CTLA4又稱CTLA-4（細胞毒性T淋巴細胞相關抗原4，cytotoxic T-lymphocyte-associated protein 4）或CD152（分化群152），是一种蛋白质受体[7]。CTLA-4蛋白由小鼠的Ctla4[8]和人类的CTLA4基因编码[9]。CTLA-4于1991年首次被發現[10]。
• 细胞质的核周区域 • integral component of membrane • clathrin-coated endocytic vesicle • 细胞膜 • 高尔基体 • 膜 • external side of plasma membrane • protein complex involved in cell adhesion • integral component of plasma membrane
生物學過程
• B cell receptor signaling pathway • T cell costimulation • negative regulation of B cell proliferation • adaptive immune response • negative regulation of regulatory T cell differentiation • 免疫反应 • cellular response to DNA damage stimulus • immune system process • positive regulation of apoptotic process • negative regulation of immune response • negative regulation of T cell proliferation • regulation of regulatory T cell differentiation • regulation of T cell proliferation • T cell receptor signaling pathway
^ 3.03.13.2GRCh38: Ensembl release 89: ENSG00000163599 - Ensembl, May 2017
^ 4.04.14.2GRCm38: Ensembl release 89: ENSMUSG00000026011 - Ensembl, May 2017
^Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^De-novo and acquired resistance to immune checkpoint targeting. The Lancet. Oncology. December 2017, 18 (12): e731–e741. PMID 29208439. doi:10.1016/s1470-2045(17)30607-1.
^A new member of the immunoglobulin superfamily--CTLA-4. Nature. 1987, 328 (6127): 267–70. Bibcode:1987Natur.328..267B. PMID 3496540. doi:10.1038/328267a0.
^Human Ig superfamily CTLA-4 gene: chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains. European Journal of Immunology. December 1988, 18 (12): 1901–5. PMID 3220103. doi:10.1002/eji.1830181206.
^Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science. November 1995, 270 (5238): 985–8. Bibcode:1995Sci...270..985W. JSTOR 2888113. PMID 7481803. doi:10.1126/science.270.5238.985. 引文格式1维护：显示－作者 (link)
十月 05, 2023
ctla, ctla4又稱, 細胞毒性t淋巴細胞相關抗原4, cytotoxic, lymphocyte, associated, protein, 或cd152, 分化群152, 是一种蛋白质受体, 蛋白由小鼠的ctla4, 和人类的ctla4基因编码, 于1991年首次被發現, 細胞毒性t淋巴細胞相關抗原4已知的結構pdb直系同源搜索, pdbe, rcsbpdbid列表3osk, 1ah1, 1h6e, 1i85, 1i8l, 2x44, 3bx7識別號别名ctla4, alps5, cd152, celia. CTLA4又稱CTLA 4 細胞毒性T淋巴細胞相關抗原4 cytotoxic T lymphocyte associated protein 4 或CD152 分化群152 是一种蛋白质受体 7 CTLA 4蛋白由小鼠的Ctla4 8 和人类的CTLA4基因编码 9 CTLA 4于1991年首次被發現 10 細胞毒性T淋巴細胞相關抗原4已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表3OSK 1AH1 1H6E 1I85 1I8L 2X44 3BX7識別號别名CTLA4 ALPS5 CD CD152 CELIAC3 CTLA 4 GRD4 GSE IDDM12 cytotoxic T lymphocyte associated protein 4外部IDOMIM 123890 MGI 88556 HomoloGene 3820 GeneCards CTLA4相關疾病類風濕性關節炎 甲狀腺機能低下症 1型糖尿病 type 1 diabetes mellitus 12 autoimmune lymphoproliferative syndrome due to CTLA4 haploinsuffiency 1 為以下藥物的標靶伊匹單抗 2 基因位置 人类 染色体2號染色體 3 基因座2q33 2起始203 853 888 bp 3 终止203 873 965 bp 3 基因位置 小鼠 染色体小鼠1号染色体 4 基因座1 C2 1 30 58 cM起始60 926 159 bp 4 终止60 954 991 bp 4 RNA表达模式查阅更多表达数据基因本體分子功能 血浆蛋白结合細胞組分 细胞质的核周区域 integral component of membrane clathrin coated endocytic vesicle 细胞膜 高尔基体 膜 external side of plasma membrane protein complex involved in cell adhesion integral component of plasma membrane生物學過程 B cell receptor signaling pathway T cell costimulation negative regulation of B cell proliferation adaptive immune response negative regulation of regulatory T cell differentiation 免疫反应 cellular response to DNA damage stimulus immune system process positive regulation of apoptotic process negative regulation of immune response negative regulation of T cell proliferation regulation of regulatory T cell differentiation regulation of T cell proliferation T cell receptor signaling pathwaySources Amigo QuickGO直系同源物種人類小鼠Entrez149312477EnsemblENSG00000163599ENSMUSG00000026011UniProtP16410P09793mRNA 序列NM 001037631 NM 005214NM 001281976 NM 009843蛋白序列NP 001032720 NP 005205NP 001268905 NP 033973基因位置 UCSC Chr 2 203 85 203 87 MbChr 1 60 93 60 95 MbPubMed 查找 5 6 維基數據檢視 編輯人類檢視 編輯小鼠参考文献 编辑 與細胞毒性T淋巴細胞相關抗原4相關的疾病 在維基數據上查看 編輯參考 對細胞毒性T淋巴細胞相關抗原4起作用的藥物 在維基數據上查看 編輯參考 3 0 3 1 3 2 GRCh38 Ensembl release 89 ENSG00000163599 Ensembl May 2017 4 0 4 1 4 2 GRCm38 Ensembl release 89 ENSMUSG00000026011 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine De novo and acquired resistance to immune checkpoint targeting The Lancet Oncology December 2017 18 12 e731 e741 PMID 29208439 doi 10 1016 s1470 2045 17 30607 1 A new member of the immunoglobulin superfamily CTLA 4 Nature 1987 328 6127 267 70 Bibcode 1987Natur 328 267B PMID 3496540 doi 10 1038 328267a0 Human Ig superfamily CTLA 4 gene chromosomal localization and identity of protein sequence between murine and human CTLA 4 cytoplasmic domains European Journal of Immunology December 1988 18 12 1901 5 PMID 3220103 doi 10 1002 eji 1830181206 Lymphoproliferative disorders with early lethality in mice deficient in Ctla 4 Science November 1995 270 5238 985 8 Bibcode 1995Sci 270 985W JSTOR 2888113 PMID 7481803 doi 10 1126 science 270 5238 985 引文格式1维护 显示 作者 link 取自 https zh wikipedia org w index php title CTLA 4 amp oldid 68235298, 维基百科，wiki，书籍，书籍，图书馆，
