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维基百科

LAMA1

四月 11, 2024

层粘连蛋白亚基α1是一个层粘连蛋白的蛋白亚基。层粘蛋白是一种组成核纤层的蛋白，在细胞核的形态维持中扮演重要角色。此蛋白質在人体内由LAMA1基因编码[7][8]。

LAMA1
已知的結構
PDB直系同源搜索: PDBe RCSB
識別號
别名LAMA1；, LAMA, S-LAM-alpha, PTBHS, Laminin, alpha 1, laminin subunit alpha 1
外部IDOMIM：150320 MGI：99892 HomoloGene：21146 GeneCards：LAMA1
相關疾病
2型糖尿病、​ataxia-intellectual disability-oculomotor apraxia-cerebellar cysts syndrome[1]
為以下藥物的標靶
ocriplasmin[2]
基因位置（人类）
染色体18號染色體[3]
基因座18p11.31起始6,941,742 bp[3]
终止7,117,797 bp[3]
RNA表达模式


查阅更多表达数据
直系同源
物種人類小鼠
Entrez

284217

16772

Ensembl

ENSG00000101680

ENSMUSG00000032796

UniProt

P25391

P19137

mRNA​序列

NM_005559

NM_008480

蛋白序列

NP_005550

NP_032506

基因位置​（UCSC）Chr 18: 6.94 – 7.12 MbChr 17: 68 – 68.13 Mb
PubMed​查找[5][6]
維基數據
檢視/編輯人類檢視/編輯小鼠

相互作用 编辑

层粘蛋白亚基α1会与FBLN2（英语：FBLN2）发生蛋白质相互作用[9][10]。

参考资料 编辑

  1. ^ 與LAMA1相關的疾病；在維基數據上查看/編輯參考. 
  2. ^ 對Laminin subunit alpha 1起作用的藥物；在維基數據上查看/編輯參考. 
  3. ^ 3.0 3.1 3.2 GRCh38: Ensembl release 89: ENSG00000101680 - Ensembl, May 2017
  4. ^ 4.0 4.1 4.2 GRCm38: Ensembl release 89: ENSMUSG00000032796 - Ensembl, May 2017
  5. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  6. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  7. ^ Nagayoshi, T.; Mattei, M. G.; Passage, E.; Knowlton, R.; Chu, M. L.; Uitto, J. . Genomics. 1989-11, 5 (4): 932–935 [2021-11-10]. ISSN 0888-7543. PMID 2591971. doi:10.1016/0888-7543(89)90136-5. （原始内容存档于2021-11-10）. 
  8. ^ . www.ncbi.nlm.nih.gov. [2021-11-10]. （原始内容存档于2021-11-10）. 
  9. ^ Utani, A.; Nomizu, M.; Yamada, Y. . The Journal of Biological Chemistry. 1997-01-31, 272 (5): 2814–2820 [2021-11-10]. ISSN 0021-9258. PMID 9006922. doi:10.1074/jbc.272.5.2814. （原始内容存档于2021-11-10）. 
  10. ^ Talts, J. F.; Sasaki, T.; Miosge, N.; Göhring, W.; Mann, K.; Mayne, R.; Timpl, R. . The Journal of Biological Chemistry. 2000-11-10, 275 (45): 35192–35199 [2021-11-10]. ISSN 0021-9258. PMID 10934193. doi:10.1074/jbc.M003261200. （原始内容存档于2022-01-21）. 

