· plasma membrane · integral to plasma membrane · ER to Golgi transport vesicle membrane · membrane · integral to membrane · phagocytic vesicle membrane · early endosome membrane · MHC class I protein complex
· integral to lumenal side of endoplasmic reticulum membrane
生物过程
· antigen processing and presentation of peptide antigen via MHC class I
· antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent · antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent · regulation of T cell anergy · defense response · immune response · detection of bacterium · virus-host interaction · cytokine-mediated signaling pathway · regulation of interleukin-12 production · regulation of interleukin-6 production · antigen processing and presentation of exogenous peptide antigen via MHC class I · innate immune response · regulation of immune response · interferon-gamma-mediated signaling pathway · type I interferon-mediated signaling pathway
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This article incorporates public domain text from The U.S. National Library of Medicine（页面存档备份，存于互联网档案馆）
是人類白細胞抗原, 的一个基因座位于6号染色体上, major, histocompatibility, complex, class, b主要组织相容性抗原复合物, 第一类, billustration, complexed, peptide, 有效结构pdb, 直系同源检索, pdbe, rcsbpdb查询代码列表3vcl标识代号, hlab, spda1扩展标识遗传学, 142830, 同源基因, 128184, genecards, gene基因本体论描述分子功能, receptor, binding细胞成. HLA B是人類白細胞抗原 HLA 的一个基因座位于6号染色体上 Major histocompatibility complex class I B主要组织相容性抗原复合物 第一类 BIllustration of HLA B complexed peptide 有效结构PDB 直系同源检索 PDBe RCSBPDB查询代码列表3VCL标识代号HLA B AS HLAB SPDA1扩展标识遗传学 142830 同源基因 128184 GeneCards HLA B Gene基因本体论描述分子功能 receptor binding细胞成分 Golgi membrane plasma membrane integral to plasma membrane ER to Golgi transport vesicle membrane membrane integral to membrane phagocytic vesicle membrane early endosome membrane MHC class I protein complex integral to lumenal side of endoplasmic reticulum membrane生物过程 antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of exogenous peptide antigen via MHC class I TAP dependent antigen processing and presentation of exogenous peptide antigen via MHC class I TAP independent regulation of T cell anergy defense response immune response detection of bacterium virus host interaction cytokine mediated signaling pathway regulation of interleukin 12 production regulation of interleukin 6 production antigen processing and presentation of exogenous peptide antigen via MHC class I innate immune response regulation of immune response interferon gamma mediated signaling pathway type I interferon mediated signaling pathway regulation of dendritic cell differentiationSources Amigo QuickGORNA表达模式更多表达数据直系同源体物种人类小鼠Entrez310614963EnsemblENSG00000206450ENSMUSG00000073406UniProtP01889n amRNA序列NM 005514NM 008199蛋白序列NP 005505NP 032225基因位置Chr 6 31 32 31 32 MbChr 17 36 06 36 08 MbPubMed查询 1 2 查论编参考文献 编辑延伸阅读 编辑Brown MA Crane AM Wordsworth BP Genetic aspects of susceptibility severity and clinical expression in ankylosing spondylitis Curr Opin Rheumatol 2002 14 4 354 60 PMID 12118167 doi 10 1097 00002281 200207000 00004 Carrington M O Brien SJ The influence of HLA genotype on AIDS Annu Rev Med 2003 54 535 51 PMID 12525683 doi 10 1146 annurev med 54 101601 152346 Chung WH Hung SI Hong HS Hsih MS Yang LC Ho HC Wu JY Chen YT Medical genetics a marker for Stevens Johnson syndrome Nature 2004 428 6982 486 Bibcode 2004Natur 428 486C PMID 15057820 doi 10 1038 428486a Colbert RA The