• positive regulation of histone deacetylation • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • rhythmic process • replicative senescence • negative regulation of telomerase activity • oligodendrocyte apoptotic process • cellular response to DNA damage stimulus • intrinsic apoptotic signaling pathway • positive regulation of neuron apoptotic process • regulation of mitochondrial membrane permeability • positive regulation of reactive oxygen species metabolic process • cellular response to ionizing radiation • positive regulation of thymocyte apoptotic process • negative regulation of helicase activity • 細胞週期 • Ras protein signal transduction • 細胞增殖 • cellular response to hypoxia • negative regulation of cell population proliferation • 核苷酸切除修复 • cellular response to glucose starvation • regulation of transcription, DNA-templated • response to antibiotic • transcription, DNA-templated • ER overload response • positive regulation of transcription, DNA-templated • negative regulation of cell growth • intrinsic apoptotic signaling pathway by p53 class mediator • positive regulation of peptidyl-tyrosine phosphorylation • viral process • response to gamma radiation • negative regulation of fibroblast proliferation • positive regulation of intrinsic apoptotic signaling pathway • 细胞分化 • determination of adult lifespan • positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress • cellular response to UV • DNA damage response, signal transduction by p53 class mediator • negative regulation of apoptotic process • protein tetramerization • oxidative stress-induced premature senescence • positive regulation of release of cytochrome c from mitochondria • circadian behavior • negative regulation of transcription, DNA-templated • protein localization • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • positive regulation of execution phase of apoptosis • multicellular organism development • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • positive regulation of gene expression • mitotic G1 DNA damage checkpoint signaling • positive regulation of protein oligomerization • positive regulation of apoptotic process • entrainment of circadian clock by photoperiod • response to X-ray • positive regulation of transcription by RNA polymerase II • base-excision repair • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator • regulation of cell cycle G2/M phase transition • proteasome-mediated ubiquitin-dependent protein catabolic process • regulation of signal transduction by p53 class mediator • 细胞凋亡 • transcription by RNA polymerase II • positive regulation of protein export from nucleus • 细胞程序性死亡 • regulation of apoptotic process • protein deubiquitination • phosphatidylinositol-mediated signaling • negative regulation of transcription by RNA polymerase II • 自噬 • mRNA transcription • cytokine-mediated signaling pathway • positive regulation of RNA polymerase II transcription preinitiation complex assembly • RNA polymerase II preinitiation complex assembly • protein homotetramerization • protein-containing complex assembly • cellular response to gamma radiation • signal transduction by p53 class mediator • cellular response to actinomycin D • positive regulation of pri-miRNA transcription by RNA polymerase II • positive regulation of production of miRNAs involved in gene silencing by miRNA • in utero embryonic development • somitogenesis • release of cytochrome c from mitochondria • hematopoietic progenitor cell differentiation • T cell proliferation involved in immune response • B cell lineage commitment • T cell lineage commitment • response to ischemia • double-strand