拓展阅读 编辑

  • Haaparanta, T.; Uitto, J.; Ruoslahti, E.; Engvall, E. . Matrix (Stuttgart, Germany). 1991-06, 11 (3): 151–160 [2021-11-10]. ISSN 0934-8832. PMID 1714537. doi:10.1016/s0934-8832(11)80153-8. （原始内容存档于2021-11-10）. 
  • Nissinen, M; Vuolteenaho, R; Boot-Handford, R; Kallunki, P; Tryggvason, K. . Biochemical Journal. 1991-06-01, 276 (2): 369–379 [2021-11-10]. ISSN 0264-6021. PMC 1151101  . PMID 2049067. doi:10.1042/bj2760369. （原始内容存档于2021-08-12） （英语）. 
  • Taraboletti, G.; Rao, C. N.; Krutzsch, H. C.; Liotta, L. A.; Roberts, D. D. . The Journal of Biological Chemistry. 1990-07-25, 265 (21): 12253–12258 [2021-11-10]. ISSN 0021-9258. PMID 2373692. （原始内容存档于2021-11-10）. 
  • Olsen, D.; Nagayoshi, T.; Fazio, M.; Peltonen, J.; Jaakkola, S.; Sanborn, D.; Sasaki, T.; Kuivaniemi, H.; Chu, M. L. . Laboratory Investigation; a Journal of Technical Methods and Pathology. 1989-06, 60 (6): 772–782 [2021-11-10]. ISSN 0023-6837. PMID 2733383. （原始内容存档于2021-11-10）. 
  • Leivo, I; Engvall, E. . The Journal of Cell Biology. 1986-09-01, 103 (3): 1091–1100 [2021-11-10]. ISSN 0021-9525. PMC 2114300  . PMID 3488995. doi:10.1083/jcb.103.3.1091. （原始内容存档于2022-01-21） （英语）. 
  • Wewer, U. M.; Gerecke, D. R.; Durkin, M. E.; Kurtz, K. S.; Mattei, M. G.; Champliaud, M. F.; Burgeson, R. E.; Albrechtsen, R. . Genomics. 1994-11-15, 24 (2): 243–252 [2021-11-10]. ISSN 0888-7543. PMID 7698745. doi:10.1006/geno.1994.1612. （原始内容存档于2021-11-10）. 
  • Yamada, H.; Shimizu, T.; Tanaka, T.; Campbell, K. P.; Matsumura, K. . FEBS letters. 1994-09-19, 352 (1): 49–53 [2021-11-10]. ISSN 0014-5793. PMID 7925941. doi:10.1016/0014-5793(94)00917-1. （原始内容存档于2022-03-13）. 
  • Moser, T. L.; Enghild, J. J.; Pizzo, S. V.; Stack, M. S. . The Journal of Biological Chemistry. 1993-09-05, 268 (25): 18917–18923 [2021-11-10]. ISSN 0021-9258. PMID 8360181. （原始内容存档于2021-11-10）. 、
  • Yurchenco, P. D.; Sung, U.; Ward, M. D.; Yamada, Y.; O'Rear, J. J. . The Journal of Biological Chemistry. 1993-04-15, 268 (11): 8356–8365 [2021-11-10]. ISSN 0021-9258. PMID 8463343. （原始内容存档于2021-11-10）. 
  • Ancsin, J. B.; Kisilevsky, R. . The Journal of Biological Chemistry. 1997-01-03, 272 (1): 406–413 [2021-11-10]. ISSN 0021-9258. PMID 8995276. doi:10.1074/jbc.272.1.406. （原始内容存档于2021-11-10）. 
  • Zahedi, K. . The Journal of Biological Chemistry. 1997-01-24, 272 (4): 2143–2148 [2021-11-10]. ISSN 0021-9258. PMID 8999915. （原始内容存档于2021-11-10）. 
  • Utani, A.; Nomizu, M.; Yamada, Y. . The Journal of Biological Chemistry. 1997-01-31, 272 (5): 2814–2820 [2021-11-10]. ISSN 0021-9258. PMID 9006922. doi:10.1074/jbc.272.5.2814. （原始内容存档于2021-11-10）. 
  • Cáceres, J.; Brandan, E. . Journal of Cellular Biochemistry. 1997-05, 65 (2): 145–158 [2021-11-10]. ISSN 0730-2312. PMID 9136074. doi:10.1002/(sici)1097-4644(199705)65:2<145::aid-jcb2>3.0.co;2-u. （原始内容存档于2021-11-10）. 
  • Chen, M.; Marinkovich, M. P.; Veis, A.; Cai, X.; Rao, C. N.; O'Toole, E. A.; Woodley, D. T. . The Journal of Biological Chemistry. 1997-06-06, 272 (23): 14516–14522 [2021-11-10]. ISSN 0021-9258. PMID 9169408. doi:10.1074/jbc.272.23.14516. （原始内容存档于2022-04-06）. 
  • Schuger, L.; Skubitz, A. P.; Zhang, J.; Sorokin, L.; He, L. . The Journal of Cell Biology. 1997-10-20, 139 (2): 553–562 [2021-11-10]. ISSN 0021-9525. PMC 2139794  . PMID 9334356. doi:10.1083/jcb.139.2.553. （原始内容存档于2021-11-10）. 
  • Mrowiec, T.; Melchar, C.; Górski, A. . Archivum Immunologiae Et Therapiae Experimentalis. 1997, 45 (2-3): 255–259 [2021-11-10]. ISSN 0004-069X. PMID 9597096. （原始内容存档于2021-11-10）. 
  • O'Grady, P.; Thai, T. C.; Saito, H. . The Journal of Cell Biology. 1998-06-29, 141 (7): 1675–1684 [2021-11-10]. ISSN 0021-9525. PMC 2133008  . PMID 9647658. doi:10.1083/jcb.141.7.1675. （原始内容存档于2021-11-10）. 
  • Ettner, N.; Göhring, W.; Sasaki, T.; Mann, K.; Timpl, R. . FEBS letters. 1998-07-03, 430 (3): 217–221 [2021-11-10]. ISSN 0014-5793. PMID 9688542. doi:10.1016/s0014-5793(98)00601-2. （原始内容存档于2021-11-10）. 
  • Ludwig, H. C.; Rausch, S.; Schallock, K.; Markakis, E. . Anticancer Research. 1999-05, 19 (3A): 1747–1752 [2021-11-10]. ISSN 0250-7005. PMID 10470109. （原始内容存档于2021-11-10）. 


