• integral component of membrane • 细胞膜 • 外排體 • 膜 • 細胞質 • 早期内吞体 • cell surface • neuronal cell body membrane • recycling endosome
生物學過程
• 細胞粘附 • regulation of endocytosis • regulation of B cell proliferation • B cell activation • regulation of immune response • negative regulation of calcium-mediated signaling • negative regulation of B cell receptor signaling pathway
^Lee M, Kiefel H, LaJevic MD, Macauley MS, Kawashima H, O'Hara E, Pan J, Paulson JC, Butcher EC. Transcriptional programs of lymphoid tissue capillary and high endothelium reveal control mechanisms for lymphocyte homing. Nature Immunology. October 2014, 15 (10): 982–95. PMC 4222088. PMID 25173345. doi:10.1038/ni.2983.
^Dörner T, Shock A, Smith KG. CD22 and Autoimmune Disease 31 (5). International Reviews of Immunology. 2012. doi:10.3109/08830185.2012.709890.
^ 8.08.18.28.3Poe JC, Fujimoto M, Jansen PJ, Miller AS, Tedder TF. CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux. The Journal of Biological Chemistry. June 2000, 275 (23): 17420–7. PMID 10748054. doi:10.1074/jbc.M001892200.
^ 9.09.1Otipoby KL, Draves KE, Clark EA. CD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1. The Journal of Biological Chemistry. November 2001, 276 (47): 44315–22. PMID 11551923. doi:10.1074/jbc.M105446200.
^Blasioli J, Paust S, Thomas ML. Definition of the sites of interaction between the protein tyrosine phosphatase SHP-1 and CD22. The Journal of Biological Chemistry. January 1999, 274 (4): 2303–7. PMID 9890995. doi:10.1074/jbc.274.4.2303.
^ 11.011.1Greer SF, Justement LB. CD45 regulates tyrosine phosphorylation of CD22 and its association with the protein tyrosine phosphatase SHP-1. Journal of Immunology. May 1999, 162 (9): 5278–86. PMID 10228003.
^Law CL, Sidorenko SP, Chandran KA, Zhao Z, Shen SH, Fischer EH, Clark EA. CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation. The Journal of Experimental Medicine. February 1996, 183 (2): 547–60. PMC 2192439. PMID 8627166. doi:10.1084/jem.183.2.547.
^Adachi T, Wienands J, Wakabayashi C, Yakura H, Reth M, Tsubata T. SHP-1 requires inhibitory co-receptors to down-modulate B cell antigen receptor-mediated phosphorylation of cellular substrates. The Journal of Biological Chemistry. July 2001, 276 (28): 26648–55. PMID 11356834. doi:10.1074/jbc.M100997200.
^BL22 Immunotoxin in Treating Patients Previously Treated With Cladribine for Hairy Cell Leukemia. ClinicalTrials.gov - U.S. National Institutes of Health. [2018-08-14]. （原始内容于2007-10-07）.
^Epratuzumab. DrugBank. Canadian Institutes of Health Research. [2018-08-16]. （原始内容于2016-03-04）.
cd22, 名为分化簇, 英語, cluster, differentiation, 是成熟b细胞表面的一種跨膜受体, 属于siglec, 英语, siglec, 家族, 識別號别名, siglec, siglec2, molecule外部idomim, 107266, 88322, homologene, 31052, genecards, 基因位置, 小鼠, 染色体小鼠7号染色体, 基因座7, cm起始30, 终止30, rna表达模式查阅更多表达数据基因本體分子功能, 血浆蛋白结合, carbohydrate. CD22 名为分化簇 22 英語 cluster of differentiation 22 是成熟B细胞表面的一種跨膜受体 属于SIGLEC 英语 SIGLEC 家族 4 CD22識別號别名CD22 SIGLEC 2 SIGLEC2 CD22 molecule外部IDOMIM 107266 MGI 88322 HomoloGene 31052 GeneCards CD22基因位置 小鼠 染色体小鼠7号染色体 1 基因座7 B1 7 19 26 cM起始30 564 827 bp 1 终止30 579 767 bp 1 RNA表达模式查阅更多表达数据基因本體分子功能 血浆蛋白结合 carbohydrate binding IgM binding signaling receptor binding protein phosphatase binding sialic acid binding CD4 receptor binding細胞組分 integral component of membrane 细胞膜 外排體 膜 細胞質 早期内吞体 cell surface neuronal cell body membrane recycling endosome生物學過程 細胞粘附 regulation of endocytosis regulation of B cell proliferation B cell activation regulation of immune response negative regulation of calcium mediated signaling negative regulation of B cell receptor signaling pathwaySources Amigo QuickGO直系同源物種人類小鼠Entrez93312483Ensembl无数据ENSMUSG00000030577UniProtP20273P35329mRNA 序列NM 024916 NM 001185099 NM 001185100 NM 001185101 NM 001278417 NM 001771NM 001043317 