break repair • regulation of transcription by RNA polymerase II • protein import into nucleus • response to oxidative stress • transforming growth factor beta receptor signaling pathway • 原腸胚形成 • negative regulation of neuroblast proliferation • central nervous system development • 心脏发育 • 昼夜节律 • negative regulation of DNA replication • rRNA transcription • response to UV • response to salt stress • embryo development ending in birth or egg hatching • negative regulation of gene expression • positive regulation of cardiac muscle cell apoptotic process • cerebellum development • negative regulation of transforming growth factor beta receptor signaling pathway • T cell differentiation in thymus • regulation of tissue remodeling • multicellular organism growth • positive regulation of mitochondrial membrane permeability • positive regulation of transcription from RNA polymerase II promoter in response to stress • regulation of cell population proliferation • mitochondrial DNA repair • regulation of DNA damage response, signal transduction by p53 class mediator • regulation of neuron apoptotic process • negative regulation of proteolysis • negative regulation of mitotic cell cycle • bone marrow development • embryonic organ development • protein stabilization • chromosome organization • neuron apoptotic process • regulation of cell cycle • hematopoietic stem cell differentiation • interferon-gamma-mediated signaling pathway • cardiac septum morphogenesis • positive regulation of transcription from RNA polymerase II promoter in response to hypoxia • positive regulation of programmed necrotic cell death • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress • regulation of thymocyte apoptotic process • 程序性坏死 • cellular response to UV-C • negative regulation of mitophagy • regulation of mitochondrial membrane permeability involved in apoptotic process • regulation of intrinsic apoptotic signaling pathway by p53 class mediator • negative regulation of production of miRNAs involved in gene silencing by miRNA • negative regulation of glucose catabolic process to lactate via pyruvate • intrinsic apoptotic signaling pathway in response to hypoxia • regulation of fibroblast apoptotic process • negative regulation of reactive oxygen species metabolic process • regulation of cellular senescence
是一系列被称为腫瘤抑制蛋白, 也稱為蛋白或腫瘤蛋白, 的同源异构蛋白的统称, 由tp53, 人体, 及tr, 老鼠, 基因编码, 该蛋白是最早发现的肿瘤抑制基因所编码的蛋白之一, 蛋白能調節細胞週期, 促使細胞出現凋亡或細胞衰老, cell, senescence, 等現象, 从而避免细胞癌变發生, 蛋白能保持基因組的穩定性, 避免或减少突變的發生, 因此被稱為基因組守護者, p53已知的結構pdb直系同源搜索, pdbe, rcsbpdbid列表4qo1, 1a1u, 1aie, 1c26, 1dt7, 1gzh. p53是一系列被称为腫瘤抑制蛋白 也稱為p53蛋白或p53腫瘤蛋白 的同源异构蛋白的统称 由TP53 人体 及Trp53 老鼠 基因编码 该蛋白是最早发现的肿瘤抑制基因所编码的蛋白之一 p53蛋白能調節細胞週期 促使細胞出現凋亡或細胞衰老 cell senescence 等現象 从而避免细胞癌变發生 p53蛋白能保持基因組的穩定性 避免或减少突變的發生 因此被稱為基因組守護者 P53已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表4QO1 1A1U 1AIE 1C26 1DT7 1GZH 1H26 1HS5 1KZY 1MA3 1OLG 1OLH 1PES 1PET 1SAE 1SAF 1SAK 1SAL 1TSR 1TUP 1UOL 1XQH 1YC5 1YCQ 1YCR 1YCS 2AC0 2ADY 2AHI 2ATA 2B3G 2BIM 2BIN 2BIO 2BIP 2BIQ 2FEJ 2FOJ 2FOO 2GS0 2H1L 2H2D 2H2F 2H4F 2H4H 2H4J 2H59 2J0Z 2J10 2J11 2J1W 2J1X 2J1Y 2J1Z 2J20 2J21 2K8F 2L14 2LY4 2MEJ 2MWO 2MWP 2MZD 2OCJ 2PCX 2RUK 2VUK 2WGX 2X0U 2X0V 2X0W 2XWR 2YBG 2YDR 2Z5S 2Z5T 3D05 3D06 3D07 3D08 3D09 3D0A 3DAB 3DAC 3IGK 3IGL 3KMD 3KZ8 3LW1 3OQ5 3PDH 3Q01 3Q05 3Q06 3SAK 3TG5 3TS8 3ZME 4AGL 4AGM 4AGN 4AGO 4AGP 4AGQ 4BUZ 4BV2 4HFZ 4HJE 4IBQ 4IBS 4IBT 4IBU 4IBV 4IBW 4IBY 4IBZ 4IJT 4KVP 4LO9 4LOE 4LOF 4MZI 4MZR 4X34 4ZZJ 5AOL 5ABA 5AOK 2MWY 5A7B 5AOJ 5AOI 5ECG 5AB9 4FZ3 4RP6 4XR8 5AOM 4RP7 5HOU 5HP0 5HPD 5LGY 5G4M 5G4O 5G4N 5BUA識別號别名TP53 BCC7 LFS1 P53 TRP53 tumor protein p53 BMFS5 Genes