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维基百科

凝血酶

一月 07, 2023

凝血酶（英語：Thrombin，EC 3.4.21.5）是一种“胰蛋白酶样”丝氨酸蛋白酶蛋白质，在人体中被F2基因所编码[2][3]。在凝血作用第一级级联反应中，凝血酶原（凝血因子Ⅱ）被蛋白水解性切除以生成凝血酶，级联反应最终阻止了血液的继续流失。凝血酶转而作为一种丝氨酸蛋白酶以使可溶性的纖維蛋白原转变为不溶性的纖維蛋白，同时催化其他许多与凝血相关的反应。

凝血因子II（凝血酶）
人类凝血酶结构，与其抑制剂水蛭素结合在一起[1]
有效结构
PDB 直系同源检索：PDBe, RCSB
标识
代号 F2; PT
扩展标识 遗传学：176930 鼠基因：88380 同源基因：426 GeneCards: F2 Gene
EC編號 3.4.21.5
RNA表达模式
更多表达数据
直系同源体
物种 人类 小鼠
Entrez 2147 14061
Ensembl ENSG00000180210 ENSMUSG00000027249
UniProt P00734 Q3TJ94
mRNA序列 NM_000506 NM_010168
蛋白序列 NP_000497 NP_034298
基因位置 Chr 11:
46.7 – 46.72 Mb		 Chr 2:
91.43 – 91.44 Mb
PubMed查询 [1] [2]

另见

  • 蛋白质水解图
  • 纤维蛋白胶

参考文献

  1. ^ PDB 2C93; Howard N, Abell C, Blakemore W, Chessari G, Congreve M, Howard S, Jhoti H, Murray CW, Seavers LC, van Montfort RL. Application of fragment screening and fragment linking to the discovery of novel thrombin inhibitors. J. Med. Chem. February 2006, 49 (4): 1346–55. PMID 16480269. doi:10.1021/jm050850v. 
  2. ^ Royle NJ, Irwin DM, Koschinsky ML, MacGillivray RT, Hamerton JL. Human genes encoding prothrombin and ceruloplasmin map to 11p11-q12 and 3q21-24, respectively. Somat. Cell Mol. Genet. May 1987, 13 (3): 285–92. PMID 3474786. doi:10.1007/BF01535211. 
  3. ^ Degen SJ, Davie EW. Nucleotide sequence of the gene for human prothrombin. Biochemistry. September 1987, 26 (19): 6165–77. PMID 2825773. doi:10.1021/bi00393a033. 

深入阅读

  • Esmon CT. Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface. FASEB J. 1995, 9 (10): 946–55. PMID 7615164. 
  • Lenting PJ, van Mourik JA, Mertens K. The life cycle of coagulation factor VIII in view of its structure and function. Blood. 1999, 92 (11): 3983–96. PMID 9834200. 
  • Plow EF, Cierniewski CS, Xiao Z; et al. AlphaIIbbeta3 and its antagonism at the new millennium. Thromb. Haemost. 2002, 86 (1): 34–40. PMID 11487023. 
  • Maragoudakis ME, Tsopanoglou NE, Andriopoulou P. Mechanism of thrombin-induced angiogenesis. Biochem. Soc. Trans. 2002, 30 (2): 173–7. PMID 12023846. doi:10.1042/BST0300173. 
  • Howell DC, Laurent GJ, Chambers RC. Role of thrombin and its major cellular receptor, protease-activated receptor-1, in pulmonary fibrosis. Biochem. Soc. Trans. 2002, 30 (2): 211–6. PMID 12023853. doi:10.1042/BST0300211. 
  • Firth SM, Baxter RC. Cellular actions of the insulin-like growth factor binding proteins. Endocr. Rev. 2003, 23 (6): 824–54. PMID 12466191. doi:10.1210/er.2001-0033. 
  • Minami T, Sugiyama A, Wu SQ; et al. Thrombin and phenotypic modulation of the endothelium. Arterioscler. Thromb. Vasc. Biol. 2004, 24 (1): 41–53. PMID 14551154. doi:10.1161/01.ATV.0000099880.09014.7D. 
  • De Cristofaro R, De Candia E. Thrombin domains: structure, function and interaction with platelet receptors. J. Thromb. Thrombolysis. 2004, 15 (3): 151–63. PMID 14739624. doi:10.1023/B:THRO.0000011370.80989.7b. 
  • Tsopanoglou NE, Maragoudakis ME. Role of thrombin in angiogenesis and tumor progression. Semin. Thromb. Hemost. 2004, 30 (1): 63–9. PMID 15034798. doi:10.1055/s-2004-822971. 
  • Bode W. Structure and interaction modes of thrombin. Blood Cells Mol. Dis. 2007, 36 (2): 122–30. PMID 16480903. doi:10.1016/j.bcmd.2005.12.027. 
  • Wolberg AS. Thrombin generation and fibrin clot structure. Blood Rev. 2007, 21 (3): 131–42. PMID 17208341. doi:10.1016/j.blre.2006.11.001. 
  • Degen S: Prothrombin. In: High K, Roberts H, eds. Molecular Basis of Thrombosis and Hemostasis. New York, NY: Marcel Dekker; 1995:75.

