垂體醣蛋白激素家族包括促卵泡激素、黄体生成素、人绒毛膜促性腺激素和促甲状腺激素，所有这些糖蛋白激素都包括一个共同的α亚基和一个特异的β亚基。FSHB 基因编码的就是促卵泡激素的β亚基。 In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production.[3]
参考文献编辑
^Watkins PC, Eddy R, Beck AK, Vellucci V, Leverone B, Tanzi RE, Gusella JF, Shows TB. DNA sequence and regional assignment of the human follicle-stimulating hormone beta-subunit gene to the short arm of human chromosome 11. DNA. Aug 1987, 6 (3): 205–12. PMID 2885163. doi:10.1089/dna.1987.6.205.
^Shome B, Parlow AF, Liu WK, Nahm HS, Wen T, Ward DN. A reevaluation of the amino acid sequence of human follitropin beta-subunit. J Protein Chem. Sep 1989, 7 (4): 325–39. PMID 3151250. doi:10.1007/BF01024882.
Barrios-De-Tomasi J; Timossi C; Merchant H; et al. Assessment of the in vitro and in vivo biological activities of the human follicle-stimulating isohormones. Mol. Cell. Endocrinol. 2002, 186 (2): 189–98. PMID 11900895. doi:10.1016/S0303-7207(01)00657-8.已忽略未知参数|author-separator= (帮助)
Saxena BB, Rathnam P. Amino acid sequence of the beta subunit of follicle-stimulating hormone from human pituitary glands. J. Biol. Chem. 1976, 251 (4): 993–1005. PMID 1249074.
Keene JL; Matzuk MM; Otani T; et al. Expression of biologically active human follitropin in Chinese hamster ovary cells. J. Biol. Chem. 1989, 264 (9): 4769–75. PMID 2494176.已忽略未知参数|author-separator= (帮助)
Shome B, Parlow AF. Human follicle stimulating hormone: first proposal for the amino acid sequence of the hormone-specific, beta subunit (hFSHb). J. Clin. Endocrinol. Metab. 1974, 39 (1): 203–5. PMID 4835136. doi:10.1210/jcem-39-1-203.
Fujiki Y, Rathnam P, Saxena BB. Studies on the disulfide bonds in human pituitary follicle-stimulating hormone. Biochim. Biophys. Acta. 1980, 624 (2): 428–35. PMID 6774759.
Böckers TM, Nieschlag E, Kreutz MR, Bergmann M. Localization of follicle-stimulating hormone (FSH) immunoreactivity and hormone receptor mRNA in testicular tissue of infertile men. Cell Tissue Res. 1995, 278 (3): 595–600. PMID 7850869. doi:10.1007/BF00331379.
Matthews CH; Borgato S; Beck-Peccoz P; et al. Primary amenorrhoea and infertility due to a mutation in the beta-subunit of follicle-stimulating hormone. Nat. Genet. 1993, 5 (1): 83–6. PMID 8220432. doi:10.1038/ng0993-83.已忽略未知参数|author-separator= (帮助)
Layman LC; Lee EJ; Peak DB; et al. Delayed puberty and hypogonadism caused by mutations in the follicle-stimulating hormone beta-subunit gene. N. Engl. J. Med. 1997, 337 (9): 607–11. PMID 9271483. doi:10.1056/NEJM199708283370905.已忽略未知参数|author-separator= (帮助)
Cargill M; Altshuler D; Ireland J; et al. Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat. Genet. 1999, 22 (3): 231–8. PMID 10391209. doi:10.1038/10290.已忽略未知参数|author-separator= (帮助)
Grasso P, Rozhavskaya-Arena M, Reichert LE. Cysteine residues in a synthetic peptide corresponding to human follicle-stimulating hormone beta-subunit receptor-binding domain 81-95 [hFSH-beta-(81-95)] modulate the in vivo effects of hFSH-beta-(81-95) on the mouse estrous cycle. Regul. Pept. 1999, 81 (1–3): 67–71. PMID 10395410. doi:10.1016/S0167-0115(99)00022-1.
Ben-Menahem D; Hyde R; Pixley M; et al. Synthesis of multi-subunit domain gonadotropin complexes: a model for alpha/beta heterodimer formation. Biochemistry. 1999, 38 (46): 15070–7. PMID 10563789. doi:10.1021/bi991510c.已忽略未知参数|author-separator= (帮助)
Dias Neto E; Correa RG; Verjovski-Almeida S; et al. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. Proc. Natl. Acad. Sci. U.S.A. 2000, 97 (7): 3491–6. PMC 16267. PMID 10737800. doi:10.1073/pnas.97.7.3491.已忽略未知参数|author-separator= (帮助)
Hartley JL, Temple GF, Brasch MA. DNA Cloning Using In Vitro Site-Specific Recombination. Genome Res. 2001, 10 (11): 1788–95. PMC 310948. PMID 11076863. doi:10.1101/gr.143000.
