Nichols BL, Avery S, Sen P, et al. The maltase-glucoamylase gene: common ancestry to sucrase-isomaltase with complementary starch digestion activities.. Proc. Natl. Acad. Sci. U.S.A. 2003, 100 (3): 1432–7. PMC 298790. PMID 12547908. doi:10.1073/pnas.0237170100.
Takeshita F, Ishii KJ, Kobiyama K, et al. TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF.. Eur. J. Immunol. 2005, 35 (8): 2477–85. PMID 16052631. doi:10.1002/eji.200526151.
Hillier LW, Fulton RS, Fulton LA, et al. The DNA sequence of human chromosome 7.. Nature. 2003, 424 (6945): 157–64. PMID 12853948. doi:10.1038/nature01782.
Danielsen EM. Tyrosine sulfation, a post-translational modification of microvillar enzymes in the small intestinal enterocyte.. EMBO J. 1987, 6 (10): 2891–6. PMC 553723. PMID 3121301.
Korpela MP, Paetau A, Löfberg MI, et al. A novel mutation of the GAA gene in a Finnish late-onset Pompe disease patient: clinical phenotype and follow-up with enzyme replacement therapy.. Muscle Nerve. 2009, 40 (1): 143–8. PMID 19472353. doi:10.1002/mus.21291.
Sim L, Quezada-Calvillo R, Sterchi EE, et al. Human intestinal maltase-glucoamylase: crystal structure of the N-terminal catalytic subunit and basis of inhibition and substrate specificity.. J. Mol. Biol. 2008, 375 (3): 782–92. PMID 18036614. doi:10.1016/j.jmb.2007.10.069.
Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2002, 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899.
Naim HY, Sterchi EE, Lentze MJ. Structure, biosynthesis, and glycosylation of human small intestinal maltase-glucoamylase.. J. Biol. Chem. 1988, 263 (36): 19709–17. PMID 3143729.
Ao Z, Quezada-Calvillo R, Sim L, et al. Evidence of native starch degradation with human small intestinal maltase-glucoamylase (recombinant).. FEBS Lett. 2007, 581 (13): 2381–8. PMID 17485087. doi:10.1016/j.febslet.2007.04.035.
Tuğrul S, Kutlu T, Pekin O, et al. Clinical, endocrine, and metabolic effects of acarbose, an alpha-glucosidase inhibitor, in overweight and nonoverweight patients with polycystic ovarian syndrome.. Fertil. Steril. 2008, 90 (4): 1144–8. PMID 18377903. doi:10.1016/j.fertnstert.2007.07.1326.
^Nichols BL, Eldering J, Avery S, Hahn D, Quaroni A, Sterchi E. Human small intestinal maltase-glucoamylase cDNA cloning. Homology to sucrase-isomaltase. J. Biol. Chem. January 1998, 273 (5): 3076–81. PMID 9446624. doi:10.1074/jbc.273.5.3076.
^Luminal starch substrate "brake" on maltase-glucoamylase activity is located within the glucoamylase subunit. J. Nutr. 2008, 138 (4): 685–92. PMID 18356321.
十月 06, 2023
麦芽糖酶, 葡糖淀粉酶, 英語, maltase, glucoamylase, 是一种由人体, mgam, 基因编码的酶, 已知的結構pdb直系同源搜索, pdbe, rcsbpdbid列表2qly, 2qmj, 3ctt, 3l4t, 3l4u, 3l4v, 3l4w, 3l4x, 3l4y, 3l4z, 3ton, 3top識別號别名mgam, maltase, glucoamylase外部idomim, 154360, 1203495, homologene, 130099, genecards, mgam為. 麦芽糖酶 葡糖淀粉酶 英語 Maltase glucoamylase 是一种由人体 MGAM 基因编码的酶 6 7 麦芽糖酶 葡糖淀粉酶已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表2QLY 2QMJ 3CTT 3L4T 3L4U 3L4V 3L4W 3L4X 3L4Y 3L4Z 3TON 3TOP識別號别名MGAM MG MGA Maltase glucoamylase外部IDOMIM 154360 MGI 1203495 HomoloGene 130099 GeneCards MGAM為以下藥物的標靶米格列醇 1 基因位置 人类 染色体7號染色體 2 基因座7q34起始141 907 813 bp 2 终止142 106 747 bp 2 基因位置 小鼠 染色体小鼠6号染色体 3 基因座6 6 B1起始40 605 765 bp 3 终止40 746 057 bp 3 基因本體分子功能 hydrolase activity acting on glycosyl bonds maltose alpha glucosidase activity hydrolase activity hydrolyzing O glycosyl compounds 催化活性 alpha 1 4 glucosidase activity 水解酶活性 amylase activity glucan 1 4 alpha glucosidase activity carbohydrate binding alpha glucosidase activity細胞組分 