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促甲状腺激素β亚基, 英語, thyroid, stimulating, hormone, beta, 简称tshb, 是一个由人类基因tshb, 编码的蛋白质, thyroid, stimulating, hormone, beta标识代号tshb, beta扩展标识遗传学, 188540, 鼠基因, 98848, 同源基因, genecards, tshb, gene基因本体论描述分子功能, hormone, activity细胞成分, extracellular, region生物过程, protein, c. 促甲状腺激素b亚基 英語 Thyroid stimulating hormone beta 简称TSHB 是一个由人类基因TSHB 编码的蛋白质 1 2 Thyroid stimulating hormone beta促甲状腺激素b亚基标识代号TSHB TSH B TSH BETA扩展标识遗传学 188540 鼠基因 98848 同源基因 463 GeneCards TSHB Gene基因本体论描述分子功能 hormone activity细胞成分 extracellular region生物过程 G protein coupled receptor signaling pathway cell cell signaling anatomical structure morphogenesis peptide hormone processing response to vitamin A response to estrogen stimulus cellular protein metabolic process response to calcium ionSources Amigo QuickGO直系同源体物种人类小鼠Entrez725222094EnsemblENSG00000134200ENSMUSG00000027857UniProtP01222P12656mRNA序列NM 000549NM 001165939蛋白序列NP 000540NP 001159411基因位置Chr 1 115 57 115 58 MbChr 3 102 78 102 78 MbPubMed查询 1 2 查论编 目录 1 功能 2 另见 3 参考文献 4 延伸阅读功能 编辑促甲状腺激素 TSH 是由两个亚基非共价连接而成的糖蛋白 其a亚基为该类激素所共有 而b亚基则是独有的 3 另见 编辑促甲状腺激素参考文献 编辑 Wondisford FE Radovick S Moates JM Usala SJ Weintraub BD Isolation and characterization of the human thyrotropin beta subunit gene Differences in gene structure and promoter function from murine species J Biol Chem September 1988 263 25 12538 42 2014 03 29 PMID 2457586 原始内容存档于2020 04 25 Tatsumi K Hayashizaki Y Hiraoka Y Miyai K Matsubara K The structure of the human thyrotropin beta subunit gene Gene December 1988 73 2 489 97 PMID 3243440 doi 10 1016 0378 1119 88 90513 6 Entrez Gene TSHB 原始内容存档于2010 04 12 延伸阅读 编辑Bonomi M Proverbio MC Weber G et al Hyperplastic pituitary gland high serum glycoprotein hormone alpha subunit and variable circulating thyrotropin TSH levels as hallmark of central hypothyroidism due to mutations of the TSH beta gene J Clin Endocrinol Metab 2001 86 4 1600 4 PMID 11297590 doi 10 1210 jc 86 4 1600 引文格式1维护 显式使用等标签 link Vuissoz JM DeladoA y J Buyukgebiz A et al New autosomal recessive mutation of the TSH beta subunit gene causing central isolated hypothyroidism J Clin Endocrinol Metab 2001 86 9 4468 71 PMID 11549695 doi 10 1210 jc 86 9 4468 引文格式1维护 显式使用等标签 link Karges B LeHeup B Schoenle E et al Compound heterozygous and homozygous mutations of the TSHbeta gene as a cause of congenital central hypothyroidism in Europe Horm Res 2004 62 3 149 55 PMID 15297803 doi 10 1159 000080071 引文格式1维护 显式使用等标签 link Kabadi UM Premachandra BN Serum thyrotropin in Graves disease a more reliable index of circulating thyroid stimulating immunoglobulin level than thyroid function Endocr Pract 2007 13 6 615 9 PMID 17954417 Miyai S Yoshimura S Iwasaki Y et al Induction of GH PRL and TSH beta mRNA by transfection of Pit 1 in a human pituitary adenoma derived cell line Cell Tissue Res 2005 322 2 269 77 PMID 16133148 doi 10 1007 s00441 005 0033 z 引文格式1维护 显式使用等标签 link Pierce JG Eli Lilly lecture The subunits of pituitary thyrotropin their relationship to other glycoprotein hormones Endocrinology 1971 89 6 1331 44 PMID 5002675 doi 10 1210 endo 89 6 1331 Atzmon G Barzilai N Surks MI Gabriely I Genetic Predisposition to Elevated Serum Thyrotropin Is Associated with Exceptional Longevity J Clin