Rangnekar VM, Aplin AC, Sukhatme VP. The serum and TPA responsive promoter and intron-exon structure of EGR2, a human early growth response gene encoding a zinc finger protein. Nucleic Acids Res. 1990, 18 (9): 2749–57. PMC 330760. PMID 2111009. doi:10.1093/nar/18.9.2749.
Chavrier P; Janssen-Timmen U; Mattéi MG; et al. Structure, chromosome location, and expression of the mouse zinc finger gene Krox-20: multiple gene products and coregulation with the proto-oncogene c-fos. Mol. Cell. Biol. 1989, 9 (2): 787–97. PMC 362656. PMID 2496302.已忽略未知参数|author-separator= (帮助)
Joseph LJ; Le Beau MM; Jamieson GA; et al. Molecular cloning, sequencing, and mapping of EGR2, a human early growth response gene encoding a protein with "zinc-binding finger" structure. Proc. Natl. Acad. Sci. U.S.A. 1988, 85 (19): 7164–8. PMC 282144. PMID 3140236. doi:10.1073/pnas.85.19.7164.已忽略未知参数|author-separator= (帮助)
Topilko P; Schneider-Maunoury S; Levi G; et al. Krox-20 controls myelination in the peripheral nervous system. Nature. 1994, 371 (6500): 796–9. PMID 7935840. doi:10.1038/371796a0.已忽略未知参数|author-separator= (帮助)
Sham MH; Vesque C; Nonchev S; et al. The zinc finger gene Krox20 regulates HoxB2 (Hox2.8) during hindbrain segmentation. Cell. 1993, 72 (2): 183–96. PMID 8093858. doi:10.1016/0092-8674(93)90659-E.已忽略未知参数|author-separator= (帮助)
Levi G; Topilko P; Schneider-Maunoury S; et al. Role of Krox-20 in endochondral bone formation. Ann. N. Y. Acad. Sci. 1996, 785: 288–91. PMID 8702157. doi:10.1111/j.1749-6632.1996.tb56286.x.已忽略未知参数|author-separator= (帮助)
Warner LE; Mancias P; Butler IJ; et al. Mutations in the early growth response 2 (EGR2) gene are associated with hereditary myelinopathies. Nat. Genet. 1998, 18 (4): 382–4. PMID 9537424. doi:10.1038/ng0498-382.已忽略未知参数|author-separator= (帮助)
Warner LE, Svaren J, Milbrandt J, Lupski JR. Functional consequences of mutations in the early growth response 2 gene (EGR2) correlate with severity of human myelinopathies. Hum. Mol. Genet. 1999, 8 (7): 1245–51. PMID 10369870. doi:10.1093/hmg/8.7.1245.
Timmerman V; De Jonghe P; Ceuterick C; et al. Novel missense mutation in the early growth response 2 gene associated with Dejerine-Sottas syndrome phenotype. Neurology. 1999, 52 (9): 1827–32. PMID 10371530.已忽略未知参数|author-separator= (帮助)
Bellone E; Di Maria E; Soriani S; et al. A novel mutation (D305V) in the early growth response 2 gene is associated with severe Charcot-Marie-Tooth type 1 disease. Hum. Mutat. 1999, 14 (4): 353–4. PMID 10502832. doi:10.1002/(SICI)1098-1004(199910)14:4<353::AID-HUMU17>3.0.CO;2-4.已忽略未知参数|author-separator= (帮助)
Pareyson D; Taroni F; Botti S; et al. Cranial nerve involvement in CMT disease type 1 due to early growth response 2 gene mutation. Neurology. 2000, 54 (8): 1696–8. PMID 10762521.已忽略未知参数|author-separator= (帮助)
Gambardella L; Schneider-Maunoury S; Voiculescu O; et al. Pattern of expression of the transcription factor Krox-20 in mouse hair follicle. Mech. Dev. 2000, 96 (2): 215–8. PMID 10960786. doi:10.1016/S0925-4773(00)00398-1.已忽略未知参数|author-separator= (帮助)
