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维基百科

內輸蛋白亞基α-2

四月 10, 2024

內輸蛋白亞基α-2（英語：Importin subunit alpha-2）是人體內的一種蛋白質，為內輸蛋白α（英语：Importin α）的一種，由17號染色體上的KPNA2基因編碼。[5][6]

內輸蛋白亞基α-2
已知的結構
PDB直系同源搜索: PDBe RCSB
識別號
别名KPNA2；, IPOA1, QIP2, RCH1, SRP1alpha, Karyopherin alpha 2, SRP1-alpha, karyopherin subunit alpha 2, PTAC58
外部IDOMIM：600685 MGI：103561 HomoloGene：1708 GeneCards：KPNA2
基因位置（人类）
染色体17號染色體[1]
基因座17q24.2起始68,035,636 bp[1]
终止68,047,364 bp[1]
直系同源
物種人類小鼠
Entrez

3838

16647

Ensembl

ENSG00000182481

ENSMUSG00000018362

UniProt

P52292

P52293

mRNA​序列

NM_002266
​NM_001320611

NM_010655

蛋白序列

NP_001307540
​NP_002257

NP_034785

基因位置​（UCSC）Chr 17: 68.04 – 68.05 MbChr 11: 106.88 – 106.89 Mb
PubMed​查找[3][4]
維基數據
檢視/編輯人類檢視/編輯小鼠

功能 编辑

內輸蛋白亞基α-2參與了蛋白質由細胞質轉運進細胞核的過程，細胞質中，內輸蛋白α可結合具有核定位序列的蛋白質[7]，接著再與內輸蛋白β結合而形成二聚體，後者可與核孔複合物互動，使二聚體和蛋白質一起進入細胞核中。入核後，內輸蛋白二聚體與Ran-GTP結合而將原本結合的蛋白質釋出，再回到細胞質中。此過程與Ran循環（英语：Ran (protein)）偶連，並需消耗能量[8]。

除了協助蛋白質進入細胞核外，KPNA2可能也參與V(D)J重組（英语：V(D)J recombination）[9]。

交互作用 编辑

核轉運蛋白α-2會與以下的蛋白質產生交互作用：

  • ADP-核糖基化因子樣蛋白4A（英语：ARL4A）[10]
  • 白細胞介素-2誘導性T細胞激酶（英语：ITK (gene)）[11]
  • 內輸蛋白亞基b-1（英语：KPNB1）[12][13][14]
  • 鋅指蛋白PLAG1（英语：PLAG1）[15]
  • ATP依賴性DNA螺旋酶Q1（英语：RECQL）[16]
  • 絲氨酸/蘇氨酸蛋白激酶（英语：SGK）[17]

