^ 1.01.11.2GRCh38: Ensembl release 89: ENSG00000136826 - Ensembl, May 2017
^ 2.02.12.2GRCm38: Ensembl release 89: ENSMUSG00000003032 - Ensembl, May 2017
^Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Black AR, Black JD, Azizkhan-Clifford J. Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancer. Journal of Cellular Physiology. August 2001, 188 (2): 143–60. PMID 11424081. doi:10.1002/jcp.1111.
^ 6.06.1Dang DT, Pevsner J, Yang VW. The biology of the mammalian Krüppel-like family of transcription factors. The International Journal of Biochemistry & Cell Biology. November 2000, 32 (11–12): 1103–21. PMC 2754176. PMID 11137451. doi:10.1016/s1357-2725(00)00059-5.
^Shields JM, Yang VW. Two potent nuclear localization signals in the gut-enriched Krüppel-like factor define a subfamily of closely related Krüppel proteins. The Journal of Biological Chemistry. July 1997, 272 (29): 18504–7. PMC 2268085. PMID 9218496. doi:10.1074/jbc.272.29.18504.
klf4, kruppel样因子4, 英語, kruppel, like, factor, 缩写, 或肠富集krüppel样因子, 英語, enriched, krüppel, like, factor, 缩写gklf, 是锌指转录因子klf家族, 的一个成员, 后者属于一个较大的sp1, 英语, transcription, factor, 样转录因子家族, 参与細胞增殖, 细胞分化, 细胞凋亡和体细胞重编程, 英语, reprogramming, 的调节, 有证据表明在包括大腸癌在内的一些癌症中是肿瘤抑制基因,. Kruppel样因子4 英語 Kruppel like factor 4 缩写KLF4 或肠富集Kruppel样因子 英語 gut enriched Kruppel like factor 缩写GKLF 是锌指转录因子KLF家族 的一个成员 后者属于一个较大的SP1 英语 Sp1 transcription factor 样转录因子家族 5 6 7 KLF4参与細胞增殖 细胞分化 细胞凋亡和体细胞重编程 英语 Reprogramming 的调节 有证据表明KLF4在包括大腸癌在内的一些癌症中是肿瘤抑制基因 8 与KLF2 英语 KLF2 类似 它在C端有三个C2H2型锌指 6 它有两个核定位序列指引它定位于细胞核内 9 在胚胎幹細胞 ESCs 和間充質幹細胞 MSCs 中KLF4是显示多能化的很好标记 KLF4已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表2WBS 2WBU 4M9E識別號别名KLF4 EZF GKLF Kruppel like factor 4 gut Kruppel like factor 4外部IDOMIM 602253 MGI 1342287 HomoloGene 3123 GeneCards KLF4基因位置 人类 染色体9號染色體 1 基因座9q31 2起始107 484 852 bp 1 终止107 490 482 bp 1 基因位置 小鼠 染色体小鼠4号染色体 2 基因座4 B3 4 29 76 cM起始55 527 143 bp 2 终止55 532 466 bp 2 RNA表达模式查阅更多表达数据基因本體分子功能 DNA结合 sequence specific DNA binding beta catenin binding phosphatidylinositol 3 kinase regulator activity DNA结合转录因子活性 鋅離子結合 DNA binding transcription activator activity RNA polymerase II specific 转录因子结合 核心启动子近端区域序列特异性DNA结合 金屬離子結合 RNA polymerase II sequence specific DNA binding transcription factor recruiting activity 血浆蛋白结合 nucleic acid binding double stranded DNA binding promoter specific chromatin binding RNA polymerase II cis regulatory region sequence specific DNA binding DNA binding transcription factor activity RNA polymerase II specific transcription coregulator binding histone deacetylase binding細胞組分 細胞質 轉錄調節複合物 核质 染色质 细胞核生物學過程 negative regulation of chemokine C X C motif ligand 2 production epidermal cell differentiation cellular response to retinoic acid negative regulation of protein kinase B signaling negative regulation of muscle hyperplasia 平滑肌細胞增殖的負調控 positive regulation of protein metabolic process negative regulation of cysteine type endopeptidase activity involved in apoptotic process regulation of axon regeneration cellular response to peptide regulation of transcription DNA templated positive regulation of hemoglobin biosynthetic process response to retinoic acid somatic stem cell population maintenance cellular response to laminar fluid shear stress regulation of transcription by RNA polymerase II 细胞分化 epidermis morphogenesis positive regulation of nitric oxide biosynthetic process cellular response to growth factor stimulus cellular response to organic cyclic compound post embryonic hemopoiesis negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II response to organic substance negative regulation of gene expression negative regulation of response to cytokine stimulus transcription DNA templated negative regulation of DNA binding transcription factor activity negative regulation of phosphatidylinositol 3 kinase signaling stem cell population maintenance negative regulation of cell migration involved in sprouting angiogenesis positive regulation of gene expression negative regulation of cell migration regulation of cell population proliferation post embryonic camera type eye development regulation of phosphatidylinositol 3 kinase activity positive regulation of telomerase activity canonical Wnt signaling pathway negative regulation of ERK1 and ERK2 cascade regulation of cell differentiation mesodermal cell fate determination negative regulation of heterotypic cell cell adhesion negative regulation of transcription DNA templated negative regulation of NF kappaB transcription factor activity cellular response to cycloheximide negative regulation of inflammatory response fat cell differentiation positive regulation of transcription by RNA polymerase II negative regulation of cell population proliferation cellular response to hydrogen peroxide negative regulation of leukocyte adhesion to arterial endothelial cell positive regulation of core promoter binding cellular response to leukemia inhibitory factor negative regulation of angiogenesis pri miRNA transcription by RNA polymerase II negative regulation of G1 S transition of mitotic cell cycle positive regulation of transcription DNA templated positive regulation of sprouting angiogenesisSources Amigo QuickGO直系同源物種人類小鼠Entrez931416600EnsemblENSG00000136826ENSMUSG00000003032UniProtO43474Q60793mRNA 序列NM 001314052 NM 004235NM 010637蛋白序列NP 001300981 NP 004226NP 034767基因位置 UCSC Chr 9 107 48 107 49 MbChr 4 55 53 55 53 MbPubMed 查找 3 4 維基數據檢視 編輯人類檢視 編輯小鼠参考 编辑 1 0 1 1 1 2 GRCh38 Ensembl release 89 ENSG00000136826 Ensembl May 2017 2 0 2 1 2 2 GRCm38 Ensembl release 89 ENSMUSG00000003032 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Black AR Black JD Azizkhan Clifford J Sp1 and kruppel like factor family of transcription factors in cell growth regulation and cancer Journal of Cellular Physiology August 2001 188 2 143 60 PMID 11424081 doi 10 1002 jcp 1111 6 0 6 1 Dang DT Pevsner J Yang VW The biology of the mammalian Kruppel like family of transcription factors The International Journal of Biochemistry amp Cell Biology November 2000 32 11 12 1103 21 PMC 2754176 nbsp PMID 11137451 doi 10 1016 s1357 2725 00 00059 5 Kaczynski J Cook T Urrutia R Sp1 and Kruppel like transcription factors Genome Biology 2003 4 2 206 PMC 151296 nbsp PMID 12620113 doi 10 1186 gb 2003 4 2 206 El Karim EA Hagos EG Ghaleb AM Yu B Yang VW Kruppel like factor 4 regulates genetic stability in mouse embryonic fibroblasts Molecular Cancer August 2013 12 89 PMC 3750599 nbsp PMID 23919723 doi 10 1186 1476 4598 12 89 Shields JM Yang VW Two potent nuclear localization signals in the gut enriched Kruppel like factor define a subfamily of closely related Kruppel proteins The Journal of Biological Chemistry July 1997 272 29 18504 7 PMC 2268085 nbsp PMID 9218496 doi 10 1074 jbc 272 29 18504 外部链接 编辑醫學主題詞表 MeSH KLF4 protein human KLF4 microarray expression results and literature 失效連結 KLF4引用了美国国家医学图书馆提供的資料 这些資料属于公共领域 取自 https zh wikipedia org w index php title KLF4 amp oldid 79406288, 维基百科，wiki，书籍，书籍，图书馆，
