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维基百科

5-HT4受體

一月 28, 2023

5-HT4受體或5-羥色胺受體4（英語：5-Hydroxytryptamine receptor 4）是在人類上由HTR4基因編碼的蛋白質[6][7]。

5-HT4受體
識別號
别名HTR4；, 5-HT4, 5-HT4R, 5-HT4 receptor, 5-hydroxytryptamine receptor 4
外部IDOMIM：602164 MGI：109246 HomoloGene：20243 GeneCards：HTR4
為以下藥物的標靶
维拉佐酮、​血清素、​5-甲氧基色胺、​α-methyl-5-HT、​莫沙必利、​伦扎必利、​zacopride、​prucalopride、​RS 67333、​GR-113808、​piboserod、​SB 204070[1]
基因位置（人类）
染色体5號染色體[2]
基因座5q32起始148,451,032 bp[2]
终止148,677,235 bp[2]
RNA表达模式




查阅更多表达数据
直系同源
物種人類小鼠
Entrez

3360

15562

Ensembl

ENSG00000164270

ENSMUSG00000026322

UniProt

Q13639

P97288

mRNA​序列

NM_008313
​NM_001364956
​NM_001364957
​NM_001364958
​NM_001364959

蛋白序列

NP_032339
​NP_001351885
​NP_001351886
​NP_001351887
​NP_001351888

基因位置​（UCSC）Chr 5: 148.45 – 148.68 MbChr 18: 62.46 – 62.63 Mb
PubMed​查找[4][5]
維基數據
檢視/編輯人類檢視/編輯小鼠

配體

激動劑

  • BIMU-8（英语：BIMU-8）
  • Cisapride（英语：Cisapride）
  • ML-10302[8]
  • 莫沙必利
  • Prucalopride（英语：Prucalopride）
  • Renzapride（英语：Renzapride）
  • RS-67506
  • Tegaserod（英语：Tegaserod）
  • Zacopride（英语：Zacopride）
  • Metoclopramide
  • 舒必利
  • RS-67333（英语：RS-67333） - partial agonist
  • SL65.0155（英语：SL65.0155） - partial agonist
  • CJ-033,466（英语：CJ-033,466） - partial agonist

拮抗劑

  • Piboserod（英语：Piboserod）
  • GR-113,808（英语：GR-113,808） (1-methyl-1H-indole-3-carboxylic acid, [1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyl ester)[9]
  • GR-125,487
  • RS-39604 (1-[4-Amino-5-chloro-2-(3,5-dimethoxyphenyl)methyloxy]-3-[1-[2-methylsulphonylamino]piperidin-4-yl]propan-1-one)
  • SB-203,186
  • SB-204,070（英语：SB-204,070）
  • ([Methoxy-11C]1-butylpiperidin-4-yl)methyl 4-amino-3-methoxybenzoate[10]
  • 洋甘菊(酒精萃取)[11]

參見

  • 5-羟色胺受体
  • 5-HT1受體（英语：5-HT1 receptor）
  • 5-HT2受體
  • 5-HT3受體（英语：5-HT3 receptor）
  • 5-HT5受體（英语：5-HT5 receptor）
  • 5-HT6受體（英语：5-HT6 receptor）
  • 5-HT7受體（英语：5-HT7 receptor）