immunobiology of HLA B27 variations on a theme Curr Mol Med 2004 4 1 21 30 PMID 15011956 doi 10 2174 1566524043479293 Colmegna I Cuchacovich R Espinoza LR HLA B27 associated reactive arthritis pathogenetic and clinical considerations Clin Microbiol Rev 2004 17 2 348 69 PMC 387405 PMID 15084505 doi 10 1128 CMR 17 2 348 369 2004 Full text Cooke GS Hill AV Genetics of susceptibility to human infectious disease Nat Rev Genet 2001 2 12 967 77 PMID 11733749 doi 10 1038 35103577 Gao X Nelson GW Karacki P Martin MP Phair J Kaslow R Goedert JJ Buchbinder S Hoots K Vlahov D O Brien SJ Carrington M Effect of a single amino acid change in MHC class I molecules on the rate of progression to AIDS N Engl J Med 2001 344 22 1668 75 PMID 11386265 doi 10 1056 NEJM200105313442203 Hetherington S Hughes AR Mosteller M Shortino D Baker KL Spreen W Lai E Davies K Handley A Dow DJ Fling ME Stocum M Bowman C Thurmond LM Roses AD Genetic variations in HLA B region and hypersensitivity reactions to abacavir Lancet 2002 359 9312 1121 2 PMID 11943262 doi 10 1016 S0140 6736 02 08158 8 Hung SI Chung WH Liou LB Chu CC Lin M Huang HP Lin YL Lan JL Yang LC Hong HS Chen MJ Lai PC Wu MS Chu CY Wang KH Chen CH Fann CS Wu JY Chen YT HLA B 5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol Proc Natl Acad Sci USA 2005 102 11 4134 9 Bibcode 2005PNAS 102 4134H PMC 554812 PMID 15743917 doi 10 1073 pnas 0409500102 Full text Khan MA Ball EJ Genetic aspects of ankylosing spondylitis Best Pract Res Clin Rheumatol 2002 16 4 675 90 PMID 12406434 Khan MA Update on spondyloarthropathies Ann Intern Med 2002 136 12 896 907 PMID 12069564 Full text PDF 页面存档备份 存于互联网档案馆 Letvin NL Walker BD Immunopathogenesis and immunotherapy in AIDS virus infections Nat Med 2003 9 7 861 6 PMID 12835706 doi 10 1038 nm0703 861 Migueles SA Sabbaghian MS Shupert WL Bettinotti MP Marincola FM Martino L Hallahan CW Selig SM Schwartz D Sullivan J Connors M HLA B 5701 is highly associated with restriction of virus replication in a subgroup of HIV infected long term nonprogressors Proc Natl Acad Sci USA 2000 97 6 2709 14 Bibcode 2000PNAS 97 2709M PMC 15994 PMID 10694578 doi 10 1073 pnas 050567397 Full text 页面存档备份 存于互联网档案馆 Sheehan NJ The ramifications of HLA B27 J R Soc Med 2004 97 1 10 4 PMC 1079257 PMID 14702356 doi 10 1258 jrsm 97 1 10 Tassaneeyakul W Jantararoungtong T Chen P Lin PY Tiamkao S Khunarkornsiri U Chucherd P Konyoung P Vannaprasaht S Choonhakarn C Pisuttimarn P Sangviroon A Tassaneeyakul W Strong association between HLA B 5801 and allopurinol induced Stevens Johnson syndrome and toxic epidermal necrolysis in a Thai population Pharmacogenet Genomics 2009 19 9 704 9 PMID 19696695 doi 10 1097 FPC 0b013e328330a3b8 Tassaneeyakul W Tiamkao S Jantararoungtong T Chen P Lin SY Chen WH Konyoung P Khunarkornsiri U Auvichayapat N Pavakul K Kulkantrakorn K Choonhakarn C Phonhiamhan S Piyatrakul N Aungaree T Pongpakdee S Yodnopaglaw P Association between HLA B 1502 and carbamazepine induced severe cutaneous adverse drug reactions in a Thai population Epilepsia 2010 51 5 926 30 PMID 20345939 doi 10 1111 j 1528 1167 2010 02533 x Full text PDF 页面存档备份 存于互联网档案馆 This article incorporates public domain text from The U S National Library of Medicine 页面存档备份 存于互联网档案馆 外部链接 编辑OMIM 142830 EntrezGene 3106 Template GeneCard Nomenclature for factors of the HLA system 取自 https zh wikipedia org w index php title HLA B amp oldid 68256906, 维基百科，wiki，书籍，书籍，图书馆，