Endocrinol Metab 2009 94 12 4768 75 PMC 2795660 nbsp PMID 19837933 doi 10 1210 jc 2009 0808 Landa I Ruiz Llorente S Montero Conde C et al Gibson Greg 编 The Variant rs1867277 in FOXE1 Gene Confers Thyroid Cancer Susceptibility through the Recruitment of USF1 USF2 Transcription Factors PLoS Genet 2009 5 9 e1000637 PMC 2727793 nbsp PMID 19730683 doi 10 1371 journal pgen 1000637 引文格式1维护 显式使用等标签 link Pohlenz J Dumitrescu A Aumann U et al Congenital secondary hypothyroidism caused by exon skipping due to a homozygous donor splice site mutation in the TSHbeta subunit gene J Clin Endocrinol Metab 2002 87 1 336 9 PMID 11788671 doi 10 1210 jc 87 1 336 引文格式1维护 显式使用等标签 link Miyoshi I Kasai N Hayashizaki Y Structure and regulation of human thyroid stimulating hormone TSH gene Nippon Rinsho 1994 52 4 940 7 PMID 8196184 Borck G Topaloglu AK Korsch E et al Four new cases of congenital secondary hypothyroidism due to a splice site mutation in the thyrotropin beta gene phenotypic variability and founder effect J Clin Endocrinol Metab 2004 89 8 4136 41 PMID 15292359 doi 10 1210 jc 2004 0494 引文格式1维护 显式使用等标签 link Comings DE Gade Andavolu R Gonzalez N et al A multivariate analysis of 59 candidate genes in personality traits the temperament and character inventory Clin Genet 2000 58 5 375 85 PMID 11140838 doi 10 1034 j 1399 0004 2000 580508 x 引文格式1维护 显式使用等标签 link Gerhard DS Wagner L Feingold EA et al The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 2004 14 10B 2121 7 PMC 528928 nbsp PMID 15489334 doi 10 1101 gr 2596504 引文格式1维护 显式使用等标签 link Clark AG Glanowski S Nielsen R et al Inferring nonneutral evolution from human chimp mouse orthologous gene trios Science 2003 302 5652 1960 3 PMID 14671302 doi 10 1126 science 1088821 引文格式1维护 显式使用等标签 link Loinder K Soderstrom M An LXXLL motif in nuclear receptor corepressor mediates ligand induced repression of the thyroid stimulating hormone beta gene J Steroid Biochem Mol Biol 2005 97 4 322 7 PMID 16216492 doi 10 1016 j jsbmb 2005 06 031 Luttrell LM Reviews in molecular biology and biotechnology transmembrane signaling by G protein coupled receptors Mol Biotechnol 2008 39 3 239 64 PMID 18240029 doi 10 1007 s12033 008 9031 1 Strausberg RL Feingold EA Grouse LH et al Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 2002 99 26 16899 903 PMC 139241 nbsp PMID 12477932 doi 10 1073 pnas 242603899 引文格式1维护 显式使用等标签 link Brumm H Pfeufer A Biebermann H et al Congenital central hypothyroidism due to homozygous thyrotropin beta 313 Delta T mutation is caused by a Founder effect J Clin Endocrinol Metab 2002 87 10 4811 6 PMID 12364478 doi 10 1210 jc 2002 020297 引文格式1维护 显式使用等标签 link Benhadi N Wiersinga WM Reitsma JB et al Higher maternal TSH levels in pregnancy are associated with increased risk for miscarriage fetal or neonatal death Eur J Endocrinol 2009 160 6 985 91 PMID 19273570 doi 10 1530 EJE 08 0953 引文格式1维护 显式使用等标签 link Schaefer JS Klein JR A novel thyroid stimulating hormone b subunit isoform in human pituitary peripheral blood leukocytes and thyroid Gen Comp Endocrinol 2009 162 3 241 4 PMC 2689139 nbsp PMID 19364510 doi 10 1016 j ygcen 2009 04 006 促甲状腺激素b亚基引用了美国国家医学图书馆提供的資料 这些資料属于公共领域 取自 https zh wikipedia org w index php title 促甲状腺激素b亚基 amp oldid 68261602, 维基百科，wiki，书籍，书籍，图书馆，
