• protein dimerization activity • leptomycin B binding • transcription corepressor activity • protein domain specific binding • DNA结合转录因子活性 • 转录因子结合 • 血浆蛋白结合 • DNA-binding transcription factor activity, RNA polymerase II-specific
細胞組分
• 細胞質 • 细胞核
生物學過程
• negative regulation of myoblast differentiation • regulation of transcription, DNA-templated • epithelial cell differentiation • rhythmic process • regulation of DNA replication • muscle organ development • notochord development • negative regulation of transcription by RNA polymerase II • negative regulation of DNA-binding transcription factor activity • negative regulation of osteoblast differentiation • transcription, DNA-templated • negative regulation of gene expression • regulation of cell cycle • odontogenesis • multicellular organism development • 心脏发育 • central nervous system development • response to wounding • 昼夜节律 • neuron differentiation • positive regulation of apoptotic process • metanephros development • negative regulation of transcription, DNA-templated • cellular response to leptomycin B • negative regulation of DNA binding • negative regulation of neuron differentiation
^ 1.01.11.2GRCh38: Ensembl release 89: ENSG00000283060、ENSG00000117318 - Ensembl, May 2017
^ 2.02.12.2GRCm38: Ensembl release 89: ENSMUSG00000007872 - Ensembl, May 2017
^Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Ellmeier W, Aguzzi A, Kleiner E, Kurzbauer R, Weith A. Mutually exclusive expression of a helix-loop-helix gene and N-myc in human neuroblastomas and in normal development. EMBO J. Aug 1992, 11 (7): 2563–71. PMC 556731. PMID 1628620.
^ 6.06.1Entrez Gene: ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein. （原始内容于2019-10-17）.
^Deed RW, Jasiok M, Norton JD. Lymphoid-specific expression of the Id3 gene in hematopoietic cells. Selective antagonism of E2A basic helix-loop-helix protein associated with Id3-induced differentiation of erythroleukemia cells. J. Biol. Chem. Apr 1998, 273 (14): 8278–86. PMID 9525934. doi:10.1074/jbc.273.14.8278.
^Langlands K, Yin X, Anand G, Prochownik EV. Differential interactions of Id proteins with basic-helix-loop-helix transcription factors. J. Biol. Chem. Aug 1997, 272 (32): 19785–93. PMID 9242638. doi:10.1074/jbc.272.32.19785.
^Farioli-Vecchioli S, Saraulli D, Costanzi M, Leonardi L, Cinà I, Micheli L, Nutini M, Longone P, Oh SP, Cestari V, Tirone F. Okazawa H , 编. Impaired terminal differentiation of hippocampal granule neurons and defective contextual memory in PC3/Tis21 knockout mice. PLoS ONE. 2009, 4 (12): e8339. PMC 2791842. PMID 20020054. doi:10.1371/journal.pone.0008339.
拓展閱讀
White PS, Maris JM, Beltinger C, Sulman E, Marshall HN, Fujimori M, Kaufman BA, Biegel JA, Allen C, Hilliard C, Valentine MB, Look AT, Enomoto H, Sakiyama S, Brodeur GM. A region of consistent deletion in neuroblastoma maps within human chromosome 1p36.2-36.3. Proc. Natl. Acad. Sci. U.S.A. 1995, 92 (12): 5520–4. PMC 41727. PMID 7777541. doi:10.1073/pnas.92.12.5520.
Kato S, Sekine S, Oh SW, Kim NS, Umezawa Y, Abe N, Yokoyama-Kobayashi M, Aoki T. Construction of a human full-length cDNA bank. Gene. 1994, 150 (2): 243–50. PMID 7821789. doi:10.1016/0378-1119(94)90433-2.
Deed RW, Hirose T, Mitchell EL, Santibanez-Koref MF, Norton JD. Structural organisation and chromosomal mapping of the human Id-3 gene. Gene. 1994, 151 (1-2): 309–14. PMID 7828896. doi:10.1016/0378-1119(94)90676-9.
