^ 1.01.11.2Moser B, Clark-Lewis I, Zwahlen R, Baggiolini M. Neutrophil-activating properties of the melanoma growth-stimulatory activity. J Exp Med. 1990 May 1;171(5):1797-802.
^ 2.02.1Anisowicz, A., Bardwell, L., Sager, R. Constitutive overexpression of a growth-regulated gene in transformed Chinese hamster and human cells. Proc. Nat. Acad. Sci. 84: 7188-7192, 1987.
^ 3.03.1Richmond, A., Thomas, H. G. (1988) Melanoma growth stimulatory activity: isolation from human melanoma tumors and characterization of tissue distribution J. Cell. Biochem. 36,185-198
^Iida N, Grotendorst GR. Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue. Mol Cell Biol. 1990 Oct;10(10):5596-9.
^Becker S, Quay J, Koren HS, Haskill JS. Constitutive and stimulated MCP-1, GRO alpha, beta, and gamma expression in human airway epithelium and bronchoalveolar macrophages. Am J Physiol. 1994 Mar;266(3 Pt 1):L278-86.
^ 6.06.1Devalaraja, R. M., Nanney, L. B., Du, J., Qian, Q., Yu, Y., Devalaraja, M. N., Richmond, A. (2000) Delayed wound healing in CXCR2 knockout mice J. Investig. Dermatol. 115,234-244
^Richmond A, Balentien E, Thomas HG, Flaggs G, Barton DE, Spiess J, Bordoni R, Francke U, Derynck R. Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin. EMBO J. 1988 Jul;7(7):2025-33.
一月 30, 2023
cxcl1, 英語, chemokine, motif, ligand, 是一小分子的细胞因子属于cxc趋化因子家族, 又被称作生长调节致癌基因α, growth, regulated, oncogene, alpha, groα, 趋化因子是由巨噬细胞, 中性粒细胞和上皮细胞表达的, 趋化因子对中性粒细胞有细胞趋化作用, 结合到趋化因子受体cxcr2上而起细胞趋化作用, 人类的与许多cxc类的趋化因子基因相邻聚集在第四染色体上, 的主要作用包括新血管形成, 炎症反应, 伤口愈合, 和肿瘤形成, chemokine. CXCL1 英語 Chemokine C X C motif ligand 1 是一小分子的细胞因子属于CXC趋化因子家族 1 又被称作生长调节致癌基因a Growth regulated oncogene alpha GROa 1 2 3 趋化因子CXCL1是由巨噬细胞 中性粒细胞和上皮细胞表达的 4 5 趋化因子CXCL1对中性粒细胞有细胞趋化作用 1 CXCL1结合到趋化因子受体CXCR2上而起细胞趋化作用 6 人类的CXCL1与许多CXC类的趋化因子基因相邻聚集在第四染色体上 7 CXCL1的主要作用包括新血管形成 炎症反应 伤口愈合 6 和肿瘤形成 2 3 Chemokine C X C motif ligand 1 melanoma growth stimulating activity alpha PDB rendering based on 1mgs 有效结构PDB 直系同源检索 PDBe RCSBPDB查询代码列表1MGS 1MSG 1MSH 1ROD标识代号CXCL1 FSP GRO1 GROa MGSA MGSA a NAP 3 SCYB1扩展标识遗传学 155730 鼠基因 3037818 同源基因 117693 GeneCards CXCL1 Gene基因本体论描述分子功能 receptor binding chemokine activity enzyme activator activity growth factor activity细胞成分 extracellular region extracellular space生物过程 chemotaxis inflammatory response immune response signal transduction G protein coupled receptor signaling pathway nervous system development cell proliferation negative regulation of cell proliferation actin cytoskeleton organization intracellular signal transduction positive regulation of catalytic activitySources Amigo QuickGO直系同源体物种人类小鼠Entrez2919330122EnsemblENSG00000163739ENSMUSG00000029379UniProtP09341Q6W5C0mRNA序列NM 001511NM 203320蛋白序列NP 001502NP 976065基因位置Chr 4 74 74 74 74 MbChr 5 90 79 90 79 MbPubMed查询 1 2 查论编参见 编辑CXCR2 趋化因子参考文献 编辑 1 0 1 1 1 2 Moser B Clark Lewis I Zwahlen R Baggiolini M Neutrophil activating properties of the melanoma growth stimulatory activity J Exp Med 1990 May 1 171 5 1797 802 2 0 2 1 Anisowicz A Bardwell L Sager R Constitutive overexpression of a growth regulated gene in transformed Chinese hamster and human cells Proc Nat Acad Sci 84 7188 7192 1987 3 0 3 1 Richmond A Thomas H G 1988 Melanoma growth stimulatory activity isolation from human melanoma tumors and characterization of tissue distribution J Cell Biochem 36 185 198 Iida N Grotendorst GR Cloning and sequencing of a new gro transcript from activated human monocytes expression in leukocytes and wound tissue Mol Cell Biol 1990 Oct 10 10 5596 9 Becker S Quay J Koren HS Haskill JS Constitutive and stimulated MCP 1 GRO alpha beta and gamma expression in human airway epithelium and bronchoalveolar macrophages Am J Physiol 1994 Mar 266 3 Pt 1 L278 86 6 0 6 1 Devalaraja R M Nanney L B Du J Qian Q Yu Y Devalaraja M N Richmond A 2000 Delayed wound healing in CXCR2 knockout mice J Investig Dermatol 115 234 244 Richmond A Balentien E Thomas HG Flaggs G Barton DE Spiess J Bordoni R Francke U Derynck R Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity a growth factor structurally related to beta thromboglobulin EMBO J 1988 Jul 7 7 2025 33 取自 https zh wikipedia org w index php title CXCL1 amp oldid 72276269, 维基百科，wiki，书籍，书籍，图书馆，
