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莫克雌醇

莫克雌醇(英語:Moxestrol)是一种雌激素类药物,商品名Surestryl,化学名为11β-甲氧基乙炔雌二醇,与RU-16117是11β-差向异构体,用于治疗更年期综合症月经失调,在欧洲有上市销售[3][4][2][5][6]

莫克雌醇
臨床資料
商品名英语Drug nomenclatureSurestryl
其他名稱R-2858, RU-2858, NSC-118191; 11β-Methoxy-17α-ethynylestradiol; 11β-MeO-EE 11β-Methoxy-17α-ethynylestra-1,3,5(10)-triene-3,17β-diol
懷孕分級
  • X (Contraindicated)
给药途径口服
藥物類別英语Drug classEstrogen; Estrogen ether
ATC碼
  • G03CB04 (WHO)
法律規範狀態
法律規範
  • 处方药(-only)
藥物動力學數據
生物利用度33%[1]
血漿蛋白結合率Minimal[1]
药物代谢Liver[2]
生物半衰期8.2 hours[1]
识别信息
CAS号34816-55-2  
PubChem CID
  • 11954041
ChemSpider
  • 10128336
UNII
  • 6923NT44OW
KEGG
  • C14757
ChEBI
  • CHEBI:34857
ChEMBL
  • ChEMBL1628161
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
  • DTXSID8022375
化学信息
化学式C21H26O3
摩尔质量326.44 g·mol−1
3D模型(JSmol英语JSmol
  • 交互式图像

参考资料

  1. ^ 1.0 1.1 1.2 Salmon, J.; Coussediere, D.; Cousty, C.; Raynaud, J.P. Pharmacokinetics and metabolism of moxestrol in animals—rat, dog and monkey. Journal of Steroid Biochemistry. 1983, 19 (2): 1223–1234. ISSN 0022-4731. PMID 6887930. doi:10.1016/0022-4731(83)90421-1. 
  2. ^ 2.0 2.1 Jonathan J. Li; Satyabrata Nandi; Sara A. Li. Hormonal Carcinogenesis: Proceedings of the First International Symposium. Springer Science & Business Media. 6 December 2012: 184– [2021-11-30]. ISBN 978-1-4613-9208-8. (原始内容于2021-11-30). 
  3. ^ J. Elks. The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014: 841– [2021-11-30]. ISBN 978-1-4757-2085-3. (原始内容于2021-11-30). 
  4. ^ Dr. Ian Morton; I.K. Morton; Judith M. Hall. Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. 31 October 1999: 186– [2021-11-30]. ISBN 978-0-7514-0499-9. (原始内容于2021-11-30). 
  5. ^ Adrain D. Nunn. Radiopharmaceuticals: Chemistry and Pharmacology. CRC Press. 19 June 1992: 342– [2021-11-30]. ISBN 978-0-8247-8624-3. (原始内容于2021-11-30). 
  6. ^ William Martindale; Royal Pharmaceutical Society of Great Britain. Dept. of Pharmaceutical Sciences. The Extra Pharmacopoeia. Pharmaceutical Press. 1993: 1188 [2021-11-30]. ISBN 978-0-85369-300-0. (原始内容于2021-11-30). Moxestrol is a synthetic oestrogen with actions and uses similar to thosre described for the oestrogens in general. Moxestrol is reponed to have a prolonged duration of action. It has been given by mouth in the treatment of menopausal, postmenopausal, and menstrual symptoms. Dose have ranged from 50 to 100 µg weekly for long-term therapy to 25 to 250 µg daily for short-term use. 