p53外部IDOMIM 191170 MGI 98834 HomoloGene 460 GeneCards TP53相關疾病基底細胞癌 BCC 头颈部鳞状细胞癌 李 佛美尼症候群 Li Fraumeni syndrome 1 B細胞慢性淋巴性白血病 liver carcinoma 急性骨髓性白血病 breast adenocarcinoma gastric adenocarcinoma 肺腺癌 骨肉瘤 prostate adenocarcinoma lung small cell carcinoma 肺鱗狀上皮癌 large intestine cancer pancreatic adenocarcinoma 1 基因位置 人类 染色体17號染色體 2 基因座17p13 1起始7 661 779 bp 2 终止7 687 538 bp 2 基因位置 小鼠 染色体小鼠11号染色体 3 基因座11 B3 11 42 83 cM起始69 471 185 bp 3 终止69 482 699 bp 3 RNA表达模式查阅更多表达数据基因本體分子功能 protein N terminus binding DNA结合转录因子活性 蛋白質自締合 core promoter sequence specific DNA binding DNA binding transcription factor activity RNA polymerase II specific protein phosphatase binding ATP結合 转录因子结合 金屬離子結合 protein phosphatase 2A binding 酶结合 鋅離子結合 chromatin binding 蛋白酶結合 damaged DNA binding 血浆蛋白结合 histone acetyltransferase binding copper ion binding protein kinase binding chaperone binding DNA binding transcription activator activity RNA polymerase II specific receptor tyrosine kinase binding p53 binding 相同蛋白质结合 protein heterodimerization activity 泛素蛋白连接酶结合 RNA polymerase II transcription regulatory region sequence specific DNA binding DNA结合 RNA polymerase II cis regulatory region sequence specific DNA binding TFIID class transcription factor complex binding mRNA 3 UTR binding histone deacetylase binding 无序域特异性结合 promoter specific chromatin binding histone deacetylase regulator activity protein homodimerization activity MDM2 MDM4 family protein binding細胞組分 細胞質 線粒體 细胞核 nuclear body transcription factor TFIID complex nuclear matrix replication fork 核仁 内质网 核质 线粒体基质 PML body 细胞质基质 胞內 轉錄調節複合物 大分子复合体 site of double strand break生物學過程 positive regulation of histone deacetylation DNA damage response signal transduction by p53 class mediator resulting in cell cycle arrest rhythmic process replicative senescence negative regulation of telomerase activity oligodendrocyte apoptotic process cellular response to DNA damage stimulus intrinsic apoptotic signaling pathway positive regulation of neuron apoptotic process regulation of mitochondrial membrane permeability positive regulation of reactive oxygen species metabolic process cellular response to ionizing radiation positive regulation of thymocyte apoptotic process negative regulation of helicase activity 細胞週期 Ras protein signal transduction 細胞增殖 cellular response to hypoxia negative regulation of cell population proliferation 核苷酸切除修复 cellular response to glucose starvation regulation of transcription DNA templated response to antibiotic transcription DNA templated ER overload response positive regulation of transcription DNA templated negative regulation of cell growth intrinsic apoptotic signaling pathway by p53 class mediator positive regulation of peptidyl tyrosine phosphorylation viral process response to gamma radiation negative regulation of fibroblast proliferation positive regulation of intrinsic apoptotic signaling pathway 细胞分化 determination of adult lifespan positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress cellular response to UV DNA damage response signal transduction by p53 class mediator negative regulation of apoptotic process protein tetramerization oxidative stress induced premature senescence positive regulation of release of cytochrome c from mitochondria circadian behavior negative regulation of transcription DNA templated protein localization intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of execution phase of apoptosis multicellular organism development positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway positive regulation of gene expression mitotic G1 DNA damage checkpoint signaling positive regulation