Deed RW, Bianchi SM, Atherton GT, Johnston D, Santibanez-Koref M, Murphy JJ, Norton JD. An immediate early human gene encodes an Id-like helix-loop-helix protein and is regulated by protein kinase C activation in diverse cell types. Oncogene. 1993, 8 (3): 599–607. PMID 8437843.
Ishiguro A, Spirin K, Shiohara M, Tobler A, Norton JD, Rigolet M, Shimbo T, Koeffler HP. Expression of Id2 and Id3 mRNA in human lymphocytes. Leuk. Res. 1995, 19 (12): 989–96. PMID 8632670. doi:10.1016/0145-2126(95)00084-4.
Wibley J, Deed R, Jasiok M, Douglas K, Norton J. A homology model of the Id-3 helix-loop-helix domain as a basis for structure-function predictions. Biochim. Biophys. Acta. 1996, 1294 (2): 138–46. PMID 8645731. doi:10.1016/0167-4838(96)00008-8.
Loveys DA, Streiff MB, Kato GJ. E2A basic-helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the Id3 protein. Nucleic Acids Res. 1996, 24 (14): 2813–20. PMC 145994. PMID 8759016. doi:10.1093/nar/24.14.2813.
Deed RW, Armitage S, Norton JD. Nuclear localization and regulation of Id protein through an E protein-mediated chaperone mechanism. J. Biol. Chem. 1996, 271 (39): 23603–6. PMID 8798572. doi:10.1074/jbc.271.39.23603.
Deed RW, Jasiok M, Norton JD. Attenuated function of a variant form of the helix-loop-helix protein, Id-3, generated by an alternative splicing mechanism. FEBS Lett. 1996, 393 (1): 113–6. PMID 8804437. doi:10.1016/0014-5793(96)00868-X.
Chen B, Lim RW. Physical and functional interactions between the transcriptional inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism regulating muscle-specific gene expression. J. Biol. Chem. 1997, 272 (4): 2459–63. PMID 8999959. doi:10.1074/jbc.272.4.2459.
Langlands K, Yin X, Anand G, Prochownik EV. Differential interactions of Id proteins with basic-helix-loop-helix transcription factors. J. Biol. Chem. 1997, 272 (32): 19785–93. PMID 9242638. doi:10.1074/jbc.272.32.19785.
Deed RW, Hara E, Atherton GT, Peters G, Norton JD. Regulation of Id3 cell cycle function by Cdk-2-dependent phosphorylation. Mol. Cell. Biol. 1997, 17 (12): 6815–21. PMC 232537. PMID 9372912.
Deed RW, Jasiok M, Norton JD. Lymphoid-specific expression of the Id3 gene in hematopoietic cells. Selective antagonism of E2A basic helix-loop-helix protein associated with Id3-induced differentiation of erythroleukemia cells. J. Biol. Chem. 1998, 273 (14): 8278–86. PMID 9525934. doi:10.1074/jbc.273.14.8278.
Asp J, Thornemo M, Inerot S, Lindahl A. The helix-loop-helix transcription factors Id1 and Id3 have a functional role in control of cell division in human normal and neoplastic chondrocytes. FEBS Lett. 1998, 438 (1-2): 85–90. PMID 9821964. doi:10.1016/S0014-5793(98)01268-X.
Yates PR, Atherton GT, Deed RW, Norton JD, Sharrocks AD. Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors. EMBO J. 1999, 18 (4): 968–76. PMC 1171189. PMID 10022839. doi:10.1093/emboj/18.4.968.
Moldes M, Boizard M, Liepvre XL, Fève B, Dugail I, Pairault J. Functional antagonism between inhibitor of DNA binding (Id) and adipocyte determination and differentiation factor 1/sterol regulatory element-binding protein-1c (ADD1/SREBP-1c) trans-factors for the regulation of fatty acid synthase promoter in adipocytes. Biochem. J. 344. 1999,. 344 Pt 3: 873–80. PMC 1220711. PMID 10585876. doi:10.1042/0264-6021:3440873.