外部链接

  • The MEROPS online database for peptidases and their inhibitors: S01.217（页面存档备份，存于互联网档案馆）
  • GeneReviews/NCBI/NIH/UW entry on Prothrombin Thrombophilia（页面存档备份，存于互联网档案馆）
  • [3]（页面存档备份，存于互联网档案馆） Anti-coagulation & proteases by The Proteolysis Map-animation
  • PMAP: The Proteolysis Map/Thrombin

Template:凝固作用

一月 07, 2023
凝血酶, 此條目需要擴充, 2011年9月14日, 请協助改善这篇條目, 更進一步的信息可能會在討論頁或扩充请求中找到, 请在擴充條目後將此模板移除, 英語, thrombin, 是一种, 胰蛋白酶样, 丝氨酸蛋白酶蛋白质, 在人体中被f2基因所编码, 在凝血作用第一级级联反应中, 凝血因子, 被蛋白水解性切除以生成, 级联反应最终阻止了血液的继续流失, 转而作为一种丝氨酸蛋白酶以使可溶性的纖維蛋白原转变为不溶性的纖維蛋白, 同时催化其他许多与凝血相关的反应, 凝血因子ii, 人类结构, 与其抑制剂水蛭素结合在一起. 此條目需要擴充 2011年9月14日 请協助改善这篇條目 更進一步的信息可能會在討論頁或扩充请求中找到 请在擴充條目後將此模板移除 凝血酶 英語 Thrombin EC 3 4 21 5 是一种 胰蛋白酶样 丝氨酸蛋白酶蛋白质 在人体中被F2基因所编码 2 3 在凝血作用第一级级联反应中 凝血酶原 凝血因子 被蛋白水解性切除以生成凝血酶 级联反应最终阻止了血液的继续流失 凝血酶转而作为一种丝氨酸蛋白酶以使可溶性的纖維蛋白原转变为不溶性的纖維蛋白 同时催化其他许多与凝血相关的反应 凝血因子II 凝血酶 人类凝血酶结构 与其抑制剂水蛭素结合在一起 1 有效结构PDB 直系同源检索 PDBe RCSBPDB查询代码列表1a2c 1a3b 1a3e 1a46 1a4w 1a5g 1a61 1abi 1abj 1ad8 1ae8 1afe 1aht 1ai8 1aix 1awf 1awh 1ay6 1b5g 1b7x 1ba8 1bb0 1bbr 1bcu 1bhx 1bmm 1bmn 1bth 1c1u 1c1v 1c1w 1c4u 1c4v 1c4y 1c5l 1c5n 1c5o 1ca8 1d3d 1d3p 1d3q 1d3t 1d4p 1d6w 1d9i 1de7 1dit 1dm4 1doj 1dwb 1dwc 1dwd 1dwe 1dx5 1e0f 1eb1 1eoj 1eol 1fpc 1fph 1g30 1g32 1g37 1ghv 1ghw 1ghx 1ghy 1gj4 1gj5 1h8d 1h8i 1hag 1hah 1hai 1hao 1hap 1hbt 1hdt 1hgt 1hlt 1hut 1hxe 1hxf 1ihs 1iht 1jmo 1jou 1jwt 1k21 1k22 1kts 1ktt 1lhc 1lhd 1lhe 1lhf 1lhg 1mh0 1mu6 1mu8 1mue 1nm6 1no9 1nrn 1nro 1nrp 1nrq 1nrr 1nrs 1nt1 1nu7 1nu9 1ny2 1nzq 1o0d 1o2g 1o5g 1ook 1oyt 1p8v 1ppb 1qbv 1qhr 1qj1 1qj6 1qj7 1qur 1rd3 1riw 1sb1 1sfq 1sg8 1sgi 1shh 1sl3 1sr5 1t4u 1t4v 1ta2 1ta6 1tb6 1tbz 1thp 1thr 1ths 1tmb 1tmt 1tmu 1tom 1tq0 1tq7 1twx 1ucy 1uma 1uvs 1vit 1vr1 1vzq 1w7g 1way 1wbg 1xm1 1xmn 1ycp 1ype 1ypg 1ypj 1ypk 1ypl 1ypm 1z71 1z8i 1z8j 1zgi 1zgv 1zrb 2a0q 2a2x 2a45 2afq 2ank 2anm 2b5t 2bdy 2bvr 2bvs 2bvx 2bxt 2bxu 2c8w 2c8x 2c8y 2c8z 2c90 2c93 2cf8 2cf9 2cn0 2feq 2fes 2gde 2gp9 2h9t 2hgt 2hnt 2hpp 2hpq 2hwl 2jh0 2jh5 2jh6 2od3 2thf 3hat 3htc 4htc 4thn 5gds 7kme 8kme标识代号F2 PT扩展标识遗传学 176930 鼠基因 88380 同源基因 426 GeneCards F2 GeneEC編號3 4 21 5基因本体论描述分子功能 thrombin activity receptor binding calcium ion binding细胞成分 extracellular region extracellular space soluble fraction生物过程 regulation of progression through cell cycle proteolysis apoptosis caspase activation acute phase response tyrosine phosphorylation of STAT protein STAT protein nuclear translocation multicellular organismal development blood coagulation response to wounding platelet activation regulation of blood coagulation fibrinolysisSources Amigo QuickGORNA表达模式更多表达数据直系同源体物种人类小鼠Entrez214714061EnsemblENSG00000180210ENSMUSG00000027249UniProtP00734Q3TJ94mRNA序列NM 000506NM 010168蛋白序列NP 000497NP 034298基因位置Chr 11 46 7 46 72 MbChr 2 91 43 91 44 MbPubMed查询 1 2 查论编 目录 1 另见 2 参考文献 3 深入阅读 4 外部链接另见 编辑蛋白质水解图 纤维蛋白胶参考文献 编辑 PDB 2C93 Howard N Abell C Blakemore W Chessari G Congreve M Howard S Jhoti H Murray CW Seavers