· signal transduction · cell-cell signaling · positive regulation of cell proliferation · gonad development · peptide hormone processing · positive regulation of cell migration · thyroid gland development · luteinizing hormone secretion · cellular response to hormone stimulus · cellular protein metabolic process · positive regulation of transcription from RNA polymerase II promoter · negative regulation of organ growth · follicle-stimulating hormone secretion
NH2 - Ala - Pro - Asp - Val - Gln - Asp - Cys - Pro - Glu - Cys - Thr - Leu - Gln - Glu - Asn - Pro - Phe - Phe - Ser - Gln - Pro - Gly - Ala - Pro - Ile - Leu - Gln - Cys - Met - Gly - Cys - Cys - Phe - Ser - Arg - Ala - Tyr - Pro - Thr - Pro - Leu - Arg - Ser - Lys - Lys - Thr - Met - Leu - Val - Gln - Lys - Asn - Val - Thr - Ser - Glu - Ser - Thr - Cys - Cys - Val - Ala - Lys - Ser - Tyr - Asn - Arg - Val - Thr - Val - Met - Gly - Gly - Phe - Lys - Val - Glu - Asn - His - Thr - Ala - Cys - His - Cys - Ser - Thr - Cys - Tyr - Tyr - His - Lys - Ser - COOH
参考文献编辑
^Fiddes JC, Goodman HM. The gene encoding the common alpha subunit of the four human glycoprotein hormones. J Mol Appl Genet. Oct 1982, 1 (1): 3–18. PMID 6286817.
Roger M, Lahlou N, Couzinet B; et al. [Free alpha-subunit glycoprotein hormones: physiological and pathological data]. J. Steroid Biochem. 1990, 33 (4B): 763–9. PMID 2481154. doi:10.1016/0022-4731(89)90489-5. 引文格式1维护：显式使用等标签 (link)
Pierce JG. Eli Lilly lecture. The subunits of pituitary thyrotropin--their relationship to other glycoprotein hormones.. Endocrinology. 1972, 89 (6): 1331–44. PMID 5002675. doi:10.1210/endo-89-6-1331.
Kourides IA, Gurr JA, Wolf O. The regulation and organization of thyroid stimulating hormone genes.. Recent Prog. Horm. Res. 1984, 40: 79–120. PMID 6207569.
Miyoshi I, Kasai N, Hayashizaki Y. [Structure and regulation of human thyroid-stimulating hormone (TSH) gene]. Nippon Rinsho. 1994, 52 (4): 940–7. PMID 8196184.
Barrios-De-Tomasi J, Timossi C, Merchant H; et al. Assessment of the in vitro and in vivo biological activities of the human follicle-stimulating isohormones.. Mol. Cell. Endocrinol. 2002, 186 (2): 189–98. PMID 11900895. doi:10.1016/S0303-7207(01)00657-8. 引文格式1维护：显式使用等标签 (link)
Moyle WR, Bahl OP, März L. Role of carbohydrate of human chorionic gonadotropin in the mechanism of hormone action.. J. Biol. Chem. 1976, 250 (23): 9163–9. PMID 172504.
Fiddes JC, Goodman HM. Isolation, cloning and sequence analysis of the cDNA for the alpha-subunit of human chorionic gonadotropin.. Nature. 1979, 281 (5730): 351–6. PMID 481597. doi:10.1038/281351a0.
Sairam MR, Li CH. Human pituitary thyrotropin. The primary structure of the alpha and beta subunits.. Can. J. Biochem. 1977, 55 (7): 755–60. PMID 890569. doi:10.1139/o77-108.
Morgan FJ, Birken S, Canfield RE. The amino acid sequence of human chorionic gonadotropin. The alpha subunit and beta subunit.. J. Biol. Chem. 1975, 250 (13): 5247–58. PMID 1150658.
Rathnam P, Saxena BB. Primary amino acid sequence of follicle-stimulating hormone from human pituitary glands. I. alpha subunit.. J. Biol. Chem. 1975, 250 (17): 6735–46. PMID 1158880.
Weisshaar G, Hiyama J, Renwick AG, Nimtz M. NMR investigations of the N-linked oligosaccharides at individual glycosylation sites of human lutropin.. Eur. J. Biochem. 1991, 195 (1): 257–68. PMID 1991473. doi:10.1111/j.1432-1033.1991.tb15702.x.
Sakakibara R, Yokoo Y, Yoshikoshi K; et al. Subcellular localization of intracellular forms of human chorionic gonadotropin in first trimester placenta.. J. Biochem. 1988, 102 (5): 993–1001. PMID 2449427. 引文格式1维护：显式使用等标签 (link)
Matzuk MM, Keene JL, Boime I. Site specificity of the chorionic gonadotropin N-linked oligosaccharides in signal transduction.. J. Biol. Chem. 1989, 264 (5): 2409–14. PMID 2536708.
