^Südhof TC, Lottspeich F, Greengard P, Mehl E, Jahn R. The cDNA and derived amino acid sequences for rat and human synaptophysin. Nucleic Acids Res. November 1987, 15 (22): 9607. PMC 306499. PMID 3120152. doi:10.1093/nar/15.22.9607.
^Calhoun ME, Jucker M（英语：Mathias Jucker (neuroscientist)）, Martin LJ, Thinakaran G, Price DL, Mouton PR. Comparative evaluation of synaptophysin-based methods for quantification of synapses. J. Neurocytol. December 1996, 25 (12): 821–8. PMID 9023727. doi:10.1007/BF02284844.温哥华格式错误 (帮助)
^McMahon HT, Bolshakov VY, Janz R, Hammer RE, Siegelbaum SA, Südhof TC. Synaptophysin, a major synaptic vesicle protein, is not essential for neurotransmitter release. Proc. Natl. Acad. Sci. U.S.A. May 1996, 93 (10): 4760–4. Bibcode:1996PNAS...93.4760M. PMC 39352. PMID 8643476. doi:10.1073/pnas.93.10.4760.
^Schmitt U, Tanimoto N, Seeliger M, Schaeffel F, Leube RE. Detection of behavioral alterations and learning deficits in mice lacking synaptophysin. Neuroscience. August 2009, 162 (2): 234–43. CiteSeerX 10.1.1.320.5309. PMID 19393300. doi:10.1016/j.neuroscience.2009.04.046.
^Horikawa HP, Kneussel M, El Far O, Betz H. Interaction of synaptophysin with the AP-1 adaptor protein gamma-adaptin. Mol. Cell. Neurosci. November 2002, 21 (3): 454–62. PMID 12498786. doi:10.1006/mcne.2002.1191.
^Wheeler TC, Chin LS, Li Y, Roudabush FL, Li L. Regulation of synaptophysin degradation by mammalian homologues of seven in absentia. J. Biol. Chem. March 2002, 277 (12): 10273–82. PMID 11786535. doi:10.1074/jbc.M107857200.
延伸閱讀
Kalina M, Lukinius A, Grimelius L, Höög A, Falkmer S. Ultrastructural localization of synaptophysin to the secretory granules of normal glucagon and insulin cells in human islets of Langerhans. Ultrastructural Pathology. 1991, 15 (3): 215–9. PMID 1908157. doi:10.3109/01913129109021883.
Ozçelik T, Lafreniere RG, Archer BT, Johnston PA, Willard HF, Francke U, Südhof TC. Synaptophysin: structure of the human gene and assignment to the X chromosome in man and mouse. Am. J. Hum. Genet. 1990, 47 (3): 551–61. PMC 1683862. PMID 1975480.
Goto S, Hirano A, Pearson J. Calcineurin and synaptophysin in the human spinal cord of normal individuals and patients with familial dysautonomia. Acta Neuropathol. 1990, 79 (6): 647–52. PMID 2163183. doi:10.1007/BF00294243.
de Koning JP, Schelen AM, Dong F, van Buitenen C, Burgering BM, Bos JL, Löwenberg B, Touw IP. Specific involvement of tyrosine 764 of human granulocyte colony-stimulating factor receptor in signal transduction mediated by p145/Shc/GRB2 or p90/GRB2 complexes. Blood. 1996, 87 (1): 132–40. PMID 8547634. doi:10.1182/blood.V87.1.132.132.
Zhang PJ, Rosenblum MK. Synaptophysin expression in the human spinal cord. Diagnostic implications of an immunohistochemical study. Am. J. Surg. Pathol. 1997, 20 (3): 273–6. PMID 8772779. doi:10.1097/00000478-199603000-00002.
Bouwens L, Lu WG, De Krijger R. Proliferation and differentiation in the human fetal endocrine pancreas. Diabetologia. 1997, 40 (4): 398–404. PMID 9112016. doi:10.1007/s001250050693.
Fisher SE, Ciccodicola A, Tanaka K, Curci A, Desicato S, D'urso M, Craig IW. Sequence-based exon prediction around the synaptophysin locus reveals a gene-rich area containing novel genes in human proximal Xp. Genomics. 1998, 45 (2): 340–7. PMID 9344658. doi:10.1006/geno.1997.4941. hdl:11858/00-001M-0000-0012-CBE6-7.
