血清素轉運體, 5-羥色胺轉運體 (SERT 或 5-HTT)，鈉離子依賴型血清素轉運體 及 溶質載體家族6成員4 是一種在人體中被SLC6A4基因所編碼的蛋白質。SERT 是一種負責傳送突觸間隙的血清素到突觸前神經元的單胺轉運蛋白。
| Solute carrier family 6 (neurotransmitter transporter), member 4 |
|---|
| 标识 |
|---|
| 代号 | SLC6A4; 5-HTT; 5-HTTLPR; 5HTT; HTT; OCD1; SERT; SERT1; hSERT |
|---|
| 扩展标识 | 遗传学：182138 鼠基因：96285 同源基因：817 ChEMBL: 228 GeneCards: SLC6A4 Gene |
|---|
| 基因本体论描述 |
|---|
| 分子功能 | · serotonin:sodium symporter activity
· protein binding
· monoamine transmembrane transporter activity
· serotonin transmembrane transporter activity
· myosin binding
· syntaxin-1 binding
· Rab GTPase binding
· cocaine binding
· protein homodimerization activity
· nitric-oxide synthase binding
· actin filament binding
|
|---|
| 细胞成分 | · cytosol
· plasma membrane
· integral component of plasma membrane
· endosome membrane
· endomembrane system
· neuron projection
· membrane raft
|
|---|
| 生物过程 | · response to hypoxia
· serotonin transport
· synaptic transmission
· response to nutrient
· memory
· circadian rhythm
· response to toxic substance
· positive regulation of gene expression
· monoamine transport
· thalamus development
· negative regulation of cerebellar granule cell precursor proliferation
· negative regulation of synaptic transmission, dopaminergic
· response to estradiol
· social behavior
· vasoconstriction
· response to drug
· sperm ejaculation
· negative regulation of neuron differentiation
· positive regulation of cell cycle
· negative regulation of organ growth
· brain morphogenesis
· protein oligomerization
· protein homooligomerization
· serotonin uptake
· transmembrane transport
· cellular response to retinoic acid
· cellular response to cGMP
|
|---|
| Sources: Amigo / QuickGO |
|
| RNA表达模式 |
|---|
| |
| 更多表达数据 |
| 直系同源体 |
|---|
| 物种 | 人类 | 小鼠 |
|---|
| Entrez | 6532 | 15567 |
|---|
| Ensembl | ENSG00000108576 | ENSMUSG00000020838 |
|---|
| UniProt | P31645 | Q60857 |
|---|
| mRNA序列 | NM_001045 | NM_010484 |
|---|
| 蛋白序列 | NP_001036 | NP_034614 |
|---|
| 基因位置 | Chr 17:
30.19 – 30.24 Mb | Chr 11:
77 – 77.03 Mb |
|---|
| PubMed查询 | [1] | [2] |
|---|
|
功能 编辑
血清素轉運體將血清素從突觸間隙發送回突触终扣，阻止了血清素的作用，同時令突觸前神經元能夠重新運用突觸間隙的血清素。
神經元之間的溝通是由神經傳導物質，如細胞之間的血清素轉運來進行。因血清素轉運體使血清素得以重新運用；平衝了血清素於突觸間隙的濃度，因此其作用於接收神經元的受體上。
血清素轉運體也存在於血小板中，作用為一種使血管收縮的物質。
參考 编辑
血清素轉運體, 羥色胺轉運體, sert, 鈉離子依賴型, 溶質載體家族6成員4, 是一種在人體中被slc6a4基因所編碼的蛋白質, sert, 是一種負責傳送突觸間隙, 英语, synaptic, cleft, 的血清素到突觸前神經元的單胺轉運蛋白, 英语, monoamine, transporter, solute, carrier, family, neurotransmitter, transporter, member, 4标识代号slc6a4, httlpr, 5htt, ocd1, sert, se. 血清素轉運體 5 羥色胺轉運體 SERT 或 5 HTT 鈉離子依賴型血清素轉運體 及 溶質載體家族6成員4 是一種在人體中被SLC6A4基因所編碼的蛋白質 SERT 是一種負責傳送突觸間隙 英语 synaptic cleft 的血清素到突觸前神經元的單胺轉運蛋白 英语 Monoamine transporter Solute carrier family 6 neurotransmitter transporter member 4标识代号SLC6A4 5 HTT 5 HTTLPR 5HTT HTT OCD1 SERT SERT1 hSERT扩展标识遗传学 182138 鼠基因 96285 同源基因 817 ChEMBL 228 GeneCards SLC6A4 Gene基因本体论描述分子功能 serotonin sodium symporter activity protein binding monoamine transmembrane transporter activity serotonin transmembrane transporter activity myosin binding syntaxin 1 binding Rab GTPase binding cocaine binding protein homodimerization activity nitric oxide synthase binding actin filament binding细胞成分 cytosol plasma membrane integral component of plasma membrane endosome membrane endomembrane system neuron projection membrane raft生物过程 response to hypoxia serotonin transport synaptic transmission response to nutrient memory circadian rhythm response to toxic substance positive regulation of gene expression monoamine transport thalamus development negative regulation of cerebellar granule cell precursor proliferation negative regulation of synaptic transmission dopaminergic response to estradiol social behavior vasoconstriction response to drug sperm ejaculation negative regulation of neuron differentiation positive regulation of cell cycle negative regulation of organ growth brain morphogenesis protein oligomerization protein homooligomerization serotonin uptake transmembrane transport cellular response to retinoic acid cellular response to cGMPSources Amigo QuickGORNA表达模式更多表达数据直系同源体物种人类小鼠Entrez653215567EnsemblENSG00000108576ENSMUSG00000020838UniProtP31645Q60857mRNA序列NM 001045NM 010484蛋白序列NP 001036NP 034614基因位置Chr 17 30 19 30 24 MbChr 11 77 77 03 MbPubMed查询 1 2 查论编功能 编辑血清素轉運體將血清素從突觸間隙發送回突触终扣 阻止了血清素的作用 同時令突觸前神經元能夠重新運用突觸間隙的血清素 神經元之間的溝通是由神經傳導物質 如細胞之間的血清素轉運來進行 因血清素轉運體使血清素得以重新運用 平衝了血清素於突觸間隙的濃度 因此其作用於接收神經元的受體上 血清素轉運體也存在於血小板中 作用為一種使血管收縮的物質 nbsp 血清素參考 编辑Template 血清張力素 取自 https zh wikipedia org w index php title 血清素轉運體 amp oldid 71382382, 维基百科，wiki，书籍，书籍，图书馆，
文章
，阅读，下载，免费，免费下载，mp3，视频，mp4，3gp， jpg，jpeg，gif，png，图片，音乐，歌曲，电影，书籍，游戏，游戏。