• integral component of membrane • 膜 • cell surface • 外排體 • external side of plasma membrane • 內膜系統 • 细胞膜 • early endosome membrane • recycling endosome membrane • 核内体
生物學過程
• negative regulation of interleukin-10 production • response to cytokine • negative regulation of interferon-gamma production • negative regulation of tumor necrosis factor superfamily cytokine production • positive regulation of cell migration • T cell costimulation • toxin transport • negative regulation of activated T cell proliferation • regulation of activated T cell proliferation • cell surface receptor signaling pathway • negative regulation of T cell proliferation • regulation of T cell apoptotic process • 免疫反应 • positive regulation of T cell proliferation • 訊息傳遞 • regulation of activated CD4-positive, alpha-beta T cell apoptotic process • positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process • positive regulation of tolerance induction to tumor cell • negative regulation of CD8-positive, alpha-beta T cell activation • immune system process • negative regulation of CD4-positive, alpha-beta T cell proliferation • cellular response to lipopolysaccharide • adaptive immune response
^Chemnitz JM, Parry RV, Nichols KE, June CH, Riley JL. SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation. Journal of Immunology. July 2004, 173 (2): 945–54. PMID 15240681.
^Dranoff, Glenn. Faculty of 1000 evaluation for Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target.. F1000 - Post-publication peer review of the biomedical literature. 2004-12-09 [2019-12-21].
^Association Between Clinicopathological Features and Programmed Death Ligand 1 Expression in Non-small Cell Lung Cancer. Anticancer Research. 2018-01-20, 38 (2). ISSN 0250-7005. doi:10.21873/anticanres.12326.
^American Cancer Society | Information and Resources about for Cancer: Breast, Colon, Lung, Prostate, Skin. www.cancer.org. [2019-12-21]. （原始内容于2018-08-03） （英语）.
^Spiros, A. Vlahopoulos. Aberrant control of NF-κB in cancer permits transcriptional and phenotypic plasticity, to curtail dependence on host tissue: molecular mode. Cancer Biology & Medicine. 2017, 14 (3): 254. ISSN 2095-3941. doi:10.20892/j.issn.2095-3941.2017.0029.
細胞程式死亡, 配體1, 英語, programmed, cell, death, ligand, 也稱為表面抗原分化簇274, cluster, differentiation, cd274, b7同源體1, homolog, 是人類體內的一種蛋白質, 由cd274基因編碼, 已知的結構pdb直系同源搜索, pdbe, rcsbpdbid列表3bik, 3bis, 3fn3, 3sbw, 4z18, 4zqk, 5c3t, 5j89, 5j8o識別號别名cd274, b7h1, pdcd1l1, pdcd1lg1. 細胞程式死亡 配體1 英語 Programmed cell death 1 ligand 1 PD L1 也稱為表面抗原分化簇274 cluster of differentiation 274 CD274 或 B7同源體1 B7 homolog 1 B7 H1 是人類體內的一種蛋白質 由CD274基因編碼 5 細胞程式死亡 配體1已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表3BIK 3BIS 3FN3 3SBW 4Z18 4ZQK 5C3T 5J89 5J8O識別號别名CD274 B7 H B7H1 PD L1 PDCD1L1 PDCD1LG1 PDL1 CD274 molecule Programmed cell death ligand 1 hPD L1外部IDOMIM 605402 MGI 1926446 HomoloGene 8560 GeneCards CD274基因位置 人类 染色体9號染色體 1 基因座9p24 1起始5 450 503 bp 1 终止5 470 566 bp 1 基因位置 小鼠 染色体小鼠19号染色体 2 基因座19 19 C1起始29 344 855 bp 2 终止29 365 495 bp 2 基因本體分子功能 血浆蛋白结合細胞組分 integral component of membrane 膜 cell surface 外排體 external side of plasma membrane 內膜系統 细胞膜 early endosome membrane recycling endosome membrane 核内体生物學過程 negative regulation of interleukin 10 production response to cytokine negative regulation of interferon