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维基百科

補體成分6

十月 22, 2023

補體成分C6（Complement component 6），在人體內是一個由C6基因編碼的蛋白質，是補體系統的一部分，功能是形成膜攻擊複合物（MAC）。C6缺陷的患者更易被細菌感染[6][7]:41-45。

補體成分6
已知的結構
PDB直系同源搜索: PDBe RCSB
識別號
别名C6；, complement C6
外部IDOMIM：217050 MGI：88233 HomoloGene：47 GeneCards：C6
相關疾病
complement component 9 deficiency[1]
基因位置（人类）
染色体5號染色體[2]
基因座5p13.1起始41,142,116 bp[2]
终止41,261,438 bp[2]
直系同源
物種人類小鼠
Entrez

729

12274

Ensembl

ENSG00000039537

ENSMUSG00000022181

UniProt

P13671

无数据

mRNA​序列

NM_000065
​NM_001115131

NM_016704

蛋白序列

NP_000056
​NP_001108603

无数据

基因位置​（UCSC）Chr 5: 41.14 – 41.26 MbChr 15: 4.76 – 4.84 Mb
PubMed​查找[4][5]
維基數據
檢視/編輯人類檢視/編輯小鼠

參考 编辑

  1. ^ 與補體成分6相關的疾病；在維基數據上查看/編輯參考. 
  2. ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000039537 - Ensembl, May 2017
  3. ^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000022181 - Ensembl, May 2017
  4. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  6. ^ Entrez Gene: complement component 6. 
  7. ^ 曹雪濤等. 醫學免疫學 第6版. 北京: 人民衛生出版社. 2013. ISBN 978-7-117-17101-4. 

拓展閱讀 编辑

  • Davila S, Froeling FE, Tan A, et al. New genetic associations detected in a host response study to hepatitis B vaccine.. Genes Immun. 2010, 11 (3): 232–8. PMID 20237496. doi:10.1038/gene.2010.1. 
  • Rajaraman P, Brenner AV, Butler MA, et al. Common variation in genes related to innate immunity and risk of adult glioma.. Cancer Epidemiol. Biomarkers Prev. 2009, 18 (5): 1651–8. PMC 2771723  . PMID 19423540. doi:10.1158/1055-9965.EPI-08-1041. 
  • Cerhan JR, Novak AJ, Fredericksen ZS, et al. Risk of non-Hodgkin lymphoma in association with germline variation in complement genes.. Br. J. Haematol. 2009, 145 (5): 614–23. PMC 2820509  . PMID 19344414. doi:10.1111/j.1365-2141.2009.07675.x. 
  • Han S, Lan Q, Park AK, et al. Polymorphisms in innate immunity genes and risk of childhood leukemia.. Hum. Immunol. 2010, 71 (7): 727–30. PMC 2967770  . PMID 20438785. doi:10.1016/j.humimm.2010.04.004. 
  • Liu T, Qian WJ, Gritsenko MA, et al. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.. J. Proteome Res.: 2070–80. PMC 1850943  . PMID 16335952. doi:10.1021/pr0502065. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.. Genome Res. 2006, 16 (1): 55–65. PMC 1356129  . PMID 16344560. doi:10.1101/gr.4039406. 
  • Talmud PJ, Drenos F, Shah S, et al. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.. Am. J. Hum. Genet. 2009, 85 (5): 628–42. PMC 2775832  . PMID 19913121. doi:10.1016/j.ajhg.2009.10.014. 
  • Müller-Eberhard HJ. Molecular organization and function of the complement system.. Annu. Rev. Biochem. 1988, 57: 321–47. PMID 3052276. doi:10.1146/annurev.bi.57.070188.001541. 
  • Gerhard DS, Wagner L, Feingold EA, et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928  . PMID 15489334. doi:10.1101/gr.2596504. 
  • Eid NA, Hussein AA, Elzein AM, et al. Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring.. Malar. J. 2010, 9: 119. PMC 2877684  . PMID 20459687. doi:10.1186/1475-2875-9-119. 
  • Fosbrink M, Cudrici C, Tegla CA, et al. Response gene to complement 32 is required for C5b-9 induced cell cycle activation in endothelial cells.. Exp. Mol. Pathol. 2009, 86 (2): 87–94. PMC 2699899  . PMID 19162005. doi:10.1016/j.yexmp.2008.12.005. 
  • Rajaraman P, Brenner AV, Neta G, et al. Risk of meningioma and common variation in genes related to innate immunity.. Cancer Epidemiol. Biomarkers Prev. 2010, 19 (5): 1356–61. PMC 3169167  . PMID 20406964. doi:10.1158/1055-9965.EPI-09-1151. 
  • Ennis S, Jomary C, Mullins R, et al. Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study.. Lancet. 2008, 372 (9652): 1828–34. PMID 18842294. doi:10.1016/S0140-6736(08)61348-3. 
  • Soejima M, Tachida H, Tsuneoka M, et al. Nucleotide sequence analyses of human complement 6 (C6) gene suggest balancing selection.. Ann. Hum. Genet. 2005, 69 (Pt 3): 239–52. PMID 15845028. doi:10.1046/j.1529-8817.2005.00165.x. 
  • Bulla R, Bossi F, Agostinis C, et al. Complement production by trophoblast cells at the feto-maternal interface.. J. Reprod. Immunol. 2009, 82 (2): 119–25. PMID 19665237. doi:10.1016/j.jri.2009.06.124. 
  • Gancz D, Donin N, Fishelson Z. Involvement of the c-jun N-terminal kinases JNK1 and JNK2 in complement-mediated cell death.. Mol. Immunol. 2009, 47 (2-3): 310–7. PMID 19864026. doi:10.1016/j.molimm.2009.09.016. 
  • Parham KL, Roberts A, Thomas A, et al. Prevalence of mutations leading to complete C6 deficiency (C6Q0) in the Western Cape, South Africa and detection of novel mutations leading to C6Q0 in an Irish family.. Mol. Immunol. 2007, 44 (10): 2756–60. PMID 17257682. doi:10.1016/j.molimm.2006.11.022. 
  • Wu C, Ma MH, Brown KR, et al. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.. Proteomics. 2007, 7 (11): 1775–85. PMID 17474147. doi:10.1002/pmic.200601006. 
  • Bailey SD, Xie C, Do R, et al. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.. Diabetes Care. 2010, 33 (10): 2250–3. PMC 2945168  . PMID 20628086. doi:10.2337/dc10-0452. 

