维基百科
Lon蛋白酶家族
在分子生物学中,Lon蛋白酶家族是一个依赖ATP的丝氨酸蛋白酶家族,在细菌、古菌以及真核生物中都有发现。在真核生物中,大部分的Lon蛋白酶都定位于线粒体基质[1][2]。在釀酒酵母中,Lon蛋白酶PIM1定位于线粒体基质,是线粒体功能所必需的。PIM1通常为基础性表达,但在热胁迫增加时表达量会增加,这表示PIM1可能和热休克反应有关[3]。
参考文献s 编辑
- ^ Wang N, Gottesman S, Willingham MC, Gottesman MM, Maurizi MR. A human mitochondrial ATP-dependent protease that is highly homologous to bacterial Lon protease. Proc. Natl. Acad. Sci. U.S.A. December 1993, 90 (23): 11247–51. PMC 47959 . PMID 8248235. doi:10.1073/pnas.90.23.11247.
- ^ Barakat S, Pearce DA, Sherman F, Rapp WD. Maize contains a Lon protease gene that can partially complement a yeast pim1-deletion mutant. Plant Mol. Biol. May 1998, 37 (1): 141–54. PMID 9620272.
- ^ Van Dyck L, Pearce DA, Sherman F. PIM1 encodes a mitochondrial ATP-dependent protease that is required for mitochondrial function in the yeast Saccharomyces cerevisiae. J. Biol. Chem. January 1994, 269 (1): 238–42. PMID 8276800.
外部链接 编辑
- MEROPS family S16 (页面存档备份,存于互联网档案馆)