參考文獻 编辑

  1. ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000182481 - Ensembl, May 2017
  2. ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000018362 - Ensembl, May 2017
  3. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Cuomo CA, Kirch SA, Gyuris J, Brent R, Oettinger MA. Rch1, a protein that specifically interacts with the RAG-1 recombination-activating protein. Proceedings of the National Academy of Sciences of the United States of America. Jun 1994, 91 (13): 6156–60. PMC 44157  . PMID 8016130. doi:10.1073/pnas.91.13.6156. 
  6. ^ Weis K, Mattaj IW, Lamond AI. Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences. Science. May 1995, 268 (5213): 1049–53. PMID 7754385. doi:10.1126/science.7754385. 
  7. ^ Moroianu, J; Blobel, G; Radu, A. Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes.. Proceedings of the National Academy of Sciences of the United States of America. 1995-03-14, 92 (6): 2008–2011. ISSN 0027-8424. PMC 42412  . PMID 7892216. doi:10.1073/pnas.92.6.2008. 
  8. ^ Goldfarb, David S.; Corbett, Anita H.; Mason, D. Adam; Harreman, Michelle T.; Adam, Stephen A. Importin α: a multipurpose nuclear-transport receptor. Trends in Cell Biology. 2004, 14 (9): 505–514. PMID 15350979. doi:10.1016/j.tcb.2004.07.016. 
  9. ^ Entrez Gene: KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1). （原始内容于2010-12-05）. 
  10. ^ Lin CY, Huang PH, Liao WL, Cheng HJ, Huang CF, Kuo JC, Patton WA, Massenburg D, Moss J, Lee FJ. ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli. The Journal of Biological Chemistry. Dec 2000, 275 (48): 37815–23. PMID 10980193. doi:10.1074/jbc.M002470200. 
  11. ^ Perez-Villar JJ, O'Day K, Hewgill DH, Nadler SG, Kanner SB. Nuclear localization of the tyrosine kinase Itk and interaction of its SH3 domain with karyopherin alpha (Rch1alpha). International Immunology. Oct 2001, 13 (10): 1265–74. PMID 11581171. doi:10.1093/intimm/13.10.1265. 
  12. ^ Nagoshi E, Yoneda Y. Dimerization of sterol regulatory element-binding protein 2 via the helix-loop-helix-leucine zipper domain is a prerequisite for its nuclear localization mediated by importin beta. Molecular and Cellular Biology. Apr 2001, 21 (8): 2779–89. PMC 86908  . PMID 11283257. doi:10.1128/MCB.21.8.2779-2789.2001. 
  13. ^ Köhler M, Speck C, Christiansen M, Bischoff FR, Prehn S, Haller H, Görlich D, Hartmann E. Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import. Molecular and Cellular Biology. Nov 1999, 19 (11): 7782–91. PMC 84838  . PMID 10523667. doi:10.1128/mcb.19.11.7782. 
  14. ^ Kutay U, Bischoff FR, Kostka S, Kraft R, Görlich D. Export of importin alpha from the nucleus is mediated by a specific nuclear transport factor. Cell. Sep 1997, 90 (6): 1061–71. PMID 9323134. doi:10.1016/s0092-8674(00)80372-4. 
  15. ^ Braem CV, Kas K, Meyen E, Debiec-Rychter M, Van De Ven WJ, Voz ML. Identification of a karyopherin alpha 2 recognition site in PLAG1, which functions as a nuclear localization signal. The Journal of Biological Chemistry. May 2002, 277 (22): 19673–8. PMID 11882654. doi:10.1074/jbc.M112112200. 
  16. ^ Seki T, Tada S, Katada T, Enomoto T. Cloning of a cDNA encoding a novel importin-alpha homologue, Qip1: discrimination of Qip1 and Rch1 from hSrp1 by their ability to interact with DNA helicase Q1/RecQL. Biochemical and Biophysical Research Communications. May 1997, 234 (1): 48–53. PMID 9168958. doi:10.1006/bbrc.1997.6535. 
  17. ^ Maiyar AC, Leong ML, Firestone GL. Importin-alpha mediates the regulated nuclear targeting of serum- and glucocorticoid-inducible protein kinase (Sgk) by recognition of a nuclear localization signal in the kinase central domain. Molecular Biology of the Cell. Mar 2003, 14 (3): 1221–39. PMC 151592  . PMID 12631736. doi:10.1091/mbc.E02-03-0170. 