Bounpheng MA, Dimas JJ, Dodds SG, Christy BA. Degradation of Id proteins by the ubiquitin-proteasome pathway. FASEB J. 1999, 13 (15): 2257–64. PMID 10593873.
Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y. Protein-protein interaction panel using mouse full-length cDNAs. Genome Res. 2001, 11 (10): 1758–65. PMC 311163. PMID 11591653. doi:10.1101/gr.180101.
Jögi A, Persson P, Grynfeld A, Påhlman S, Axelson H. Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation. J. Biol. Chem. 2002, 277 (11): 9118–26. PMID 11756408. doi:10.1074/jbc.M107713200.
基因, 分化抑制因子3, inhibitor, differentiation, 正式名稱爲, inhibitor, binding, protein, dna結合抑制因子3, 螺旋, 螺旋, 蛋白, 人id3蛋白由id3基因編碼, id3已知的結構pdb直系同源搜索, pdbe, rcsbpdbid列表2lfh識別號别名id3, heir, bhlhb25, inhibitor, binding, protein外部idomim, 600277, 96398, homologene, 1633, genecard. ID3 分化抑制因子3 Inhibitor of Differentiation 3 正式名稱爲 inhibitor of DNA binding 3 HLH protein DNA結合抑制因子3 HLH 螺旋 環 螺旋 蛋白 人ID3蛋白由ID3基因編碼 5 6 ID3已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表2LFH識別號别名ID3 HEIR 1 bHLHb25 inhibitor of DNA binding 3 HLH protein外部IDOMIM 600277 MGI 96398 HomoloGene 1633 GeneCards ID3基因位置 人类 染色体1號染色體 1 基因座1p36 12起始23 557 926 bp 1 终止23 559 501 bp 1 基因位置 小鼠 染色体小鼠4号染色体 2 基因座4 D3 4 68 34 cM起始135 870 808 bp 2 终止135 873 066 bp 2 RNA表达模式查阅更多表达数据基因本體分子功能 protein dimerization activity leptomycin B binding transcription corepressor activity protein domain specific binding DNA结合转录因子活性 转录因子结合 血浆蛋白结合 DNA binding transcription factor activity RNA polymerase II specific細胞組分 細胞質 细胞核生物學過程 negative regulation of myoblast differentiation regulation of transcription DNA templated epithelial cell differentiation rhythmic process regulation of DNA replication muscle organ development notochord development negative regulation of transcription by RNA polymerase II negative regulation of DNA binding transcription factor activity negative regulation of osteoblast differentiation transcription DNA templated negative regulation of gene expression regulation of cell cycle odontogenesis multicellular organism development 心脏发育 central nervous system development response to wounding 昼夜节律 neuron differentiation positive regulation of apoptotic process metanephros development negative regulation of transcription DNA templated cellular response to leptomycin B negative regulation of DNA binding negative regulation of neuron differentiationSources Amigo QuickGO直系同源物種人類小鼠Entrez339915903EnsemblENSG00000283060 ENSG00000117318ENSMUSG00000007872UniProtQ02535P41133mRNA 序列NM 002167NM 008321蛋白序列NP 002158NP 032347基因位置 UCSC Chr 1 23 56 23 56 MbChr 4 135 87 135 87 MbPubMed 查找 3 4 維基數據檢視 編輯人類檢視 編輯小鼠 目录 1 功能 2 相互作用 3 ID3的抑制劑 4 參見 5 參考 6 拓展閱讀 7 外部連結功能 编辑分化抑制因子 ID 家族螺旋 環 螺旋 HLH 蛋白質缺乏基因的DNA結合結構域 它通過與其他的HLH蛋白形成異二聚體 阻止其與DNA結合 進而抑制其功能 6 相互作用 编辑ID3能與TCF3 英语 TCF3 轉錄因子3 發生相互作用 7 8 ID3的抑制劑 编辑BTG2 英语 BTG2 能與ID3基因的啓動子結合 進而抑制其ID3基因的活性 如果敲除海馬的BTG2基因的話 海馬ID3表達就會上調 進而使其神經元無法發生末端分化 9 參見 编辑DNA結合抑制蛋白 英语 Inhibitor of DNA binding protein 參考 编辑 1 0 1 1 1 2 GRCh38 Ensembl release 89 ENSG00000283060 