Yoshihara T; Kanda F; Yamamoto M; et al. A novel missense mutation in the early growth response 2 gene associated with late-onset Charcot--Marie--Tooth disease type 1. J. Neurol. Sci. 2001, 184 (2): 149–53. PMID 11239949. doi:10.1016/S0022-510X(00)00504-9.已忽略未知参数|author-separator= (帮助)
Boerkoel CF; Takashima H; Bacino CA; et al. EGR2 mutation R359W causes a spectrum of Dejerine-Sottas neuropathy. Neurogenetics. 2002, 3 (3): 153–7. PMID 11523566. doi:10.1007/s100480100107.已忽略未知参数|author-separator= (帮助)
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Vandenberghe N; Upadhyaya M; Gatignol A; et al. Frequency of mutations in the early growth response 2 gene associated with peripheral demyelinating neuropathies. J. Med. Genet. 2003, 39 (12): e81. PMC 1757229. PMID 12471219. doi:10.1136/jmg.39.12.e81.已忽略未知参数|author-separator= (帮助)
Strausberg RL; Feingold EA; Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899.已忽略未知参数|author-separator= (帮助)
Musso M; Balestra P; Taroni F; et al. Different consequences of EGR2 mutants on the transactivation of human Cx32 promoter. Neurobiol. Dis. 2003, 12 (1): 89–95. PMID 12609493. doi:10.1016/S0969-9961(02)00018-9.已忽略未知参数|author-separator= (帮助)
Unoki M, Nakamura Y. EGR2 induces apoptosis in various cancer cell lines by direct transactivation of BNIP3L and BAK. Oncogene. 2003, 22 (14): 2172–85. PMID 12687019. doi:10.1038/sj.onc.1206222.
Numakura C; Shirahata E; Yamashita S; et al. Screening of the early growth response 2 gene in Japanese patients with Charcot-Marie-Tooth disease type 1. J. Neurol. Sci. 2003, 210 (1–2): 61–4. PMID 12736090. doi:10.1016/S0022-510X(03)00028-5.已忽略未知参数|author-separator= (帮助)
外部链接编辑
GeneReviews/NCBI/NIH/UW entry on Charcot-Marie-Tooth Neuropathy Type 1（页面存档备份，存于互联网档案馆）
GeneReviews/NCBI/NIH/UW entry on Charcot-Marie-Tooth Neuropathy Type 4（页面存档备份，存于互联网档案馆）
egr2, 早期生长反应蛋白2, 英語, early, growth, response, protein, 是一个由人类基因编码的蛋白质, 早期生长应答蛋白2early, growth, response, 2pdb, rendering, based, 1a1i, 有效结构pdb, 直系同源检索, pdbe, rcsbpdb查询代码列表1a1i, 1a1j, 1a1k, 1a1l, 1aay, 1jk1, 1jk2, 1p47, 1zaa标识代号, at591, cmt1d, cmt4e, krox20扩展标识. 早期生长反应蛋白2 英語 Early growth response protein 2 EGR 2 是一个由人类基因EGR2编码的蛋白质 早期生长应答蛋白2Early growth response 2PDB rendering based on 1a1i 有效结构PDB 直系同源检索 PDBe RCSBPDB查询代码列表1a1i 1a1j 1a1k 1a1l 1aay 1jk1 1jk2 1p47 1zaa标识代号EGR2 AT591 CMT1D CMT4E KROX20扩展标识遗传学 129010 鼠基因 95296 同源基因 20123 GeneCards EGR2 Gene基因本体论描述分子功能 RNA polymerase II activating transcription factor binding chromatin binding sequence specific DNA binding transcription factor activity protein binding zinc ion binding ligase activity ubiquitin protein ligase binding transcription regulatory region DNA binding HMG box domain binding细胞成分 nucleus cytoplasm生物过程 transcription from RNA polymerase II promoter protein export from nucleus brain development peripheral nervous system development learning or