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维基百科

CXCL7

趋化因子CXCL7(英語:Chemokine (C-X-C motif) ligand 7,CXCL7)是一个人类基因[1]。其编码的蛋白质为趋化因子(C-X-C基序)配体7 Chemokine (C-X-C motif) ligand,是一种CXC趋化因子细胞因子,其蛋白异型体为β-血小板球蛋白或原血小板碱性蛋白(英語:Pro-Platelet basic protein,PPBP)[2]

Pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PDB rendering based on 1f9p.
有效结构
PDB 直系同源检索:PDBe, RCSB
标识
代号 PPBP; B-TG1; Beta-TG; CTAP-III; CTAP3; CTAPIII; CXCL7; LA-PF4; LDGF; MDGF; NAP-2; PBP; SCYB7; TC1; TC2; TGB; TGB1; THBGB; THBGB1
扩展标识 遗传学:121010 鼠基因:1888712 同源基因:48122 GeneCards: PPBP Gene
RNA表达模式
更多表达数据
直系同源体
物种 人类 小鼠
Entrez 5473 57349
Ensembl ENSG00000163736 ENSMUSG00000029372
UniProt P02775 Q9EQI5
mRNA序列 NM_002704 NM_023785
蛋白序列 NP_002695 NP_076274
基因位置 Chr 4:
74.85 – 74.85 Mb
Chr 5:
90.77 – 90.77 Mb
PubMed查询 [1] [2]

这种蛋白在血小板活化时被大量释放[3] ,能刺激多种过程,包括有丝分裂细胞外基质的合成、糖代谢英语glucose metabolism纤溶酶原激活物的合成[4][5]

参考文献 编辑

  1. ^ Entrez Gene: PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7). (原始内容于2019-09-24). 
  2. ^ Hristov M, Zernecke A, Bidzhekov K; et al. Importance of CXC chemokine receptor 2 in the homing of human peripheral blood endothelial progenitor cells to sites of arterial injury. Circ. Res. March 2007, 100 (4): 590–7. PMID 17272812. doi:10.1161/01.RES.0000259043.42571.68. 
  3. ^ Majumdar S, Gonder D, Koutsis B, Poncz M. Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4. J Biol Chem. 1991, 266 (9): 5785–9. PMID 1826003. 
  4. ^ Castor C, Miller J, Walz D. Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor. Proc Natl Acad Sci USA. 1983, 80 (3): 765–9. PMC 393460 . PMID 6572368. doi:10.1073/pnas.80.3.765. 
  5. ^ Castor C, Furlong A, Carter-Su C. Connective tissue activation: stimulation of glucose transport by connective tissue activating peptide III. Biochemistry. 1985, 24 (7): 1762–7. PMID 4005226. doi:10.1021/bi00328a029. 