外部連結 编辑

十月 22, 2023
補體成分6, 補體成分c6, complement, component, 在人體內是一個由c6基因編碼的蛋白質, 是補體系統的一部分, 功能是形成膜攻擊複合物, c6缺陷的患者更易被細菌感染, 已知的結構pdb直系同源搜索, pdbe, rcsbpdbid列表3t5o, 4a5w, 4e0s識別號别名c6, complement, c6外部idomim, 217050, 88233, homologene, genecards, c6相關疾病complement, component, deficiency, 基. 補體成分C6 Complement component 6 在人體內是一個由C6基因編碼的蛋白質 是補體系統的一部分 功能是形成膜攻擊複合物 MAC C6缺陷的患者更易被細菌感染 6 7 41 45 補體成分6已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表3T5O 4A5W 4E0S識別號别名C6 complement C6外部IDOMIM 217050 MGI 88233 HomoloGene 47 GeneCards C6相關疾病complement component 9 deficiency 1 基因位置 人类 染色体5號染色體 2 基因座5p13 1起始41 142 116 bp 2 终止41 261 438 bp 2 基因位置 小鼠 染色体小鼠15号染色体 3 基因座15 A1 15 1 97 cM起始4 756 657 bp 3 终止4 844 449 bp 3 基因本體分子功能 血浆蛋白结合細胞組分 細胞外區域 外排體 補體系統膜攻擊複合物生物學過程 positive regulation of activation of membrane attack complex immune system process complement activation in utero embryonic development 細胞溶解 regulation of complement activation 免疫反应 positive regulation of angiogenesis 經典途徑 positive regulation of complement activation 先天免疫系統Sources Amigo QuickGO直系同源物種人類小鼠Entrez72912274EnsemblENSG00000039537ENSMUSG00000022181UniProtP13671无数据mRNA 序列NM 000065 NM 001115131NM 016704蛋白序列NP 000056 NP 001108603无数据基因位置 UCSC Chr 5 41 14 41 26 MbChr 15 4 76 4 84 MbPubMed 查找 4 5 維基數據檢視 編輯人類檢視 編輯小鼠參考 编辑 與補體成分6相關的疾病 在維基數據上查看 編輯參考 2 0 2 1 2 2 GRCh38 Ensembl release 89 ENSG00000039537 Ensembl May 2017 3 0 3 1 3 2 GRCm38 Ensembl release 89 ENSMUSG00000022181 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene complement component 6 曹雪濤等 醫學免疫學 第6版 北京 人民衛生出版社 2013 ISBN 978 7 117 17101 4 拓展閱讀 编辑Davila S Froeling FE Tan A et al New genetic associations detected in a host response study to hepatitis B vaccine Genes Immun 2010 11 3 232 8 PMID 20237496 doi 10 1038 gene 2010 1 Rajaraman P Brenner AV Butler MA et al Common variation in genes related to innate immunity and risk of adult glioma Cancer Epidemiol Biomarkers Prev 2009 18 5 1651 8 PMC 2771723 nbsp PMID 19423540 doi 10 1158 1055 9965 EPI 08 1041 Cerhan JR Novak AJ Fredericksen ZS et al Risk of non Hodgkin lymphoma in association with germline variation in complement genes Br J Haematol 2009 145 5 614 23 PMC 2820509 nbsp PMID 19344414 doi 10 1111 j 1365 2141 2009 07675 x Han S Lan Q Park AK et al Polymorphisms in innate immunity genes and risk of childhood leukemia Hum Immunol 2010 71 7 727 30 PMC 2967770 nbsp PMID 20438785 doi 10 1016 j humimm 2010 04 004 Liu T Qian WJ Gritsenko MA et al Human plasma N glycoproteome analysis by immunoaffinity subtraction hydrazide chemistry and mass spectrometry J Proteome Res 2070 80 PMC 1850943 nbsp PMID 16335952 doi 10 1021 pr0502065 Kimura K Wakamatsu A Suzuki Y et al Diversification of transcriptional modulation large scale identification and characterization of putative alternative promoters of human genes Genome Res 2006 16 1 55 65 PMC 1356129 nbsp PMID 16344560 doi 10 1101 gr 4039406 Talmud PJ Drenos F Shah S et al Gene centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip Am J Hum Genet 2009 85 5 628 42 PMC 2775832 nbsp PMID 19913121 doi 10 1016 j ajhg 2009 10 014 Muller Eberhard HJ Molecular organization and function of the complement system Annu Rev Biochem 1988 57 321 47 PMID 3052276 doi 10 1146 annurev bi 57 070188 001541 Gerhard DS Wagner L Feingold EA et al The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 2004 14 10B 2121 7 PMC 528928 nbsp PMID 15489334 doi 10 1101 gr 2596504 Eid NA Hussein AA Elzein AM et al Candidate malaria susceptibility protective SNPs in hospital and population based studies the effect of sub structuring Malar J 2010 9 119 PMC 2877684 nbsp PMID 20459687 doi 10 1186 1475 2875 9 119 Fosbrink M Cudrici C Tegla CA et al Response gene to complement 32 is required for C5b 9 induced cell cycle activation in endothelial cells Exp Mol Pathol 2009 86 2 87 94 PMC 2699899 nbsp PMID 19162005 doi 10 1016 j yexmp 2008 12 005 Rajaraman P Brenner AV Neta G et al Risk of meningioma and common variation in genes related to innate immunity Cancer Epidemiol Biomarkers Prev 2010 19 5 1356 61 PMC 3169167 nbsp PMID 20406964 doi 10 1158 1055 9965 EPI 09 1151 Ennis S Jomary C Mullins R et al Association between the SERPING1 gene and age related macular degeneration a two stage case control study Lancet 2008 372 9652 1828 34 PMID 18842294 doi 10 1016 S0140 6736 08 61348 3 Soejima M Tachida H Tsuneoka M et al Nucleotide sequence analyses of human complement 6 C6 gene suggest balancing selection Ann Hum Genet 2005 69 Pt 3 239 52 PMID 15845028 doi 10 1046 j 1529 8817 2005 00165 x Bulla R Bossi F Agostinis C et al Complement production by trophoblast cells at the feto maternal interface J Reprod Immunol 2009 82 2 119 25 PMID 19665237 doi 10 1016 j jri 2009 06 124 Gancz D Donin N Fishelson Z Involvement of the c jun N terminal kinases JNK1 and JNK2 in complement mediated cell death Mol Immunol 2009 47 2 3 310 7 PMID 19864026 doi 10 1016 j molimm 2009 09 016 Parham KL Roberts A Thomas A et al Prevalence of mutations leading to complete C6 deficiency C6Q0 in the Western Cape South Africa and detection of novel mutations leading to C6Q0 in an Irish family Mol Immunol 2007 44 10 2756 60 PMID 17257682 doi 10 1016 j molimm 2006 11 022 Wu C Ma MH Brown KR et al Systematic identification of SH3 domain mediated human protein protein interactions by peptide array target screening Proteomics 2007 7 11 1775 85 PMID 17474147 doi 10 1002 pmic 200601006 Bailey SD Xie C Do R et al Variation at the NFATC2 locus increases the risk of thiazolidinedione induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication DREAM study Diabetes Care 2010 33 10 2250 3 PMC 2945168 nbsp PMID 20628086 doi 10 2337 dc10 0452 外部連結 编辑醫學主題詞表 MeSH Complement C6 nbsp 这是一篇與生物化學相關的小作品 你可以通过编辑或修订扩充其内容 查论编 取自 https zh wikipedia org w index php title 補體成分6 amp oldid 72866142, 维基百科，wiki，书籍，书籍，图书馆，

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