^Schwarz, K; Simons M; Reiser J; Saleem M A; Faul C; Kriz W; Shaw A S; Holzman L B; Mundel P. Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin. J. Clin. Invest. (United States). Dec 2001, 108 (11): 1621–9. ISSN 0021-9738. PMC 200981. PMID 11733557. doi:10.1172/JCI12849. 引文格式1维护：显示－作者 (link)
^Lehtonen, Sanna; Lehtonen Eero; Kudlicka Krystyna; Holthöfer Harry; Farquhar Marilyn G. Nephrin Forms a Complex with Adherens Junction Proteins and CASK in Podocytes and in Madin-Darby Canine Kidney Cells Expressing Nephrin. Am. J. Pathol. (United States). Sep 2004, 165 (3): 923–36. ISSN 0002-9440. PMC 1618613. PMID 15331416. doi:10.1016/S0002-9440(10)63354-8.
^Haglund, Kaisa; Ivankovic-Dikic Inga, Shimokawa Noriaki, Kruh Gary D, Dikic Ivan. Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites. J. Cell. Sci. (England). May 2004, 117 (Pt 12): 2557–68. ISSN 0021-9533. PMID 15128873. doi:10.1242/jcs.01148.引文使用过时参数coauthors (帮助)
^Kirsch, K H; Georgescu M M; Shishido T; Langdon W Y; Birge R B; Hanafusa H. The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction. J. Biol. Chem. (United States). Feb 2001, 276 (7): 4957–63. ISSN 0021-9258. PMID 11067845. doi:10.1074/jbc.M005784200.
^ 7.07.1Cormont, Mireille; Metón Isidoro, Mari Muriel, Monzo Pascale, Keslair Frédérique, Gaskin Chantell, McGraw Timothy E, Le Marchand-Brustel Yannick. CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl. Traffic (Denmark). Feb 2003, 4 (2): 97–112. ISSN 1398-9219. PMID 12559036. doi:10.1034/j.1600-0854.2003.40205.x.引文使用过时参数coauthors (帮助)
延伸閱讀编辑
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Kirsch KH, Georgescu MM, Shishido T; et al. The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction. J. Biol. Chem. 2001, 276 (7): 4957–63. PMID 11067845. doi:10.1074/jbc.M005784200. 引文格式1维护：显式使用等标签 (link)
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Scott MP, Zappacosta F, Kim EY; et al. Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1. J. Biol. Chem. 2002, 277 (31): 28238–46. PMID 12029088. doi:10.1074/jbc.M202783200. 引文格式1维护：显式使用等标签 (link)
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Badour K, Zhang J, Shi F; et al. The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse. Immunity. 2003, 18 (1): 141–54. PMID 12530983. doi:10.1016/S1074-7613(02)00516-2. 引文格式1维护：显式使用等标签 (link)
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九月 25, 2023
cd2ap, cd2相關蛋白質, associated, protein, 是在人類中由基因所編碼的蛋白質, cd2相關蛋白質, associated, protein, 基於2j6f的pdb繪製, 有效结构pdb, 直系同源检索, pdbe, rcsbpdb查询代码列表2fei, 2j6f, 2j6k, 2j6o, 2j7i, 3aa6, 3lk4, 3u23标识代号, cms扩展标识遗传学, 604241, 鼠基因, 1330281, 同源基因, 7663, genecards, gene基因本体论描述分子功能. CD2相關蛋白質 CD2 associated protein 是在人類中由CD2AP基因所編碼的蛋白質 1 2 CD2相關蛋白質 CD2 associated protein 基於2j6f的PDB繪製 有效结构PDB 直系同源检索 PDBe RCSBPDB查询代码列表2FEI 2J6F 2J6K 2J6O 2J7I 3AA6 3LK4 3U23标识代号CD2AP CMS扩展标识遗传学 604241 鼠基因 1330281 同源基因 7663 GeneCards CD2AP Gene基因本体论描述分子功能 vascular endothelial growth factor receptor binding structural constituent of cytoskeleton protein binding beta catenin binding protein C terminus binding SH3 domain binding protein complex binding cadherin binding细胞成分 ruffle cytoplasm plasma membrane actin cytoskeleton endocytic vesicle filamentous actin perinuclear region of cytoplasm extracellular vesicular exosome生物过程 protein complex assembly substrate dependent cell migration cell extension mitotic nuclear division signal transduction vesicle organization single organismal cell cell adhesion