memory rhythmic behavior motor neuron axon guidance Schwann cell differentiation protein sumoylation facial nerve structural organization rhombomere 3 formation rhombomere 5 formation regulation of ossification response to insulin stimulus brain segmentation myelination fat cell differentiation positive regulation of transcription DNA dependent positive regulation of transcription from RNA polymerase II promoter regulation of neuronal synaptic plasticity cellular response to organic substanceSources Amigo QuickGORNA表达模式更多表达数据直系同源体物种人类小鼠Entrez195913654EnsemblENSG00000122877ENSMUSG00000037868UniProtP11161P08152mRNA序列NM 000399NM 010118蛋白序列NP 000390NP 034248基因位置Chr 10 64 57 64 68 MbChr 10 67 54 67 54 MbPubMed查询 1 2 查论编EGR2是一个转录因子 包含三个串联的Cys2His2型锌指结构 该基因的多态性与I型进行性神经性腓骨肌萎缩症有关 1 参考文献 编辑 Entrez Gene EGR2 early growth response 2 Krox 20 homolog Drosophila 原始内容存档于2019 10 16 延伸阅读 编辑Rangnekar VM Aplin AC Sukhatme VP The serum and TPA responsive promoter and intron exon structure of EGR2 a human early growth response gene encoding a zinc finger protein Nucleic Acids Res 1990 18 9 2749 57 PMC 330760 nbsp PMID 2111009 doi 10 1093 nar 18 9 2749 Chavrier P Janssen Timmen U Mattei MG et al Structure chromosome location and expression of the mouse zinc finger gene Krox 20 multiple gene products and coregulation with the proto oncogene c fos Mol Cell Biol 1989 9 2 787 97 PMC 362656 nbsp PMID 2496302 已忽略未知参数 author separator 帮助 Joseph LJ Le Beau MM Jamieson GA et al Molecular cloning sequencing and mapping of EGR2 a human early growth response gene encoding a protein with zinc binding finger structure Proc Natl Acad Sci U S A 1988 85 19 7164 8 PMC 282144 nbsp PMID 3140236 doi 10 1073 pnas 85 19 7164 已忽略未知参数 author separator 帮助 Topilko P Schneider Maunoury S Levi G et al Krox 20 controls myelination in the peripheral nervous system Nature 1994 371 6500 796 9 PMID 7935840 doi 10 1038 371796a0 已忽略未知参数 author separator 帮助 Sham MH Vesque C Nonchev S et al The zinc finger gene Krox20 regulates HoxB2 Hox2 8 during hindbrain segmentation Cell 1993 72 2 183 96 PMID 8093858 doi 10 1016 0092 8674 93 90659 E 已忽略未知参数 author separator 帮助 Levi G Topilko P Schneider Maunoury S et al Role of Krox 20 in endochondral bone formation Ann N Y Acad Sci 1996 785 288 91 PMID 8702157 doi 10 1111 j 1749 6632 1996 tb56286 x 已忽略未知参数 author separator 帮助 Warner LE Mancias P Butler IJ et al Mutations in the early growth response 2 EGR2 gene are associated with hereditary myelinopathies Nat Genet 1998 18 4 382 4 PMID 9537424 doi 10 1038 ng0498 382 已忽略未知参数 author separator 帮助 Warner LE Svaren J Milbrandt J Lupski JR Functional consequences of mutations in the early growth response 2 gene EGR2 correlate with severity of human myelinopathies Hum Mol Genet 1999 8 7 1245 51 PMID 10369870 doi 10 1093 hmg 8 7 1245 Timmerman V De Jonghe P Ceuterick C et al Novel missense mutation in the early growth response 2 gene associated with Dejerine Sottas syndrome phenotype Neurology 