^ 1.01.1PDB 3MV5; Freeman-Cook KD, Autry C, Borzillo G, Gordon D, Barbacci-Tobin E, Bernardo V, Briere D, Clark T, Corbett M, Jakubczak J, Kakar S, Knauth E, Lippa B, Luzzio MJ, Mansour M, Martinelli G, Marx M, Nelson K, Pandit J, Rajamohan F, Robinson S, Subramanyam C, Wei L, Wythes M, Morris J. Design of selective, ATP-competitive inhibitors of Akt. J. Med. Chem. June 2010, 53 (12): 4615–22. PMID 20481595. doi:10.1021/jm1003842.
^PDB 3D0E; Heerding DA, Rhodes N, Leber JD, Clark TJ, Keenan RM, Lafrance LV, Li M, Safonov IG, Takata DT, Venslavsky JW, Yamashita DS, Choudhry AE, Copeland RA, Lai Z, Schaber MD, Tummino PJ, Strum SL, Wood ER, Duckett DR, Eberwein D, Knick VB, Lansing TJ, McConnell RT, Zhang S, Minthorn EA, Concha NO, Warren GL, Kumar R. Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7[(3S)-3-piperidinylmethyl]oxy1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase. J. Med. Chem. September 2008, 51 (18): 5663–79. PMID 18800763. doi:10.1021/jm8004527.
^Staal SP, Hartley JW, Rowe WP. Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma. Proc. Natl. Acad. Sci. U.S.A. July 1977, 74 (7): 3065–7. PMC 431413. PMID 197531. doi:10.1073/pnas.74.7.3065.
^Garofalo RS, Orena SJ, Rafidi K, Torchia AJ, Stock JL, Hildebrandt AL, Coskran T, Black SC, Brees DJ, Wicks JR, McNeish JD, Coleman KG. Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta. J. Clin. Invest. July 2003, 112 (2): 197–208. PMC 164287. PMID 12843127. doi:10.1172/JCI16885.
^Yang ZZ, Tschopp O, Baudry A, Dümmler B, Hynx D, Hemmings BA. Physiological functions of protein kinase B/Akt. Biochem. Soc. Trans. April 2004, 32 (Pt 2): 350–4. PMID 15046607. doi:10.1042/BST0320350.
深入阅读
Los M, Maddika S, Erb B, Schulze-Osthoff K. Switching Akt: from survival signaling to deadly response. BioEssays. May 2009, 31 (5): 492–5. PMC 2954189. PMID 19319914. doi:10.1002/bies.200900005.
Quaresma AJ, Sievert R, Nickerson JA. Regulation of mRNA export by the PI3 kinase/AKT signal transduction pathway.. Mol. Biol. Cell. 2013, April (8): 1208–21. PMC 3623641. PMID 23427269. doi:10.1091/mbc.E12-06-0450.
蛋白激酶b, 亦被称为, 是在如葡萄糖代谢, 凋亡, 细胞增殖转录及细胞迁移等多种细胞过程中起到重要作用的一种丝氨酸, 苏氨酸特异性蛋白激酶, 英语, serine, threonine, specific, protein, kinase, akt鼠胸腺瘤病毒癌基因同源物1akt, 抑制复合体的晶体结构, 識別符號, akt1entrez, 207hugo, 391omim, 164730refseq, 005163uniprot, p31749其他資料基因座, akt鼠胸腺瘤病毒癌基因同源物1以丝带模型表示的a. Akt 亦被称为蛋白激酶B PKB 是在如葡萄糖代谢 凋亡 细胞增殖转录及细胞迁移等多种细胞过程中起到重要作用的一种丝氨酸 苏氨酸特异性蛋白激酶 英语 serine threonine specific protein kinase v akt鼠胸腺瘤病毒癌基因同源物1Akt 1 抑制复合体的晶体结构 1 識別符號 AKT1Entrez 207HUGO 391OMIM 164730RefSeq NM 005163UniProt P31749其他資料基因座 14 q32 32 32 33v akt鼠胸腺瘤病毒癌基因同源物1以丝带模型表示的Akt 1 抑制复合体的晶体结构 1 識別符號 AKT1Entrez 207HUGO 391OMIM 164730RefSeq NM 005163UniProt P31749其他資料基因座 14 q32 32 32 33v akt鼠胸腺瘤病毒癌基因同源物2Akt 2 抑制复合体的晶体结构 