整联蛋白β-3 （Integrin β3）或 CD61 （Cluster of differentiation 61）是一种蛋白质 ，在人类基因组中由 ITGB3 基因 编码。[6] CD61 是一种在血小板 上表达的分化簇 。[7]
CD61 已知的結構 PDB 直系同源搜索: PDBe RCSB PDBID列表 4O02、1JV2、1KUP、1KUZ、1L5G、1M1X、1M8O、1MIZ、1MK7、1MK9、1S4X、1TYE、1U8C、2K9J、2KNC、2KV9、2L1C、2L91、2LJD、2LJE、2LJF、2MTP、2Q6W、2RMZ、2RN0、2VC2、2VDK、2VDL、2VDM、2VDN、2VDP、2VDQ、2VDR、3FCS、3FCU、3IJE、3NID、3NIF、3NIG、3T3M、3T3P、3ZDX、3ZDY、3ZDZ、3ZE0、3ZE1、3ZE2、4CAK、4G1E、4G1M、4MMX、4MMY、4MMZ、5HDB、4Z7Q、4Z7O、4Z7N
識別號 别名 ITGB3 ；, BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT, integrin subunit beta 3, BDPLT24, GT2外部ID OMIM ：173470 MGI ：96612 HomoloGene：55444 GeneCards ：ITGB3 相關疾病 血小板无力症 、platelet-type bleeding disorder 16[1] RNA表达 模式查阅更多表达数据 基因本體 分子功能 • vascular endothelial growth factor receptor 2 binding• fibronectin binding• virus receptor activity• extracellular matrix binding• protein disulfide isomerase activity• 蛋白酶結合• platelet-derived growth factor receptor binding• 血浆蛋白结合• 相同蛋白质结合• 酶结合• cell adhesion molecule binding• neuregulin binding• coreceptor activity• fibroblast growth factor binding• insulin-like growth factor I binding• C-X3-C chemokine binding• integrin binding• fibrinogen binding細胞組分 • integral component of membrane• cell projection• alphav-beta3 integrin-vitronectin complex• 膜• 粘着斑• 黑色素体• receptor complex• 细胞膜• integral component of plasma membrane• ruffle membrane• cell surface• 细胞连接• integrin complex• platelet alpha granule membrane• integrin alphav-beta3 complex• 外排體• lamellipodium membrane• 细胞核• microvillus membrane• filopodium membrane• alphav-beta3 integrin-IGF-1-IGF1R complex• alphav-beta3 integrin-PKCalpha complex• alphav-beta3 integrin-HMGB1 complex• glutamatergic synapse• 突触生物學過程 • negative regulation of lipoprotein metabolic process• apolipoprotein A-I-mediated signaling pathway• positive regulation of vascular endothelial growth factor receptor signaling pathway• positive regulation of protein phosphorylation• regulation of cell migration• negative chemotaxis• positive regulation of endothelial cell proliferation• tube development• heterotypic cell-cell adhesion• angiogenesis involved in wound healing• 傷口癒合• platelet degranulation• 凝血• extracellular matrix organization• smooth muscle cell migration• positive regulation of endothelial cell migration• 增殖• cell-substrate adhesion• vascular endothelial growth factor receptor signaling pathway• 細胞粘附• positive regulation of peptidyl-tyrosine phosphorylation• mesodermal cell differentiation• cell-substrate junction assembly• integrin-mediated signaling pathway• negative regulation of lipid storage• substrate adhesion-dependent cell spreading• negative regulation of lipid transport• cell-matrix adhesion• viral process• regulation of bone resorption• platelet aggregation• 细胞迁移• negative regulation of macrophage derived foam cell differentiation• activation of protein kinase activity• leukocyte migration• cell adhesion mediated by integrin• platelet activation• apoptotic cell clearance• regulation of postsynaptic neurotransmitter receptor internalization• regulation of protein localization• regulation of serotonin uptakeSources:Amigo / QuickGO
直系同源 物種 人類 小鼠 Entrez Ensembl UniProt mRNA序列 蛋白序列 基因位置（UCSC） Chr 17: 47.25 – 47.31 Mb Chr 11: 104.5 – 104.56 Mb PubMed 查找[4] [5] 維基數據
参考文献 ^ 與CD61相關的疾病；在維基數據上查看/編輯參考. ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000259207 - Ensembl , May 2017 ^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000020689 - Ensembl , May 2017 ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. ^ Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa. J Clin Invest. August 1988, 81 (6): 1993–8. PMC 442653 PMID 2454952 . doi:10.1172/JCI113548 . ^ Heemskerk, J. W. M.; Mattheij, N. J. A.; Cosemans, J. M. E. M. Platelet-based coagulation: different populations, different functions. Journal of Thrombosis and Haemostasis. 2013, 11 (1): 2–16. ISSN 1538-7933 . doi:10.1111/jth.12045 .