1999 52 9 1827 32 PMID 10371530 已忽略未知参数 author separator 帮助 Bellone E Di Maria E Soriani S et al A novel mutation D305V in the early growth response 2 gene is associated with severe Charcot Marie Tooth type 1 disease Hum Mutat 1999 14 4 353 4 PMID 10502832 doi 10 1002 SICI 1098 1004 199910 14 4 lt 353 AID HUMU17 gt 3 0 CO 2 4 已忽略未知参数 author separator 帮助 Pareyson D Taroni F Botti S et al Cranial nerve involvement in CMT disease type 1 due to early growth response 2 gene mutation Neurology 2000 54 8 1696 8 PMID 10762521 已忽略未知参数 author separator 帮助 Gambardella L Schneider Maunoury S Voiculescu O et al Pattern of expression of the transcription factor Krox 20 in mouse hair follicle Mech Dev 2000 96 2 215 8 PMID 10960786 doi 10 1016 S0925 4773 00 00398 1 已忽略未知参数 author separator 帮助 Yoshihara T Kanda F Yamamoto M et al A novel missense mutation in the early growth response 2 gene associated with late onset Charcot Marie Tooth disease type 1 J Neurol Sci 2001 184 2 149 53 PMID 11239949 doi 10 1016 S0022 510X 00 00504 9 已忽略未知参数 author separator 帮助 Boerkoel CF Takashima H Bacino CA et al EGR2 mutation R359W causes a spectrum of Dejerine Sottas neuropathy Neurogenetics 2002 3 3 153 7 PMID 11523566 doi 10 1007 s100480100107 已忽略未知参数 author separator 帮助 Yang Y Dong B Mittelstadt PR et al HIV Tat binds Egr proteins and enhances Egr dependent transactivation of the Fas ligand promoter J Biol Chem 2002 277 22 19482 7 PMID 11909874 doi 10 1074 jbc M201687200 已忽略未知参数 author separator 帮助 Vandenberghe N Upadhyaya M Gatignol A et al Frequency of mutations in the early growth response 2 gene associated with peripheral demyelinating neuropathies J Med Genet 2003 39 12 e81 PMC 1757229 nbsp PMID 12471219 doi 10 1136 jmg 39 12 e81 已忽略未知参数 author separator 帮助 Strausberg RL Feingold EA Grouse LH et al Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 2003 99 26 16899 903 PMC 139241 nbsp PMID 12477932 doi 10 1073 pnas 242603899 已忽略未知参数 author separator 帮助 Musso M Balestra P Taroni F et al Different consequences of EGR2 mutants on the transactivation of human Cx32 promoter Neurobiol Dis 2003 12 1 89 95 PMID 12609493 doi 10 1016 S0969 9961 02 00018 9 已忽略未知参数 author separator 帮助 Unoki M Nakamura Y EGR2 induces apoptosis in various cancer cell lines by direct transactivation of BNIP3L and BAK Oncogene 2003 22 14 2172 85 PMID 12687019 doi 10 1038 sj onc 1206222 Numakura C Shirahata E Yamashita S et al Screening of the early growth response 2 gene in Japanese patients with Charcot Marie Tooth disease type 1 J Neurol Sci 2003 210 1 2 61 4 PMID 12736090 doi 10 1016 S0022 510X 03 00028 5 已忽略未知参数 author separator 帮助 外部链接 编辑GeneReviews NCBI NIH UW entry on Charcot Marie Tooth Neuropathy Type 1 页面存档备份 存于互联网档案馆 GeneReviews NCBI NIH UW entry on Charcot Marie Tooth Neuropathy Type 4 页面存档备份 存于互联网档案馆 醫學主題詞表 MeSH EGR2 protein humanEGR2引用了美国国家医学图书馆提供的資料 这些資料属于公共领域 取自 https zh wikipedia org w index php title EGR2 amp oldid 71196583, 维基百科，wiki，书籍，书籍，图书馆，