gamma production negative regulation of tumor necrosis factor superfamily cytokine production positive regulation of cell migration T cell costimulation toxin transport negative regulation of activated T cell proliferation regulation of activated T cell proliferation cell surface receptor signaling pathway negative regulation of T cell proliferation regulation of T cell apoptotic process 免疫反应 positive regulation of T cell proliferation 訊息傳遞 regulation of activated CD4 positive alpha beta T cell apoptotic process positive regulation of activated CD8 positive alpha beta T cell apoptotic process positive regulation of tolerance induction to tumor cell negative regulation of CD8 positive alpha beta T cell activation immune system process negative regulation of CD4 positive alpha beta T cell proliferation cellular response to lipopolysaccharide adaptive immune responseSources Amigo QuickGO直系同源物種人類小鼠Entrez2912660533EnsemblENSG00000120217ENSMUSG00000016496UniProtQ9NZQ7Q9EP73mRNA 序列NM 001314029 NM 001267706 NM 014143NM 021893蛋白序列NP 001254635 NP 001300958 NP 054862NP 068693基因位置 UCSC Chr 9 5 45 5 47 MbChr 19 29 34 29 37 MbPubMed 查找 3 4 維基數據檢視 編輯人類檢視 編輯小鼠此條目需要擴充 2014年3月16日 请協助改善这篇條目 更進一步的信息可能會在討論頁或扩充请求中找到 请在擴充條目後將此模板移除 PD L1 是大小為 40kDa 的第一型跨膜蛋白 據信其在某些特殊情形 例如懷孕 組織移植 自體免疫疾病 以及諸如肝炎等某些疾病 下 免疫系統的抑制有關 正常情形下免疫系統會對聚集在淋巴結或脾臟的外來抗原產生反應 促發具抗原特異性的细胞毒性T细胞 CD8 T细胞 增殖 而細胞程式死亡受體 1 PD 1 與細胞程式死亡 配體1 PD L1 結合 可以傳導抑制性的信號 減低淋巴結CD8 T細胞的增生 而且PD 1還可以藉由調節Bcl 2基因 控制淋巴結中抗原特異性T細胞的聚積 6 目前發現PD L1表現的增加可能使癌症逃避宿主免疫系統 在來自腎細胞癌患者的196份腫瘤標本進行的分析發現 PD L1的表現增加與腫瘤侵襲性增加和死亡風險增加4 5倍有關 7 目前許多PD L1抑製劑正在作為免疫腫瘤療法發展中 並在臨床試驗中顯示出良好的效果 8 臨床上可用的例子包括Durvalumab atezolizumab和avelumab 9 在正常組織中 STAT3和NF kB等轉錄因子之間的反饋會限制免疫反應 從而保護宿主組織並限制發炎症狀 在癌症中 轉錄因子之間反饋限制的喪失會導致局部PD L1表達增加 這可能會限制針對PD L1藥物的全身治療有效性 10 B7蛋白质家族与CD28家族的相互结合关系參考資料 编辑 1 0 1 1 1 2 GRCh38 Ensembl release 89 ENSG00000120217 Ensembl May 2017 2 0 2 1 2 2 GRCm38 Ensembl release 89 ENSMUSG00000016496 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene CD274 CD274 molecule Chemnitz JM Parry RV Nichols KE June CH Riley JL SHP 1 and SHP 2 associate with immunoreceptor tyrosine based switch motif of programmed death 1 upon primary human T cell stimulation but only receptor ligation prevents T cell activation Journal of Immunology July 2004 173 2 945 54 PMID 15240681 Dranoff Glenn Faculty of 1000 evaluation for Costimulatory B7 H1 in renal cell carcinoma patients Indicator of tumor aggressiveness and potential therapeutic target F1000 Post publication peer review of the biomedical literature 2004 12 09 2019 12 21 Association Between Clinicopathological Features and Programmed Death Ligand 1 Expression in Non small Cell Lung Cancer Anticancer Research 2018 01 20 38 2 ISSN 0250 7005 doi 10 21873 anticanres 12326 American Cancer Society Information and Resources about for Cancer Breast Colon Lung Prostate Skin www cancer org 2019 12 21 原始内容存档于2018 08 03 英语 Spiros A Vlahopoulos Aberrant control of NF kB in cancer permits transcriptional and phenotypic plasticity to curtail dependence on host tissue molecular mode Cancer Biology amp Medicine 2017 14 3 254 ISSN 2095 3941 doi 10 20892 j issn 2095 3941 2017 0029 外部連結 编辑醫學主題詞表 MeSH CD274 protein human免疫療法 Anti PD1 和Anti PD L1 取自 https zh wikipedia org w index php title 細胞程式死亡 配體1 amp oldid 70055857, 维基百科，wiki，书籍，书籍，图书馆，
