· immune response · multicellular organismal development · embryo implantation · positive regulation of cell proliferation · negative regulation of cell proliferation · stem cell maintenance · positive regulation of peptidyl-serine phosphorylation · positive regulation of peptidyl-serine phosphorylation of STAT protein · tyrosine phosphorylation of Stat3 protein · positive regulation of tyrosine phosphorylation of Stat1 protein · positive regulation of tyrosine phosphorylation of Stat3 protein · positive regulation of MAPK cascade · positive regulation of macrophage differentiation · negative regulation of meiosis · positive regulation of transcription from RNA polymerase II promoter · decidualization · negative regulation of hormone secretion · lung alveolus development · muscle organ morphogenesis · neuron development · positive regulation of astrocyte differentiation · leukemia inhibitory factor signaling pathway · positive regulation of peptidyl-tyrosine phosphorylation · lung vasculature development · lung lobe morphogenesis · trophoblast giant cell differentiation · spongiotrophoblast differentiation · negative regulation of ERK1 and ERK2 cascade · positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis · regulation of metanephric nephron tubule epithelial cell differentiation · positive regulation of protein localization to nucleus
· positive regulation of histone H3-K27 acetylation
^Wenwei Hu, Zhaohui Feng, Angelika K. Teresky1, Arnold J. Levine. p53 regulates maternal reproduction through LIF. Nature. November 29, 2007, 450 (7170): 721–724 [2017-01-27]. PMID 18046411. doi:10.1038/nature05993. （原始内容于2017-03-15）.
^Aghajanova, L. Leukemia inhibitory factor and human embryo implantation. Annals of the New York Academy of Sciences. 2004, 1034: 176–83. PMID 15731310. doi:10.1196/annals.1335.020.
^Bradford A. Youngblood; et al. Application of recombinant human leukemia inhibitory factor (LIF) produced in rice (Oryza sativa L.) for maintenance of mouse embryonic stem cells. Journal of Biotechnology Volume 172. 2014-02-20: 67–72. 引文格式1维护：显式使用等标签 (link)
^Stewart, C. L.; Kaspar, P; Brunet, L. J.; Bhatt, H; Gadi, I; Köntgen, F; Abbondanzo, S. J. Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor. Nature. 1992, 359 (6390): 76–9. PMID 1522892. doi:10.1038/359076a0.
^Martello, Graziano; Smith, Austin. The Nature of Embryonic Stem Cells. Annual Review Cell Developmental Biology. 2014, 30: 647. doi:10.1146/annurev-cellbio-100913-013116.
^Kawahara Y, Manabe T, Matsumoto M, Kajiume T, Matsumoto M, Yuge L. Zwaka, Thomas , 编. LIF-Free Embryonic Stem Cell Culture in Simulated Microgravity. PLoS ONE. 2009, 4 (7): e6343 [2017-01-27]. PMC 2710515. PMID 19626124. doi:10.1371/journal.pone.0006343. （原始内容于2014-02-22）.
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白血病抑制因子, 此條目需要擴充, 2014年3月19日, 请協助改善这篇條目, 更進一步的信息可能會在討論頁或扩充请求中找到, 请在擴充條目後將此模板移除, leukemia, inhibitory, factor, 缩写, 是一種屬於白介素, 6大類的細胞因子, 它能通過抑制分化影響細胞生长, lif水平下降會使細胞開始分化, leukemia, inhibitory, factorpdb, rendering, based, 1lki, 有效结构pdb, 直系同源检索, pdbe, rcsbpdb查询代码列表. 此條目需要擴充 2014年3月19日 请協助改善这篇條目 更進一步的信息可能會在討論頁或扩充请求中找到 请在擴充條目後將此模板移除 白血病抑制因子 Leukemia inhibitory factor 缩写 LIF 是一種屬於白介素 6大類的細胞因子 它能通過抑制分化影響細胞生长 LIF水平下降會使細胞開始分化 Leukemia inhibitory factor白血病抑制因子PDB rendering based on 1LKI 有效结构PDB 直系同源检索 PDBe RCSBPDB查询代码列表1EMR 1PVH 2Q7N标识代号LIF CDF DIA HILDA MLPLI扩展标识遗传学 159540 鼠基因 96787 同源基因 1734 GeneCards LIF Gene基因本体论描述分子功能 RNA polymerase II transcription factor recruiting transcription factor activity receptor binding cytokine activity leukemia inhibitory factor receptor binding growth factor activity细胞成分 extracellular space cytoplasm生物过程 blood vessel remodeling immune response multicellular organismal development embryo implantation positive regulation of cell proliferation