參考資料

  1. ^ 對5-hydroxytryptamine receptor 4起作用的藥物；在維基數據上查看/編輯參考. 
  2. ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000164270 - Ensembl, May 2017
  3. ^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000026322 - Ensembl, May 2017
  4. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  6. ^ Claeysen S, Faye P, Sebben M, Lemaire S, Bockaert J, Dumuis A, Taviaux S. Assignment of 5-hydroxytryptamine receptor (HTR4) to human chromosome 5 bands q31-->q33 by in situ hybridization. Cytogenetics and Cell Genetics. December 1997, 78 (2): 133–4. PMID 9371406. doi:10.1159/000134646. 
  7. ^ Blondel O, Vandecasteele G, Gastineau M, Leclerc S, Dahmoune Y, Langlois M, Fischmeister R. Molecular and functional characterization of a 5-HT4 receptor cloned from human atrium. FEBS Letters. August 1997, 412 (3): 465–74. PMID 9276448. doi:10.1016/S0014-5793(97)00820-X. 
  8. ^ Godínez-Chaparro B, Barragán-Iglesias P, Castañeda-Corral G, Rocha-González HI, Granados-Soto V. Role of peripheral 5-HT(4), 5-HT(6), and 5-HT(7) receptors in development and maintenance of secondary mechanical allodynia and hyperalgesia. Pain. March 2011, 152 (3): 687–97. PMID 21239110. doi:10.1016/j.pain.2010.12.020. 
  9. ^ Gale JD, Grossman CJ, Whitehead JW, Oxford AW, Bunce KT, Humphrey PP. GR113808: a novel, selective antagonist with high affinity at the 5-HT4 receptor. British Journal of Pharmacology. January 1994, 111 (1): 332–8. PMC 1910004  . PMID 8012715. doi:10.1111/j.1476-5381.1994.tb14064.x. 
  10. ^ Xu R, Hong J, Morse CL, Pike VW. Synthesis, structure-affinity relationships, and radiolabeling of selective high-affinity 5-HT4 receptor ligands as prospective imaging probes for positron emission tomography. Journal of Medicinal Chemistry. October 2010, 53 (19): 7035–47. PMC 2951497  . PMID 20812727. doi:10.1021/jm100668r. 
  11. ^ Simmen U, Kelber O, Okpanyi SN, Jaeggi R, Bueter B, Weiser D. Binding of STW 5 (Iberogast) and its components to intestinal 5-HT, muscarinic M3, and opioid receptors. Phytomedicine: 51–5. PMID 16973340. doi:10.1016/j.phymed.2006.03.012. 