四月 11, 2024
lama1, 层粘连蛋白亚基α1是一个层粘连蛋白的蛋白亚基, 层粘蛋白是一种组成核纤层的蛋白, 在细胞核的形态维持中扮演重要角色, 此蛋白質在人体内由基因编码, 已知的結構pdb直系同源搜索, pdbe, rcsbpdbid列表2jd4識別號别名, lama, alpha, ptbhs, laminin, alpha, laminin, subunit, alpha, 1外部idomim, 150320, 99892, homologene, 21146, genecards, 相關疾病2型糖尿病, ataxia,. 层粘连蛋白亚基a1是一个层粘连蛋白的蛋白亚基 层粘蛋白是一种组成核纤层的蛋白 在细胞核的形态维持中扮演重要角色 此蛋白質在人体内由LAMA1基因编码 7 8 LAMA1已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表2JD4識別號别名LAMA1 LAMA S LAM alpha PTBHS Laminin alpha 1 laminin subunit alpha 1外部IDOMIM 150320 MGI 99892 HomoloGene 21146 GeneCards LAMA1相關疾病2型糖尿病 ataxia intellectual disability oculomotor apraxia cerebellar cysts syndrome 1 為以下藥物的標靶ocriplasmin 2 基因位置 人类 染色体18號染色體 3 基因座18p11 31起始6 941 742 bp 3 终止7 117 797 bp 3 基因位置 小鼠 染色体小鼠17号染色体 4 基因座17 E1 1 17 38 8 cM起始68 004 254 bp 4 终止68 129 642 bp 4 RNA表达模式查阅更多表达数据基因本體分子功能 signaling receptor binding extracellular matrix structural constituent 血浆蛋白结合 protein C terminus binding glycosphingolipid binding細胞組分 细胞外间质 細胞外區域 基底膜 laminin 1 complex laminin 3 complex 細胞外空間 膜 cell cell junction laminin complex collagen containing extracellular matrix生物學過程 cell surface receptor signaling pathway regulation of cell adhesion 細胞粘附 extracellular matrix organization regulation of cell migration regulation of embryonic development morphogenesis of an epithelial sheet protein phosphorylation 组织发生 neuron projection development establishment of epithelial cell apical basal polarity retina development in camera type eye epithelial tube branching involved in lung morphogenesis branching involved in salivary gland morphogenesis retinal blood vessel morphogenesis 轴突导向 animal organ morphogenesis camera type eye development blood vessel morphogenesisSources Amigo QuickGO直系同源物種人類小鼠Entrez28421716772EnsemblENSG00000101680ENSMUSG00000032796UniProtP25391P19137mRNA 序列NM 005559NM 008480蛋白序列NP 005550NP 032506基因位置 UCSC Chr 18 6 94 7 12 MbChr 17 68 68 13 MbPubMed 查找 5 6 維基數據檢視 編輯人類檢視 編輯小鼠相互作用 编辑层粘蛋白亚基a1会与FBLN2 英语 FBLN2 发生蛋白质相互作用 9 10 参考资料 编辑 與LAMA1相關的疾病 在維基數據上查看 編輯參考 對Laminin subunit alpha 1起作用的藥物 在維基數據上查看 編輯參考 3 0 3 1 3 2 GRCh38 Ensembl release 89 ENSG00000101680 Ensembl May 2017 4 0 4 1 4 2 GRCm38 Ensembl release 89 ENSMUSG00000032796 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Nagayoshi T Mattei M G Passage E Knowlton R Chu M L Uitto J Human laminin A chain LAMA gene chromosomal mapping to locus 18p11 3 Genomics 1989 11 5 4 932 935 2021 11 10 ISSN 0888 7543 PMID 2591971 doi 10 1016 0888 7543 89 90136 5 原始内容存档于2021 11 10 LAMA1 laminin subunit alpha 1 Homo sapiens human Gene NCBI www ncbi nlm nih gov 2021 11 10 原始内容存档于2021 11 10 Utani A Nomizu M Yamada Y Fibulin 2 binds to the short arms of laminin 5 and laminin 1 via conserved amino acid sequences The Journal of Biological Chemistry 1997 01 31 272 5 2814 2820 2021 11 10 ISSN 0021 9258 PMID 9006922 doi 10 1074 jbc 272 5 2814 原始内容存档于2021 11 10 Talts J F Sasaki T Miosge N Gohring W Mann K Mayne R Timpl R Structural and functional analysis of the recombinant G domain of the laminin alpha4 