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维基百科

小RNA

小RNAsmall RNA,簡稱sRNA)泛指长度小于200个核苷酸(nt)的RNA分子,多為非编码RNA(ncRNA)[1][2]真核生物中此類RNA經常可與Ago等蛋白結合以進行RNA干擾,抑制其他基因mRNA的表現。小RNA的種類包括微小RNA(miRNA)、小干扰RNA(siRNA,包含tasiRNA[3])、piwi作用RNA(piRNA,包含rasiRNA[4][5]小核RNA(snRNA)、小核仁RNA(snoRNA)[6]小卡哈氏體RNA(scaRNA)、tsRNA(衍生自tRNA的小RNA)和srRNA(衍生自rRNA的小RNA)[7]等。現有miRNA定序英语MicroRNA sequencing次世代定序英语next-generation sequencing技術專門用來偵測細胞中的小RNA[8][9]。許多小RNA與數種癌症等疾病有關[10]

miRNA与目標mRNA結合以達成RNA干擾

細菌也具有許多小RNA(細菌小RNA),可與其他RNA或蛋白質結合,有調控基因表現,代謝、感染毒力、對環境反應與影響細胞結構等諸多功能[11][12]

参考资料 编辑

  1. ^ Margarita Pesheva; Martin Dimitrov. Carcinogen. BoD – Books on Demand. 2012: 121. ISBN 978-953-51-0658-6. 
  2. ^ Storz, G. An expanding universe of noncoding RNAs.. Science. 2002, 296 (5571): 1260–3. PMID 12016301. doi:10.1126/science.1072249. 
  3. ^ Vazquez F, Vaucheret H, Rajagopalan R, Lepers C, Gasciolli V, Mallory AC, Hilbert JL, Bartel DP, Crété P. Endogenous trans-acting siRNAs regulate the accumulation of Arabidopsis mRNAs. Mol. Cell. October 2004, 16 (1): 69–79. PMID 15469823. doi:10.1016/j.molcel.2004.09.028. 
  4. ^ Klattenhoff C, Theurkauf W. Biogenesis and germline functions of piRNAs. Development. 2008, 135 (1): 3–9. PMID 18032451. doi:10.1242/dev.006486. 
  5. ^ Mei, Yuping; Wang, Yuyan; Kumari, Priti; Shetty, Amol Carl; Clark, David; Gable, Tyler; MacKerell, Alexander D.; Ma, Mark Z.; Weber, David J.; Yang, Austin J.; Edelman, Martin J.; Mao, Li. A piRNA-like small RNA interacts with and modulates p-ERM proteins in human somatic cells. Nature Communications. 2015, 6 (1). ISSN 2041-1723. doi:10.1038/ncomms8316. 
  6. ^ Morgado, Lionel. Diversity and types of small RNA: 37–47. 2020. doi:10.1016/B978-0-12-817112-7.00002-X. 
  7. ^ Lambert M, Benmoussa A, Provost P. Small Non-Coding RNAs Derived From Eukaryotic Ribosomal RNA.. Noncoding RNA. 2019, 5 (1). PMC 6468398 . PMID 30720712. doi:10.3390/ncrna5010016. 
  8. ^ Lu, C; Tej, SS; Luo, S; Haudenschild, CD; Meyers, BC; Green, PJ. Elucidation of the small RNA component of the transcriptome.. Science. Sep 2, 2005, 309 (5740): 1567–9. PMID 16141074. doi:10.1126/science.1114112. 
  9. ^ Ruby, J. Graham; Jan, Calvin; Player, Christopher; Axtell, Michael J.; Lee, William; Nusbaum, Chad; Ge, Hui; Bartel, David P. Large-Scale Sequencing Reveals 21U-RNAs and Additional MicroRNAs and Endogenous siRNAs in C. elegans. Cell. 2006, 127 (6): 1193–1207. ISSN 0092-8674. PMID 17174894. doi:10.1016/j.cell.2006.10.040. 
  10. ^ Wu, Qian; Lu, Zuhong; Li, Hailing; Lu, Jiafeng; Guo, Li; Ge, Qinyu. Next-Generation Sequencing of MicroRNAs for Breast Cancer Detection. Journal of Biomedicine and Biotechnology. 2011, 2011: 1–7. ISSN 1110-7243. PMC 3118289 . PMID 21716661. doi:10.1155/2011/597145. 
  11. ^ Vogel J. A rough guide to the non-coding RNA world of Salmonella. Mol. Microbiol. January 2009, 71 (1): 1–11. PMID 19007416. doi:10.1111/j.1365-2958.2008.06505.x. 
  12. ^ Felden, Brice; Vandenesch, François; Bouloc, Philippe; Romby, Pascale. The Staphylococcus aureus RNome and Its Commitment to Virulence. PLoS Pathogens. 2011-03-10, 7 (3): e1002006. ISSN 1553-7366. PMC 3053349 . PMID 21423670. doi:10.1371/journal.ppat.1002006. 