深入閱讀

  • Licht CL, 2009, Changes in the 5-HT4 receptor in animal models of depression（英语：animal models of depression） and antidepressant treatment, PhD thesis, University of Copenhagen.
  • Ullmer C, Schmuck K, Kalkman HO, Lübbert H. Expression of serotonin receptor mRNAs in blood vessels. FEBS Letters. August 1995, 370 (3): 215–21. PMID 7656980. doi:10.1016/0014-5793(95)00828-W. 
  • Blondel O, Vandecasteele G, Gastineau M, Leclerc S, Dahmoune Y, Langlois M, Fischmeister R. Molecular and functional characterization of a 5-HT4 receptor cloned from human atrium. FEBS Letters. August 1997, 412 (3): 465–74. PMID 9276448. doi:10.1016/S0014-5793(97)00820-X. 
  • Van den Wyngaert I, Gommeren W, Verhasselt P, Jurzak M, Leysen J, Luyten W, Bender E. Cloning and expression of a human serotonin 5-HT4 receptor cDNA. Journal of Neurochemistry. November 1997, 69 (5): 1810–9. PMID 9349523. doi:10.1046/j.1471-4159.1997.69051810.x. 
  • Claeysen S, Faye P, Sebben M, Lemaire S, Bockaert J, Dumuis A. Cloning and expression of human 5-HT4S receptors. Effect of receptor density on their coupling to adenylyl cyclase. NeuroReport. October 1997, 8 (15): 3189–96. PMID 9351641. doi:10.1097/00001756-199710200-00002. 
  • Blondel O, Gastineau M, Dahmoune Y, Langlois M, Fischmeister R. Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus. Journal of Neurochemistry. June 1998, 70 (6): 2252–61. PMID 9603189. doi:10.1046/j.1471-4159.1998.70062252.x. 
  • Cichon S, Kesper K, Propping P, Nöthen MM. Assignment of the human serotonin 4 receptor gene (HTR4) to the long arm of chromosome 5 (5q31-q33). Molecular Membrane Biology. 1998, 15 (2): 75–8. PMID 9724925. doi:10.3109/09687689809027521. 
  • Claeysen S, Sebben M, Becamel C, Bockaert J, Dumuis A. Novel brain-specific 5-HT4 receptor splice variants show marked constitutive activity: role of the C-terminal intracellular domain. Molecular Pharmacology. May 1999, 55 (5): 910–20. PMID 10220570. 
  • Bender E, Pindon A, van Oers I, Zhang YB, Gommeren W, Verhasselt P, Jurzak M, Leysen J, Luyten W. Structure of the human serotonin 5-HT4 receptor gene and cloning of a novel 5-HT4 splice variant. Journal of Neurochemistry. February 2000, 74 (2): 478–89. PMID 10646498. doi:10.1046/j.1471-4159.2000.740478.x. 
  • Mialet J, Berque-Bestel I, Eftekhari P, Gastineau M, Giner M, Dahmoune Y, Donzeau-Gouge P, Hoebeke J, Langlois M, Sicsic S, Fischmeister R, Lezoualc'h F. Isolation of the serotoninergic 5-HT4(e) receptor from human heart and comparative analysis of its pharmacological profile in C6-glial and CHO cell lines. British Journal of Pharmacology. February 2000, 129 (4): 771–81. PMC 1571890  . PMID 10683202. doi:10.1038/sj.bjp.0703101. 
  • Bach T, Syversveen T, Kvingedal AM, Krobert KA, Brattelid T, Kaumann AJ, Levy FO. 5HT4(a) and 5-HT4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle. Naunyn-Schmiedeberg's Archives of Pharmacology. February 2001, 363 (2): 146–60. PMID 11218067. doi:10.1007/s002100000299. 
  • Medhurst AD, Lezoualc'h F, Fischmeister R, Middlemiss DN, Sanger GJ. Quantitative mRNA analysis of five C-terminal splice variants of the human 5-HT4 receptor in the central nervous system by TaqMan real time RT-PCR. Brain Research. Molecular Brain Research. June 2001, 90 (2): 125–34. PMID 11406291. doi:10.1016/S0169-328X(01)00095-X. 
  • Hiroi T, Hayashi-Kobayashi N, Nagumo S, Ino M, Okawa Y, Aoba A, Matsui H. Identification and characterization of the human serotonin-4 receptor gene promoter. Biochemical and Biophysical Research Communications. November 2001, 289 (2): 337–44. PMID 11716477. doi:10.1006/bbrc.2001.5979. 
  • Vilaró MT, Doménech T, Palacios JM, Mengod G. Cloning and characterization of a novel human 5-HT4 receptor variant that lacks the alternatively spliced carboxy terminal exon. RT-PCR distribution in human brain and periphery of multiple 5-HT4 receptor variants. Neuropharmacology. January 2002, 42 (1): 60–73. PMID 11750916. doi:10.1016/S0028-3908(01)00154-X. 
  • López-Rodríguez ML, Murcia M, Benhamú B, Olivella M, Campillo M, Pardo L. Computational model of the complex between GR113808 and the 5-HT4 receptor guided by site-directed mutagenesis and the crystal structure of rhodopsin. Journal of Computer-Aided Molecular Design. November 2001, 15 (11): 1025–33. PMID 11989623. doi:10.1023/A:1014895611874. 
  • Ohtsuki T, Ishiguro H, Detera-Wadleigh SD, Toyota T, Shimizu H, Yamada K, Yoshitsugu K, Hattori E, Yoshikawa T, Arinami T. Association between serotonin 4 receptor gene polymorphisms and bipolar disorder in Japanese case-control samples and the NIMH Genetics Initiative Bipolar Pedigrees. Molecular Psychiatry. 2003, 7 (9): 954–61. PMID 12399948. doi:10.1038/sj.mp.4001133. 
  • Norum JH, Hart K, Levy FO. Ras-dependent ERK activation by the human G(s)-coupled serotonin receptors 5-HT4(b) and 5-HT7(a). The Journal of Biological Chemistry. January 2003, 278 (5): 3098–104. PMID 12446729. doi:10.1074/jbc.M206237200. 
  • Cartier D, Lihrmann I, Parmentier F, Bastard C, Bertherat J, Caron P, Kuhn JM, Lacroix A, Tabarin A, Young J, Vaudry H, Lefebvre H. Overexpression of serotonin4 receptors in cisapride-responsive adrenocorticotropin-independent bilateral macronodular adrenal hyperplasia causing Cushing's syndrome. The Journal of Clinical Endocrinology and Metabolism. January 2003, 88 (1): 248–54. PMID 12519861. doi:10.1210/jc.2002-021107. 
  • Manzke T, Guenther U, Ponimaskin EG, Haller M, Dutschmann M, Schwarzacher S, Richter DW. 5-HT4(a) receptors avert opioid-induced breathing depression without loss of analgesia. Science. July 2003, 301 (5630): 226–9. PMID 12855812. doi:10.1126/science.1084674. 

外部連結

  • 5-HT4. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. （原始内容于2016-06-05）. 
  • Human HTR4 genome location and HTR4 gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）.