延伸閱讀 编辑

  • Bukrinsky MI, Haffar OK. HIV-1 nuclear import: in search of a leader. Frontiers in Bioscience. Dec 1997, 2 (4): d578–87. PMID 9366553. doi:10.2741/A213. 
  • Bukrinsky MI, Haffar OK. HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr. Molecular Medicine. Mar 1998, 4 (3): 138–43. PMC 2230352  . PMID 9562972. doi:10.1007/BF03401911. 
  • Kino T, Pavlakis GN. Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1. DNA and Cell Biology. Apr 2004, 23 (4): 193–205 [2019-07-18]. PMID 15142377. doi:10.1089/104454904773819789. （原始内容于2020-11-07）. 
  • Teng SC, Wu KJ, Tseng SF, Wong CW, Kao L. Importin KPNA2, NBS1, DNA repair and tumorigenesis. Journal of Molecular Histology. Sep 2006, 37 (5–7): 293–9. PMID 16752129. doi:10.1007/s10735-006-9032-y. 
  • Bukrinsky MI, Sharova N, Dempsey MP, Stanwick TL, Bukrinskaya AG, Haggerty S, Stevenson M. Active nuclear import of human immunodeficiency virus type 1 preintegration complexes. Proceedings of the National Academy of Sciences of the United States of America. Jul 1992, 89 (14): 6580–4. PMC 49545  . PMID 1631159. doi:10.1073/pnas.89.14.6580. 
  • Sharova N, Bukrinskaya A. p17 and p17-containing gag precursors of input human immunodeficiency virus are transported into the nuclei of infected cells. AIDS Research and Human Retroviruses. Mar 1991, 7 (3): 303–6. PMID 2064827. doi:10.1089/aid.1991.7.303. 
  • Di Marzio P, Choe S, Ebright M, Knoblauch R, Landau NR. Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr. Journal of Virology. Dec 1995, 69 (12): 7909–16. PMC 189735  . PMID 7494303. 
  • Küssel P, Frasch M. Yeast Srp1, a nuclear protein related to Drosophila and mouse pendulin, is required for normal migration, division, and integrity of nuclei during mitosis. Molecular & General Genetics. Aug 1995, 248 (3): 351–63. PMID 7565597. doi:10.1007/BF02191602. 
  • Gallay P, Swingler S, Song J, Bushman F, Trono D. HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase. Cell. Nov 1995, 83 (4): 569–76. PMID 7585960. doi:10.1016/0092-8674(95)90097-7. 
  • Moroianu J, Hijikata M, Blobel G, Radu A. Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins. Proceedings of the National Academy of Sciences of the United States of America. Jul 1995, 92 (14): 6532–6. PMC 41552  . PMID 7604027. doi:10.1073/pnas.92.14.6532. 
  • Freed EO, Englund G, Martin MA. Role of the basic domain of human immunodeficiency virus type 1 matrix in macrophage infection. Journal of Virology. Jun 1995, 69 (6): 3949–54. PMC 189124  . PMID 7745752. 
  • Gallay P, Swingler S, Aiken C, Trono D. HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator. Cell. Feb 1995, 80 (3): 379–88. PMID 7859280. doi:10.1016/0092-8674(95)90488-3. 
  • von Schwedler U, Kornbluth RS, Trono D. The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. Jul 1994, 91 (15): 6992–6. PMC 44324  . PMID 8041734. doi:10.1073/pnas.91.15.6992. 
  • Heinzinger NK, Bukrinsky MI, Haggerty SA, Ragland AM, Kewalramani V, Lee MA, Gendelman HE, Ratner L, Stevenson M, Emerman M. The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells. Proceedings of the National Academy of Sciences of the United States of America. Jul 1994, 91 (15): 7311–5. PMC 44389  . PMID 8041786. doi:10.1073/pnas.91.15.7311. 
  • Bukrinsky MI, Haggerty S, Dempsey MP, Sharova N, Adzhubel A, Spitz L, Lewis P, Goldfarb D, Emerman M, Stevenson M. A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells. Nature. Oct 1993, 365 (6447): 666–9. PMID 8105392. doi:10.1038/365666a0. 
  • Dubrovsky L, Ulrich P, Nuovo GJ, Manogue KR, Cerami A, Bukrinsky M. Nuclear localization signal of HIV-1 as a novel target for therapeutic intervention. Molecular Medicine. Jan 1995, 1 (2): 217–30. PMC 2229944  . PMID 8529100. doi:10.1007/BF03401569. 
  • Gallay P, Stitt V, Mundy C, Oettinger M, Trono D. Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import. Journal of Virology. Feb 1996, 70 (2): 1027–32. PMC 189908  . PMID 8551560. 
  • Bukrinskaya AG, Ghorpade A, Heinzinger NK, Smithgall TE, Lewis RE, Stevenson M. Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA. Proceedings of the National Academy of Sciences of the United States of America. Jan 1996, 93 (1): 367–71. PMC 40239  . PMID 8552640. doi:10.1073/pnas.93.1.367. 

