^De La Luz Sierra et al. Differential processing of stromal-derived factor-1alpha and beta explains functional diversity. Blood 103:2452-2459, 2004.
^Bleul et al. A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1). J. Exp. Med. 184: 1101-1109, 1996.
^Ara et al. Impaired colonization of the gonads by primordial germ cells in mice lacking a chemokine, stromal cell-derived factor-1 (SDF-1). Proc. Nat. Acad. Sci. 100: 5319-5323, 2003.
^Ma et al. Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proc. Nat. Acad. Sci. 95: 9448-9453, 1998.
^Bleul et al. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature 382: 829-833, 1996.
^Balabanian et al. The chemokine SDF-1/CXCl12 binds to and signals through the orphan receptor RDC1 in T lymphocytes. J Biol Chem 280:35760-35766, 2005.
九月 24, 2023
cxcl12, 趋化因子, 又称基质细胞衍生因子, 是小分子的细胞因子, 属于趋化因子蛋白家族, 它有两种形式, a和sdf, 趋化因子有四个保守的半胱氨酸残基形成两对双硫键以构成趋化因子的特殊结构, 第一第二半胱氨酸残基之间隔着一个介入氨基酸残基, chemokine, motif, ligand, 12pdb, rendering, based, 1a15, 有效结构pdb, 直系同源检索, pdbe, rcsbpdb查询代码列表1a15, 1qg7, 1sdf, 1vmc, 2j7z, 2k01, 2k03,. 趋化因子CXCL12 又称基质细胞衍生因子 1 SDF 1 是小分子的细胞因子 属于趋化因子蛋白家族 它有两种形式 SDF 1a CXCL12a和SDF 1b CXCL12b 1 趋化因子有四个保守的半胱氨酸残基形成两对双硫键以构成趋化因子的特殊结构 第一第二半胱氨酸残基之间隔着一个介入氨基酸残基 Chemokine C X C motif ligand 12PDB rendering based on 1a15 有效结构PDB 直系同源检索 PDBe RCSBPDB查询代码列表1A15 1QG7 1SDF 1VMC 2J7Z 2K01 2K03 2K04 2K05 2KEC 2KED 2KEE 2KOL 2NWG 2SDF 3GV3 3HP3标识代号CXCL12 IRH PBSF SCYB12 SDF1 SDF1A SDF1B TLSF TPAR1扩展标识遗传学 600835 鼠基因 103556 同源基因 128606 GeneCards CXCL12 Gene基因本体论描述分子功能 receptor binding chemokine activity growth factor activity CXCR chemokine receptor binding细胞成分 extracellular region extracellular space external side of plasma membrane生物过程 patterning of blood vessels ameboidal cell migration cellular calcium ion homeostasis chemotaxis immune response cell adhesion signal transduction G protein coupled receptor signaling pathway germ cell development brain development blood circulation motor neuron axon guidance regulation of actin polymerization or depolymerization germ cell migration response to virus T cell proliferation negative regulation of apoptotic process induction of positive chemotaxis chemokine mediated signaling pathway positive regulation of monocyte chemotaxis negative regulation of leukocyte apoptotic processSources Amigo QuickGORNA表达模式更多表达数据直系同源体物种人类小鼠Entrez638720315EnsemblENSG00000107562ENSMUSG00000061353UniProtP48061P40224mRNA序列NM 000609NM 001012477 2蛋白序列NP 000600NP 001012495 1基因位置Chr 10 44 79 44 88 MbChr 6 117 12 117 13 MbPubMed查询 1 2 查论编趋化因子CXCL12对淋巴细胞有强烈的趋化作用并在发育中起重要作用 2 在胚胎發育中CXCL12引导造血干细胞从胎儿肝脏到骨髓的迁徙 CXCL12基因敲除的小鼠往往在胎中或出生后1小时内死亡 3 4 SDF 1a CXCL12a还可以影响神经元的电生理 CXCL12可以在许多组织 包括脑 胸腺 心 肺 肝 肾 骨髓 脾脏 中表达 趋化因子CXCL12的受体是CXCR4 5 但是 最近有人认为CXCL12还可以与CXCR7受体结合 6 参考文献 编辑 De La Luz Sierra et al Differential processing of stromal derived factor 1alpha and beta explains functional diversity Blood 103 2452 2459 2004 Bleul et al A highly efficacious lymphocyte chemoattractant stromal cell derived factor 1 SDF 1 J Exp Med 184 1101 1109 1996 Ara et al Impaired colonization of the gonads by primordial germ cells in mice lacking a chemokine stromal cell derived factor 1 SDF 1 Proc Nat Acad Sci 100 5319 5323 2003 Ma et al Impaired B lymphopoiesis myelopoiesis and derailed cerebellar neuron migration in CXCR4 and SDF 1 deficient mice Proc Nat Acad Sci 95 9448 9453 1998 Bleul et al The lymphocyte chemoattractant SDF 1 is a ligand for LESTR fusin and blocks HIV 1 entry Nature 382 829 833 1996 Balabanian et al The chemokine SDF 1 CXCl12 binds to and signals through the orphan receptor RDC1 in T lymphocytes J Biol Chem 280 35760 35766 2005 取自 https zh wikipedia org w index php title CXCL12 amp oldid 55484256, 维基百科，wiki，书籍，书籍，图书馆，