5-HT4受體引用了美国国家医学图书馆提供的資料，这些資料属于公共领域。


一月 28, 2023
受體, ht4受體或5, 羥色胺受體4, 英語, hydroxytryptamine, receptor, 是在人類上由htr4基因編碼的蛋白質, ht4受體識別號别名htr4, ht4r, receptor, hydroxytryptamine, receptor, 4外部idomim, 602164, 109246, homologene, 20243, genecards, htr4為以下藥物的標靶维拉佐酮, 血清素, 甲氧基色胺, methyl, 莫沙必利, 伦扎必利, zacopride, prucalo. 5 HT4受體或5 羥色胺受體4 英語 5 Hydroxytryptamine receptor 4 是在人類上由HTR4基因編碼的蛋白質 6 7 5 HT4受體識別號别名HTR4 5 HT4 5 HT4R 5 HT4 receptor 5 hydroxytryptamine receptor 4外部IDOMIM 602164 MGI 109246 HomoloGene 20243 GeneCards HTR4為以下藥物的標靶维拉佐酮 血清素 5 甲氧基色胺 a methyl 5 HT 莫沙必利 伦扎必利 zacopride prucalopride RS 67333 GR 113808 piboserod SB 204070 1 基因位置 人类 染色体5號染色體 2 基因座5q32起始148 451 032 bp 2 终止148 677 235 bp 2 基因位置 小鼠 染色体小鼠18号染色体 3 基因座18 18 E1起始62 457 275 bp 3 终止62 629 648 bp 3 RNA表达模式查阅更多表达数据基因本體分子功能 G protein coupled receptor activity signal transducer activity G protein coupled serotonin receptor activity trace amine receptor activity 相同蛋白质结合 neurotransmitter receptor activity 血浆蛋白结合細胞組分 細胞質 integral component of membrane 核内体 细胞膜 integral component of plasma membrane 膜 树突生物學過程 gamma aminobutyric acid signaling pathway G protein coupled receptor signaling pathway G protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger regulation of appetite 訊息傳遞 chemical synaptic transmission G protein coupled serotonin receptor signaling pathwaySources Amigo QuickGO直系同源物種人類小鼠Entrez336015562EnsemblENSG00000164270ENSMUSG00000026322UniProtQ13639P97288mRNA 序列 NM 000870 NM 001040169 NM 001040172 NM 001040173 NM 001040174 NM 001286410 NM 199453NM 008313 NM 001364956 NM 001364957 NM 001364958 NM 001364959蛋白序列NP 000861 NP 001035259 NP 001035262 NP 001035263 NP 001273339 NP 955525NP 032339 NP 001351885 NP 001351886 NP 001351887 NP 001351888基因位置 UCSC Chr 5 148 45 148 68 MbChr 18 62 46 62 63 MbPubMed 查找 4 5 維基數據檢視 編輯人類檢視 編輯小鼠 目录 1 配體 1 1 激動劑 1 2 拮抗劑 2 參見 3 參考資料 4 深入閱讀 5 外部連結配體 编辑激動劑 编辑 BIMU 8 英语 BIMU 8 Cisapride 英语 Cisapride ML 10302 8 莫沙必利 Prucalopride 英语 Prucalopride Renzapride 英语 Renzapride RS 67506 Tegaserod 英语 Tegaserod Zacopride 英语 Zacopride Metoclopramide 舒必利 RS 67333 英语 RS 67333 partial agonist SL65 0155 英语 SL65 0155 partial agonist CJ 033 466 英语 CJ 033 466 partial agonist拮抗劑 编辑 Piboserod 英语 Piboserod GR 113 808 英语 GR 113 808 1 methyl 1H indole 3 carboxylic acid 1 2 methylsulfonyl amino ethyl 4 piperidinyl methyl ester 9 GR 125 487 RS 39604 1 4 Amino 5 chloro 2 3 5 dimethoxyphenyl methyloxy 3 1 2 methylsulphonylamino piperidin 4 yl propan 1 one SB 203 186 SB 204 070 英语 SB 204 070 Methoxy 11C 1 butylpiperidin 4 yl methyl 4 amino 3 methoxybenzoate 10 洋甘菊 酒精萃取 11 參見 编辑5 羟色胺受体 5 HT1受體 英语 5 HT1 receptor 5 HT2受體 5 HT3受體 英语 5 HT3 receptor 5 HT5受體 英语 5 HT5 receptor 5 HT6受體 英语 5 HT6 receptor 5 HT7受體 英语 5 HT7 receptor 參考資料 编辑 對5 hydroxytryptamine receptor 4起作用的藥物 在維基數據上查看 編輯參考 2 0 2 1 2 2 GRCh38 Ensembl release 89 ENSG00000164270 Ensembl May 2017 3 0 3 1 3 2 GRCm38 Ensembl release 89 ENSMUSG00000026322 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Claeysen S Faye P Sebben M Lemaire S Bockaert J Dumuis A Taviaux S Assignment of 5 hydroxytryptamine receptor HTR4 to human chromosome 5 bands q31 gt q33 by in situ hybridization Cytogenetics and Cell Genetics December 1997 78 2 133 4 PMID 9371406 doi 10 1159 000134646 Blondel O Vandecasteele G Gastineau M Leclerc S Dahmoune Y Langlois M Fischmeister R Molecular and functional characterization of a 5 HT4 receptor cloned from human atrium FEBS Letters August 1997 412 3 