延伸阅读 编辑

  • Begg GS, Pepper DS, Chesterman CN, Morgan FJ. Complete covalent structure of human beta-thromboglobulin.. Biochemistry. 1978, 17 (9): 1739–44. PMID 77677. doi:10.1021/bi00602a024. 
  • Kaplan KL, Broekman MJ, Chernoff A; et al. Platelet alpha-granule proteins: studies on release and subcellular localization.. Blood. 1979, 53 (4): 604–18. PMID 426909. 
  • Tunnacliffe A, Majumdar S, Yan B, Poncz M. Genes for beta-thromboglobulin and platelet factor 4 are closely linked and form part of a cluster of related genes on chromosome 4.. Blood. 1992, 79 (11): 2896–900. PMID 1316786. 
  • Cohen AB, Stevens MD, Miller EJ; et al. Generation of the neutrophil-activating peptide-2 by cathepsin G and cathepsin G-treated human platelets.. Am. J. Physiol. 1992, 263 (2 Pt 1): L249–56. PMID 1387511. 
  • Morris SW, Nelson N, Valentine MB; et al. Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35.. Genomics. 1992, 14 (3): 685–91. PMID 1427896. doi:10.1016/S0888-7543(05)80169-7. 
  • Majumdar S, Gonder D, Koutsis B, Poncz M. Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4.. J. Biol. Chem. 1991, 266 (9): 5785–9. PMID 1826003. 
  • Wenger RH, Hameister H, Clemetson KJ. Human platelet basic protein/connective tissue activating peptide-III maps in a gene cluster on chromosome 4q12-q13 along with other genes of the beta-thromboglobulin superfamily.. Hum. Genet. 1991, 87 (3): 367–8. PMID 1830861. doi:10.1007/BF00200921. 
  • Hjemdahl P, Perneby C, Theodorsson E; et al. A new assay for beta-thromboglobulin in urine.. Thromb. Res. 1992, 64 (1): 33–43. PMID 1837963. doi:10.1016/0049-3848(91)90203-9. 
  • Brandt E, Van Damme J, Flad HD. Neutrophils can generate their activator neutrophil-activating peptide 2 by proteolytic cleavage of platelet-derived connective tissue-activating peptide III.. Cytokine. 1991, 3 (4): 311–21. PMID 1873479. doi:10.1016/1043-4666(91)90499-4. 
  • Clark-Lewis I, Moser B, Walz A; et al. Chemical synthesis, purification, and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide.. Biochemistry. 1991, 30 (12): 3128–35. PMID 2007144. doi:10.1021/bi00226a021. 
  • Walz A, Baggiolini M. Generation of the neutrophil-activating peptide NAP-2 from platelet basic protein or connective tissue-activating peptide III through monocyte proteases.. J. Exp. Med. 1990, 171 (2): 449–54. PMC 2187709 . PMID 2406364. doi:10.1084/jem.171.2.449. 
  • Holt JC, Harris ME, Holt AM; et al. Characterization of human platelet basic protein, a precursor form of low-affinity platelet factor 4 and beta-thromboglobulin.. Biochemistry. 1986, 25 (8): 1988–96. PMID 2423119. doi:10.1021/bi00356a023. 
  • Walz A, Baggiolini M. A novel cleavage product of beta-thromboglobulin formed in cultures of stimulated mononuclear cells activates human neutrophils.. Biochem. Biophys. Res. Commun. 1989, 159 (3): 969–75. PMID 2522778. doi:10.1016/0006-291X(89)92203-1. 
  • Wenger RH, Wicki AN, Walz A; et al. Cloning of cDNA coding for connective tissue activating peptide III from a human platelet-derived lambda gt11 expression library.. Blood. 1989, 73 (6): 1498–503. PMID 2713489. 
  • Castor CW, Walz DA, Ragsdale CG; et al. Connective tissue activation. XXXIII. Biologically active cleavage products of CTAP-III from human platelets.. Biochem. Biophys. Res. Commun. 1989, 163 (2): 1071–8. PMID 2783111. doi:10.1016/0006-291X(89)92330-9. 
  • Holt JC, Rabellino EM, Gewirtz AM; et al. Occurrence of platelet basic protein, a precursor of low affinity platelet factor 4 and beta-thromboglobulin, in human platelets and megakaryocytes.. Exp. Hematol. 1988, 16 (4): 302–6. PMID 2966071. 
  • Castor CW, Furlong AM, Carter-Su C. Connective tissue activation: stimulation of glucose transport by connective tissue activating peptide III.. Biochemistry. 1985, 24 (7): 1762–7. PMID 4005226. doi:10.1021/bi00328a029. 
  • McLaren KM, Pepper DS. Immunological localisation of beta-thromboglobulin and platelet factor 4 in human megakaryocytes and platelets.. J. Clin. Pathol. 1983, 35 (11): 1227–31. PMC 497932 . PMID 6183294. doi:10.1136/jcp.35.11.1227. 
  • Castor CW, Miller JW, Walz DA. Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor.. Proc. Natl. Acad. Sci. U.S.A. 1983, 80 (3): 765–9. PMC 393460 . PMID 6572368. doi:10.1073/pnas.80.3.765. 
  • Malkowski MG, Wu JY, Lazar JB; et al. The crystal structure of recombinant human neutrophil-activating peptide-2 (M6L) at 1.9-A resolution.. J. Biol. Chem. 1995, 270 (13): 7077–87. PMID 7706245. doi:10.1074/jbc.270.13.7077. 