ENSG00000117318 Ensembl May 2017 2 0 2 1 2 2 GRCm38 Ensembl release 89 ENSMUSG00000007872 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Ellmeier W Aguzzi A Kleiner E Kurzbauer R Weith A Mutually exclusive expression of a helix loop helix gene and N myc in human neuroblastomas and in normal development EMBO J Aug 1992 11 7 2563 71 PMC 556731 PMID 1628620 6 0 6 1 Entrez Gene ID3 inhibitor of DNA binding 3 dominant negative helix loop helix protein 原始内容存档于2019 10 17 Deed RW Jasiok M Norton JD Lymphoid specific expression of the Id3 gene in hematopoietic cells Selective antagonism of E2A basic helix loop helix protein associated with Id3 induced differentiation of erythroleukemia cells J Biol Chem Apr 1998 273 14 8278 86 PMID 9525934 doi 10 1074 jbc 273 14 8278 Langlands K Yin X Anand G Prochownik EV Differential interactions of Id proteins with basic helix loop helix transcription factors J Biol Chem Aug 1997 272 32 19785 93 PMID 9242638 doi 10 1074 jbc 272 32 19785 Farioli Vecchioli S Saraulli D Costanzi M Leonardi L Cina I Micheli L Nutini M Longone P Oh SP Cestari V Tirone F Okazawa H 编 Impaired terminal differentiation of hippocampal granule neurons and defective contextual memory in PC3 Tis21 knockout mice PLoS ONE 2009 4 12 e8339 PMC 2791842 PMID 20020054 doi 10 1371 journal pone 0008339 拓展閱讀 编辑White PS Maris JM Beltinger C Sulman E Marshall HN Fujimori M Kaufman BA Biegel JA Allen C Hilliard C Valentine MB Look AT Enomoto H Sakiyama S Brodeur GM A region of consistent deletion in neuroblastoma maps within human chromosome 1p36 2 36 3 Proc Natl Acad Sci U S A 1995 92 12 5520 4 PMC 41727 PMID 7777541 doi 10 1073 pnas 92 12 5520 Kato S Sekine S Oh SW Kim NS Umezawa Y Abe N Yokoyama Kobayashi M Aoki T Construction of a human full length cDNA bank Gene 1994 150 2 243 50 PMID 7821789 doi 10 1016 0378 1119 94 90433 2 Deed RW Hirose T Mitchell EL Santibanez Koref MF Norton JD Structural organisation and chromosomal mapping of the human Id 3 gene Gene 1994 151 1 2 309 14 PMID 7828896 doi 10 1016 0378 1119 94 90676 9 Deed RW Bianchi SM Atherton GT Johnston D Santibanez Koref M Murphy JJ Norton JD An immediate early human gene encodes an Id like helix loop helix protein and is regulated by protein kinase C activation in diverse cell types Oncogene 1993 8 3 599 607 PMID 8437843 Ishiguro A Spirin K Shiohara M Tobler A Norton JD Rigolet M Shimbo T Koeffler HP Expression of Id2 and Id3 mRNA in human lymphocytes Leuk Res 1995 19 12 989 96 PMID 8632670 doi 10 1016 0145 2126 95 00084 4 Wibley J Deed R Jasiok M Douglas K Norton J A homology model of the Id 3 helix loop helix domain as a basis for structure function predictions Biochim Biophys Acta 1996 1294 2 138 46 PMID 8645731 doi 10 1016 0167 4838 96 00008 8 Loveys DA Streiff MB Kato GJ E2A basic helix loop helix transcription factors are negatively regulated by serum growth factors and by the Id3 protein Nucleic Acids Res 1996 24 14 2813 20 PMC 145994 PMID 8759016 doi 10 1093 nar 24 14 2813 Deed RW Armitage S Norton