fbpx
维基百科

VCAM-1

VCAM-1(Vascular cell adhesion protein 1(I型血管細胞黏附蛋白)),又稱CD106,是一種細胞黏附蛋白,在人體內由VCAM-1基因編碼,屬於一種唾液酸糖蛋白[5]

VCAM-1
已知的結構
PDB直系同源搜索: PDBe RCSB
識別號
别名VCAM1;, CD106, INCAM-100, vascular cell adhesion molecule 1
外部IDOMIM:192225 MGI:98926 HomoloGene:838 GeneCards:VCAM1
基因位置(人类
染色体1號染色體[1]
基因座1p21.2起始100,719,742 bp[1]
终止100,739,045 bp[1]
RNA表达模式
查阅更多表达数据
直系同源
物種人類小鼠
Entrez
Ensembl
UniProt
mRNA​序列

NM_080682
​NM_001078
​NM_001199834

NM_011693

蛋白序列

NP_001069
​NP_001186763
​NP_542413

NP_035823

基因位置​(UCSC)Chr 1: 100.72 – 100.74 MbChr 3: 115.9 – 115.92 Mb
PubMed​查找[3][4]
維基數據
檢視/編輯人類檢視/編輯小鼠

結構

VCAM-1含有6個或7個免疫球蛋白結構域,屬於免疫球蛋白蛋白超家族英语Protein superfamily(IgSF)。於人體內存在兩個由可變剪接產生的轉錄本[6]

功能與分佈

VCAM-1參與淋巴細胞—內皮細胞間黏附過程和細胞間信號識別過程,能在免疫應答中促進淋巴細胞向炎症區遷移[7]淋巴細胞軟骨細胞等細胞中都含有VCAM-1,血管內皮細胞在受到細胞因子刺激後也會表達VCAM-1蛋白[6][8]。一些間充質幹細胞亞群細胞表面表達CD106(VCAM-1)[9]

參考

  1. ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000162692 - Ensembl, May 2017
  2. ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000027962 - Ensembl, May 2017
  3. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Cybulsky M, Fries JW, Williams AJ, Sultan P, Eddy RL, Byers MG, Shows TB, Gimbrone MA Jr, Collins T. The human VCAM1 gene is assigned to chromosome 1p31-p32. Cytogenet. Cell Genet. 1991, 58: 1852. doi:10.1159/000133735. 
  6. ^ 6.0 6.1 Entrez Gene: VCAM1 vascular cell adhesion molecule 1. 
  7. ^ . Uniprot. [2018-01-10]. (原始内容存档于2017-10-03). 
  8. ^ Kienzle G.; von Kempis J. Vascular cell adhesion molecule 1 (CD106) on primary human articular chondrocytes: functional regulation of expression by cytokines and comparison with intercellular adhesion molecule 1 (CD54) and very late activation antigen 2. Arthritis Rheum. 1998 Jul;41(7):1296-305. 
  9. ^ ZX Yang; et al. CD106 identifies a subpopulation of mesenchymal stem cells with unique immunomodulatory properties. PLoS One. 2013;8(3):e59354. 