cxcl7, 趋化因子, 英語, chemokine, motif, ligand, 是一个人类基因, 其编码的蛋白质为趋化因子, c基序, 配体7, chemokine, motif, ligand, 是一种cxc趋化因子类细胞因子, 其蛋白异型体为β, 血小板球蛋白或原血小板碱性蛋白, 英語, platelet, basic, protein, ppbp, platelet, basic, protein, chemokine, motif, ligand, rendering, based, 1f9p, 有效. 趋化因子CXCL7 英語 Chemokine C X C motif ligand 7 CXCL7 是一个人类基因 1 其编码的蛋白质为趋化因子 C X C基序 配体7 Chemokine C X C motif ligand 是一种CXC趋化因子类细胞因子 其蛋白异型体为b 血小板球蛋白或原血小板碱性蛋白 英語 Pro Platelet basic protein PPBP 2 Pro platelet basic protein chemokine C X C motif ligand 7 PDB rendering based on 1f9p 有效结构PDB 直系同源检索 PDBe RCSBPDB查询代码列表1F9P 1NAP 1TVX标识代号PPBP B TG1 Beta TG CTAP III CTAP3 CTAPIII CXCL7 LA PF4 LDGF MDGF NAP 2 PBP SCYB7 TC1 TC2 TGB TGB1 THBGB THBGB1扩展标识遗传学 121010 鼠基因 1888712 同源基因 48122 GeneCards PPBP Gene基因本体论描述分子功能 glucose transmembrane transporter activity chemokine activity growth factor activity细胞成分 extracellular region extracellular space platelet alpha granule lumen生物过程 platelet degranulation blood coagulation glucose transport platelet activation neutrophil chemotaxis defense response to bacterium neutrophil degranulation positive regulation of cell divisionSources Amigo QuickGORNA表达模式更多表达数据直系同源体物种人类小鼠Entrez547357349EnsemblENSG00000163736ENSMUSG00000029372UniProtP02775Q9EQI5mRNA序列NM 002704NM 023785蛋白序列NP 002695NP 076274基因位置Chr 4 74 85 74 85 MbChr 5 90 77 90 77 MbPubMed查询 1 2 查论编这种蛋白在血小板活化时被大量释放 3 能刺激多种过程 包括有丝分裂 细胞外基质的合成 糖代谢 英语 glucose metabolism 和纤溶酶原激活物的合成 4 5 参考文献 编辑 Entrez Gene PPBP pro platelet basic protein chemokine C X C motif ligand 7 原始内容存档于2019 09 24 Hristov M Zernecke A Bidzhekov K et al Importance of CXC chemokine receptor 2 in the homing of human peripheral blood endothelial progenitor cells to sites of arterial injury Circ Res March 2007 100 4 590 7 PMID 17272812 doi 10 1161 01 RES 0000259043 42571 68 引文格式1维护 显式使用等标签 link Majumdar S Gonder D Koutsis B Poncz M Characterization of the human beta thromboglobulin gene Comparison with the gene for platelet factor 4 J Biol Chem 1991 266 9 5785 9 PMID 1826003 Castor C Miller J Walz D Structural and biological characteristics of connective tissue activating peptide CTAP III a major human platelet derived growth factor Proc Natl Acad Sci USA 1983 80 3 765 9 PMC 393460 nbsp PMID 6572368 doi 10 1073 pnas 80 3 765 Castor C Furlong A Carter Su C Connective tissue activation stimulation of glucose transport by connective tissue activating peptide III Biochemistry 1985 24 7 1762 7 PMID 4005226 doi 10 1021 bi00328a029 延伸阅读 编辑Begg GS Pepper DS Chesterman CN Morgan FJ Complete covalent structure of human beta thromboglobulin Biochemistry 1978 17 9 1739 44 PMID 77677 doi 10 1021 bi00602a024 Kaplan KL Broekman MJ Chernoff A et al Platelet alpha granule proteins studies on release and subcellular localization Blood 1979 53 4 604 18 PMID 426909 引文格式1维护 显式使用等标签 link Tunnacliffe A Majumdar S Yan B Poncz M Genes for beta thromboglobulin and platelet factor 4 are closely linked and form part of a cluster of related genes on chromosome 4 Blood 1992 79 11 2896 900 PMID 1316786 Cohen AB Stevens MD Miller EJ et al Generation of the neutrophil activating peptide 2 by cathepsin G and cathepsin G treated human platelets Am J Physiol 1992 263 2 Pt 1 L249 56 PMID 1387511 引文格式1维护 显式使用等标签 link Morris SW Nelson N Valentine MB et al Assignment of the genes encoding human interleukin 8 receptor types 1 and 2 and an interleukin 8 receptor pseudogene to chromosome 2q35 Genomics 1992 14 3 685 91 PMID 1427896 doi 10 1016 S0888 7543 05 80169 7 引文格式1维护 显式使用等标签 link Majumdar S Gonder D Koutsis B Poncz M Characterization of the human beta thromboglobulin gene Comparison