proteasome mediated ubiquitin dependent protein catabolic process regulation of receptor mediated endocytosisSources Amigo QuickGO直系同源体物种人类小鼠Entrez2360712488EnsemblENSG00000198087ENSMUSG00000061665UniProtQ9Y5K6Q9JLQ0mRNA序列NM 012120NM 009847蛋白序列NP 036252NP 033977基因位置Chr 6 47 45 47 59 MbChr 17 42 79 42 88 MbPubMed查询 1 2 查论编該基因編碼一種調節肌動蛋白細胞骨架的 支架分子 在神經元通路中的廣大連結區域聚積的蛋白分子 該蛋白質直接與絲狀肌動蛋白 及通過多種肌動蛋白結合位點的各種細胞膜的蛋白質 SH3結構域 SH3 domain 以及含有SH3結構域結合位點之 富含脯氨酸區域 proline rich region 等交互作用 胞質蛋白定位於膜皺褶 Membrane ruffling 脂筏 Lipid raft 和細胞的前緣 它牽涉到在受體的內吞作用和 胞質分裂 cytokinesis 發生動態肌動蛋白重塑 actin remodeling 和膜交換 該基因的 單倍劑量不足 Haploinsufficiency 牽涉到易感性的腎小球疾病 2 目录 1 交互作用 2 參見 3 註釋 4 延伸閱讀交互作用 编辑CD2AP已顯示出與NPHS2 3 腎病蛋白 4 CBL基因 CBL gene 5 6 7 及RAB4A 7 等有蛋白質交互作用參見 编辑局灶節段性腎小球硬化症註釋 编辑 Kirsch KH Georgescu MM Ishimaru S Hanafusa H CMS An adapter molecule involved in cytoskeletal rearrangements Proc Natl Acad Sci USA Jun 1999 96 11 6211 6 PMC 26861 nbsp PMID 10339567 doi 10 1073 pnas 96 11 6211 2 0 2 1 Entrez Gene CD2AP CD2 associated protein 原始内容存档于2010 03 08 Schwarz K Simons M Reiser J Saleem M A Faul C Kriz W Shaw A S Holzman L B Mundel P Podocin a raft associated component of the glomerular slit diaphragm interacts with CD2AP and nephrin J Clin Invest United States Dec 2001 108 11 1621 9 ISSN 0021 9738 PMC 200981 nbsp PMID 11733557 doi 10 1172 JCI12849 引文格式1维护 显示 作者 link Lehtonen Sanna Lehtonen Eero Kudlicka Krystyna Holthofer Harry Farquhar Marilyn G Nephrin Forms a Complex with Adherens Junction Proteins and CASK in Podocytes and in Madin Darby Canine Kidney Cells Expressing Nephrin Am J Pathol United States Sep 2004 165 3 923 36 ISSN 0002 9440 PMC 1618613 nbsp PMID 15331416 doi 10 1016 S0002 9440 10 63354 8 Haglund Kaisa Ivankovic Dikic Inga Shimokawa Noriaki Kruh Gary D Dikic Ivan Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites J Cell Sci England May 2004 117 Pt 12 2557 68 ISSN 0021 9533 PMID 15128873 doi 10 1242 jcs 01148 引文使用过时参数coauthors 帮助 Kirsch K H Georgescu M M Shishido T Langdon W Y Birge R B Hanafusa H The adapter type protein CMS CD2AP binds to the proto oncogenic protein c Cbl through a tyrosine phosphorylation regulated Src homology 3 domain interaction J Biol Chem United States Feb 2001 276 7 4957 63 ISSN 0021 9258 PMID 11067845 doi 10 1074 jbc M005784200 7 0 7 1 Cormont Mireille Meton Isidoro Mari Muriel Monzo Pascale Keslair Frederique Gaskin Chantell McGraw Timothy E Le Marchand Brustel Yannick CD2AP CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c Cbl Traffic Denmark Feb 2003 4 2 97 112 ISSN 1398 9219 PMID 12559036 doi 10 1034 j 1600 0854 2003 40205 x 引文使用过时参数coauthors 帮助 延伸閱讀 编辑Bonaldo MF Lennon G Soares MB Normalization and subtraction two approaches to facilitate gene discovery Genome Res 1997 6 9 791 806 PMID 8889548 doi 10 1101 gr 6 9 791 Dustin ML Olszowy MW Holdorf AD et al A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T cell contacts Cell 1998 94 5 667 77 PMID 9741631 doi 10 1016 S0092 8674 00 81608 6 引文格式1维护 显式使用等标签 link Lehtonen S Ora A Olkkonen VM et al In vivo interaction of the adapter protein CD2 associated protein with the type 2 polycystic kidney disease protein polycystin 2 J Biol Chem 2000 275 42 32888 93 PMID 10913159 doi 10 1074 jbc M006624200 引文格式1维护 显式使用等标签 link Li C Ruotsalainen V Tryggvason K et al CD2AP is expressed with nephrin in developing podocytes and is found widely in mature kidney and elsewhere Am J Physiol Renal Physiol 2000 279 4 F785 92 PMID 10997929 