Lustbader JW, Birken S, Pileggi NF; et al. Crystallization and characterization of human chorionic gonadotropin in chemically deglycosylated and enzymatically desialylated states.. Biochemistry. 1990, 28 (24): 9239–43. PMID 2611225. doi:10.1021/bi00450a001. 引文格式1维护：显式使用等标签 (link)
Harris DC, Machin KJ, Evin GM; et al. Preliminary X-ray diffraction analysis of human chorionic gonadotropin.. J. Biol. Chem. 1989, 264 (12): 6705–6. PMID 2708337. 引文格式1维护：显式使用等标签 (link)
Hayashizaki Y, Miyai K, Kato K, Matsubara K. Molecular cloning of the human thyrotropin-beta subunit gene.. FEBS Lett. 1985, 188 (2): 394–400. PMID 3839756. doi:10.1016/0014-5793(85)80409-9.
Bellisario R, Carlsen RB, Bahl OP. Human chorionic gonadotropin. Linear amino acid sequence of the alpha subunit.. J. Biol. Chem. 1973, 248 (19): 6796–809. PMID 4745444.
Shome B, Parlow AF. Human follicle stimulating hormone (hFSH): first proposal for the amino acid sequence of the alpha-subunit (hFSHa) and first demonstration of its identity with the alpha-subunit of human luteinizing hormone (hLHa).. J. Clin. Endocrinol. Metab. 1974, 39 (1): 199–202. PMID 4835135. doi:10.1210/jcem-39-1-199.
糖蛋白激素α亚基, 英語, alpha, subunit, glycoprotein, hormones, 或称为绒毛膜促性腺激素α亚基, glycoprotein, hormones, alpha, chain, 是一个由人类基因cga, 编码的蛋白质, glycoprotein, hormones, alpha, polypeptide绒毛膜促性腺激素, α多肽pdb, rendering, based, 1dz7, 有效结构pdb, 直系同源检索, pdbe, rcsbpdb查询代码列表1dz7, 1e9j,. 糖蛋白激素a亚基 英語 Alpha subunit of glycoprotein hormones 或称为绒毛膜促性腺激素a亚基 Glycoprotein hormones alpha chain 是一个由人类基因CGA 编码的蛋白质 1 Glycoprotein hormones alpha polypeptide绒毛膜促性腺激素 a多肽PDB rendering based on 1dz7 有效结构PDB 直系同源检索 PDBe RCSBPDB查询代码列表1DZ7 1E9J 1FL7 1HCN 1HD4 1HRP 1QFW 1XWD 4AY9标识代号CGA CG ALPHA FSHA GPHA1 GPHa HCG LHA TSHA扩展标识遗传学 118850 鼠基因 88390 同源基因 587 GeneCards CGA Gene基因本体论描述分子功能 hormone activity protein binding细胞成分 extracellular region生物过程 thyroid hormone generation signal transduction cell cell signaling positive regulation of cell proliferation gonad development peptide hormone processing positive regulation of cell migration thyroid gland development luteinizing hormone secretion cellular response to hormone stimulus cellular protein metabolic process positive regulation of transcription from RNA polymerase II promoter negative regulation of organ growth follicle stimulating hormone secretion developmental growthSources Amigo QuickGORNA表达模式更多表达数据直系同源体物种人类小鼠Entrez108112640EnsemblENSG00000135346ENSMUSG00000028298UniProtP01215P01216mRNA序列NM 000735NM 009889蛋白序列NP 000726NP 034019基因位置Chr 6 87 8 87 8 MbChr 4 34 89 34 91 MbPubMed查询 1 2 查论编人体的四种糖蛋白激素 英语 glycoprotein hormones 人绒毛膜促性腺激素 hCG 黄体生成素 LH 促卵泡激素 FSH 和促甲状腺激素 TSH 都是以同样的该a亚基和各自不同的b亚基组成的二聚体 2 此a链的92个氨基酸残基的序列为 NH2 Ala Pro Asp Val Gln Asp Cys Pro Glu Cys Thr Leu Gln Glu Asn Pro Phe Phe Ser Gln Pro Gly Ala Pro Ile Leu Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Leu Arg Ser Lys Lys Thr Met Leu Val Gln Lys Asn Val Thr Ser Glu Ser Thr Cys Cys Val Ala Lys Ser Tyr Asn Arg Val Thr Val Met Gly Gly Phe Lys Val Glu Asn His Thr Ala Cys His Cys Ser Thr Cys Tyr Tyr His Lys Ser COOH参考文献 编辑 Fiddes JC Goodman HM The gene encoding the common alpha subunit of the four human glycoprotein hormones J Mol Appl Genet Oct 1982 1 1 3 18 PMID 6286817 Entrez Gene CGA glycoprotein hormones alpha polypeptide 原始内容存档于2010 12 05 延伸阅读 编辑Roger M Lahlou N Couzinet B et al Free alpha subunit glycoprotein hormones physiological and pathological data J Steroid Biochem 1990 33 4B 763 