Fox KM, Dias JA, Van Roey P. Three-dimensional structure of human follicle-stimulating hormone. Mol. Endocrinol. 2001, 15 (3): 378–89. PMID 11222739. doi:10.1210/me.15.3.378.
Amoresano A; Orrù S; Siciliano RA; et al. Assignment of the complete disulphide bridge pattern in the human recombinant follitropin beta-chain. Biol. Chem. 2002, 382 (6): 961–8. PMID 11501762. doi:10.1515/BC.2001.120.已忽略未知参数|author-separator= (帮助)
Walton WJ; Nguyen VT; Butnev VY; et al. Characterization of human FSH isoforms reveals a nonglycosylated beta-subunit in addition to the conventional glycosylated beta-subunit. J. Clin. Endocrinol. Metab. 2001, 86 (8): 3675–85. PMID 11502795. doi:10.1210/jc.86.8.3675.已忽略未知参数|author-separator= (帮助)
十一月 02, 2023
促卵泡激素β亚基, 英語, follitropin, subunit, beta, follicle, stimulating, hormone, beta, subunit, 缩写fsh, 是一种由人类基因fshb, 编码的蛋白质, 其rna的选择性剪接可形成该蛋白的两种蛋白异型体, follicle, stimulating, hormone, beta, polypeptide促卵泡激素, β多肽pdb, rendering, based, 1fl7, 有效结构pdb, 直系同源检索, pdbe, rcsbp. 促卵泡激素b亚基 英語 Follitropin subunit beta 或 follicle stimulating hormone beta subunit 缩写FSH B 是一种由人类基因FSHB 编码的蛋白质 1 2 3 其RNA的选择性剪接可形成该蛋白的两种蛋白异型体 Follicle stimulating hormone beta polypeptide促卵泡激素 b多肽PDB rendering based on 1fl7 有效结构PDB 直系同源检索 PDBe RCSBPDB查询代码列表1FL7 1XWD 4AY9标识代号FSHB扩展标识遗传学 136530 鼠基因 95582 同源基因 430 GeneCards FSHB Gene基因本体论描述分子功能 hormone activity protein binding follicle stimulating hormone activity protein heterodimerization activity细胞成分 extracellular region cytoplasm生物过程 ovarian follicle development progesterone biosynthetic process signal transduction transforming growth factor beta receptor signaling pathway spermatogenesis female gamete generation female pregnancy positive regulation of cell proliferation peptide hormone processing positive regulation of cell migration cellular protein metabolic process positive regulation of transcription from RNA polymerase II promoter Sertoli cell proliferationSources Amigo QuickGORNA表达模式更多表达数据直系同源体物种人类小鼠Entrez248814308EnsemblENSG00000131808ENSMUSG00000027120UniProtP01225Q60687mRNA序列NM 000510NM 008045蛋白序列NP 000501NP 032071基因位置Chr 11 30 25 30 26 MbChr 2 107 06 107 06 MbPubMed查询 1 2 查论编功能 编辑垂體醣蛋白激素家族包括促卵泡激素 黄体生成素 人绒毛膜促性腺激素和促甲状腺激素 所有这些糖蛋白激素都包括一个共同的a亚基和一个特异的b亚基 FSHB 基因编码的就是促卵泡激素的b亚基 In conjunction with luteinizing hormone follicle stimulating hormone induces egg and sperm production 3 参考文献 编辑 Watkins PC Eddy R Beck AK Vellucci V Leverone B Tanzi RE Gusella JF Shows TB DNA sequence and regional assignment of the human follicle stimulating hormone beta subunit gene to the short arm of human chromosome 11 DNA Aug 1987 6 3 205 12 PMID 2885163 doi 10 1089 dna 1987 6 205 Shome B Parlow AF Liu WK Nahm HS Wen T Ward DN A reevaluation of the amino acid sequence of human follitropin beta subunit J Protein Chem Sep 1989 7 4 325 39 PMID 3151250 doi 10 1007 BF01024882 3 0 3 1 Entrez Gene FSHB follicle stimulating hormone beta polypeptide 原始内容存档于2009 05 11 延伸阅读 编辑Barrios De Tomasi J Timossi C Merchant H et al Assessment of the in vitro and in vivo biological activities of the human follicle stimulating isohormones Mol Cell Endocrinol 2002 186 2 189 98 PMID 11900895 doi 10 1016 S0303 7207 01 00657 8 已忽略未知参数 author separator 帮助 Saxena BB Rathnam P Amino acid sequence of the beta subunit of follicle stimulating hormone from human pituitary glands J Biol Chem 1976 251 4 993 1005 PMID 1249074 Keene JL Matzuk MM Otani T