^. Vioxxlawyer.org. [4 January 2015]. （原始内容存档于2015年1月5日）.
参考文献编辑
FDA (2005). "Summary minutes for the February 16, 17 and 18, 2005, Joint meeting of the Arthritis Advisory Committee and the Drug Safety and Risk Management Advisory Committee." Published on the internet, March 2005. Link （页面存档备份，存于互联网档案馆）
Fitzgerald GA, Coxibs and Cardiovascular Disease, N Engl J Med 2004;351(17): 1709–1711. PMID 15470192.
Grassley CE (15 Oct 2004). Press Release.
Jüni P, Nartey L, Reichenbach S, Sterchi R, Dieppe PA, Egger M (2004). Lancet (published online; see also Merck response below)
Karha J and Topol EJ. The sad story of Vioxx, and what we should learn from it （页面存档备份，存于互联网档案馆） Cleve Clin J Med 2004; 71(12):933-939. PMID 15641522
Michaels, D. (June 2005) DOUBT Is Their Product Archive.is的存檔，存档日期2006-03-21, Scientific American, 292 (6).
Merck & Co., (5 Nov 2004). Press Release.
Merck & Co (30 Sep 2004) Merck Announces Voluntary Worldwide Withdrawal of VIOXX. Press release .
D. M. Mukherjee, S. E. Nissen, and E. J. Topol, "Risk of Cardiovascular Events Associated with Selective COX-2 Inhibitors," Journal of the American Medical Association 186 (2001): 954–959.
Nussmeier NA, Whelton AA, Brown MT, Langford RM, Hoeft A, Parlow JL, et al. Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery. N Engl J Med 2005;352(11):1081-91. PMID 15713945
Okie, S (2005) "Raising the safety bar--the FDA's coxib meeting." N Engl J Med. 2005 Mar 31;352(13):1283-5. PMID 15800221.
Leleti Rajender Reddy, Corey EJ. Facile air oxidation of the conjugate base of rofecoxib (Vioxx), a possible contributor to chronic human toxicity Tetrahedron Lett 2005, 46: 927. doi:10.1016/j.tetlet.2004.12.055
Swan SK et al., Effect of Cyclooxygenase-2 Inhibition on Renal Function in Elderly Persons Receiving a Low-Salt Diet. Annals of Int Med 2000; 133:1–9
Targum, SL. (1 Feb. 2001) Review of cardiovascular safety database. FDA memorandum.[2] （页面存档备份，存于互联网档案馆）
Wolfe, MM et al., Gastrointestinal Toxicity of Nonsteroidal Anti-anflamattory Drugs, New England Journal of Medicine. 1999; 340; 1888-98.
Ted Frank, American Enterprise Institute, The Vioxx Litigation, and , December 2005
briandeer.com - Vioxx: the UK connection （页面存档备份，存于互联网档案馆）
一月 01, 1970
罗非昔布, 维基百科中的醫學内容仅供参考, 並不能視作專業意見, 如需獲取醫療幫助或意見, 请咨询专业人士, 詳見醫學聲明, 或罗非考昔, 英語, rofecoxib, 商品名vioxx, ceoxx和ceeoxx, 是一种非甾体类抗炎药, nsaid, 由默克公司製造, 出售, 美国食品药品监督管理局, 于1999年5月20日批准上市, 用以治疗骨关节炎, 急性疼痛和痛经, 臨床資料懷孕分級澳, c给药途径oralatc碼m01ah02, 法律規範狀態法律規範澳, 限医生处方, withdrawn藥物動力學數據生. 维基百科中的醫學内容仅供参考 並不能視作專業意見 如需獲取醫療幫助或意見 请咨询专业人士 詳見醫學聲明 罗非昔布或罗非考昔 英語 Rofecoxib ˌ r ɒ f ɪ ˈ k ɒ k s ɪ b 商品名Vioxx Ceoxx和Ceeoxx 是一种非甾体类抗炎药 NSAID 由默克公司製造 出售 美国食品药品监督管理局 FDA 于1999年5月20日批准上市 用以治疗骨关节炎 急性疼痛和痛经 罗非昔布臨床資料懷孕分級澳 C给药途径oralATC碼M01AH02 WHO 法律規範狀態法律規範澳 限医生处方 S4 withdrawn藥物動力學數據生物利用度93 血漿蛋白結合率87 药物代谢hepatic生物半衰期17 hours排泄途徑biliary renal识别信息IUPAC命名法 4 4 methylsulfonylphenyl 3 phenyl 5H furan 2 oneCAS号162011 90 7 YPubChem CID5090DrugBankDB00533 YChemSpider4911 YUNII0QTW8Z7MCRKEGGD00568 YChEBICHEBI 8887 YChEMBLChEMBL122 YCompTox Dashboard 英语 CompTox Chemicals Dashboard EPA DTXSID2023567ECHA InfoCard100 230 077化学信息化学式C 17H 14O 4S摩尔质量314 357 g mol3D模型 JSmol 英语 JSmol 交互式图像SMILES O C2OCC C2 c1ccccc1 c3ccc cc3 S O O CInChI InChI 1S C17H14O4S c1 22 19 20 14 9 7 12 8 10 14 15 11 21 17 18 16 