integral component of membrane 细胞膜 apical plasma membrane 外排體 膜 tertiary granule membrane ficolin 1 rich granule membrane生物學過程 polysaccharide digestion 代謝 starch catabolic process maltose metabolic process neutrophil degranulation 碳水化合物代謝Sources Amigo QuickGO直系同源物種人類小鼠Entrez8972232714EnsemblENSG00000257335 ENSG00000282607ENSMUSG00000068587UniProtO43451无数据mRNA 序列NM 004668 NM 001365693NM 001171003 NM 001368875蛋白序列NP 004659 NP 001352622无数据基因位置 UCSC Chr 7 141 91 142 11 MbChr 6 40 61 40 75 MbPubMed 查找 4 5 維基數據檢視 編輯人類檢視 編輯小鼠麦芽糖酶 葡糖淀粉酶是a 葡糖苷酶消化酶 它由两个具有不同底物特异性的亚基组成 重组酶研究表明 其N 末端催化结构域对麦芽糖具有最高活性 而C 末端结构域具有更广泛的底物特异性和对葡萄糖寡聚体的活性 8 在小肠中 这种酶与蔗糖 异麦芽糖酶和a 淀粉酶协同作用 以消化各种淀粉 延伸阅读 编辑Nichols BL Avery S Sen P et al The maltase glucoamylase gene common ancestry to sucrase isomaltase with complementary starch digestion activities Proc Natl Acad Sci U S A 2003 100 3 1432 7 PMC 298790 nbsp PMID 12547908 doi 10 1073 pnas 0237170100 Takeshita F Ishii KJ Kobiyama K et al TRAF4 acts as a silencer in TLR mediated signaling through the association with TRAF6 and TRIF Eur J Immunol 2005 35 8 2477 85 PMID 16052631 doi 10 1002 eji 200526151 Hillier LW Fulton RS Fulton LA et al The DNA sequence of human chromosome 7 Nature 2003 424 6945 157 64 PMID 12853948 doi 10 1038 nature01782 Danielsen EM Tyrosine sulfation a post translational modification of microvillar enzymes in the small intestinal enterocyte EMBO J 1987 6 10 2891 6 PMC 553723 nbsp PMID 3121301 Korpela MP Paetau A Lofberg MI et al A novel mutation of the GAA gene in a Finnish late onset Pompe disease patient clinical phenotype and follow up with enzyme replacement therapy Muscle Nerve 2009 40 1 143 8 PMID 19472353 doi 10 1002 mus 21291 Sim L Quezada Calvillo R Sterchi EE et al Human intestinal maltase glucoamylase crystal structure of the N terminal catalytic subunit and basis of inhibition and substrate specificity J Mol Biol 2008 375 3 782 92 PMID 18036614 doi 10 1016 j jmb 2007 10 069 Strausberg RL Feingold EA Grouse LH et al Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 2002 99 26 16899 903 PMC 139241 nbsp PMID 12477932 doi 10 1073 pnas 242603899 Naim HY Sterchi EE Lentze MJ Structure biosynthesis and glycosylation of human small intestinal maltase glucoamylase J Biol Chem 1988 263 36 19709 17 PMID 3143729 Ao Z Quezada Calvillo R Sim L et al Evidence of native starch degradation with human small intestinal maltase glucoamylase recombinant FEBS Lett 2007 581 13 2381 8 PMID 17485087 doi 10 1016 j febslet 2007 04 035 Tugrul S Kutlu T Pekin O et al Clinical endocrine and metabolic effects of acarbose an alpha glucosidase inhibitor in overweight and nonoverweight patients with polycystic ovarian syndrome Fertil Steril 2008 90 4 1144 8 PMID 18377903 doi 10 1016 j fertnstert 2007 07 1326 参考文献 编辑 對Maltase glucoamylase起作用的藥物 在維基數據上查看 編輯參考 2 0 2 1 2 2 GRCh38 Ensembl release 89 ENSG00000257335 ENSG00000282607 Ensembl May 2017 3 0 3 1 3 2 GRCm38 Ensembl release 89 ENSMUSG00000068587 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene maltase glucoamylase alpha glucosidase Nichols BL Eldering J Avery S Hahn D Quaroni A Sterchi E Human small intestinal maltase glucoamylase cDNA cloning Homology to sucrase isomaltase J Biol Chem January 1998 273 5 3076 81 PMID 9446624 doi 10 1074 jbc 273 5 3076 Luminal starch substrate brake on maltase glucoamylase activity is located within the glucoamylase subunit J Nutr 2008 138 4 685 92 PMID 18356321 取自 https zh wikipedia org w index php title 麦芽糖酶 葡糖淀粉酶 amp oldid 69153148, 维基百科，wiki，书籍，书籍，图书馆，