进一步阅读 Bray PF. Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization.. Thromb. Haemost. 1995, 72 (4): 492–502. PMID 7878622 . Bennett JS. Platelet-fibrinogen interactions.. Ann. N. Y. Acad. Sci. 2001, 936 : 340–54. Bibcode:2001NYASA.936..340B . PMID 11460491 . doi:10.1111/j.1749-6632.2001.tb03521.x . Sajid M, Stouffer GA. The role of alpha(v)beta3 integrins in vascular healing.. Thromb. Haemost. 2002, 87 (2): 187–93. PMID 11858476 . Quinn MJ, Byzova TV, Qin J, et al. Integrin alphaIIbbeta3 and its antagonism.. Arterioscler. Thromb. Vasc. Biol. 2004, 23 (6): 945–52. PMID 12637342 . doi:10.1161/01.ATV.0000066686.46338.F1 . Charakida M, Tousoulis D, Stefanadis C, Toutouzas P. The impact of platelet glycoprotein IIIa and Ia polymorphisms in cardiovascular thrombotic disease.. Italian Heart Journal. 2003, 4 (1): 17–22. PMID 12690916 . Smith FB, Connor JM, Lee AJ, et al. Relationship of the platelet glycoprotein PlA and fibrinogen T/G+1689 polymorphisms with peripheral arterial disease and ischaemic heart disease.. Thromb. Res. 2004, 112 (4): 209–16. PMID 14987913 . doi:10.1016/j.thromres.2003.11.010 . Fullard JF. The role of the platelet glycoprotein IIb/IIIa in thrombosis and haemostasis.. Curr. Pharm. Des. 2004, 10 (14): 1567–76. PMID 15134555 . doi:10.2174/1381612043384682 . Cacciari B, Spalluto G. Non peptidic alphavbeta3 antagonists: recent developments.. Curr. Med. Chem. 2005, 12 (1): 51–70. PMID 15638730 . doi:10.2174/0929867053363522 . Watson SP, Auger JM, McCarty OJ, Pearce AC. GPVI and integrin alphaIIb beta3 signaling in platelets.. J. Thromb. Haemost. 2005, 3 (8): 1752–62. PMID 16102042 . doi:10.1111/j.1538-7836.2005.01429.x . Bennett JS. Structure and function of the platelet integrin alphaIIbbeta3.. J. Clin. Invest. 2006, 115 (12): 3363–9. PMC 1297263 PMID 16322781 . doi:10.1172/JCI26989 .