Maggiano N, Lauriola L, Serra FG, Ricci R, Capelli A, Ranelletti FO. Detection of synaptophysin-producing cells in human thymus by immunohistochemistry and nonradioactive in situ hybridization. J. Histochem. Cytochem. 1999, 47 (2): 237–43. PMID 9889259. doi:10.1177/002215549904700212.
Portela-Gomes GM, Stridsberg M, Johansson H, Grimelius L. Co-localization of synaptophysin with different neuroendocrine hormones in the human gastrointestinal tract. Histochem. Cell Biol. 1999, 111 (1): 49–54. PMID 9930883. doi:10.1007/s004180050332.
Davidsson P, Gottfries J, Bogdanovic N, Ekman R, Karlsson I, Gottfries CG, Blennow K. The synaptic-vesicle-specific proteins rab3a and synaptophysin are reduced in thalamus and related cortical brain regions in schizophrenic brains. Schizophrenia Research（英语：Schizophrenia Research）. 1999, 40 (1): 23–9. PMID 10541003. doi:10.1016/S0920-9964(99)00037-7.
Cassiman D, van Pelt J, De Vos R, Van Lommel F, Desmet V, Yap SH, Roskams T. Synaptophysin: A Novel Marker for Human and Rat Hepatic Stellate Cells. Am. J. Pathol. 1999, 155 (6): 1831–9. PMC 1866940. PMID 10595912. doi:10.1016/S0002-9440(10)65501-0.
Thiele C, Hannah MJ, Fahrenholz F, Huttner WB. Cholesterol binds to synaptophysin and is required for biogenesis of synaptic vesicles. Nat. Cell Biol. 2000, 2 (1): 42–9. PMID 10620806. doi:10.1038/71366.
Nag TC, Wadhwa S. Differential expression of syntaxin-1 and synaptophysin in the developing and adult human retina. J. Biosci. 2001, 26 (2): 179–91. PMID 11426054. doi:10.1007/BF02703642.
Roudenok V, Kühnel W. The development of synaptophysin immunoreactivity in the human sympathetic ganglia. Ann. Anat. 2001, 183 (4): 345–51. PMID 11508360. doi:10.1016/S0940-9602(01)80177-1.
Wheeler TC, Chin LS, Li Y, Roudabush FL, Li L. Regulation of synaptophysin degradation by mammalian homologues of seven in absentia. J. Biol. Chem. 2002, 277 (12): 10273–82. PMID 11786535. doi:10.1074/jbc.M107857200.
Ulfig N, Chan WY. Expression of a kinase anchoring protein 79 and synaptophysin in the developing human red nucleus. Neurosignals. 2003, 11 (2): 95–102. PMID 12077483. doi:10.1159/000058546.
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Wistow G, Bernstein SL, Wyatt MK, Ray S, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K. Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts. Mol. Vis. 2002, 8: 196–204. PMID 12107411.