et al Expression of biologically active human follitropin in Chinese hamster ovary cells J Biol Chem 1989 264 9 4769 75 PMID 2494176 已忽略未知参数 author separator 帮助 Jameson JL Becker CB Lindell CM Habener JF Human follicle stimulating hormone beta subunit gene encodes multiple messenger ribonucleic acids Mol Endocrinol 1988 2 9 806 15 PMID 3139991 doi 10 1210 mend 2 9 806 Shome B Parlow AF Human follicle stimulating hormone first proposal for the amino acid sequence of the hormone specific beta subunit hFSHb J Clin Endocrinol Metab 1974 39 1 203 5 PMID 4835136 doi 10 1210 jcem 39 1 203 Fujiki Y Rathnam P Saxena BB Studies on the disulfide bonds in human pituitary follicle stimulating hormone Biochim Biophys Acta 1980 624 2 428 35 PMID 6774759 Bockers TM Nieschlag E Kreutz MR Bergmann M Localization of follicle stimulating hormone FSH immunoreactivity and hormone receptor mRNA in testicular tissue of infertile men Cell Tissue Res 1995 278 3 595 600 PMID 7850869 doi 10 1007 BF00331379 Matthews CH Borgato S Beck Peccoz P et al Primary amenorrhoea and infertility due to a mutation in the beta subunit of follicle stimulating hormone Nat Genet 1993 5 1 83 6 PMID 8220432 doi 10 1038 ng0993 83 已忽略未知参数 author separator 帮助 Layman LC Lee EJ Peak DB et al Delayed puberty and hypogonadism caused by mutations in the follicle stimulating hormone beta subunit gene N Engl J Med 1997 337 9 607 11 PMID 9271483 doi 10 1056 NEJM199708283370905 已忽略未知参数 author separator 帮助 Cargill M Altshuler D Ireland J et al Characterization of single nucleotide polymorphisms in coding regions of human genes Nat Genet 1999 22 3 231 8 PMID 10391209 doi 10 1038 10290 已忽略未知参数 author separator 帮助 Grasso P Rozhavskaya Arena M Reichert LE Cysteine residues in a synthetic peptide corresponding to human follicle stimulating hormone beta subunit receptor binding domain 81 95 hFSH beta 81 95 modulate the in vivo effects of hFSH beta 81 95 on the mouse estrous cycle Regul Pept 1999 81 1 3 67 71 PMID 10395410 doi 10 1016 S0167 0115 99 00022 1 Ben Menahem D Hyde R Pixley M et al Synthesis of multi subunit domain gonadotropin complexes a model for alpha beta heterodimer formation Biochemistry 1999 38 46 15070 7 PMID 10563789 doi 10 1021 bi991510c 已忽略未知参数 author separator 帮助 Dias Neto E Correa RG Verjovski Almeida S et al Shotgun sequencing of the human transcriptome with ORF expressed sequence tags Proc Natl Acad Sci U S A 2000 97 7 3491 6 PMC 16267 nbsp PMID 10737800 doi 10 1073 pnas 97 7 3491 已忽略未知参数 author separator 帮助 Hartley JL Temple GF Brasch MA DNA Cloning Using In Vitro Site Specific Recombination Genome Res 2001 10 11 1788 95 PMC 310948 nbsp PMID 11076863 doi 10 1101 gr 143000 Fox KM Dias JA Van Roey P Three dimensional structure of human follicle stimulating hormone Mol Endocrinol 2001 15 3 378 89 PMID 11222739 doi 10 1210 me 15 3 378 Amoresano A Orru S Siciliano RA et al Assignment of the complete disulphide bridge pattern in the human recombinant follitropin beta chain Biol Chem 2002 382 6 961 8 PMID 11501762 doi 10 1515 BC 2001 120 已忽略未知参数 author separator 帮助 Walton WJ Nguyen VT Butnev VY et al Characterization of human FSH isoforms reveals a nonglycosylated beta subunit in addition to the conventional glycosylated beta subunit J Clin Endocrinol Metab 2001 86 8 3675 85 PMID 11502795 doi 10 1210 jc 86 8 3675 已忽略未知参数 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