15 13 5 3 2 4 6 13 h2 10H 11H2 1H3 YKey RZJQGNCSTQAWON UHFFFAOYSA N Y 由於發現到長期且高劑量用藥有增加心臟病的風險 1 2 默克公司於2004年9月30日起從市場撤回此藥 目录 1 合成 2 注脚 3 参考文献 4 外部链接合成 编辑 nbsp 罗非昔布的合成 3 注脚 编辑 偉克適致死 藥廠賠10億 2017 02 26 原始内容存档于2017 09 12 食品藥物釣愚 釣愚 操縱與欺騙的經濟學 選摘 3 食安 藥物 釣愚 操縱與欺騙的經濟學 風傳媒 喬治 艾克羅夫 羅伯 席勒 2017 02 26 原始内容存档于2017 04 23 Vioxxlawyer org Vioxxlawyer org 4 January 2015 原始内容存档于2015年1月5日 参考文献 编辑FDA 2005 Summary minutes for the February 16 17 and 18 2005 Joint meeting of the Arthritis Advisory Committee and the Drug Safety and Risk Management Advisory Committee Published on the internet March 2005 Link 页面存档备份 存于互联网档案馆 Fitzgerald GA Coxibs and Cardiovascular Disease N Engl J Med 2004 351 17 1709 1711 PMID 15470192 Grassley CE 15 Oct 2004 Grassley questions Merck about communication with the FDA on Vioxx Press Release Juni P Nartey L Reichenbach S Sterchi R Dieppe PA Egger M 2004 Risk of cardiovascular events and rofecoxib cumulative meta analysis Lancet published online see also Merck response below Karha J and Topol EJ The sad story of Vioxx and what we should learn from it 页面存档备份 存于互联网档案馆 Cleve Clin J Med 2004 71 12 933 939 PMID 15641522 Michaels D June 2005 DOUBT Is Their Product Archive is的存檔 存档日期2006 03 21 Scientific American 292 6 Merck amp Co 5 Nov 2004 Response to Article by Juni et al Published in The Lancet on Nov 5 Press Release Merck amp Co 30 Sep 2004 Merck Announces Voluntary Worldwide Withdrawal of VIOXX Press release 1 D M Mukherjee S E Nissen and E J Topol Risk of Cardiovascular Events Associated with Selective COX 2 Inhibitors Journal of the American Medical Association 186 2001 954 959 Nussmeier NA Whelton AA Brown MT Langford RM Hoeft A Parlow JL et al Complications of the COX 2 inhibitors parecoxib and valdecoxib after cardiac surgery N Engl J Med 2005 352 11 1081 91 PMID 15713945 Okie S 2005 Raising the safety bar the FDA s coxib meeting N Engl J Med 2005 Mar 31 352 13 1283 5 PMID 15800221 Leleti Rajender Reddy Corey EJ Facile air oxidation of the conjugate base of rofecoxib Vioxx a possible contributor to chronic human toxicity Tetrahedron Lett 2005 46 927 doi 10 1016 j tetlet 2004 12 055 Swan SK et al Effect of Cyclooxygenase 2 Inhibition on Renal Function in Elderly Persons Receiving a Low Salt Diet Annals of Int Med 2000 133 1 9 Targum SL 1 Feb 2001 Review of cardiovascular safety database FDA memorandum 2 页面存档备份 存于互联网档案馆 Wolfe MM et al Gastrointestinal Toxicity of Nonsteroidal Anti anflamattory Drugs New England Journal of Medicine 1999 340 1888 98 外部链接 编辑此條目使用外部链接的方式可能不符合维基百科的方针或指引 或致使內文成為链接農場 2015年1月1日 請協助清理過度與不適當的外部連結 并将有用的链接移到参考文献中 详情请参见条目的讨论页 National Public Radio 2004 Q amp A on the case following withdrawal announcement 页面存档备份 存于互联网档案馆 Court TV s full coverage of the Vioxx civil trials Merck website on Vioxx litigation FDA Public Health Advisory on Vioxx 页面存档备份 存于互联网档案馆 David Michaels Doubt is Their Product Scientific American June 2004 p 96 101 JURIST Much Pain Much Gain Skeptical Ruminations on the Vioxx Litigation Ted Frank American Enterprise Institute The Vioxx Litigation Part I and Part II December 2005 briandeer com Vioxx the UK connection 页面存档备份 存于互联网档案馆 Campaign for compensation for Vioxx victims outside the US 取自 https zh wikipedia org w index php title 罗非昔布 amp oldid 78950039, 维基百科，wiki，书籍，书籍，图书馆，