NM 009845蛋白序列NP 001172028 NP 001172029 NP 001172030 NP 001265346 NP 001762NP 001036782 NP 033975基因位置 UCSC 无数据Chr 7 30 56 30 58 MbPubMed 查找 2 3 維基數據檢視 編輯人類檢視 編輯小鼠维基百科中的醫學内容仅供参考 並不能視作專業意見 如需獲取醫療幫助或意見 请咨询专业人士 詳見醫學聲明 目录 1 功能 2 機制 3 蛋白質交互作用 4 應用 5 参考文献 6 外部链接功能 编辑CD22表現於成熟B细胞的表面 也表現於少量未成熟B细胞的表面 其主要功能是避免免疫系统过度激活 可降低罹患自體免疫性疾病的风险 5 CD22是一种可高度特异性识别糖基化蛋白 如CD45 英语 CD45 的跨膜蛋白 可通过N端的一个免疫球蛋白 Ig 结构域 英语 immunoglobulin domain 與唾液酸結合 因擁有Ig结构域 CD22也属于免疫球蛋白超家族 英语 immunoglobulin superfamily 人类体内 CD22主要功能为抑制B細胞表面受體的活化 另外 小鼠實驗的結果發現B细胞運輸至派亞氏淋巴叢 英语 Peyer s patch 的過程亦有CD22的參與 6 機制 编辑CD22是B细胞受体的一個輔助受體 英语 co receptor 其與連結在抗原B细胞受体表面的抗原連接後 自己會被磷酸化 進而活化一些磷酸酶以抑制免疫反應 7 蛋白質交互作用 编辑CD22经过实验证明会与以下蛋白質产生交互作用 Grb2 英语 Grb2 8 9 PTPN6 英语 PTPN6 9 10 11 12 13 LYN 英语 LYN 8 11 SHC1 英语 SHC1 8 和INPP5D 英语 INPP5D 8 應用 编辑CD22也可能作為抗癌藥物的標的 美国國立衛生研究院正在测试一种名为BL22 英语 Anti CD22 immunotoxin 的免疫毒素 英语 immunotoxin BL22是一種抗CD22的單株抗體 與CD22結合後可以進入細胞中 達到殺死細胞的效果 可能有助於治療某些種類的白血病 14 另外一種針對CD22的單株抗體藥物Epratuzumab 英语 Epratuzumab 也正在測試中 可能有助於治療白血病與全身性紅斑狼瘡 15 参考文献 编辑 1 0 1 1 1 2 GRCm38 Ensembl release 89 ENSMUSG00000030577 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Crocker PR et al Siglecs a family of sialic acid binding lectins Glycobiology February 1998 8 2 v PMID 9498912 doi 10 1093 glycob 8 2 0 Hatta et al Identification of the gene variations in human CD22 Immunogenetics 1999 49 4 280 286 2018 08 15 doi 10 1007 s002510050494 原始内容存档于2019 09 24 Lee M Kiefel H LaJevic MD Macauley MS Kawashima H O Hara E Pan J Paulson JC Butcher EC Transcriptional programs of lymphoid tissue capillary and high endothelium reveal control mechanisms for lymphocyte homing Nature Immunology October 2014 15 10 982 95 PMC 4222088 PMID 25173345 doi 10 1038 ni 2983 Dorner T Shock A Smith KG CD22 and Autoimmune Disease 31 5 International Reviews of Immunology 2012 doi 10 3109 08830185 2012 709890 8 0 8 1 8 2 8 3 Poe JC Fujimoto M Jansen PJ Miller AS Tedder TF CD22 forms a quaternary complex with SHIP Grb2 and Shc A pathway for regulation of B lymphocyte antigen receptor induced calcium flux The Journal of Biological Chemistry June 2000 275 23 17420 7 PMID 10748054 doi 10 1074 jbc M001892200 9 0 9 1 Otipoby KL Draves KE Clark EA CD22 regulates B cell receptor mediated signals via two domains that independently recruit Grb2 and SHP 1 The Journal of Biological Chemistry November 2001 276 47 44315 22 PMID 11551923 doi 10 1074 jbc M105446200 Blasioli J Paust S Thomas ML Definition of the sites of interaction between the protein tyrosine phosphatase SHP 1 and CD22 The Journal of Biological Chemistry January 1999 274 4 2303 7 PMID 9890995 doi 10 1074 jbc 274 4 2303 11 0 11 1 Greer SF Justement LB CD45 regulates tyrosine phosphorylation of CD22 and its association with the protein tyrosine phosphatase SHP 1 Journal of Immunology May 1999 162 9 5278 86 PMID 10228003 Law CL Sidorenko SP Chandran KA Zhao Z Shen SH Fischer EH Clark EA CD22 associates with protein tyrosine phosphatase 1C Syk and phospholipase C gamma 1 upon B cell activation The Journal of Experimental Medicine February 1996 183 2 547 60 PMC 2192439 PMID 8627166 doi 10 1084 jem 183 2 547 Adachi T Wienands J Wakabayashi C Yakura H Reth M Tsubata T SHP 1 requires inhibitory co receptors to down modulate B cell antigen receptor mediated phosphorylation of cellular substrates The Journal of Biological Chemistry July 2001 276 28 26648 55 PMID 11356834 doi 10 1074 jbc M100997200 BL22 Immunotoxin in Treating Patients Previously Treated With Cladribine for Hairy Cell Leukemia ClinicalTrials gov U S National Institutes of Health 2018 08 14 原始内容存档于2007 10 07 Epratuzumab DrugBank Canadian Institutes of Health Research 2018 08 16 原始内容存档于2016 03 04 外部链接 编辑醫學主題詞表 MeSH CD22 Antigen 取自 https zh wikipedia org w index php title CD22 amp oldid 68256646, 维基百科，wiki，书籍，书籍，图书馆，