四月 10, 2024
內輸蛋白亞基α, 英語, importin, subunit, alpha, 是人體內的一種蛋白質, 為內輸蛋白α, 英语, importin, 的一種, 由17號染色體上的kpna2基因編碼, 已知的結構pdb直系同源搜索, pdbe, rcsbpdbid列表1efx, 1qgk, 1qgr, 3fex, 3fey, 3wpt, 4e4v, 4wv6識別號别名kpna2, ipoa1, qip2, rch1, srp1alpha, karyopherin, alpha, srp1, alpha, karyophe. 內輸蛋白亞基a 2 英語 Importin subunit alpha 2 是人體內的一種蛋白質 為內輸蛋白a 英语 Importin a 的一種 由17號染色體上的KPNA2基因編碼 5 6 內輸蛋白亞基a 2已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表1EFX 1QGK 1QGR 3FEX 3FEY 3WPT 4E4V 4WV6識別號别名KPNA2 IPOA1 QIP2 RCH1 SRP1alpha Karyopherin alpha 2 SRP1 alpha karyopherin subunit alpha 2 PTAC58外部IDOMIM 600685 MGI 103561 HomoloGene 1708 GeneCards KPNA2基因位置 人类 染色体17號染色體 1 基因座17q24 2起始68 035 636 bp 1 终止68 047 364 bp 1 基因位置 小鼠 染色体小鼠11号染色体 2 基因座11 11 E1起始106 879 455 bp 2 终止106 890 367 bp 2 基因本體分子功能 histone deacetylase binding 血浆蛋白结合 nuclear localization sequence binding RNA binding nuclear import signal receptor activity細胞組分 膜 核孔 核质 细胞核 細胞質 细胞质基质 host cell extrinsic component of postsynaptic specialization membrane glutamatergic synapse生物學過程 regulation of DNA recombination protein import into nucleus DNA代谢过程 protein transport viral process NLS bearing protein import into nucleus modulation by virus of host cellular process intracellular transport of virus transport postsynapse to nucleus signaling pathway entry of viral genome into host nucleus through nuclear pore complex via importin positive regulation of viral life cycleSources Amigo QuickGO直系同源物種人類小鼠Entrez383816647EnsemblENSG00000182481ENSMUSG00000018362UniProtP52292P52293mRNA 序列NM 002266 NM 001320611NM 010655蛋白序列NP 001307540 NP 002257NP 034785基因位置 UCSC Chr 17 68 04 68 05 MbChr 11 106 88 106 89 MbPubMed 查找 3 4 維基數據檢視 編輯人類檢視 編輯小鼠 目录 1 功能 2 交互作用 3 參考文獻 4 延伸閱讀功能 编辑內輸蛋白亞基a 2參與了蛋白質由細胞質轉運進細胞核的過程 細胞質中 內輸蛋白a可結合具有核定位序列的蛋白質 7 接著再與內輸蛋白b結合而形成二聚體 後者可與核孔複合物互動 使二聚體和蛋白質一起進入細胞核中 入核後 內輸蛋白二聚體與Ran GTP結合而將原本結合的蛋白質釋出 再回到細胞質中 此過程與Ran循環 英语 Ran protein 偶連 並需消耗能量 8 除了協助蛋白質進入細胞核外 KPNA2可能也參與V D J重組 英语 V D J recombination 9 交互作用 编辑核轉運蛋白a 2會與以下的蛋白質產生交互作用 ADP 核糖基化因子樣蛋白4A 英语 ARL4A 10 白細胞介素 2誘導性T細胞激酶 英语 ITK gene 11 內輸蛋白亞基b 1 英语 KPNB1 12 13 14 鋅指蛋白PLAG1 英语 PLAG1 15 ATP依賴性DNA螺旋酶Q1 英语 RECQL 16 絲氨酸 蘇氨酸蛋白激酶 英语 SGK 17 參考文獻 编辑 1 0 1 1 1 2 GRCh38 Ensembl release 89 ENSG00000182481 Ensembl May 2017 2 0 2 1 2 2 GRCm38 Ensembl release 89 ENSMUSG00000018362 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Cuomo CA Kirch SA Gyuris J Brent R Oettinger MA Rch1 a protein that specifically interacts with the RAG 1 recombination activating protein Proceedings of the National Academy of Sciences of the United States of America Jun 1994 91 13 6156 60 PMC 44157 nbsp PMID 8016130 doi 10 1073 pnas 91 13 6156 Weis K Mattaj IW Lamond AI Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences Science May 1995 268 5213 1049 53 PMID 7754385 doi 10 1126 science 7754385 Moroianu J Blobel G Radu A Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes Proceedings of the National Academy of Sciences of the United States of America 1995 03 14 92 6 2008 2011 ISSN 0027 8424 PMC 42412 nbsp PMID 7892216 doi 10 1073 pnas 92 6 2008 Goldfarb David S Corbett Anita H Mason D Adam Harreman Michelle T Adam Stephen A Importin a a multipurpose nuclear transport receptor Trends in Cell Biology 2004 14 9 505 514 PMID 15350979 doi 10 1016 j tcb 2004 07 016 Entrez Gene KPNA2 karyopherin alpha 2 RAG cohort 1 importin alpha 1 原始内容存档于2010 