Template:Tumor markers Template:Nerve tissue protein
一月 26, 2023
突觸素, synaptophysin, 又稱主要突觸小泡蛋白p38, major, synaptic, vesicle, protein, 是一種人體中由, 基因轉譯而成的蛋白質, 識別號别名syp, mrx96, mrxsynaptophysin, xlid96外部idomim, 313475, 98467, homologene, 2391, genecards, syp基因位置, 人类, 染色体x染色體, 基因座xp11, 23起始49, 终止49, 基因位置, 小鼠, 染色体小鼠x染色体, 基因座x, cm. 突觸素 Synaptophysin 又稱主要突觸小泡蛋白p38 major synaptic vesicle protein p38 是一種人體中由 SYP 基因轉譯而成的蛋白質 5 6 突觸素識別號别名SYP MRX96 MRXsynaptophysin XLID96外部IDOMIM 313475 MGI 98467 HomoloGene 2391 GeneCards SYP基因位置 人类 染色体X染色體 1 基因座Xp11 23起始49 187 815 bp 1 终止49 200 218 bp 1 基因位置 小鼠 染色体小鼠X染色体 2 基因座X A1 1 X 3 44 cM起始7 504 710 bp 2 终止7 519 495 bp 2 RNA表达模式查阅更多表达数据基因本體分子功能 SH2 domain binding 蛋白質自締合 cholesterol binding 相同蛋白质结合 syntaxin 1 binding細胞組分 integral component of membrane 膜 突觸小泡 突触 興奮性突觸 synaptic vesicle membrane presynaptic active zone 细胞连接 末梢神經 integral component of synaptic vesicle membrane neuron projection neuron projection terminus presynaptic membrane cytoplasmic vesicle 神经肌肉接点 Schaffer collateral CA1 synapse 细胞质的核周区域生物學過程 cellular response to organic substance regulation of long term neuronal synaptic plasticity 內吞作用 regulation of opioid receptor signaling pathway regulation of short term neuronal synaptic plasticity synaptic vesicle membrane organization regulation of neuronal synaptic plasticity synaptic vesicle maturation synaptic vesicle endocytosis regulation of synaptic vesicle exocytosisSources Amigo QuickGO直系同源物種人類小鼠Entrez685520977EnsemblENSG00000102003ENSMUSG00000031144UniProtP08247Q62277mRNA 序列NM 003179NM 009305蛋白序列NP 003170NP 033331基因位置 UCSC Chr X 49 19 49 2 MbChr X 7 5 7 52 MbPubMed 查找 3 4 維基數據檢視 編輯人類檢視 編輯小鼠 目录 1 遺傳學 2 分子生物學 3 交互作用 4 參見 5 參考文獻 6 延伸閱讀 7 外部連結遺傳學 编辑該基因位於X染色體的短臂上 Xp11 23 p11 22 約由12 406個鹼基對所構成 位於反義股上 該蛋白由313個胺基所構成 分子量約為33 845kDa 分子生物學 编辑該蛋白質為突触小泡上的醣蛋白 擁有四個穿膜區 該蛋白主要表現於神經內分泌細胞 基本上只要擁有突觸傳輸功能的神經元皆會表達 在免疫染色組織學上 該蛋白常被作為神經內分泌腫瘤的標誌蛋白 或是用於突觸豐度的定量 7 目前該蛋白的確切功能尚未闡明 僅知他會與重要的突觸蛋白synaptobrevin 英语 synaptobrevin 產生交互作用 但在動物實驗中 即使將突觸素的基因敲除 似乎並沒有對動物的發育或功能上產生任何影響 8 近期研究顯示 突觸素的缺失可能導致小鼠出現行為異常 例如探索行為增加 新奇物辨識 object novelty recognition 以及空間感上產生影響 9 交互作用 编辑突觸素可與AP1G1 英语 AP1G1 10 和SIAH2 英语 SIAH2 11 產生交互作用 參見 编辑人類基因列表 英语 List of human genes 參考文獻 编辑 1 0 1 1 1 2 GRCh38 Ensembl release 89 ENSG00000102003 Ensembl May 2017 2 0 2 1 2 2 GRCm38 Ensembl release 89 ENSMUSG00000031144 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene SYP synaptophysin 2021 01 14 原始内容存档于2010 12 05 Sudhof TC Lottspeich F Greengard P Mehl E Jahn R The cDNA and derived amino acid sequences for rat and human synaptophysin Nucleic Acids Res November 1987 15 22 9607 PMC 306499 PMID 3120152 doi 10 1093 nar 15 22 9607 Calhoun ME Jucker M 英语 Mathias Jucker neuroscientist Martin LJ Thinakaran G Price DL Mouton PR Comparative evaluation of synaptophysin based methods for quantification of synapses J Neurocytol December 1996 25 12 821 8 PMID 9023727 doi 10 1007 BF02284844 温哥华格式错误 帮助 McMahon HT Bolshakov VY Janz R Hammer RE Siegelbaum SA Sudhof TC Synaptophysin a major synaptic vesicle protein is not essential for neurotransmitter release Proc Natl Acad Sci U S A May 1996 93 10 4760 4 Bibcode 1996PNAS 93 4760M PMC 39352 PMID 8643476 doi 10 1073 pnas 93 10 4760 Schmitt U Tanimoto N Seeliger M Schaeffel F Leube RE Detection of behavioral alterations and learning deficits