小rna, 提示, 此条目的主题不是微, small, 簡稱srna, 泛指长度小于200个核苷酸, 的rna分子, 多為非编码rna, ncrna, 真核生物中此類rna經常可與ago等蛋白結合以進行rna干擾, 抑制其他基因mrna的表現, 的種類包括微, mirna, 小干扰rna, sirna, 包含tasirna, piwi作用rna, pirna, 包含rasirna, 小核rna, snrna, 小核仁rna, snorna, 小卡哈氏體rna, scarna, tsrna, 衍生自trna的, 和s. 提示 此条目的主题不是微小RNA 小RNA small RNA 簡稱sRNA 泛指长度小于200个核苷酸 nt 的RNA分子 多為非编码RNA ncRNA 1 2 真核生物中此類RNA經常可與Ago等蛋白結合以進行RNA干擾 抑制其他基因mRNA的表現 小RNA的種類包括微小RNA miRNA 小干扰RNA siRNA 包含tasiRNA 3 piwi作用RNA piRNA 包含rasiRNA 4 5 小核RNA snRNA 小核仁RNA snoRNA 6 小卡哈氏體RNA scaRNA tsRNA 衍生自tRNA的小RNA 和srRNA 衍生自rRNA的小RNA 7 等 現有miRNA定序 英语 MicroRNA sequencing 等次世代定序 英语 next generation sequencing 技術專門用來偵測細胞中的小RNA 8 9 許多小RNA與數種癌症等疾病有關 10 miRNA与目標mRNA結合以達成RNA干擾細菌也具有許多小RNA 細菌小RNA 可與其他RNA或蛋白質結合 有調控基因表現 代謝 感染毒力 對環境反應與影響細胞結構等諸多功能 11 12 参考资料 编辑 nbsp 分子与细胞生物学主题 Margarita Pesheva Martin Dimitrov Carcinogen BoD Books on Demand 2012 121 ISBN 978 953 51 0658 6 Storz G An expanding universe of noncoding RNAs Science 2002 296 5571 1260 3 PMID 12016301 doi 10 1126 science 1072249 Vazquez F Vaucheret H Rajagopalan R Lepers C Gasciolli V Mallory AC Hilbert JL Bartel DP Crete P Endogenous trans acting siRNAs regulate the accumulation of Arabidopsis mRNAs Mol Cell October 2004 16 1 69 79 PMID 15469823 doi 10 1016 j molcel 2004 09 028 Klattenhoff C Theurkauf W Biogenesis and germline functions of piRNAs Development 2008 135 1 3 9 PMID 18032451 doi 10 1242 dev 006486 Mei Yuping Wang Yuyan Kumari Priti Shetty Amol Carl Clark David Gable Tyler MacKerell Alexander D Ma Mark Z Weber David J Yang Austin J Edelman Martin J Mao Li A piRNA like small RNA interacts with and modulates p ERM proteins in human somatic cells Nature Communications 2015 6 1 ISSN 2041 1723 doi 10 1038 ncomms8316 Morgado Lionel Diversity and types of small RNA 37 47 2020 doi 10 1016 B978 0 12 817112 7 00002 X Lambert M Benmoussa A Provost P Small Non Coding RNAs Derived From Eukaryotic Ribosomal RNA Noncoding RNA 2019 5 1 PMC 6468398 nbsp PMID 30720712 doi 10 3390 ncrna5010016 Lu C Tej SS Luo S Haudenschild CD Meyers BC Green PJ Elucidation of the small RNA component of the transcriptome Science Sep 2 2005 309 5740 1567 9 PMID 16141074 doi 10 1126 science 1114112 Ruby J Graham Jan Calvin Player Christopher Axtell Michael J Lee William Nusbaum Chad Ge Hui Bartel David P Large Scale Sequencing Reveals 21U RNAs and Additional MicroRNAs and Endogenous siRNAs in C elegans Cell 2006 127 6 1193 1207 ISSN 0092 8674 PMID 17174894 doi 10 1016 j cell 2006 10 040 Wu Qian Lu Zuhong Li Hailing Lu Jiafeng Guo Li Ge Qinyu Next Generation Sequencing of MicroRNAs for Breast Cancer Detection Journal of Biomedicine and Biotechnology 2011 2011 1 7 ISSN 1110 7243 PMC 3118289 nbsp PMID 21716661 doi 10 1155 2011 597145 Vogel J A rough guide to the non coding RNA world of Salmonella Mol Microbiol January 2009 71 1 1 11 PMID 19007416 doi 10 1111 j 1365 2958 2008 06505 x Felden Brice Vandenesch Francois Bouloc Philippe Romby Pascale The Staphylococcus aureus RNome and Its Commitment to Virulence PLoS Pathogens 2011 03 10 7 3 e1002006 ISSN 1553 7366 PMC 3053349 nbsp PMID 21423670 doi 10 1371 journal ppat 1002006 取自 https zh wikipedia org w index php title 小RNA amp oldid 73446959, 维基百科,wiki,书籍,书籍,图书馆,

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