12 05 Lin CY Huang PH Liao WL Cheng HJ Huang CF Kuo JC Patton WA Massenburg D Moss J Lee FJ ARL4 an ARF like protein that is developmentally regulated and localized to nuclei and nucleoli The Journal of Biological Chemistry Dec 2000 275 48 37815 23 PMID 10980193 doi 10 1074 jbc M002470200 Perez Villar JJ O Day K Hewgill DH Nadler SG Kanner SB Nuclear localization of the tyrosine kinase Itk and interaction of its SH3 domain with karyopherin alpha Rch1alpha International Immunology Oct 2001 13 10 1265 74 PMID 11581171 doi 10 1093 intimm 13 10 1265 Nagoshi E Yoneda Y Dimerization of sterol regulatory element binding protein 2 via the helix loop helix leucine zipper domain is a prerequisite for its nuclear localization mediated by importin beta Molecular and Cellular Biology Apr 2001 21 8 2779 89 PMC 86908 nbsp PMID 11283257 doi 10 1128 MCB 21 8 2779 2789 2001 Kohler M Speck C Christiansen M Bischoff FR Prehn S Haller H Gorlich D Hartmann E Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import Molecular and Cellular Biology Nov 1999 19 11 7782 91 PMC 84838 nbsp PMID 10523667 doi 10 1128 mcb 19 11 7782 Kutay U Bischoff FR Kostka S Kraft R Gorlich D Export of importin alpha from the nucleus is mediated by a specific nuclear transport factor Cell Sep 1997 90 6 1061 71 PMID 9323134 doi 10 1016 s0092 8674 00 80372 4 Braem CV Kas K Meyen E Debiec Rychter M Van De Ven WJ Voz ML Identification of a karyopherin alpha 2 recognition site in PLAG1 which functions as a nuclear localization signal The Journal of Biological Chemistry May 2002 277 22 19673 8 PMID 11882654 doi 10 1074 jbc M112112200 Seki T Tada S Katada T Enomoto T Cloning of a cDNA encoding a novel importin alpha homologue Qip1 discrimination of Qip1 and Rch1 from hSrp1 by their ability to interact with DNA helicase Q1 RecQL Biochemical and Biophysical Research Communications May 1997 234 1 48 53 PMID 9168958 doi 10 1006 bbrc 1997 6535 Maiyar AC Leong ML Firestone GL Importin alpha mediates the regulated nuclear targeting of serum and glucocorticoid inducible protein kinase Sgk by recognition of a nuclear localization signal in the kinase central domain Molecular Biology of the Cell Mar 2003 14 3 1221 39 PMC 151592 nbsp PMID 12631736 doi 10 1091 mbc E02 03 0170 延伸閱讀 编辑Bukrinsky MI Haffar OK HIV 1 nuclear import in search of a leader Frontiers in Bioscience Dec 1997 2 4 d578 87 PMID 9366553 doi 10 2741 A213 Bukrinsky MI Haffar OK HIV 1 nuclear import matrix protein is back on center stage this time together with Vpr Molecular Medicine Mar 1998 4 3 138 43 PMC 2230352 nbsp PMID 9562972 doi 10 1007 BF03401911 Kino T Pavlakis GN Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1 DNA and Cell Biology Apr 2004 23 4 193 205 2019 07 18 PMID 15142377 doi 10 1089 104454904773819789 原始内容存档于2020 11 07 Teng SC Wu KJ Tseng SF Wong CW Kao L Importin KPNA2 NBS1 DNA repair and tumorigenesis Journal of Molecular Histology Sep 2006 37 5 7 293 9 PMID 16752129 doi 10 1007 s10735 006 9032 y Bukrinsky MI Sharova N Dempsey MP Stanwick TL Bukrinskaya AG Haggerty S Stevenson M Active nuclear import of human immunodeficiency virus type 1 preintegration complexes Proceedings of the National Academy of Sciences of the United States of America Jul 1992 89 14 6580 4 PMC 49545 nbsp PMID 1631159 doi 10 1073 pnas 89 14 6580 Sharova N Bukrinskaya A p17 and