JD Nuclear localization and regulation of Id protein through an E protein mediated chaperone mechanism J Biol Chem 1996 271 39 23603 6 PMID 8798572 doi 10 1074 jbc 271 39 23603 Deed RW Jasiok M Norton JD Attenuated function of a variant form of the helix loop helix protein Id 3 generated by an alternative splicing mechanism FEBS Lett 1996 393 1 113 6 PMID 8804437 doi 10 1016 0014 5793 96 00868 X Chen B Lim RW Physical and functional interactions between the transcriptional inhibitors Id3 and ITF 2b Evidence toward a novel mechanism regulating muscle specific gene expression J Biol Chem 1997 272 4 2459 63 PMID 8999959 doi 10 1074 jbc 272 4 2459 Langlands K Yin X Anand G Prochownik EV Differential interactions of Id proteins with basic helix loop helix transcription factors J Biol Chem 1997 272 32 19785 93 PMID 9242638 doi 10 1074 jbc 272 32 19785 Deed RW Hara E Atherton GT Peters G Norton JD Regulation of Id3 cell cycle function by Cdk 2 dependent phosphorylation Mol Cell Biol 1997 17 12 6815 21 PMC 232537 PMID 9372912 Deed RW Jasiok M Norton JD Lymphoid specific expression of the Id3 gene in hematopoietic cells Selective antagonism of E2A basic helix loop helix protein associated with Id3 induced differentiation of erythroleukemia cells J Biol Chem 1998 273 14 8278 86 PMID 9525934 doi 10 1074 jbc 273 14 8278 Asp J Thornemo M Inerot S Lindahl A The helix loop helix transcription factors Id1 and Id3 have a functional role in control of cell division in human normal and neoplastic chondrocytes FEBS Lett 1998 438 1 2 85 90 PMID 9821964 doi 10 1016 S0014 5793 98 01268 X Yates PR Atherton GT Deed RW Norton JD Sharrocks AD Id helix loop helix proteins inhibit nucleoprotein complex formation by the TCF ETS domain transcription factors EMBO J 1999 18 4 968 76 PMC 1171189 PMID 10022839 doi 10 1093 emboj 18 4 968 Moldes M Boizard M Liepvre XL Feve B Dugail I Pairault J Functional antagonism between inhibitor of DNA binding Id and adipocyte determination and differentiation factor 1 sterol regulatory element binding protein 1c ADD1 SREBP 1c trans factors for the regulation of fatty acid synthase promoter in adipocytes Biochem J 344 1999 344 Pt 3 873 80 PMC 1220711 PMID 10585876 doi 10 1042 0264 6021 3440873 Bounpheng MA Dimas JJ Dodds SG Christy BA Degradation of Id proteins by the ubiquitin proteasome pathway FASEB J 1999 13 15 2257 64 PMID 10593873 Suzuki H Fukunishi Y Kagawa I Saito R Oda H Endo T Kondo S Bono H Okazaki Y Hayashizaki Y Protein protein interaction panel using mouse full length cDNAs Genome Res 2001 11 10 1758 65 PMC 311163 PMID 11591653 doi 10 1101 gr 180101 Jogi A Persson P Grynfeld A Pahlman S Axelson H Modulation of basic helix loop helix transcription complex formation by Id proteins during neuronal differentiation J Biol Chem 2002 277 11 9118 26 PMID 11756408 doi 10 1074 jbc M107713200 外部連結 编辑醫學主題詞表 MeSH ID3 protein humanID3 基因 引用了美国国家医学图书馆提供的資料 这些資料属于公共领域 取自 https zh wikipedia org w index php title ID3 基因 amp oldid 71196727, 维基百科，wiki，书籍，书籍，图书馆，
