• negative regulation of neuron apoptotic process • positive regulation of oligodendrocyte differentiation • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • regulation of transcription, DNA-templated • negative regulation of neuron differentiation • 肾的发生 • cellular response to UV • negative regulation of transcription by RNA polymerase II • protein tetramerization • transcription, DNA-templated • cellular response to DNA damage stimulus • mitotic G1 DNA damage checkpoint signaling • response to organonitrogen compound • intrinsic apoptotic signaling pathway in response to DNA damage • regulation of mitotic cell cycle • positive regulation of apoptotic process • 基因調節 • DNA错配修复 • 細胞週期 • negative regulation of cardiac muscle cell proliferation • viral process • negative regulation of JUN kinase activity • response to gamma radiation • response to X-ray • positive regulation of transcription by RNA polymerase II • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator • negative regulation of cell population proliferation • 细胞凋亡 • regulation of signal transduction by p53 class mediator • transcription by RNA polymerase II • regulation of apoptotic process • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • positive regulation of transcription, DNA-templated • regulation of hematopoietic stem cell differentiation
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又稱爲t, 是p53蛋白家族的成員之一, 以其分子量爲73kd而得名, 存在多種轉錄變體, p73的結構和功能均與p53類似, 爲腫瘤抑制蛋白, 能調控細胞增殖並促進細胞凋亡, 過表達p73的細胞增殖會停止, 已知的結構pdb直系同源搜索, pdbe, rcsbpdbid列表4guq, 1cok, 1dxs, 2kby, 2mps, 2wqi, 2wqj, 2wtt, 2xwc, 3vd0, 3vd1, 3vd2, 4a63, 4g82, 4g83, 4guo識別號别名t, tumor, protein, cild. p73 又稱爲TP73 是p53蛋白家族的成員之一 以其分子量爲73kD而得名 存在多種轉錄變體 p73的結構和功能均與p53類似 爲腫瘤抑制蛋白 能調控細胞增殖並促進細胞凋亡 過表達p73的細胞增殖會停止 P73已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表4GUQ 1COK 1DXS 2KBY 2MPS 2WQI 2WQJ 2WTT 2XWC 3VD0 3VD1 3VD2 4A63 4G82 4G83 4GUO識別號别名TP73 P73 tumor protein p73 CILD47外部IDOMIM 601990 MGI 1336991 HomoloGene 3960 GeneCards TP73基因位置 人类 染色体1號染色體 1 基因座1p36 32起始3 652 516 bp 1 终止3 736 201 bp 1 基因位置 小鼠 染色体小鼠4号染色体 2 基因座4 E2 4 83 79 cM起始154 140 706 bp 2 终止154 224 665 bp 2 RNA表达模式查阅更多表达数据基因本體分子功能 DNA结合 sequence specific DNA binding DNA binding transcription activator activity RNA polymerase II specific 转录因子结合 chromatin binding 金屬離子結合 RNA polymerase II cis regulatory region sequence specific DNA binding damaged DNA binding 血浆蛋白结合 相同蛋白质结合 protein kinase binding p53 binding DNA结合转录因子活性 MDM2 MDM4 family protein binding DNA binding transcription factor activity RNA polymerase II specific細胞組分 細胞質 高尔基体 細胞內膜結合細胞器 轉錄調節複合物 细胞连接 染色质 细胞核 線粒體 核质 细胞质基质生物學過程 negative regulation of neuron apoptotic process positive regulation of oligodendrocyte differentiation intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of transcription DNA templated negative regulation of neuron differentiation 肾的发生 cellular response to UV negative regulation of transcription by RNA polymerase II protein tetramerization transcription DNA templated cellular response to DNA damage stimulus mitotic G1 DNA damage checkpoint signaling response to organonitrogen compound intrinsic apoptotic signaling pathway in response to DNA damage regulation of mitotic cell cycle positive regulation of apoptotic process 基因調節 DNA错配修复 細胞週期 negative regulation of cardiac muscle cell proliferation viral process negative regulation of JUN kinase activity response to gamma radiation response to X ray positive regulation of transcription by RNA polymerase II DNA damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediator negative regulation of cell population proliferation 细胞凋亡 regulation of signal transduction by p53 class mediator transcription by RNA polymerase II regulation of apoptotic process positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway positive regulation of transcription DNA templated regulation of hematopoietic stem cell differentiationSources Amigo QuickGO直系同源物種人類小鼠Entrez716122062EnsemblENSG00000078900ENSMUSG00000029026UniProtO15350Q9JJP2mRNA 序列NM 001126240 NM 001126241 NM 001126242 NM 001204184 NM 001204185 NM 001204186 NM 001204187 NM 001204188 NM 001204189 NM 001204190 NM 001204191 NM 001204192 NM 005427NM 001126330 NM 001126331 NM 011642蛋白序列NP 001119712 NP 001119713 NP 001119714 NP 001191113 NP 001191114 NP 001191115 NP 001191116 NP 001191117 NP 001191118 NP 001191119 NP 001191120 NP 