外部链接 醫學主題詞表（MeSH） ：CD61+Antigens 信息的链接在 Human ITGB3 genome location and ITGB3 gene details page in the UCSC Genome Browser
cd61, 整联蛋白β, integrin, cluster, differentiation, 是一种蛋白质, 在人类基因组中由, itgb3, 基因编码, 是一种在血小板上表达的分化簇, 已知的結構pdb直系同源搜索, pdbe, rcsbpdbid列表4o02, 1jv2, 1kup, 1kuz, 1l5g, 1m1x, 1m8o, 1miz, 1mk7, 1mk9, 1s4x, 1tye, 1u8c, 2k9j, 2knc, 2kv9, 2l1c, 2l91, 2ljd, 2lje, 2ljf, 2mtp,. 整联蛋白b 3 Integrin b3 或 CD61 Cluster of differentiation 61 是一种蛋白质 在人类基因组中由 ITGB3 基因编码 6 CD61 是一种在血小板上表达的分化簇 7 CD61已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表4O02 1JV2 1KUP 1KUZ 1L5G 1M1X 1M8O 1MIZ 1MK7 1MK9 1S4X 1TYE 1U8C 2K9J 2KNC 2KV9 2L1C 2L91 2LJD 2LJE 2LJF 2MTP 2Q6W 2RMZ 2RN0 2VC2 2VDK 2VDL 2VDM 2VDN 2VDP 2VDQ 2VDR 3FCS 3FCU 3IJE 3NID 3NIF 3NIG 3T3M 3T3P 3ZDX 3ZDY 3ZDZ 3ZE0 3ZE1 3ZE2 4CAK 4G1E 4G1M 4MMX 4MMY 4MMZ 5HDB 4Z7Q 4Z7O 4Z7N識別號别名ITGB3 BDPLT16 BDPLT2 CD61 GP3A GPIIIa GT integrin subunit beta 3 BDPLT24 GT2外部IDOMIM 173470 MGI 96612 HomoloGene 55444 GeneCards ITGB3相關疾病血小板无力症 platelet type bleeding disorder 16 1 基因位置 人类 染色体17號染色體 2 基因座17q21 32起始47 253 827 bp 2 终止47 313 743 bp 2 基因位置 小鼠 染色体小鼠11号染色体 3 基因座11 E1 11 67 84 cM起始104 498 826 bp 3 终止104 561 302 bp 3 RNA表达模式查阅更多表达数据基因本體分子功能 vascular endothelial growth factor receptor 2 binding fibronectin binding virus receptor activity extracellular matrix binding protein disulfide isomerase activity 蛋白酶結合 platelet derived growth factor receptor binding 血浆蛋白结合 相同蛋白质结合 酶结合 cell adhesion molecule binding neuregulin binding coreceptor activity fibroblast growth factor binding insulin like growth factor I binding C X3 C chemokine binding integrin binding fibrinogen binding細胞組分 integral component of membrane cell projection alphav beta3 integrin vitronectin complex 膜 粘着斑 黑色素体 receptor complex 细胞膜 integral component of plasma membrane ruffle membrane cell surface 细胞连接 integrin complex platelet alpha granule membrane integrin alphav beta3 complex 外排體 lamellipodium membrane 细胞核 microvillus membrane filopodium membrane alphav beta3 integrin IGF 1 IGF1R complex alphav beta3 integrin PKCalpha complex alphav beta3 integrin HMGB1 complex glutamatergic synapse 突触生物學過程 negative regulation of lipoprotein metabolic process apolipoprotein A I mediated signaling pathway positive regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of protein phosphorylation regulation of cell migration negative chemotaxis positive regulation of endothelial cell proliferation tube development heterotypic cell cell adhesion angiogenesis involved in wound healing 傷口癒合 platelet degranulation 凝血 extracellular matrix organization smooth muscle cell migration positive regulation of endothelial cell migration 增殖 cell substrate adhesion vascular endothelial growth factor receptor signaling pathway 細胞粘附 positive regulation of peptidyl tyrosine phosphorylation mesodermal cell differentiation cell substrate junction assembly integrin mediated signaling pathway negative regulation of lipid storage substrate adhesion dependent cell spreading negative regulation of lipid transport cell matrix adhesion viral process regulation of bone resorption platelet aggregation 