vcam, vascular, cell, adhesion, protein, i型血管細胞黏附蛋白, 又稱cd106, 是一種細胞黏附蛋白, 在人體內由基因編碼, 屬於一種唾液酸糖蛋白, 已知的結構pdb直系同源搜索, pdbe, rcsbpdbid列表1ij9, 1vca, 1vsc識別號别名vcam1, cd106, incam, vascular, cell, adhesion, molecule, 1外部idomim, 192225, 98926, homologene, genecards, vcam. VCAM 1 Vascular cell adhesion protein 1 I型血管細胞黏附蛋白 又稱CD106 是一種細胞黏附蛋白 在人體內由VCAM 1基因編碼 屬於一種唾液酸糖蛋白 5 VCAM 1已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表1IJ9 1VCA 1VSC識別號别名VCAM1 CD106 INCAM 100 vascular cell adhesion molecule 1外部IDOMIM 192225 MGI 98926 HomoloGene 838 GeneCards VCAM1基因位置 人类 染色体1號染色體 1 基因座1p21 2起始100 719 742 bp 1 终止100 739 045 bp 1 基因位置 小鼠 染色体小鼠3号染色体 2 基因座3 G1 3 50 17 cM起始115 903 598 bp 2 终止115 923 337 bp 2 RNA表达模式查阅更多表达数据基因本體分子功能 primary amine oxidase activity integrin binding cell adhesion molecule binding細胞組分 integral component of membrane 高尔基体 alpha9 beta1 integrin vascular cell adhesion molecule 1 complex 膜 絲狀偽足 细胞膜 apical part of cell 微绒毛 cell surface 早期内吞体 内质网 podosome 肌膜 外排體 external side of plasma membrane 細胞外空間 integral component of plasma membrane生物學過程 leukocyte cell cell adhesion response to ionizing radiation heterophilic cell cell adhesion via plasma membrane cell adhesion molecules response to hypoxia response to nutrient interferon gamma mediated signaling pathway cellular response to tumor necrosis factor response to nicotine 老化 response to zinc ion extracellular matrix organization amine metabolic process response to lipopolysaccharide 細胞粘附 acute inflammatory response positive regulation of T cell proliferation membrane to membrane docking regulation of immune response leukocyte tethering or rolling cell chemotaxis B cell differentiation cellular response to vascular endothelial growth factor stimulus cell matrix adhesion viral process response to ethanol calcium mediated signaling using intracellular calcium source chronic inflammatory response cell cell adhesion cytokine mediated signaling pathway heterotypic cell cell adhesion innervation cardiac neuron differentiation cell cell adhesion in response to extracellular stimulus cellular response to amyloid betaSources Amigo QuickGO直系同源物種人類小鼠Entrez741222329EnsemblENSG00000162692ENSMUSG00000027962UniProtP19320P29533mRNA 序列NM 080682 NM 001078 NM 001199834NM 011693蛋白序列NP 001069 NP 001186763 NP 542413NP 035823基因位置 UCSC Chr 1 100 72 100 74 MbChr 3 115 9 115 92 MbPubMed 查找 3 4 維基數據檢視 編輯人類檢視 編輯小鼠結構 编辑VCAM 1含有6個或7個免疫球蛋白結構域 屬於免疫球蛋白蛋白超家族 英语 Protein superfamily IgSF 於人體內存在兩個由可變剪接產生的轉錄本 6 功能與分佈 编辑VCAM 1參與淋巴細胞 內皮細胞間黏附過程和細胞間信號識別過程 能在免疫應答中促進淋巴細胞向炎症區遷移 7 淋巴細胞 軟骨細胞等細胞中都含有VCAM 1 血管內皮細胞在受到細胞因子刺激後也會表達VCAM 1蛋白 6 8 一些間充質幹細胞亞群細胞表面表達CD106 VCAM 1 9 參考 编辑 1 0 1 1 1 2 GRCh38 Ensembl release 89 ENSG00000162692 Ensembl May 2017 2 0 2 1 2 2 GRCm38 Ensembl release 89 ENSMUSG00000027962 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Cybulsky M Fries JW Williams AJ Sultan P Eddy RL Byers MG Shows TB Gimbrone MA Jr Collins T The human VCAM1 gene is assigned to chromosome 1p31 p32 Cytogenet Cell Genet 1991 58 1852 doi 10 1159 000133735 6 0 6 1 Entrez Gene VCAM1 vascular cell adhesion molecule 1 VCAM1 Uniprot 2018 01 10 原始内容存档于2017 10 03 Kienzle G von Kempis J Vascular cell adhesion molecule 1 CD106 on primary human articular chondrocytes functional regulation of expression by cytokines and comparison with intercellular adhesion molecule 1 CD54 and very late activation antigen 2 Arthritis Rheum 1998 Jul 41 7 1296 305 ZX Yang et al CD106 identifies a subpopulation of mesenchymal stem cells with unique immunomodulatory properties PLoS One 2013 8 3 e59354 引文格式1维护 显式使用等标签 link 取自 https zh wikipedia org w index php title VCAM 1 amp oldid 71696302, 维基百科,wiki,书籍,书籍,图书馆,

文章

,阅读,下载,免费,免费下载,mp3,视频,mp4,3gp, jpg,jpeg,gif,png,图片,音乐,歌曲,电影,书籍,游戏,游戏。