of protein oligomerization positive regulation of apoptotic process entrainment of circadian clock by photoperiod response to X ray positive regulation of transcription by RNA polymerase II base excision repair DNA damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediator regulation of cell cycle G2 M phase transition proteasome mediated ubiquitin dependent protein catabolic process regulation of signal transduction by p53 class mediator 细胞凋亡 transcription by RNA polymerase II positive regulation of protein export from nucleus 细胞程序性死亡 regulation of apoptotic process protein deubiquitination phosphatidylinositol mediated signaling negative regulation of transcription by RNA polymerase II 自噬 mRNA transcription cytokine mediated signaling pathway positive regulation of RNA polymerase II transcription preinitiation complex assembly RNA polymerase II preinitiation complex assembly protein homotetramerization protein containing complex assembly cellular response to gamma radiation signal transduction by p53 class mediator cellular response to actinomycin D positive regulation of pri miRNA transcription by RNA polymerase II positive regulation of production of miRNAs involved in gene silencing by miRNA in utero embryonic development somitogenesis release of cytochrome c from mitochondria hematopoietic progenitor cell differentiation T cell proliferation involved in immune response B cell lineage commitment T cell lineage commitment response to ischemia double strand break repair regulation of transcription by RNA polymerase II protein import into nucleus response to oxidative stress transforming growth factor beta receptor signaling pathway 原腸胚形成 negative regulation of neuroblast proliferation central nervous system development 心脏发育 昼夜节律 negative regulation of DNA replication rRNA transcription response to UV response to salt stress embryo development ending in birth or egg hatching negative regulation of gene expression positive regulation of cardiac muscle cell apoptotic process cerebellum development negative regulation of transforming growth factor beta receptor signaling pathway T cell differentiation in thymus regulation of tissue remodeling multicellular organism growth positive regulation of mitochondrial membrane permeability positive regulation of transcription from RNA polymerase II promoter in response to stress regulation of cell population proliferation mitochondrial DNA repair regulation of DNA damage response signal transduction by p53 class mediator regulation of neuron apoptotic process negative regulation of proteolysis negative regulation of mitotic cell cycle bone marrow development embryonic organ development protein stabilization chromosome organization neuron apoptotic process regulation of cell cycle hematopoietic stem cell differentiation interferon gamma mediated signaling pathway cardiac septum morphogenesis positive regulation of transcription from RNA polymerase II promoter in response to hypoxia positive regulation of programmed necrotic cell death intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress regulation of thymocyte apoptotic process 程序性坏死 cellular response to UV C negative regulation of mitophagy regulation of mitochondrial membrane permeability involved in apoptotic process regulation of intrinsic apoptotic signaling pathway by p53 class mediator negative regulation of production of miRNAs involved in gene silencing by miRNA negative regulation of glucose catabolic process to lactate via pyruvate intrinsic apoptotic signaling pathway in response to hypoxia regulation of fibroblast apoptotic process negative regulation