465 74 PMID 9276448 doi 10 1016 S0014 5793 97 00820 X Godinez Chaparro B Barragan Iglesias P Castaneda Corral G Rocha Gonzalez HI Granados Soto V Role of peripheral 5 HT 4 5 HT 6 and 5 HT 7 receptors in development and maintenance of secondary mechanical allodynia and hyperalgesia Pain March 2011 152 3 687 97 PMID 21239110 doi 10 1016 j pain 2010 12 020 Gale JD Grossman CJ Whitehead JW Oxford AW Bunce KT Humphrey PP GR113808 a novel selective antagonist with high affinity at the 5 HT4 receptor British Journal of Pharmacology January 1994 111 1 332 8 PMC 1910004 PMID 8012715 doi 10 1111 j 1476 5381 1994 tb14064 x Xu R Hong J Morse CL Pike VW Synthesis structure affinity relationships and radiolabeling of selective high affinity 5 HT4 receptor ligands as prospective imaging probes for positron emission tomography Journal of Medicinal Chemistry October 2010 53 19 7035 47 PMC 2951497 PMID 20812727 doi 10 1021 jm100668r Simmen U Kelber O Okpanyi SN Jaeggi R Bueter B Weiser D Binding of STW 5 Iberogast and its components to intestinal 5 HT muscarinic M3 and opioid receptors Phytomedicine 51 5 PMID 16973340 doi 10 1016 j phymed 2006 03 012 深入閱讀 编辑Licht CL 2009 Changes in the 5 HT4 receptor in animal models of depression 英语 animal models of depression and antidepressant treatment PhD thesis University of Copenhagen Ullmer C Schmuck K Kalkman HO Lubbert H Expression of serotonin receptor mRNAs in blood vessels FEBS Letters August 1995 370 3 215 21 PMID 7656980 doi 10 1016 0014 5793 95 00828 W Blondel O Vandecasteele G Gastineau M Leclerc S Dahmoune Y Langlois M Fischmeister R Molecular and functional characterization of a 5 HT4 receptor cloned from human atrium FEBS Letters August 1997 412 3 465 74 PMID 9276448 doi 10 1016 S0014 5793 97 00820 X Van den Wyngaert I Gommeren W Verhasselt P Jurzak M Leysen J Luyten W Bender E Cloning and expression of a human serotonin 5 HT4 receptor cDNA Journal of Neurochemistry November 1997 69 5 1810 9 PMID 9349523 doi 10 1046 j 1471 4159 1997 69051810 x Claeysen S Faye P Sebben M Lemaire S Bockaert J Dumuis A Cloning and expression of human 5 HT4S receptors Effect of receptor density on their coupling to adenylyl cyclase NeuroReport October 1997 8 15 3189 96 PMID 9351641 doi 10 1097 00001756 199710200 00002 Blondel O Gastineau M Dahmoune Y Langlois M Fischmeister R Cloning expression and pharmacology of four human 5 hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus Journal of Neurochemistry June 1998 70 6 2252 61 PMID 9603189 doi 10 1046 j 1471 4159 1998 70062252 x Cichon S Kesper K Propping P Nothen MM Assignment of the human serotonin 4 receptor gene HTR4 to the long arm of chromosome 5 5q31 q33 Molecular Membrane Biology 1998 15 2 75 8 PMID 9724925 doi 10 3109 09687689809027521 Claeysen S Sebben M Becamel C Bockaert J Dumuis A Novel brain specific 5 HT4 receptor splice variants show marked constitutive activity role of the C terminal intracellular domain Molecular Pharmacology May 1999 55 5 910 20 PMID 10220570 Bender E Pindon A van Oers I Zhang YB Gommeren W Verhasselt P Jurzak M Leysen J Luyten W Structure of the human serotonin 5 HT4 receptor gene and cloning of a novel 5 HT4 splice variant Journal of Neurochemistry February 2000 74 2 478 89 PMID 10646498 doi 10 1046 j 1471 4159 2000 740478 x Mialet J Berque Bestel I Eftekhari P Gastineau M Giner M Dahmoune Y Donzeau Gouge P Hoebeke J Langlois M Sicsic S Fischmeister R Lezoualc h F Isolation