negative regulation of cell proliferation stem cell maintenance positive regulation of peptidyl serine phosphorylation positive regulation of peptidyl serine phosphorylation of STAT protein tyrosine phosphorylation of Stat3 protein positive regulation of tyrosine phosphorylation of Stat1 protein positive regulation of tyrosine phosphorylation of Stat3 protein positive regulation of MAPK cascade positive regulation of macrophage differentiation negative regulation of meiosis positive regulation of transcription from RNA polymerase II promoter decidualization negative regulation of hormone secretion lung alveolus development muscle organ morphogenesis neuron development positive regulation of astrocyte differentiation leukemia inhibitory factor signaling pathway positive regulation of peptidyl tyrosine phosphorylation lung vasculature development lung lobe morphogenesis trophoblast giant cell differentiation spongiotrophoblast differentiation negative regulation of ERK1 and ERK2 cascade positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis regulation of metanephric nephron tubule epithelial cell differentiation positive regulation of protein localization to nucleus positive regulation of histone H3 K27 acetylationSources Amigo QuickGORNA表达模式更多表达数据直系同源体物种人类小鼠Entrez397616878EnsemblENSG00000128342ENSMUSG00000034394UniProtP15018P09056mRNA序列NM 001257135NM 001039537蛋白序列NP 001244064NP 001034626基因位置Chr 22 30 64 30 64 MbChr 11 4 26 4 27 MbPubMed查询 1 2 查论编 目录 1 功能 2 表達 3 幹細胞培養 4 參考 5 拓展閱讀 6 參見 7 外部链接功能 编辑白血病抑制因子能夠誘導骨髓性白血病細胞的末端分化 進而阻止其生長 因而得名 白血病抑制因子還有以下功能 能促進多種細胞的生長與分化 影響骨代謝 惡病質體 神經發育 英语 Neural development 胚胎發育以及炎症作用 受p53調控的白血病抑制因子能促進小鼠和人的胚胎着床 1 一篇文章提出重組人白血病抑制因子可能可以提高意外懷孕的婦女 體內胚胎 的着床成功率 2 表達 编辑LIF在正常情況下會由囊胚中的滋養層 TE 表達 而其受體LIFR則會由內細胞群 ICM 的細胞表達 胚胎幹細胞取自內細胞群的細胞 在體外培養時就需要額外補充LIF 目前 重組LIF已可以通過基因工程的手段由植物 水稻 產生 3 幹細胞培養 编辑幹細胞培養基中大都含有LIF 可用於替代餵養層 feeder layer 細胞 因爲餵養層細胞的主要作用即產生LIF 不表達LIF基因的餵養層細胞難以支持幹細胞的培養 4 LIF通過招募信號誘導分子以及轉錄激活因子3 STAT3 促進細胞的自我更新 活化的LIFR能徵募Stat3 隨後 JAK激酶能將其磷酸化 不過LIF和Stat3是不足以阻止細胞分化的 一旦移去培養基中的血清 幹細胞就會分化 在原生多能性幹細胞分化的可逆階段 加入LIF可以使細胞重回原生多能性階段 5 6 7 參考 编辑 Wenwei Hu Zhaohui Feng Angelika K Teresky1 Arnold J Levine p53 regulates maternal reproduction through LIF Nature November 29 2007 450 7170 721 724 2017 01 27 PMID 18046411 doi 10 1038 nature05993 原始内容存档于2017 03 15 Aghajanova L Leukemia inhibitory factor and human embryo implantation Annals of the New York Academy of Sciences 2004 1034 176 83 PMID 15731310 doi 10 1196 annals 1335 020 Bradford A Youngblood et al Application of recombinant human leukemia inhibitory factor LIF produced in rice Oryza sativa L for maintenance of mouse embryonic stem cells Journal of Biotechnology Volume 172 2014 02 20 67 72 引文格式1维护 显式使用等标签 link Stewart C L Kaspar P Brunet L J Bhatt H Gadi I Kontgen F Abbondanzo S J Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor Nature 1992 359 6390 76 9 PMID 1522892 doi 10 1038 359076a0 Martello Graziano Smith Austin The Nature of Embryonic Stem Cells Annual Review Cell Developmental Biology 2014 30 647 doi 10 1146 annurev cellbio 100913 013116 Kawahara Y Manabe T Matsumoto M Kajiume T Matsumoto M Yuge L Zwaka Thomas 编 LIF Free Embryonic Stem Cell Culture in Simulated Microgravity PLoS ONE 2009 4 7 e6343 2017 01 27 PMC 2710515 PMID 19626124 doi 10 1371 journal pone 0006343 原始内容存档于2014 02 22 CGS PTO Finds Stem Cell Patent Anticipated Obvious in Light of Significant Guideposts 原始内容存档于2011 10 04 拓展閱讀 编辑Patterson PH Leukemia inhibitory factor a cytokine at the interface between neurobiology and immunology Proc Natl Acad Sci U S A 1994 91 17 7833 5 PMC 44497 PMID 8058719 doi 10 1073 pnas 91 17 7833 Aghajanova L Leukemia inhibitory factor and human embryo implantation Ann N Y Acad Sci 2005 1034 176 83 PMID 15731310 doi 10 1196 annals 1335 020 Kralickova M Sima