LC van Montfort RL Application of fragment screening and fragment linking to the discovery of novel thrombin inhibitors J Med Chem February 2006 49 4 1346 55 PMID 16480269 doi 10 1021 jm050850v Royle NJ Irwin DM Koschinsky ML MacGillivray RT Hamerton JL Human genes encoding prothrombin and ceruloplasmin map to 11p11 q12 and 3q21 24 respectively Somat Cell Mol Genet May 1987 13 3 285 92 PMID 3474786 doi 10 1007 BF01535211 Degen SJ Davie EW Nucleotide sequence of the gene for human prothrombin Biochemistry September 1987 26 19 6165 77 PMID 2825773 doi 10 1021 bi00393a033 深入阅读 编辑Esmon CT Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface FASEB J 1995 9 10 946 55 PMID 7615164 Lenting PJ van Mourik JA Mertens K The life cycle of coagulation factor VIII in view of its structure and function Blood 1999 92 11 3983 96 PMID 9834200 Plow EF Cierniewski CS Xiao Z et al AlphaIIbbeta3 and its antagonism at the new millennium Thromb Haemost 2002 86 1 34 40 PMID 11487023 引文格式1维护 显式使用等标签 link Maragoudakis ME Tsopanoglou NE Andriopoulou P Mechanism of thrombin induced angiogenesis Biochem Soc Trans 2002 30 2 173 7 PMID 12023846 doi 10 1042 BST0300173 Howell DC Laurent GJ Chambers RC Role of thrombin and its major cellular receptor protease activated receptor 1 in pulmonary fibrosis Biochem Soc Trans 2002 30 2 211 6 PMID 12023853 doi 10 1042 BST0300211 Firth SM Baxter RC Cellular actions of the insulin like growth factor binding proteins Endocr Rev 2003 23 6 824 54 PMID 12466191 doi 10 1210 er 2001 0033 Minami T Sugiyama A Wu SQ et al Thrombin and phenotypic modulation of the endothelium Arterioscler Thromb Vasc Biol 2004 24 1 41 53 PMID 14551154 doi 10 1161 01 ATV 0000099880 09014 7D 引文格式1维护 显式使用等标签 link De Cristofaro R De Candia E Thrombin domains structure function and interaction with platelet receptors J Thromb Thrombolysis 2004 15 3 151 63 PMID 14739624 doi 10 1023 B THRO 0000011370 80989 7b Tsopanoglou NE Maragoudakis ME Role of thrombin in angiogenesis and tumor progression Semin Thromb Hemost 2004 30 1 63 9 PMID 15034798 doi 10 1055 s 2004 822971 Bode W Structure and interaction modes of thrombin Blood Cells Mol Dis 2007 36 2 122 30 PMID 16480903 doi 10 1016 j bcmd 2005 12 027 Wolberg AS Thrombin generation and fibrin clot structure Blood Rev 2007 21 3 131 42 PMID 17208341 doi 10 1016 j blre 2006 11 001 Degen S Prothrombin In High K Roberts H eds Molecular Basis of Thrombosis and Hemostasis New York NY Marcel Dekker 1995 75 外部链接 编辑The MEROPS online database for peptidases and their inhibitors S01 217 页面存档备份 存于互联网档案馆 GeneReviews NCBI NIH UW entry on Prothrombin Thrombophilia 页面存档备份 存于互联网档案馆 3 页面存档备份 存于互联网档案馆 Anti coagulation amp proteases by The Proteolysis Map animation 4 PMAP The Proteolysis Map ThrombinTemplate 凝固作用 取自 https zh wikipedia org w index php title 凝血酶 amp oldid 68985302, 维基百科，wiki，书籍，书籍，图书馆，

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