chain and its proteolytic processing in tissues The Journal of Biological Chemistry 2000 11 10 275 45 35192 35199 2021 11 10 ISSN 0021 9258 PMID 10934193 doi 10 1074 jbc M003261200 原始内容存档于2022 01 21 拓展阅读 编辑Haaparanta T Uitto J Ruoslahti E Engvall E Molecular cloning of the cDNA encoding human laminin A chain Matrix Stuttgart Germany 1991 06 11 3 151 160 2021 11 10 ISSN 0934 8832 PMID 1714537 doi 10 1016 s0934 8832 11 80153 8 原始内容存档于2021 11 10 Nissinen M Vuolteenaho R Boot Handford R Kallunki P Tryggvason K Primary structure of the human laminin A chain Limited expression in human tissues Biochemical Journal 1991 06 01 276 2 369 379 2021 11 10 ISSN 0264 6021 PMC 1151101 nbsp PMID 2049067 doi 10 1042 bj2760369 原始内容存档于2021 08 12 英语 Taraboletti G Rao C N Krutzsch H C Liotta L A Roberts D D Sulfatide binding domain of the laminin A chain The Journal of Biological Chemistry 1990 07 25 265 21 12253 12258 2021 11 10 ISSN 0021 9258 PMID 2373692 原始内容存档于2021 11 10 Olsen D Nagayoshi T Fazio M Peltonen J Jaakkola S Sanborn D Sasaki T Kuivaniemi H Chu M L Human laminin cloning and sequence analysis of cDNAs encoding A B1 and B2 chains and expression of the corresponding genes in human skin and cultured cells Laboratory Investigation a Journal of Technical Methods and Pathology 1989 06 60 6 772 782 2021 11 10 ISSN 0023 6837 PMID 2733383 原始内容存档于2021 11 10 Leivo I Engvall E C3d fragment of complement interacts with laminin and binds to basement membranes of glomerulus and trophoblast The Journal of Cell Biology 1986 09 01 103 3 1091 1100 2021 11 10 ISSN 0021 9525 PMC 2114300 nbsp PMID 3488995 doi 10 1083 jcb 103 3 1091 原始内容存档于2022 01 21 英语 Wewer U M Gerecke D R Durkin M E Kurtz K S Mattei M G Champliaud M F Burgeson R E Albrechtsen R Human beta 2 chain of laminin formerly S chain cDNA cloning chromosomal localization and expression in carcinomas Genomics 1994 11 15 24 2 243 252 2021 11 10 ISSN 0888 7543 PMID 7698745 doi 10 1006 geno 1994 1612 原始内容存档于2021 11 10 Yamada H Shimizu T Tanaka T Campbell K P Matsumura K Dystroglycan is a binding protein of laminin and merosin in peripheral nerve FEBS letters 1994 09 19 352 1 49 53 2021 11 10 ISSN 0014 5793 PMID 7925941 doi 10 1016 0014 5793 94 00917 1 原始内容存档于2022 03 13 Moser T L Enghild J J Pizzo S V Stack M S The extracellular matrix proteins laminin and fibronectin contain binding domains for human plasminogen and tissue plasminogen activator The Journal of Biological Chemistry 1993 09 05 268 25 18917 18923 2021 11 10 ISSN 0021 9258 PMID 8360181 原始内容存档于2021 11 10 Yurchenco P D Sung U Ward M D Yamada Y O Rear J J Recombinant laminin G domain mediates myoblast adhesion and heparin binding The Journal of Biological Chemistry 1993 04 15 268 11 8356 8365 2021 11 10 ISSN 0021 9258 PMID 8463343 原始内容存档于2021 11 10 Ancsin J B Kisilevsky R Characterization of high affinity binding between laminin and the acute phase protein serum amyloid A The Journal of Biological Chemistry 1997 01 03 272 1 406 413 2021 11 10 ISSN 0021 9258 PMID 