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维基百科

蛋白酪氨酸磷酸酶C型受體

蛋白酪氨酸磷酸酶C型受體(英語:Protein tyrosine phosphatase, receptor type, C縮寫PTPRC)是一個由PTPRC人類基因編碼的[6] 蛋白酪氨酸磷酸酶C型受體又叫做45號分化簇抗原,以前曾叫白細胞常見抗原(英語:leukocyte common antigen縮寫LCA)。[7]

蛋白酪氨酸磷酸酶C型受體
已知的結構
PDB直系同源搜索: PDBe RCSB
識別號
别名PTPRC;, B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, protein tyrosine phosphatase, receptor type C, protein tyrosine phosphatase receptor type C
外部IDOMIM:151460 MGI:97810 HomoloGene:2126 GeneCards:PTPRC
相關疾病
溃疡性结肠炎[1]
基因位置(人类
染色体1號染色體[2]
基因座1q31.3-q32.1起始198,638,457 bp[2]
终止198,757,476 bp[2]
RNA表达模式




查阅更多表达数据
直系同源
物種人類小鼠
Entrez
Ensembl
UniProt
mRNA​序列

​NM_001267798
​NM_002838
​NM_080921
​NM_080922

NM_001111316
​NM_001268286
​NM_011210

蛋白序列

NP_001254727
​NP_002829
​NP_563578
NP_563578.2
NP_002829.3

NP_001104786
​NP_001255215
​NP_035340

基因位置​(UCSC)Chr 1: 198.64 – 198.76 MbChr 1: 137.99 – 138.1 Mb
PubMed​查找[4][5]
維基數據
檢視/編輯人類檢視/編輯小鼠

参考文献 编辑

  1. ^ 與蛋白酪氨酸磷酸酶C型受體相關的疾病;在維基數據上查看/編輯參考. 
  2. ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000081237、​ENSG00000262418 - Ensembl, May 2017
  3. ^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000026395 - Ensembl, May 2017
  4. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  6. ^ Kaplan R, Morse B, Huebner K, Croce C, Howk R, Ravera M, Ricca G, Jaye M, Schlessinger J. Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain. Proc. Natl. Acad. Sci. U.S.A. September 1990, 87 (18): 7000–4 [2019-05-01]. PMC 54670 . PMID 2169617. doi:10.1073/pnas.87.18.7000. (原始内容于2019-10-17). 
  7. ^ Entrez Gene: PTPRC protein tyrosine phosphatase, receptor type, C. (原始内容于2010-12-05). 

蛋白酪氨酸磷酸酶c型受體, 英語, protein, tyrosine, phosphatase, receptor, type, 縮寫, ptprc, 是一個由ptprc人類基因編碼的酶, 又叫做45號分化簇抗原, 以前曾叫白細胞常見抗原, 英語, leukocyte, common, antigen, 縮寫, 已知的結構pdb直系同源搜索, pdbe, rcsbpdbid列表1ygu, 1ygr, 5fmv, 5fn6, 5fn7識別號别名ptprc, b220, cd45, cd45r, gp180, t20. 蛋白酪氨酸磷酸酶C型受體 英語 Protein tyrosine phosphatase receptor type C 縮寫 PTPRC 是一個由PTPRC人類基因編碼的酶 6 蛋白酪氨酸磷酸酶C型受體又叫做45號分化簇抗原 以前曾叫白細胞常見抗原 英語 leukocyte common antigen 縮寫 LCA 7 蛋白酪氨酸磷酸酶C型受體已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表1YGU 1YGR 5FMV 5FN6 5FN7識別號别名PTPRC B220 CD45 CD45R GP180 L CA LCA LY5 T200 protein tyrosine phosphatase receptor type C protein tyrosine phosphatase receptor type C外部IDOMIM 151460 MGI 97810 HomoloGene 2126 GeneCards PTPRC相關疾病溃疡性结肠炎 1 基因位置 人类 染色体1號染色體 2 基因座1q31 3 q32 1起始198 638 457 bp 2 终止198 757 476 bp 2 基因位置 小鼠 染色体小鼠1号染色体 3 基因座1 E4 1 60 73 cM起始137 990 599 bp 3 终止138 103 446 bp 3 RNA表达模式查阅更多表达数据基因本體分子功能 phosphoprotein phosphatase activity phosphatase activity 血浆蛋白结合 transmembrane receptor protein tyrosine phosphatase activity protein kinase binding 水解酶活性 protein tyrosine phosphatase activity細胞組分 integral component of membrane 膜 粘着斑 细胞膜 integral component of plasma membrane cell surface 脂筏模型 外排體 external side of plasma membrane secretory granule membrane生物學過程 B cell receptor signaling pathway cell cycle phase transition release of sequestered calcium ion into cytosol negative regulation of protein kinase activity bone marrow development stem cell development 蛋白质去磷酸化 negative regulation of cytokine mediated signaling pathway positive regulation of hematopoietic stem cell migration regulation of cell cycle negative regulation of cell adhesion involved in substrate bound cell migration negative regulation of T cell mediated cytotoxicity cell surface receptor signaling pathway B cell proliferation T cell differentiation positive regulation of B cell proliferation defense response to virus positive regulation of T cell proliferation hematopoietic progenitor cell differentiation positive regulation of antigen receptor mediated signaling pathway T cell receptor signaling pathway positive regulation of stem cell proliferation 去磷酸化 positive regulation of protein kinase activity peptidyl tyrosine dephosphorylation neutrophil degranulationSources Amigo QuickGO直系同源物種人類小鼠Entrez578819264EnsemblENSG00000081237 ENSG00000262418ENSMUSG00000026395UniProtP08575P06800mRNA 序列 NM 001267798 NM 002838 NM 080921 NM 080922NM 001111316 NM 001268286 NM 011210蛋白序列NP 001254727 NP 002829 NP 563578NP 563578 2NP 002829 3NP 001104786 NP 001255215 NP 035340基因位置 UCSC Chr 1 198 64 198 76 MbChr 1 137 99 138 1 MbPubMed 查找 4 5 維基數據檢視 編輯人類檢視 編輯小鼠参考文献 编辑 與蛋白酪氨酸磷酸酶C型受體相關的疾病 在維基數據上查看 編輯參考 2 0 2 1 2 2 GRCh38 Ensembl release 89 ENSG00000081237 ENSG00000262418 Ensembl May 2017 3 0 3 1 3 2 GRCm38 Ensembl release 89 ENSMUSG00000026395 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Kaplan R Morse B Huebner K Croce C Howk R Ravera M Ricca G Jaye M Schlessinger J Cloning of three human tyrosine phosphatases reveals a multigene family of receptor linked protein tyrosine phosphatases expressed in brain Proc Natl Acad Sci U S A September 1990 87 18 7000 4 2019 05 01 PMC 54670 nbsp PMID 2169617 doi 10 1073 pnas 87 18 7000 原始内容存档于2019 10 17 Entrez Gene PTPRC protein tyrosine phosphatase receptor type C 原始内容存档于2010 12 05 取自 https zh wikipedia org w index php title 蛋白酪氨酸磷酸酶C型受體 amp oldid 71723644, 维基百科,wiki,书籍,书籍,图书馆,

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