9 PMID 2481154 doi 10 1016 0022 4731 89 90489 5 引文格式1维护 显式使用等标签 link Pierce JG Eli Lilly lecture The subunits of pituitary thyrotropin their relationship to other glycoprotein hormones Endocrinology 1972 89 6 1331 44 PMID 5002675 doi 10 1210 endo 89 6 1331 Kourides IA Gurr JA Wolf O The regulation and organization of thyroid stimulating hormone genes Recent Prog Horm Res 1984 40 79 120 PMID 6207569 Miyoshi I Kasai N Hayashizaki Y Structure and regulation of human thyroid stimulating hormone TSH gene Nippon Rinsho 1994 52 4 940 7 PMID 8196184 Barrios De Tomasi J Timossi C Merchant H et al Assessment of the in vitro and in vivo biological activities of the human follicle stimulating isohormones Mol Cell Endocrinol 2002 186 2 189 98 PMID 11900895 doi 10 1016 S0303 7207 01 00657 8 引文格式1维护 显式使用等标签 link Moyle WR Bahl OP Marz L Role of carbohydrate of human chorionic gonadotropin in the mechanism of hormone action J Biol Chem 1976 250 23 9163 9 PMID 172504 Fiddes JC Goodman HM Isolation cloning and sequence analysis of the cDNA for the alpha subunit of human chorionic gonadotropin Nature 1979 281 5730 351 6 PMID 481597 doi 10 1038 281351a0 Sairam MR Li CH Human pituitary thyrotropin The primary structure of the alpha and beta subunits Can J Biochem 1977 55 7 755 60 PMID 890569 doi 10 1139 o77 108 Morgan FJ Birken S Canfield RE The amino acid sequence of human chorionic gonadotropin The alpha subunit and beta subunit J Biol Chem 1975 250 13 5247 58 PMID 1150658 Rathnam P Saxena BB Primary amino acid sequence of follicle stimulating hormone from human pituitary glands I alpha subunit J Biol Chem 1975 250 17 6735 46 PMID 1158880 Weisshaar G Hiyama J Renwick AG Nimtz M NMR investigations of the N linked oligosaccharides at individual glycosylation sites of human lutropin Eur J Biochem 1991 195 1 257 68 PMID 1991473 doi 10 1111 j 1432 1033 1991 tb15702 x Sakakibara R Yokoo Y Yoshikoshi K et al Subcellular localization of intracellular forms of human chorionic gonadotropin in first trimester placenta J Biochem 1988 102 5 993 1001 PMID 2449427 引文格式1维护 显式使用等标签 link Matzuk MM Keene JL Boime I Site specificity of the chorionic gonadotropin N linked oligosaccharides in signal transduction J Biol Chem 1989 264 5 2409 14 PMID 2536708 Lustbader JW Birken S Pileggi NF et al Crystallization and characterization of human chorionic gonadotropin in chemically deglycosylated and enzymatically desialylated states Biochemistry 1990 28 24 9239 43 PMID 2611225 doi 10 1021 bi00450a001 引文格式1维护 显式使用等标签 link Harris DC Machin KJ Evin GM et al Preliminary X ray diffraction analysis of human chorionic gonadotropin J Biol Chem 1989 264 12 6705 6 PMID 2708337 引文格式1维护 显式使用等标签 link Hayashizaki Y Miyai K Kato K Matsubara K Molecular cloning of the human thyrotropin beta subunit gene FEBS Lett 1985 188 2 394 400 PMID 3839756 doi 10 1016 0014 5793 85 80409 9 Bellisario R Carlsen RB Bahl OP Human chorionic gonadotropin Linear amino acid sequence of the alpha subunit J Biol Chem 1973 248 19 6796 809 PMID 4745444 Shome B Parlow AF Human follicle stimulating hormone hFSH first proposal for the amino acid sequence of the alpha subunit hFSHa and first demonstration of its identity with the alpha subunit of human luteinizing hormone hLHa J Clin Endocrinol Metab 1974 39 1 199 202 PMID 4835135 doi 10 1210 jcem 39 1 199 糖蛋白激素a亚基引用了美国国家医学图书馆提供的資料 这些資料属于公共领域 取自 https zh wikipedia org w index php title 糖蛋白激素a亚基 amp oldid 67755042, 维基百科，wiki，书籍，书籍，图书馆，
