10 1152 ajprenal 00143 2004 El Achkar TM Wu XR Rauchman M McCracken R Kiefer S Dagher PC Tamm Horsfall protein protects the kidney from ischemic injury by decreasing inflammation and altering TLR4 expression Am J Physiol Renal Physiol 2008 Aug 295 2 F534 44 doi 10 1152 ajprenal 00083 2008 Epub 2008 May 21 PMID 18495803延伸閱讀 编辑Scolari F Viola BF Ghiggeri GM et al Towards the identification of a gene s for autosomal dominant medullary cystic kidney disease J Nephrol 2003 16 3 321 8 PMID 12832729 Rindler MJ Naik SS Li N et al Uromodulin Tamm Horsfall glycoprotein uromucoid is a phosphatidylinositol linked membrane protein J Biol Chem 1991 265 34 20784 9 PMID 2249987 Muchmore AV Decker JM Uromodulin a unique 85 kilodalton immunosuppressive glycoprotein isolated from urine of pregnant women Science 1985 229 4712 479 81 PMID 2409603 doi 10 1126 science 2409603 Pennica D Kohr WJ Kuang WJ et al Identification of human uromodulin as the Tamm Horsfall urinary glycoprotein Science 1987 236 4797 83 8 PMID 3453112 doi 10 1126 science 3453112 Hession C Decker JM Sherblom AP et al Uromodulin Tamm Horsfall glycoprotein a renal ligand for lymphokines Science 1987 237 4821 1479 84 PMID 3498215 doi 10 1126 science 3498215 Prasadan K Bates J Badgett A et al Nucleotide sequence and peptide motifs of mouse uromodulin Tamm Horsfall protein the most abundant protein in mammalian urine Biochim Biophys Acta 1995 1260 3 328 32 PMID 7873609 doi 10 1016 0167 4781 94 00240 4 Huang ZQ Kirk KA Connelly KG Sanders PW Bence Jones proteins bind to a common peptide segment of Tamm Horsfall glycoprotein to promote heterotypic aggregation J Clin Invest 1994 92 6 2975 83 PMC 288501 nbsp PMID 8254051 doi 10 1172 JCI116920 Rhodes DC Hinsman EJ Rhodes JA Tamm Horsfall glycoprotein binds IgG with high affinity Kidney Int 1994 44 5 1014 21 PMID 8264130 doi 10 1038 ki 1993 343 Fukushima K Watanabe H Takeo K et al N linked sugar chain structure of recombinant human lymphotoxin produced by CHO cells the functional role of carbohydrate as to its lectin like character and clearance velocity Arch Biochem Biophys 1993 304 1 144 53 PMID 8323280 doi 10 1006 abbi 1993 1332 Thomas DB Davies M Peters JR Williams JD Tamm Horsfall protein binds to a single class of carbohydrate specific receptors on human neutrophils Kidney Int 1993 44 2 423 9 PMID 8397318 doi 10 1038 ki 1993 260 Badgett A Kumar S Phylogeny of Tamm Horsfall protein Urol Int 1999 61 2 72 5 PMID 9873244 doi 10 1159 000030292 van Rooijen JJ Voskamp AF Kamerling JP Vliegenthart JF Glycosylation sites and site specific glycosylation in human Tamm Horsfall glycoprotein Glycobiology 1999 9 1 21 30 PMID 9884403 doi 10 1093 glycob 9 1 21 Scolari F Puzzer D Amoroso A et al Identification of a new locus for medullary cystic disease on chromosome 16p12 Am J Hum Genet 1999 64 6 1655 60 PMC 1377908 nbsp PMID 10330352 doi 10 1086 302414 Kamatani N Moritani M Yamanaka H et al Localization of a gene for familial juvenile hyperuricemic nephropathy causing underexcretion type gout to 16p12 by genome wide linkage analysis of a large family Arthritis Rheum 2000 43 4 925 9 PMID 10765940 doi 10 1002 1529 0131 200004 43 4 lt 925 AID ANR26 gt 3 0 CO 2 B Pirulli D Puzzer D De Fusco M et al Molecular analysis of uromodulin and SAH genes positional candidates for autosomal dominant medullary cystic kidney disease linked to 16p12 J Nephrol 2002 14 5 392 6 PMID 11730273 Menozzi FD Debrie AS Tissier JP et al Interaction of human Tamm Horsfall glycoprotein with Bordetella pertussis toxin Microbiology Reading Engl 2002 148 Pt 4 1193 201 PMID 11932463 doi 10 1099 00221287 148 4 1193 Zbikowska HM Soukhareva N Behnam R et al Uromodulin promoter directs high level expression of biologically active human alpha1 antitrypsin into mouse urine Biochem J 2002 365 Pt 1 7 11 PMC 1222653 nbsp PMID 11982485 doi 10 1042 BJ20020643 Hart TC Gorry MC Hart PS et al Mutations of the UMOD gene are responsible for medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathy J Med Genet 2003 39 12 882 92 PMC 1757206 nbsp PMID 12471200 doi 10 1136 jmg 39 12 882 Strausberg RL Feingold EA Grouse LH et al Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 2003 99 26 16899 903 PMC 139241 nbsp PMID 12477932 doi 10 1073 pnas 242603899 外部連結 编辑GeneReviews NCBI NIH UW entry on UMOD Related Kidney Disease Includes Familial Juvenile Hyperuricemic Nephropathy Medullary Cystic Kidney Disease 2 页面存档备份 存于互联网档案馆 OMIM entries on UMOD Related Kidney Disease Includes Familial Juvenile Hyperuricemic Nephropathy Medullary Cystic Kidney Disease 2 Tamm Horsfall protein deposition Archive is的存檔 存档日期2007 06 24 取自 https zh wikipedia org w index php title 尿調理素 amp oldid 68702229, 维基百科，wiki，书籍，书籍，图书馆，