of reactive oxygen species metabolic process regulation of cellular senescenceSources Amigo QuickGO直系同源物種人類小鼠Entrez715722059EnsemblENSG00000141510ENSMUSG00000059552UniProtP04637P02340mRNA 序列NM 001276761 NM 000546 NM 001126112 NM 001126113 NM 001126114 NM 001126115 NM 001126116 NM 001126117 NM 001126118 NM 001276695 NM 001276696 NM 001276697 NM 001276698 NM 001276699 NM 001276760NM 001127233 NM 011640蛋白序列NP 000537 NP 001119584 NP 001119585 NP 001119586 NP 001119587 NP 001119588 NP 001119589 NP 001119590 NP 001263624 NP 001263625 NP 001263626 NP 001263627 NP 001263628 NP 001263689 NP 001263690NP 001120705 NP 035770基因位置 UCSC Chr 17 7 66 7 69 MbChr 11 69 47 69 48 MbPubMed 查找 4 5 維基數據檢視 編輯人類檢視 編輯小鼠p53得名于1979年 因为其的分子量於SDS凝膠電泳中測得約為53kDa 不过依據胺基酸序列进行計算后发现p53蛋白的分子量應為43 7kDa 兩者所測得之分子量差別是因为该蛋白中存在大量的脯胺酸殘基 減緩了其在SDS膠電泳中的遷移速度 而此遷移速度減緩的效應在跨物種的p53蛋白皆已被觀察 如人類 嚙齒動物 青蛙和魚類 目前在人体内发现的p53同源异构蛋白有15种 另外由於FOXO4可和p53結合以促進細胞衰老之故 6 因此一些和FOXO4有競爭效應的胜肽 可藉由將p53屏除於細胞核之外而成為返老藥 Senolytic 6 目录 1 功能 2 調節 3 参考文献 4 外部链接 5 参见功能 编辑p53蛋白在避免癌症發生機制上扮演重要的角色 例如 細胞凋亡 apoptosis 細胞衰老 cell senescence 基因組穩定性 genetic stability 抑制血管新生 angiogenesis p53蛋白通過下列之機構達成避免癌症發生 當DNA受損時 p53蛋白能活化DNA修復蛋白 DNA repair proteins p53蛋白能抑制細胞生長 通过使细胞周期停留於G1 S的節律點上 以達成DNA損壞辨識 若能將細胞於此節律點上停留夠久 DNA修复蛋白將有更充裕的時間修復DNA損壞部位 並繼續細胞的生長週期 若細胞的DNA受損已不能修復 p53蛋白能起始細胞凋亡程序 避免擁有不正常遺傳資訊的細胞繼續分裂生長 活化的p53蛋白能接合於DNA 促使多個基因表現 包括基因WAF1 CIP1 其為p21蛋白之編碼基因 p21 WAF1 接合於G1 S CDK CDK2 和S CDK複合體 此蛋白在G1 S細胞週期節律點上有重要功能 以抑制該複合體的活性 當p21蛋白 WAF1 與CDK2形成複合體時 細胞將無法進入到細胞分裂的階段 而突變後的p53蛋白將可能喪失與DNA形成有效結合的能力 造成p21蛋白將無法形成 以發出停止細胞分裂的信號 因此 受損細胞將不受控制的進行細胞分裂 最終形成腫瘤 根據最近的研究 p53蛋白與RB1程序經由p14ARF蛋白相互調節的可能性更加提高 調節 编辑p53蛋白藉由許多不同的壓力形式而激發其活性 其中包括但不僅僅侷限於DNA損傷 包括 UV IR或化學物質如過氧化氫 hydrogen peroxide 所造成的損傷 氧化壓力 oxidative stress 滲透壓力 osmotic stress 核糖核苷酸缺乏 nucleotide depletion 和喪失調節癌基因表現能力 這些活性激發可由兩個主要的事件得出 首先 在受到壓力的細胞中 p53蛋白的半衰期 half life 會突然的增加 造成p53蛋白在細胞中的累積 再來則是構型變化 conformational change 使得p53蛋白被激發成為轉錄調節因子 transcription regulator 参考文献 编辑 與P53相關的疾病 在維基數據上查看 編輯參考 2 0 2 1 2 2 GRCh38 Ensembl release 89 ENSG00000141510 Ensembl May 2017 3 0 3 1 3 2 GRCm38 Ensembl release 89 ENSMUSG00000059552 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine 6 0 6 1 Baar Marjolein P Brandt Renata M C Putavet Diana A Klein Julian D D Derks Kasper W J Bourgeois Benjamin R M Stryeck Sarah Rijksen Yvonne van Willigenburg Hester Feijtel Danny A van der Pluijm Ingrid Essers Jeroen van Cappellen Wiggert A van IJcken Wilfred F Houtsmuller Adriaan B Pothof Joris de Bruin Ron W F Madl Tobias Hoeijmakers Jan H J Campisi Judith de Keizer Peter L J Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging Cell March 2017 169 1 132 147 e16 PMC 5556182 nbsp PMID 28340339 doi 10 1016 j cell 2017 02 031 外部链接 编辑维基共享资源中相关的多媒体资源 P53Lane Group at the Institute of Molecular and Cell Biology IMCB Singapore p53 Knowledgebase archived 2006 01 03 cited 2008 04 06 GeneReviews NCBI NIH UW entry on Li Fraumeni Syndrome 页面存档备份 存于互联网档案馆 TUMOR PROTEIN p53 页面存档备份 存于互联网档案馆 OMIM p53 页面存档备份 存于互联网档案馆 The Atlas of Genetics and Cytogenetics in Oncology and Haematology TP53 Gene 页面存档备份 存于互联网档案馆 GeneCards p53 News provided by insciences organisation David S Goodsell RCSB Protein Data Bank p53 Tumor Suppressor 2002 07 01 archived 2008 02 19 cited 2008 04 06 Thierry Soussi p53 Web Site archived 2012 05 15 cited 2008 04 0 6 The George Pantziarka TP53 Trust 页面存档备份 存于互联网档案馆 A support group from the UK for sufferers of Li Fraumeni Syndrome or other TP53 related disorders IARC TP53 Somatic Mutations database 页面存档备份 存于互联网档案馆 maintained at IARC Lyon by Magali Olivier参见 编辑肿瘤抑制基因 取自 https zh wikipedia org w index php title P53 amp oldid 73840042, 维基百科，wiki，书籍，书籍，图书馆，