细胞迁移 negative regulation of macrophage derived foam cell differentiation activation of protein kinase activity leukocyte migration cell adhesion mediated by integrin platelet activation apoptotic cell clearance regulation of postsynaptic neurotransmitter receptor internalization regulation of protein localization regulation of serotonin uptakeSources Amigo QuickGO直系同源物種人類小鼠Entrez369016416EnsemblENSG00000259207ENSMUSG00000020689UniProtP05106O54890mRNA 序列NM 000212NM 016780蛋白序列NP 000203NP 058060基因位置 UCSC Chr 17 47 25 47 31 MbChr 11 104 5 104 56 MbPubMed 查找 4 5 維基數據檢視 編輯人類檢視 編輯小鼠参考文献 编辑 與CD61相關的疾病 在維基數據上查看 編輯參考 2 0 2 1 2 2 GRCh38 Ensembl release 89 ENSG00000259207 Ensembl May 2017 3 0 3 1 3 2 GRCm38 Ensembl release 89 ENSMUSG00000020689 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa J Clin Invest August 1988 81 6 1993 8 PMC 442653 PMID 2454952 doi 10 1172 JCI113548 Heemskerk J W M Mattheij N J A Cosemans J M E M Platelet based coagulation different populations different functions Journal of Thrombosis and Haemostasis 2013 11 1 2 16 ISSN 1538 7933 doi 10 1111 jth 12045 进一步阅读 编辑Bray PF Inherited diseases of platelet glycoproteins considerations for rapid molecular characterization Thromb Haemost 1995 72 4 492 502 PMID 7878622 Bennett JS Platelet fibrinogen interactions Ann N Y Acad Sci 2001 936 340 54 Bibcode 2001NYASA 936 340B PMID 11460491 doi 10 1111 j 1749 6632 2001 tb03521 x Sajid M Stouffer GA The role of alpha v beta3 integrins in vascular healing Thromb Haemost 2002 87 2 187 93 PMID 11858476 Quinn MJ Byzova TV Qin J et al Integrin alphaIIbbeta3 and its antagonism Arterioscler Thromb Vasc Biol 2004 23 6 945 52 PMID 12637342 doi 10 1161 01 ATV 0000066686 46338 F1 Charakida M Tousoulis D Stefanadis C Toutouzas P The impact of platelet glycoprotein IIIa and Ia polymorphisms in cardiovascular thrombotic disease Italian Heart Journal 2003 4 1 17 22 PMID 12690916 Smith FB Connor JM Lee AJ et al Relationship of the platelet glycoprotein PlA and fibrinogen T G 1689 polymorphisms with peripheral arterial disease and ischaemic heart disease Thromb Res 2004 112 4 209 16 PMID 14987913 doi 10 1016 j thromres 2003 11 010 Fullard JF The role of the platelet glycoprotein IIb IIIa in thrombosis and haemostasis Curr Pharm Des 2004 10 14 1567 76 PMID 15134555 doi 10 2174 1381612043384682 Cacciari B Spalluto G Non peptidic alphavbeta3 antagonists recent developments Curr Med Chem 2005 12 1 51 70 PMID 15638730 doi 10 2174 0929867053363522 Watson SP Auger JM McCarty OJ Pearce AC GPVI and integrin alphaIIb beta3 signaling in platelets J Thromb Haemost 2005 3 8 1752 62 PMID 16102042 doi 10 1111 j 1538 7836 2005 01429 x Bennett JS Structure and function of the platelet integrin alphaIIbbeta3 J Clin Invest 2006 115 12 3363 9 PMC 1297263 PMID 16322781 doi 10 1172 JCI26989 外部链接 编辑醫學主題詞表 MeSH CD61 Antigens ITGB3 信息的链接在 单元的移徙网关 Human ITGB3 genome location and ITGB3 gene details page in the UCSC Genome Browser 英语 UCSC Genome Browser 取自 https zh wikipedia org w index php title CD61 amp oldid 56224410, 维基百科，wiki ，书籍，书籍，图书馆，
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