引文格式1维护 显式使用等标签 link Kirsch KH Georgescu MM Shishido T et al The adapter type protein CMS CD2AP binds to the proto oncogenic protein c Cbl through a tyrosine phosphorylation regulated Src homology 3 domain interaction J Biol Chem 2001 276 7 4957 63 PMID 11067845 doi 10 1074 jbc M005784200 引文格式1维护 显式使用等标签 link Schwarz K Simons M Reiser J et al Podocin a raft associated component of the glomerular slit diaphragm interacts with CD2AP and nephrin J Clin Invest 2002 108 11 1621 9 PMC 200981 nbsp PMID 11733557 doi 10 1172 JCI12849 引文格式1维护 显式使用等标签 link Scott MP Zappacosta F Kim EY et al Identification of novel SH3 domain ligands for the Src family kinase Hck Wiskott Aldrich syndrome protein WASP WASP interacting protein WIP and ELMO1 J Biol Chem 2002 277 31 28238 46 PMID 12029088 doi 10 1074 jbc M202783200 引文格式1维护 显式使用等标签 link Strausberg RL Feingold EA Grouse LH et al Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 2003 99 26 16899 903 PMC 139241 nbsp PMID 12477932 doi 10 1073 pnas 242603899 引文格式1维护 显式使用等标签 link Badour K Zhang J Shi F et al The Wiskott Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse Immunity 2003 18 1 141 54 PMID 12530983 doi 10 1016 S1074 7613 02 00516 2 引文格式1维护 显式使用等标签 link Cormont M Meton I Mari M et al CD2AP CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c Cbl Traffic 2003 4 2 97 112 PMID 12559036 doi 10 1034 j 1600 0854 2003 40205 x 引文格式1维护 显式使用等标签 link Lynch DK Winata SC Lyons RJ et al A Cortactin CD2 associated protein CD2AP complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton J Biol Chem 2003 278 24 21805 13 PMID 12672817 doi 10 1074 jbc M211407200 引文格式1维护 显式使用等标签 link Hutchings NJ Clarkson N Chalkley R et al Linking the T cell surface protein CD2 to the actin capping protein CAPZ via CMS and CIN85 J Biol Chem 2003 278 25 22396 403 PMID 12690097 doi 10 1074 jbc M302540200 引文格式1维护 显式使用等标签 link Kim JM Wu H Green G et al CD2 associated protein haploinsufficiency is linked to glomerular disease susceptibility Science 2003 300 5623 1298 300 PMID 12764198 doi 10 1126 science 1081068 引文格式1维护 显式使用等标签 link Schulze WX Mann M A novel proteomic screen for peptide protein interactions J Biol Chem 2004 279 11 10756 64 PMID 14679214 doi 10 1074 jbc M309909200 Haglund K Ivankovic Dikic I Shimokawa N et al Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites J Cell Sci 2004 117 Pt 12 2557 68 PMID 15128873 doi 10 1242 jcs 01148 引文格式1维护 显式使用等标签 link Lehtonen S Lehtonen E Kudlicka K et al Nephrin Forms a Complex with Adherens Junction Proteins and CASK in Podocytes and in Madin Darby Canine Kidney Cells Expressing Nephrin Am J Pathol 2004 165 3 923 36 PMC 1618613 nbsp PMID 15331416 doi 10 1016 S0002 9440 10 63354 8 引文格式1维护 显式使用等标签 link Gerhard DS Wagner L Feingold EA et al The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 2004 14 10B 2121 7 PMC 528928 nbsp PMID 15489334 doi 10 1101 gr 2596504 引文格式1维护 显式使用等标签 link Rush J Moritz A Lee KA et al Immunoaffinity profiling of tyrosine phosphorylation in cancer cells Nat Biotechnol 2005 23 1 94 101 PMID 15592455 doi 10 1038 nbt1046 引文格式1维护 显式使用等标签 link Coward RJ Foster RR Patton D et al Nephrotic plasma alters slit diaphragm dependent signaling and translocates nephrin Podocin and CD2 associated protein in cultured human podocytes J Am Soc Nephrol 2005 16 3 629 37 PMID 15659563 doi 10 1681 ASN 2004030172 引文格式1维护 显式使用等标签 link 取自 https zh wikipedia org w index php title CD2AP amp oldid 76860775, 维基百科，wiki，书籍，书籍，图书馆，