2 識別符號 AKT2Entrez 208HUGO 392OMIM 164731RefSeq NM 001626UniProt P31751其他資料基因座 19 q13 1 13 2v akt鼠胸腺瘤病毒癌基因同源物3 蛋白激酶B g 識別符號 AKT3Entrez 10000HUGO 393RefSeq NM 181690UniProt Q9Y243其他資料基因座 1 q43 44 目录 1 家族成员 2 参考文献 3 深入阅读 4 外部链接家族成员 编辑Akt1通过抑制凋亡过程从而参与细胞存活途径 Akt1亦能诱导蛋白合成通路 故其在导致骨骼肌肥大及的一般组织生长的细胞通路中是一种重要信号蛋白 因其可以阻断凋亡并继而促进细胞存活 现已表明Akt1在多种肿瘤中起到主要作用 Akt 先亦被称为Akt1 首先是在转化逆转录病毒AKT8中被鉴定为癌基因的 3 Akt2在胰岛素信号通路中是一重要的信号分子 需要其来诱导葡萄糖转运 在敲除Akt1但具正常Akt2的小鼠中 血糖稳态不受干扰 但动物体型会较小 这与Akt1在生长中起得作用是一致的 相反 Akt2缺失但具有正常Akt1的的小鼠生长略缺陷且表现出糖尿病表型 胰岛素抵抗 这从另一方面印证了Akt2对胰岛素受体信号通路更具特异性的这一设想 4 Akt3似乎主要在脑中表达 但其作用仍未明晰 有报道显示Akt3缺失的小鼠脑部较小 5 参考文献 编辑 1 0 1 1 PDB 3MV5 Freeman Cook KD Autry C Borzillo G Gordon D Barbacci Tobin E Bernardo V Briere D Clark T Corbett M Jakubczak J Kakar S Knauth E Lippa B Luzzio MJ Mansour M Martinelli G Marx M Nelson K Pandit J Rajamohan F Robinson S Subramanyam C Wei L Wythes M Morris J Design of selective ATP competitive inhibitors of Akt J Med Chem June 2010 53 12 4615 22 PMID 20481595 doi 10 1021 jm1003842 PDB 3D0E Heerding DA Rhodes N Leber JD Clark TJ Keenan RM Lafrance LV Li M Safonov IG Takata DT Venslavsky JW Yamashita DS Choudhry AE Copeland RA Lai Z Schaber MD Tummino PJ Strum SL Wood ER Duckett DR Eberwein D Knick VB Lansing TJ McConnell RT Zhang S Minthorn EA Concha NO Warren GL Kumar R Identification of 4 2 4 amino 1 2 5 oxadiazol 3 yl 1 ethyl 7 3S 3 piperidinylmethyl oxy1H imidazo 4 5 c pyridin 4 yl 2 methyl 3 butyn 2 ol GSK690693 a novel inhibitor of AKT kinase J Med Chem September 2008 51 18 5663 79 PMID 18800763 doi 10 1021 jm8004527 Staal SP Hartley JW Rowe WP Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma Proc Natl Acad Sci U S A July 1977 74 7 3065 7 PMC 431413 PMID 197531 doi 10 1073 pnas 74 7 3065 Garofalo RS Orena SJ Rafidi K Torchia AJ Stock JL Hildebrandt AL Coskran T Black SC Brees DJ Wicks JR McNeish JD Coleman KG Severe diabetes age dependent loss of adipose tissue and mild growth deficiency in mice lacking Akt2 PKB beta J Clin Invest July 2003 112 2 197 208 PMC 164287 PMID 12843127 doi 10 1172 JCI16885 Yang ZZ Tschopp O Baudry A Dummler B Hynx D Hemmings BA Physiological functions of protein kinase B Akt Biochem Soc Trans April 2004 32 Pt 2 350 4 PMID 15046607 doi 10 1042 BST0320350 深入阅读 编辑Los M Maddika S Erb B Schulze Osthoff K Switching Akt from survival signaling to deadly response BioEssays May 2009 31 5 492 5 PMC 2954189 PMID 19319914 doi 10 1002 bies 200900005 Quaresma AJ Sievert R Nickerson JA Regulation of mRNA export by the PI3 kinase AKT signal transduction pathway Mol Biol Cell 2013 April 8 1208 21 PMC 3623641 PMID 23427269 doi 10 1091 mbc E12 06 0450 外部链接 编辑醫學主題詞表 MeSH Proto Oncogene Proteins c akt 取自 https zh wikipedia org w index php title 蛋白激酶B amp oldid 73840257, 维基百科，wiki，书籍，书籍，图书馆，
