^ Janeway, Charles. Immunobiology: the immune system in health and disease 6th. New York: Garland Science. 2005. ISBN 0-8153-4101-6.
Krista Conger. Grant to fund research into preventing bioterrorism （页面存档备份，存于互联网档案馆）, Stanford Report, November 12, 2003.
Stenger S, Hanson DA, Teitelbaum R, et al. An antimicrobial activity of cytolytic T cells mediated by granulysin. Science. October 1998, 282 (5386): 121–5. PMID 9756476. doi:10.1126/science.282.5386.121.
Peña SV, Hanson DA, Carr BA, Goralski TJ, Krensky AM. Processing, subcellular localization, and function of 519 (granulysin), a human late T cell activation molecule with homology to small, lytic, granule proteins. J. Immunol. March 1997, 158 (6): 2680–8. PMID 9058801.
Krensky AM, Clayberger C. Granulysin: a novel host defense molecule. Am. J. Transplant. August 2005, 5 (8): 1789–92. PMID 15996224. doi:10.1111/j.1600-6143.2005.00970.x.
da Silva AP, Unks D, Lyu SC, et al. In vitro and in vivo antimicrobial activity of granulysin-derived peptides against Vibrio cholerae. J. Antimicrob. Chemother. May 2008, 61 (5): 1103–9. PMC 2664651. PMID 18310138. doi:10.1093/jac/dkn058.
Chung WH, Hung SI, Yang JY, Su SC, Huang SP, Wei CY, Chin SW, Chiou CC, Chu SC, Ho HC, Yang CH, Lu CF, Wu JY, Liao YD, Chen YT. Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis. Nat Med. Dec 2008, 14 (12): 1343–50. doi:10.1038/nm.1884.
^ 1.01.11.2GRCh38: Ensembl release 89: ENSG00000115523 - Ensembl, May 2017
^Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
二月 07, 2023
颗粒溶素, 英語, granulysin, 又译为, 颗粒溶解素, 是一种由细胞毒性t细胞, cd8阳性t细胞, 在接触被感染的细胞时释放的物质, 其功能为通过靶细胞的膜上形成的小孔, 从而诱导靶细胞凋亡, 另外也与抗微生物相关, 已知的結構pdb人类uniprot搜索, pdbe, rcsbpdbid列表1l9l識別號别名gnly, d2s69e, lag2, nkg5, tla519, granulysin外部idomim, 188855, homologene, 136805, genecards, gnly. 颗粒溶素 英語 Granulysin 又译为 颗粒溶解素 是一种由细胞毒性T细胞 CD8阳性T细胞 在接触被感染的细胞时释放的物质 其功能为通过靶细胞的膜上形成的小孔 从而诱导靶细胞凋亡 另外也与抗微生物相关 1 颗粒溶素已知的結構PDB人类UniProt搜索 PDBe RCSBPDBID列表1L9L識別號别名GNLY 519 D2S69E LAG 2 LAG2 NKG5 TLA519 granulysin外部IDOMIM 188855 HomoloGene 136805 GeneCards GNLY基因位置 人类 染色体2號染色體 1 基因座2p11 2起始85 685 175 bp 1 终止85 698 852 bp 1 RNA表达模式查阅更多表达数据直系同源物種人類小鼠Entrez10578无数据EnsemblENSG00000115523无数据UniProtP22749无数据mRNA 序列NM 001302758 NM 006433 NM 012483无数据蛋白序列NP 001289687 NP 006424 NP 036615无数据基因位置 UCSC Chr 2 85 69 85 7 Mb无数据PubMed 查找 2 无数据維基數據檢視 編輯人類颗粒溶素是一种能产生细胞溶解和炎症反应的分子 最早通过抑制消减杂交寻找在人细胞毒性T细胞激活3 5天时表达的基因发现 颗粒溶素会与具有穿孔能力的穿孔素和颗粒酶形成溶细胞颗粒 颗粒溶素具有广谱的抗微生物功能 能杀伤结核杆菌 疟原虫等 甚至能杀伤一些肿瘤 一系列源自颗粒溶素的氨基酸序列的多肽能作为潜在的抗细菌药 颗粒溶素最近被认为与史蒂芬斯 強森症候群的发生发展有关 参考文献 编辑 Janeway Charles Immunobiology the immune system in health and disease 6th New York Garland Science 2005 ISBN 0 8153 4101 6 Krista Conger Grant to fund research into preventing bioterrorism 页面存档备份 存于互联网档案馆 Stanford Report November 12 2003 Stenger S Hanson DA Teitelbaum R et al An antimicrobial activity of cytolytic T cells mediated by granulysin Science October 1998 282 5386 121 5 PMID 9756476 doi 10 1126 science 282 5386 121 Pena SV Hanson DA Carr BA Goralski TJ Krensky AM Processing subcellular localization and function of 519 granulysin a human late T cell activation molecule with homology to small lytic granule proteins J Immunol March 1997 158 6 2680 8 PMID 9058801 Krensky AM Clayberger C Granulysin a novel host defense molecule Am J Transplant August 2005 5 8 1789 92 PMID 15996224 doi 10 1111 j 1600 6143 2005 00970 x da Silva AP Unks D Lyu SC et al In vitro and in vivo antimicrobial activity of granulysin derived peptides against Vibrio cholerae J Antimicrob Chemother May 2008 61 5 1103 9 PMC 2664651 PMID 18310138 doi 10 1093 jac dkn058 Chung WH Hung SI Yang JY Su SC Huang SP Wei CY Chin SW Chiou CC Chu SC Ho HC Yang CH Lu CF Wu JY Liao YD Chen YT Granulysin is a key mediator for disseminated keratinocyte death in Stevens Johnson syndrome and toxic epidermal necrolysis Nat Med Dec 2008 14 12 1343 50 doi 10 1038 nm 1884 1 0 1 1 1 2 GRCh38 Ensembl release 89 ENSG00000115523 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine 取自 https zh wikipedia org w index php title 颗粒溶素 amp oldid 75340983, 维基百科，wiki，书籍，书籍，图书馆，
