^Biosynthesis of some urinary trace amines in the rat and the human. Research Communications in Chemical Pathology and Pharmacology. November 1981, 34 (2): 295–310. PMID 7335956.
^The in vitro release of endogenous m-tyramine, p-tyramine and dopamine from rat striatum. Neurochemical Research. June 1982, 7 (6): 705–16. PMID 7121718. doi:10.1007/bf00965523.
^The concentration of p- and m-tyramine in the rat mesolimbic system: its regional distribution and effect of monoamine oxidase inhibition. Brain Research. June 1987, 412 (2): 370–4. PMID 3607473. doi:10.1016/0006-8993(87)91145-0.
^The role of catecholamines, 5-hydroxytryptamine and m-tyramine in the behavioural effects of m-tyrosine in the rat. European Journal of Pharmacology. October 1982, 84 (3–4): 139–49. PMID 7173317. doi:10.1016/0014-2999(82)90196-0.
^The effects of administration of meta-tyramine and para-tyramine on dopamine and its metabolites in the rat striatum. Progress in Neuro-psychopharmacology & Biological Psychiatry. 1984, 8 (4–6): 705–9. PMID 6531442. doi:10.1016/0278-5846(84)90042-3.
^The endogenous substrates of brain CYP2D. Eur. J. Pharmacol. February 2014, 724: 211–218. PMID 24374199. doi:10.1016/j.ejphar.2013.12.025. The highest level of brain CYP2D activity was found in the substantia nigra ... The in vitro and in vivo studies have shown the contribution of the alternative CYP2D-mediated dopamine synthesis to the concentration of this neurotransmitter although the classic biosynthetic route to dopamine from tyrosine is active. ... Tyramine levels are especially high in the basal ganglia and limbic system, which are thought to be related to individual behavior and emotion (Yu et al., 2003c). ... Rat CYP2D isoforms (2D2/2D4/2D18) are less efficient than human CYP2D6 for the generation of dopamine from p-tyramine. The Km values of the CYP2D isoforms are as follows: CYP2D6 (87–121 μm) ≈ CYP2D2 ≈ CYP2D18 > CYP2D4 (256 μm) for m-tyramine and CYP2D4 (433 μm) > CYP2D2 ≈ CYP2D6 > CYP2D18 (688 μm) for p-tyramine
十月 19, 2023
间酪胺, meta, tyramine, 或称3, 酪胺, 是一种神经调节中的内源性痕量胺, 它是苯乙胺的结构类似物, 也是对酪胺, 即酪胺, 的位置异构体, 且与对酪胺相似的是, 也对肾上腺素和多巴胺系统有影响, iupac名3, aminoethyl, phenol别名, tyramine, tyramine, hydroxyphenylethylamine识别cas号, pubchem, 11492chemspider, 11008smiles, oc1cc, ccc1, ccninchi, inchi, c. 间酪胺 Meta Tyramine 或称3 酪胺 是一种神经调节中的内源性痕量胺 它是苯乙胺的结构类似物 1 2 3 也是对酪胺 即酪胺 的位置异构体 且与对酪胺相似的是 间酪胺也对肾上腺素和多巴胺系统有影响 4 5 间酪胺IUPAC名3 2 Aminoethyl phenol别名 m Tyramine 3 Tyramine 3 Hydroxyphenylethylamine识别CAS号 588 05 6 PubChem 11492ChemSpider 11008SMILES Oc1cc ccc1 CCNInChI InChI 1S C8H11NO c9 5 4 7 2 1 3 8 10 6 7 h1 3 6 10H 4 5 9H2ChEBI 89626性质化学式 C8H11NO摩尔质量 137 18 g mol 1若非注明 所有数据均出自标准状态 25 100 kPa 下 间酪胺通过芳香族氨基酸脱羧酶控制的间酪氨酸代谢产生 可通过大脑的CYP2D6酶代谢为多巴胺 6 参见 编辑对酪胺参考资料 编辑 Biosynthesis of some urinary trace amines in the rat and the human Research Communications in Chemical Pathology and Pharmacology November 1981 34 2 295 310 PMID 7335956 The in vitro release of endogenous m tyramine p tyramine and dopamine from rat striatum Neurochemical Research June 1982 7 6 705 16 PMID 7121718 doi 10 1007 bf00965523 The concentration of p and m tyramine in the rat mesolimbic system its regional distribution and effect of monoamine oxidase inhibition Brain Research June 1987 412 2 370 4 PMID 3607473 doi 10 1016 0006 8993 87 91145 0 The role of catecholamines 5 hydroxytryptamine and m tyramine in the behavioural effects of m tyrosine in the rat European Journal of Pharmacology October 1982 84 3 4 139 49 PMID 7173317 doi 10 1016 0014 2999 82 90196 0 The effects of administration of meta tyramine and para tyramine on dopamine and its metabolites in the rat striatum Progress in Neuro psychopharmacology amp Biological Psychiatry 1984 8 4 6 705 9 PMID 6531442 doi 10 1016 0278 5846 84 90042 3 The endogenous substrates of brain CYP2D Eur J Pharmacol February 2014 724 211 218 PMID 24374199 doi 10 1016 j ejphar 2013 12 025 The highest level of brain CYP2D activity was found in the substantia nigra The in vitro and in vivo studies have shown the contribution of the alternative CYP2D mediated dopamine synthesis to the concentration of this neurotransmitter although the classic biosynthetic route to dopamine from tyrosine is active Tyramine levels are especially high in the basal ganglia and limbic system which are thought to be related to individual behavior and emotion Yu et al 2003c Rat CYP2D isoforms 2D2 2D4 2D18 are less efficient than human CYP2D6 for the generation of dopamine from p tyramine The Km values of the CYP2D isoforms are as follows CYP2D6 87 121 mm CYP2D2 CYP2D18 gt CYP2D4 256 mm for m tyramine and CYP2D4 433 mm gt CYP2D2 CYP2D6 gt CYP2D18 688 mm for p tyramine 取自 https zh wikipedia org w index php title 间酪胺 amp oldid 68644353, 维基百科，wiki，书籍，书籍，图书馆，