8995276 doi 10 1074 jbc 272 1 406 原始内容存档于2021 11 10 Zahedi K Characterization of the binding of serum amyloid P to laminin The Journal of Biological Chemistry 1997 01 24 272 4 2143 2148 2021 11 10 ISSN 0021 9258 PMID 8999915 原始内容存档于2021 11 10 Utani A Nomizu M Yamada Y Fibulin 2 binds to the short arms of laminin 5 and laminin 1 via conserved amino acid sequences The Journal of Biological Chemistry 1997 01 31 272 5 2814 2820 2021 11 10 ISSN 0021 9258 PMID 9006922 doi 10 1074 jbc 272 5 2814 原始内容存档于2021 11 10 Caceres J Brandan E Interaction between Alzheimer s disease beta A4 precursor protein APP and the extracellular matrix evidence for the participation of heparan sulfate proteoglycans Journal of Cellular Biochemistry 1997 05 65 2 145 158 2021 11 10 ISSN 0730 2312 PMID 9136074 doi 10 1002 sici 1097 4644 199705 65 2 lt 145 aid jcb2 gt 3 0 co 2 u 原始内容存档于2021 11 10 Chen M Marinkovich M P Veis A Cai X Rao C N O Toole E A Woodley D T Interactions of the amino terminal noncollagenous NC1 domain of type VII collagen with extracellular matrix components A potential role in epidermal dermal adherence in human skin The Journal of Biological Chemistry 1997 06 06 272 23 14516 14522 2021 11 10 ISSN 0021 9258 PMID 9169408 doi 10 1074 jbc 272 23 14516 原始内容存档于2022 04 06 Schuger L Skubitz A P Zhang J Sorokin L He L Laminin alpha1 chain synthesis in the mouse developing lung requirement for epithelial mesenchymal contact and possible role in bronchial smooth muscle development The Journal of Cell Biology 1997 10 20 139 2 553 562 2021 11 10 ISSN 0021 9525 PMC 2139794 nbsp PMID 9334356 doi 10 1083 jcb 139 2 553 原始内容存档于2021 11 10 Mrowiec T Melchar C Gorski A HIV protein mediated alterations in T cell interactions with the extracellular matrix proteins and endothelium Archivum Immunologiae Et Therapiae Experimentalis 1997 45 2 3 255 259 2021 11 10 ISSN 0004 069X PMID 9597096 原始内容存档于2021 11 10 O Grady P Thai T C Saito H The laminin nidogen complex is a ligand for a specific splice isoform of the transmembrane protein tyrosine phosphatase LAR The Journal of Cell Biology 1998 06 29 141 7 1675 1684 2021 11 10 ISSN 0021 9525 PMC 2133008 nbsp PMID 9647658 doi 10 1083 jcb 141 7 1675 原始内容存档于2021 11 10 Ettner N Gohring W Sasaki T Mann K Timpl R The N terminal globular domain of the laminin alpha1 chain binds to alpha1beta1 and alpha2beta1 integrins and to the heparan sulfate containing domains of perlecan FEBS letters 1998 07 03 430 3 217 221 2021 11 10 ISSN 0014 5793 PMID 9688542 doi 10 1016 s0014 5793 98 00601 2 原始内容存档于2021 11 10 Ludwig H C Rausch S Schallock K Markakis E Expression of CD 73 ecto 5 nucleotidase in 165 glioblastomas by immunohistochemistry and electronmicroscopic histochemistry Anticancer Research 1999 05 19 3A 1747 1752 2021 11 10 ISSN 0250 7005 PMID 10470109 原始内容存档于2021 11 10 nbsp 这是一篇與生物化學相關的小作品 你可以通过编辑或修订扩充其内容 查论编 取自 https zh wikipedia org w index php title LAMA1 amp oldid 80031889, 维基百科，wiki，书籍，书籍，图书馆，

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