• positive regulation of T cell differentiation • dendritic cell differentiation • 內皮細胞凋亡過程的負調控 • negative regulation of complement-dependent cytotoxicity • regulation of phosphorylation • negative regulation of apoptotic process • myeloid dendritic cell differentiation • type 2 immune response • B cell activation • positive regulation of interleukin-13 production • 免疫反应 • B cell differentiation • T-helper 2 cell cytokine production • regulation of isotype switching • negative regulation of transcription, DNA-templated • negative regulation of epithelial cell migration • regulation of signaling receptor activity • cholesterol metabolic process • positive regulation of B cell proliferation • positive regulation of T cell proliferation • T细胞活化 • positive regulation of MHC class II biosynthetic process • negative regulation of osteoclast differentiation • positive regulation of transcription, DNA-templated • positive regulation of transcription by RNA polymerase II • positive regulation of isotype switching to IgE isotypes • positive regulation of isotype switching to IgG isotypes • regulation of immune response • cytokine-mediated signaling pathway • positive regulation of gene expression • positive regulation of macroautophagy • positive regulation of tyrosine phosphorylation of STAT protein • activation of Janus kinase activity • positive regulation of receptor-mediated endocytosis • positive regulation of cold-induced thermogenesis • negative regulation of neuroinflammatory response • positive regulation of amyloid-beta clearance • neuroinflammatory response • positive regulation of cellular respiration • positive regulation of ATP biosynthetic process
^ 1.01.11.2GRCm38: Ensembl release 89: ENSMUSG00000000869 - Ensembl, May 2017
^Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Yokota et al., Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities. Proceedings of the National Academy of Sciences USA, 1986, Volume 83, pages 5894-5898.
白细胞介素, 白介素, interleukin, 是ii型辅助t细胞, th2细胞, 分泌的细胞因子, 的生物作用, 包括刺激活化b细胞和t细胞增殖, t细胞分化成ii型辅助t细胞, 它也在调节体液免疫和适应性免疫中起关键作用, 诱导b细胞抗体类别转换向ige, 上调第二型主要组织兼容性复合体的产生, 这一因子是由m, 霍华德, 保罗和e, 委特塔, vitetta, 在1982共同发现的, 四年后人类的核苷酸序列中被分离, 证实它与一小鼠蛋白b细胞刺激因子, bcsf, 类似, 已知的結構pdb直系同源搜索, p. 白细胞介素 4 白介素 4 Interleukin 4 IL 4 是II型辅助T细胞 Th2细胞 分泌的细胞因子 白细胞介素 4的生物作用 包括刺激活化B细胞和T细胞增殖 CD4 T细胞分化成II型辅助T细胞 它也在调节体液免疫和适应性免疫中起关键作用 白细胞介素 4诱导B细胞抗体类别转换向IgE 上调第二型主要组织兼容性复合体的产生 这一因子是由M 霍华德 W 保罗和E 委特塔 Vitetta 在1982共同发现的 四年后人类白细胞介素 4的核苷酸序列中被分离 证实它与一小鼠蛋白B细胞刺激因子 1 BCSF 1 类似 4 白细胞介素 4已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表1BBN 1BCN 1CYL 1HIJ 1HIK 1HZI 1IAR 1ITI 1ITL 1ITM 1RCB 2B8U 2B8X 2B8Y 2B8Z 2B90 2B91 2CYK 2D48 2INT 3BPL 3BPN 3QB7 4YDY 5FHX識別號别名IL4 Interleukin 4 IL 4外部IDMGI 96556 HomoloGene 491 GeneCards IL4基因位置 人类 染色体5號染色體基因座5q31 1起始132 009 678 bp终止132 018 370 bp基因位置 小鼠 染色体小鼠11号染色体 1 基因座11 B1 3 11 31 97 cM起始53 493 809 bp 1 终止53 509 496 bp 1 基因本體分子功能 白细胞介素 4受体结合 血浆蛋白结合 生長因子活性 細胞因子受體結合 細胞因子活性細胞組分 細胞外區域 細胞外空間生物學過程 positive regulation of T cell differentiation dendritic cell differentiation 內皮細胞凋亡過程的負調控 negative regulation of complement dependent cytotoxicity regulation of phosphorylation negative regulation of apoptotic process myeloid dendritic cell differentiation type 2 immune response B cell activation positive regulation of interleukin 13 production 免疫反应 B cell differentiation T helper 2 cell cytokine production regulation of isotype switching negative regulation of transcription DNA templated negative regulation of epithelial cell migration regulation of signaling receptor activity cholesterol metabolic process positive regulation of B cell proliferation positive regulation of T cell proliferation T细胞活化 positive regulation of MHC class II biosynthetic process negative regulation of osteoclast differentiation positive regulation of transcription DNA templated positive regulation of transcription by RNA polymerase II positive regulation of isotype switching to IgE isotypes positive regulation of isotype switching to IgG isotypes regulation of immune response cytokine mediated signaling pathway positive regulation of gene expression positive regulation of macroautophagy positive regulation of tyrosine phosphorylation of STAT protein activation of Janus kinase activity positive regulation of receptor mediated endocytosis positive regulation of cold induced thermogenesis negative regulation of neuroinflammatory response positive regulation of amyloid beta clearance neuroinflammatory response positive regulation of cellular respiration positive regulation of ATP biosynthetic processSources Amigo QuickGO直系同源物種人類小鼠Entrez356516189EnsemblENSG00000113520ENSMUSG00000000869UniProtP05112P07750mRNA 序列NM 000589 4NM 021283蛋白序列NP 000580 NP 758858 NP 001341919NP 067258基因位置 UCSC Chr 5 132 01 132 02 MbChr 11 53 49 53 51 MbPubMed 查找 2 3 維基數據檢視 編輯人類檢視 編輯小鼠参看 编辑T细胞 辅助T细胞 STAT6参考文献 编辑 1 0 1 1 1 2 GRCm38 Ensembl release 89 ENSMUSG00000000869 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Yokota et al Isolation and characterization of a human interleukin cDNA clone homologous to mouse B cell stimulatory factor 1 that expresses B cell and T cell stimulating activities Proceedings of the National Academy of Sciences USA 1986 Volume 83 pages 5894 5898 外部链接 编辑MeSH Interleukin 4 页面存档备份 存于互联网档案馆 取自 https zh wikipedia org w index php title 白细胞介素 4 amp oldid 71379311, 维基百科，wiki，书籍，书籍，图书馆，