莫克雌醇, 英語, moxestrol, 是一种雌激素类药物, 商品名surestryl, 化学名为11β, 甲氧基乙炔雌二醇, 与ru, 16117是11β, 差向异构体, 用于治疗更年期综合症和月经失调, 在欧洲有上市销售, 臨床資料商品名, 英语, drug, nomenclature, surestryl其他名稱r, 2858, 2858, 118191, 11β, methoxy, 17α, ethynylestradiol, 11β, 11β, methoxy, 17α, ethynylestra, t. 莫克雌醇 英語 Moxestrol 是一种雌激素类药物 商品名Surestryl 化学名为11b 甲氧基乙炔雌二醇 与RU 16117是11b 差向异构体 用于治疗更年期综合症和月经失调 在欧洲有上市销售 3 4 2 5 6 莫克雌醇臨床資料商品名 英语 Drug nomenclature Surestryl其他名稱R 2858 RU 2858 NSC 118191 11b Methoxy 17a ethynylestradiol 11b MeO EE 11b Methoxy 17a ethynylestra 1 3 5 10 triene 3 17b diol懷孕分級X Contraindicated 给药途径口服藥物類別 英语 Drug class Estrogen Estrogen etherATC碼G03CB04 WHO 法律規範狀態法律規範处方药 only 藥物動力學數據生物利用度33 1 血漿蛋白結合率Minimal 1 药物代谢Liver 2 生物半衰期8 2 hours 1 识别信息IUPAC命名法 8S 9S 11S 13S 14S 17R 17 ethynyl 11 methoxy 13 methyl 7 8 9 11 12 14 15 16 octahydro 6H cyclopenta a phenanthrene 3 17 diolCAS号34816 55 2 PubChem CID11954041ChemSpider10128336UNII6923NT44OWKEGGC14757ChEBICHEBI 34857ChEMBLChEMBL1628161CompTox Dashboard 英语 CompTox Chemicals Dashboard EPA DTXSID8022375化学信息化学式C 21H 26O 3摩尔质量326 44 g mol 13D模型 JSmol 英语 JSmol 交互式图像SMILES CC12CC C3C C1CCC2 C C O CCC4 C3C CC C4 O OCInChI InChI 1S C21H26O3 c1 4 21 23 10 9 17 16 7 5 13 11 14 22 6 8 15 13 19 16 18 24 3 12 20 17 21 2 h1 6 8 11 16 19 22 23H 5 7 9 10 12H2 2 3H3 t16 17 18 19 20 21 m0 s1Key MTMZZIPTQITGCY OLGWUGKESA N参考资料 编辑 1 0 1 1 1 2 Salmon J Coussediere D Cousty C Raynaud J P Pharmacokinetics and metabolism of moxestrol in animals rat dog and monkey Journal of Steroid Biochemistry 1983 19 2 1223 1234 ISSN 0022 4731 PMID 6887930 doi 10 1016 0022 4731 83 90421 1 2 0 2 1 Jonathan J Li Satyabrata Nandi Sara A Li Hormonal Carcinogenesis Proceedings of the First International Symposium Springer Science amp Business Media 6 December 2012 184 2021 11 30 ISBN 978 1 4613 9208 8 原始内容存档于2021 11 30 J Elks The Dictionary of Drugs Chemical Data Chemical Data Structures and Bibliographies Springer 14 November 2014 841 2021 11 30 ISBN 978 1 4757 2085 3 原始内容存档于2021 11 30 Dr Ian Morton I K Morton Judith M Hall Concise Dictionary of Pharmacological Agents Properties and Synonyms Springer Science amp Business Media 31 October 1999 186 2021 11 30 ISBN 978 0 7514 0499 9 原始内容存档于2021 11 30 Adrain D Nunn Radiopharmaceuticals Chemistry and Pharmacology CRC Press 19 June 1992 342 2021 11 30 ISBN 978 0 8247 8624 3 原始内容存档于2021 11 30 William Martindale Royal Pharmaceutical Society of Great Britain Dept of Pharmaceutical Sciences The Extra Pharmacopoeia Pharmaceutical Press 1993 1188 2021 11 30 ISBN 978 0 85369 300 0 原始内容存档于2021 11 30 Moxestrol is a synthetic oestrogen with actions and uses similar to thosre described for the oestrogens in general Moxestrol is reponed to have a prolonged duration of action It has been given by mouth in the treatment of menopausal postmenopausal and menstrual symptoms Dose have ranged from 50 to 100 µg weekly for long term therapy to 25 to 250 µg daily for short term use 取自 https zh wikipedia org w index php title 莫克雌醇 amp oldid 76593839, 维基百科,wiki,书籍,书籍,图书馆,

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