with the gene for platelet factor 4 J Biol Chem 1991 266 9 5785 9 PMID 1826003 Wenger RH Hameister H Clemetson KJ Human platelet basic protein connective tissue activating peptide III maps in a gene cluster on chromosome 4q12 q13 along with other genes of the beta thromboglobulin superfamily Hum Genet 1991 87 3 367 8 PMID 1830861 doi 10 1007 BF00200921 Hjemdahl P Perneby C Theodorsson E et al A new assay for beta thromboglobulin in urine Thromb Res 1992 64 1 33 43 PMID 1837963 doi 10 1016 0049 3848 91 90203 9 引文格式1维护 显式使用等标签 link Brandt E Van Damme J Flad HD Neutrophils can generate their activator neutrophil activating peptide 2 by proteolytic cleavage of platelet derived connective tissue activating peptide III Cytokine 1991 3 4 311 21 PMID 1873479 doi 10 1016 1043 4666 91 90499 4 Clark Lewis I Moser B Walz A et al Chemical synthesis purification and characterization of two inflammatory proteins neutrophil activating peptide 1 interleukin 8 and neutrophil activating peptide Biochemistry 1991 30 12 3128 35 PMID 2007144 doi 10 1021 bi00226a021 引文格式1维护 显式使用等标签 link Walz A Baggiolini M Generation of the neutrophil activating peptide NAP 2 from platelet basic protein or connective tissue activating peptide III through monocyte proteases J Exp Med 1990 171 2 449 54 PMC 2187709 nbsp PMID 2406364 doi 10 1084 jem 171 2 449 Holt JC Harris ME Holt AM et al Characterization of human platelet basic protein a precursor form of low affinity platelet factor 4 and beta thromboglobulin Biochemistry 1986 25 8 1988 96 PMID 2423119 doi 10 1021 bi00356a023 引文格式1维护 显式使用等标签 link Walz A Baggiolini M A novel cleavage product of beta thromboglobulin formed in cultures of stimulated mononuclear cells activates human neutrophils Biochem Biophys Res Commun 1989 159 3 969 75 PMID 2522778 doi 10 1016 0006 291X 89 92203 1 Wenger RH Wicki AN Walz A et al Cloning of cDNA coding for connective tissue activating peptide III from a human platelet derived lambda gt11 expression library Blood 1989 73 6 1498 503 PMID 2713489 引文格式1维护 显式使用等标签 link Castor CW Walz DA Ragsdale CG et al Connective tissue activation XXXIII Biologically active cleavage products of CTAP III from human platelets Biochem Biophys Res Commun 1989 163 2 1071 8 PMID 2783111 doi 10 1016 0006 291X 89 92330 9 引文格式1维护 显式使用等标签 link Holt JC Rabellino EM Gewirtz AM et al Occurrence of platelet basic protein a precursor of low affinity platelet factor 4 and beta thromboglobulin in human platelets and megakaryocytes Exp Hematol 1988 16 4 302 6 PMID 2966071 引文格式1维护 显式使用等标签 link Castor CW Furlong AM Carter Su C Connective tissue activation stimulation of glucose transport by connective tissue activating peptide III Biochemistry 1985 24 7 1762 7 PMID 4005226 doi 10 1021 bi00328a029 McLaren KM Pepper DS Immunological localisation of beta thromboglobulin and platelet factor 4 in human megakaryocytes and platelets J Clin Pathol 1983 35 11 1227 31 PMC 497932 nbsp PMID 6183294 doi 10 1136 jcp 35 11 1227 Castor CW Miller JW Walz DA Structural and biological characteristics of connective tissue activating peptide CTAP III a major human platelet derived growth factor Proc Natl Acad Sci U S A 1983 80 3 765 9 PMC 393460 nbsp PMID 6572368 doi 10 1073 pnas 80 3 765 Malkowski MG Wu JY Lazar JB et al The crystal structure of recombinant human neutrophil activating peptide 2 M6L at 1 9 A resolution J Biol Chem 1995 270 13 7077 87 PMID 7706245 doi 10 1074 jbc 270 13 7077 引文格式1维护 显式使用等标签 link 取自 https zh wikipedia org w index php title CXCL7 amp oldid 68256711, 维基百科,wiki,书籍,书籍,图书馆,

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