p17 containing gag precursors of input human immunodeficiency virus are transported into the nuclei of infected cells AIDS Research and Human Retroviruses Mar 1991 7 3 303 6 PMID 2064827 doi 10 1089 aid 1991 7 303 Di Marzio P Choe S Ebright M Knoblauch R Landau NR Mutational analysis of cell cycle arrest nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr Journal of Virology Dec 1995 69 12 7909 16 PMC 189735 nbsp PMID 7494303 Kussel P Frasch M Yeast Srp1 a nuclear protein related to Drosophila and mouse pendulin is required for normal migration division and integrity of nuclei during mitosis Molecular amp General Genetics Aug 1995 248 3 351 63 PMID 7565597 doi 10 1007 BF02191602 Gallay P Swingler S Song J Bushman F Trono D HIV nuclear import is governed by the phosphotyrosine mediated binding of matrix to the core domain of integrase Cell Nov 1995 83 4 569 76 PMID 7585960 doi 10 1016 0092 8674 95 90097 7 Moroianu J Hijikata M Blobel G Radu A Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat containing nucleoporins Proceedings of the National Academy of Sciences of the United States of America Jul 1995 92 14 6532 6 PMC 41552 nbsp PMID 7604027 doi 10 1073 pnas 92 14 6532 Freed EO Englund G Martin MA Role of the basic domain of human immunodeficiency virus type 1 matrix in macrophage infection Journal of Virology Jun 1995 69 6 3949 54 PMC 189124 nbsp PMID 7745752 Gallay P Swingler S Aiken C Trono D HIV 1 infection of nondividing cells C terminal tyrosine phosphorylation of the viral matrix protein is a key regulator Cell Feb 1995 80 3 379 88 PMID 7859280 doi 10 1016 0092 8674 95 90488 3 von Schwedler U Kornbluth RS Trono D The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes Proceedings of the National Academy of Sciences of the United States of America Jul 1994 91 15 6992 6 PMC 44324 nbsp PMID 8041734 doi 10 1073 pnas 91 15 6992 Heinzinger NK Bukrinsky MI Haggerty SA Ragland AM Kewalramani V Lee MA Gendelman HE Ratner L Stevenson M Emerman M The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells Proceedings of the National Academy of Sciences of the United States of America Jul 1994 91 15 7311 5 PMC 44389 nbsp PMID 8041786 doi 10 1073 pnas 91 15 7311 Bukrinsky MI Haggerty S Dempsey MP Sharova N Adzhubel A Spitz L Lewis P Goldfarb D Emerman M Stevenson M A nuclear localization signal within HIV 1 matrix protein that governs infection of non dividing cells Nature Oct 1993 365 6447 666 9 PMID 8105392 doi 10 1038 365666a0 Dubrovsky L Ulrich P Nuovo GJ Manogue KR Cerami A Bukrinsky M Nuclear localization signal of HIV 1 as a novel target for therapeutic intervention Molecular Medicine Jan 1995 1 2 217 30 PMC 2229944 nbsp PMID 8529100 doi 10 1007 BF03401569 Gallay P Stitt V Mundy C Oettinger M Trono D Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import Journal of Virology Feb 1996 70 2 1027 32 PMC 189908 nbsp PMID 8551560 Bukrinskaya AG Ghorpade A Heinzinger NK Smithgall TE Lewis RE Stevenson M Phosphorylation dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA Proceedings of the National Academy of Sciences of the United States of America Jan 1996 93 1 367 71 PMC 40239 nbsp PMID 8552640 doi 10 1073 pnas 93 1 367 取自 https zh wikipedia org w index php title 內輸蛋白亞基a 2 amp oldid 69723878, 维基百科，wiki，书籍，书籍，图书馆，

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