P Rokyta Z Role of the leukemia inhibitory factor gene mutations in infertile women the embryo endometrial cytokine cross talk during implantation a delicate homeostatic equilibrium Folia Microbiol Praha 2005 50 3 179 86 PMID 16295654 doi 10 1007 BF02931563 Stahl J Gearing DP Willson TA et al Structural organization of the genes for murine and human leukemia inhibitory factor Evolutionary conservation of coding and non coding regions J Biol Chem 1990 265 15 8833 41 PMID 1692837 引文格式1维护 显式使用等标签 link Bazan JF Neuropoietic cytokines in the hematopoietic fold Neuron 1991 7 2 197 208 PMID 1714745 doi 10 1016 0896 6273 91 90258 2 Lowe DG Nunes W Bombara M et al Genomic cloning and heterologous expression of human differentiation stimulating factor DNA 1989 8 5 351 9 PMID 2475312 doi 10 1089 dna 1 1989 8 351 引文格式1维护 显式使用等标签 link Sutherland GR Baker E Hyland VJ et al The gene for human leukemia inhibitory factor LIF maps to 22q12 Leukemia 1989 3 1 9 13 PMID 2491897 引文格式1维护 显式使用等标签 link Mori M Yamaguchi K Abe K Purification of a lipoprotein lipase inhibiting protein produced by a melanoma cell line associated with cancer cachexia Biochem Biophys Res Commun 1989 160 3 1085 92 PMID 2730639 doi 10 1016 S0006 291X 89 80114 7 Gough NM Gearing DP King JA et al Molecular cloning and expression of the human homologue of the murine gene encoding myeloid leukemia inhibitory factor Proc Natl Acad Sci U S A 1988 85 8 2623 7 PMC 280050 PMID 3128791 doi 10 1073 pnas 85 8 2623 引文格式1维护 显式使用等标签 link Williams RL Hilton DJ Pease S et al Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells Nature 1989 336 6200 684 7 PMID 3143916 doi 10 1038 336684a0 引文格式1维护 显式使用等标签 link Moreau JF Donaldson DD Bennett F et al Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells Nature 1989 336 6200 690 2 PMID 3143918 doi 10 1038 336690a0 引文格式1维护 显式使用等标签 link Yamaguchi M Miki N Ono M et al Inhibition of growth hormone releasing factor production in mouse placenta by cytokines using gp130 as a signal transducer Endocrinology 1995 136 3 1072 8 PMID 7867561 doi 10 1210 en 136 3 1072 引文格式1维护 显式使用等标签 link Schmelzer CH Harris RJ Butler D et al Glycosylation pattern and disulfide assignments of recombinant human differentiation stimulating factor Arch Biochem Biophys 1993 302 2 484 9 PMID 8489250 doi 10 1006 abbi 1993 1243 引文格式1维护 显式使用等标签 link Aikawa J Ikeda Naiki S Ohgane J et al Molecular cloning of rat leukemia inhibitory factor receptor alpha chain gene and its expression during pregnancy Biochim Biophys Acta 1997 1353 3 266 76 PMID 9349722 引文格式1维护 显式使用等标签 link Hinds MG Maurer T Zhang JG et al Solution structure of leukemia inhibitory factor J Biol Chem 1998 273 22 13738 45 PMID 9593715 doi 10 1074 jbc 273 22 13738 引文格式1维护 显式使用等标签 link Toward a complete human genome sequence Genome Res 1999 8 11 1097 108 PMID 9847074 doi 10 1101 gr 8 11 1097 不活跃 2016 12 27 Tanaka M Hara T Copeland NG et al Reconstitution of the functional mouse oncostatin M OSM receptor molecular cloning of the mouse OSM receptor beta subunit Blood 1999 93 3 804 15 PMID 9920829 引文格式1维护 显式使用等标签 link Nakashima K Yanagisawa M Arakawa H et al Synergistic signaling in fetal brain by STAT3 Smad1 complex bridged by p300 Science 1999 284 5413 479 82 PMID 10205054 doi 10 1126 science 284 5413 479 引文格式1维护 显式使用等标签 link Dunham I Shimizu N Roe BA et al The DNA sequence of human chromosome 22 Nature 1999 402 6761 489 95 PMID 10591208 doi 10 1038 990031 引文格式1维护 显式使用等标签 link 參見 编辑胚胎幹細胞 細胞分化外部链接 编辑 医学主题 分子与细胞生物学主题 生物技术主题 醫學主題詞表 MeSH Leukemia Inhibitory Factor Source of Recombiant Leukemia Inhibitory Factor http www invitria com cell culture products services leukemia inhibitory factor culture media html 页面存档备份 存于互联网档案馆 取自 https zh wikipedia org w index php title 白血病抑制因子 amp oldid 69731611, 维基百科，wiki，书籍，书籍，图书馆，