of the serotoninergic 5 HT4 e receptor from human heart and comparative analysis of its pharmacological profile in C6 glial and CHO cell lines British Journal of Pharmacology February 2000 129 4 771 81 PMC 1571890 PMID 10683202 doi 10 1038 sj bjp 0703101 Bach T Syversveen T Kvingedal AM Krobert KA Brattelid T Kaumann AJ Levy FO 5HT4 a and 5 HT4 b receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle Naunyn Schmiedeberg s Archives of Pharmacology February 2001 363 2 146 60 PMID 11218067 doi 10 1007 s002100000299 Medhurst AD Lezoualc h F Fischmeister R Middlemiss DN Sanger GJ Quantitative mRNA analysis of five C terminal splice variants of the human 5 HT4 receptor in the central nervous system by TaqMan real time RT PCR Brain Research Molecular Brain Research June 2001 90 2 125 34 PMID 11406291 doi 10 1016 S0169 328X 01 00095 X Hiroi T Hayashi Kobayashi N Nagumo S Ino M Okawa Y Aoba A Matsui H Identification and characterization of the human serotonin 4 receptor gene promoter Biochemical and Biophysical Research Communications November 2001 289 2 337 44 PMID 11716477 doi 10 1006 bbrc 2001 5979 Vilaro MT Domenech T Palacios JM Mengod G Cloning and characterization of a novel human 5 HT4 receptor variant that lacks the alternatively spliced carboxy terminal exon RT PCR distribution in human brain and periphery of multiple 5 HT4 receptor variants Neuropharmacology January 2002 42 1 60 73 PMID 11750916 doi 10 1016 S0028 3908 01 00154 X Lopez Rodriguez ML Murcia M Benhamu B Olivella M Campillo M Pardo L Computational model of the complex between GR113808 and the 5 HT4 receptor guided by site directed mutagenesis and the crystal structure of rhodopsin Journal of Computer Aided Molecular Design November 2001 15 11 1025 33 PMID 11989623 doi 10 1023 A 1014895611874 Ohtsuki T Ishiguro H Detera Wadleigh SD Toyota T Shimizu H Yamada K Yoshitsugu K Hattori E Yoshikawa T Arinami T Association between serotonin 4 receptor gene polymorphisms and bipolar disorder in Japanese case control samples and the NIMH Genetics Initiative Bipolar Pedigrees Molecular Psychiatry 2003 7 9 954 61 PMID 12399948 doi 10 1038 sj mp 4001133 Norum JH Hart K Levy FO Ras dependent ERK activation by the human G s coupled serotonin receptors 5 HT4 b and 5 HT7 a The Journal of Biological Chemistry January 2003 278 5 3098 104 PMID 12446729 doi 10 1074 jbc M206237200 Cartier D Lihrmann I Parmentier F Bastard C Bertherat J Caron P Kuhn JM Lacroix A Tabarin A Young J Vaudry H Lefebvre H Overexpression of serotonin4 receptors in cisapride responsive adrenocorticotropin independent bilateral macronodular adrenal hyperplasia causing Cushing s syndrome The Journal of Clinical Endocrinology and Metabolism January 2003 88 1 248 54 PMID 12519861 doi 10 1210 jc 2002 021107 Manzke T Guenther U Ponimaskin EG Haller M Dutschmann M Schwarzacher S Richter DW 5 HT4 a receptors avert opioid induced breathing depression without loss of analgesia Science July 2003 301 5630 226 9 PMID 12855812 doi 10 1126 science 1084674 外部連結 编辑5 HT4 IUPHAR Database of Receptors and Ion Channels International Union of Basic and Clinical Pharmacology 原始内容存档于2016 06 05 Human HTR4 genome location and HTR4 gene details page in the UCSC Genome Browser 英语 UCSC Genome Browser 5 HT4受體引用了美国国家医学图书馆提供的資料 这些資料属于公共领域 取自 https zh wikipedia org w index php title 5 HT4受體 amp oldid 68256430, 维基百科，wiki，书籍，书籍，图书馆，

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