001191121 NP 005418NP 001119802 NP 001119803 NP 035772基因位置 UCSC Chr 1 3 65 3 74 MbChr 4 154 14 154 22 MbPubMed 查找 3 4 維基數據檢視 編輯人類檢視 編輯小鼠參見 编辑p53 p63參考文獻 编辑 1 0 1 1 1 2 GRCh38 Ensembl release 89 ENSG00000078900 Ensembl May 2017 2 0 2 1 2 2 GRCm38 Ensembl release 89 ENSMUSG00000029026 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Kaghad M Bonnet H Yang A Creancier L Biscan J C Valent A Minty A Chalon P Lelias J M Monoallelically expressed gene related to p53 at 1p36 a region frequently deleted in neuroblastoma and other human cancers Cell 1997 08 22 90 4 809 819 2021 11 10 ISSN 0092 8674 PMID 9288759 doi 10 1016 s0092 8674 00 80540 1 原始内容存档于2022 02 23 Levrero M De Laurenzi V Costanzo A Gong J Wang J Y Melino G The p53 p63 p73 family of transcription factors overlapping and distinct functions Journal of Cell Science 2000 05 113 Pt 10 1661 1670 2021 11 10 ISSN 0021 9533 PMID 10769197 原始内容存档于2022 03 01 Pozniak Christine D Radinovic Stevo Yang Annie McKeon Frank Kaplan David R Miller Freda D An Anti Apoptotic Role for the p53 Family Member p73 During Developmental Neuron Death Science 2000 07 14 289 5477 304 306 2021 11 10 ISSN 0036 8075 PMID 10894779 doi 10 1126 science 289 5477 304 原始内容存档于2021 11 10 英语 Yang Annie Walker Nancy Bronson Roderick Kaghad Mourad Oosterwegel Mariette Bonnin Jacques Vagner Christine Bonnet Helene Dikkes Pieter p73 deficient mice have neurological pheromonal and inflammatory defects but lack spontaneous tumours Nature 2000 03 404 6773 99 103 2021 11 10 ISSN 0028 0836 PMID 10716451 doi 10 1038 35003607 原始内容存档于2022 01 28 英语 Kaelin W G The emerging p53 gene family Journal of the National Cancer Institute 1999 04 07 91 7 594 598 2021 11 10 ISSN 0027 8874 PMID 10203277 doi 10 1093 jnci 91 7 594 原始内容存档于2021 11 10 Davis P K Dowdy S F p73 The International Journal of Biochemistry amp Cell Biology 2001 10 33 10 935 939 2021 11 10 ISSN 1357 2725 PMID 11470228 doi 10 1016 s1357 2725 01 00073 5 原始内容存档于2021 11 10 Salomoni Paolo Pandolfi Pier Paolo The role of PML in tumor suppression Cell 2002 01 25 108 2 165 170 2021 11 10 ISSN 0092 8674 PMID 11832207 doi 10 1016 s0092 8674 02 00626 8 原始内容存档于2022 03 02 Melino Gerry p73 the assistant guardian of the genome Annals of the New York Academy of Sciences 2003 12 1010 9 15 2021 11 10 ISSN 0077 8923 PMID 15033688 doi 10 1196 annals 1299 002 原始内容存档于2021 11 10 Jacobs W Bradley Walsh Gregory S Miller Freda D Neuronal survival and p73 p63 p53 a family affair The Neuroscientist A Review Journal Bringing Neurobiology Neurology and Psychiatry 2004 10 10 5 443 455 2021 11 10 ISSN 1073 8584 PMID 15359011 doi 10 1177 1073858404263456 原始内容存档于2022 02 25 Rossi Mario Sayan A Emre Terrinoni Alessandro Melino Gerry Knight Richard A Mechanism of induction of apoptosis by p73 and its relevance to neuroblastoma biology Annals of the New York Academy of Sciences 2004 12 1028 143 149 2021 11 10 ISSN 0077 8923 PMID 15650240 doi 10 1196 annals 1322 015 原始内容存档于2021 11 10 Dobbelstein M Strano S Roth J Blandino G p73 induced apoptosis a question of compartments and cooperation Biochem Biophys Res Commun 2005 331 3 688 93 PMID 15865923 doi 10 1016 j bbrc 2005 03 155 Ramadan Saafa Terrinoni Alessandro Catani Maria Valeria Sayan A Emre Knight Richard A Mueller Martina Krammer Peter H Melino Gerry Candi Eleonora p73 induces apoptosis by different mechanisms Biochemical and Biophysical Research Communications 2005 06 10 331 3 713 717 2021 11 10 ISSN 0006 291X PMID 15865927 doi 10 1016 j bbrc 2005 03 156 原始内容存档于2021 11 10 Harms Kelly Lynn Chen Xinbin p19 ras Brings a New Twist to the Regulation of p73 by Mdm2 Science s STKE 2006 05 30 2006 337 2021 11 10 ISSN 1525 8882 PMID 16738062 doi 10 1126 stke 3372006pe24 原始内容存档于2022 03 11 英语 Marabese Mirko Vikhanskaya Faina Broggini Massimo p73 a chiaroscuro gene in cancer European Journal of Cancer Oxford England 1990 2007 06 43 9 1361 1372 2021 11 10 ISSN 0959 8049 PMID 17428654 doi 10 1016 j ejca 2007 01 042 原始内容存档于2021 11 10 Levy D Adamovich Y Reuven N Shaul Y The Yes associated protein 1 stabilizes p73 by preventing Itch mediated ubiquitination of p73 Cell Death amp Differentiation 2007 04 14 4 743 751 2021 11 10 ISSN 1350 9047 PMID 17110958 doi 10 1038 sj cdd 4402063 原始内容存档于2022 03 08 英语 nbsp 这是一篇與生物化學相關的小作品 你可以通过编辑或修订扩充其内容 查论编 取自 https zh wikipedia org w index php title P73 amp oldid 73840239, 维基百科，wiki，书籍，书籍，图书馆，