in mice lacking synaptophysin Neuroscience August 2009 162 2 234 43 CiteSeerX 10 1 1 320 5309 PMID 19393300 doi 10 1016 j neuroscience 2009 04 046 Horikawa HP Kneussel M El Far O Betz H Interaction of synaptophysin with the AP 1 adaptor protein gamma adaptin Mol Cell Neurosci November 2002 21 3 454 62 PMID 12498786 doi 10 1006 mcne 2002 1191 Wheeler TC Chin LS Li Y Roudabush FL Li L Regulation of synaptophysin degradation by mammalian homologues of seven in absentia J Biol Chem March 2002 277 12 10273 82 PMID 11786535 doi 10 1074 jbc M107857200 延伸閱讀 编辑Kalina M Lukinius A Grimelius L Hoog A Falkmer S Ultrastructural localization of synaptophysin to the secretory granules of normal glucagon and insulin cells in human islets of Langerhans Ultrastructural Pathology 1991 15 3 215 9 PMID 1908157 doi 10 3109 01913129109021883 Ozcelik T Lafreniere RG Archer BT Johnston PA Willard HF Francke U Sudhof TC Synaptophysin structure of the human gene and assignment to the X chromosome in man and mouse Am J Hum Genet 1990 47 3 551 61 PMC 1683862 PMID 1975480 Goto S Hirano A Pearson J Calcineurin and synaptophysin in the human spinal cord of normal individuals and patients with familial dysautonomia Acta Neuropathol 1990 79 6 647 52 PMID 2163183 doi 10 1007 BF00294243 de Koning JP Schelen AM Dong F van Buitenen C Burgering BM Bos JL Lowenberg B Touw IP Specific involvement of tyrosine 764 of human granulocyte colony stimulating factor receptor in signal transduction mediated by p145 Shc GRB2 or p90 GRB2 complexes Blood 1996 87 1 132 40 PMID 8547634 doi 10 1182 blood V87 1 132 132 Zhang PJ Rosenblum MK Synaptophysin expression in the human spinal cord Diagnostic implications of an immunohistochemical study Am J Surg Pathol 1997 20 3 273 6 PMID 8772779 doi 10 1097 00000478 199603000 00002 Bouwens L Lu WG De Krijger R Proliferation and differentiation in the human fetal endocrine pancreas Diabetologia 1997 40 4 398 404 PMID 9112016 doi 10 1007 s001250050693 Fisher SE Ciccodicola A Tanaka K Curci A Desicato S D urso M Craig IW Sequence based exon prediction around the synaptophysin locus reveals a gene rich area containing novel genes in human proximal Xp Genomics 1998 45 2 340 7 PMID 9344658 doi 10 1006 geno 1997 4941 hdl 11858 00 001M 0000 0012 CBE6 7 Maggiano N Lauriola L Serra FG Ricci R Capelli A Ranelletti FO Detection of synaptophysin producing cells in human thymus by immunohistochemistry and nonradioactive in situ hybridization J Histochem Cytochem 1999 47 2 237 43 PMID 9889259 doi 10 1177 002215549904700212 Portela Gomes GM Stridsberg M Johansson H Grimelius L Co localization of synaptophysin with different neuroendocrine hormones in the human gastrointestinal tract Histochem Cell Biol 1999 111 1 49 54 PMID 9930883 doi 10 1007 s004180050332 Davidsson P Gottfries J Bogdanovic N Ekman R Karlsson I Gottfries CG Blennow K The synaptic vesicle specific proteins rab3a and synaptophysin are reduced in thalamus and related cortical brain regions in schizophrenic brains Schizophrenia Research 英语 Schizophrenia Research 1999 40 1 23 9 PMID 10541003 doi 10 1016 S0920 9964 99 00037 7 Cassiman D van Pelt J De Vos R Van Lommel F Desmet V Yap SH Roskams T Synaptophysin A Novel Marker for Human and Rat Hepatic Stellate Cells Am J Pathol 1999 155 6 1831 9 PMC 1866940 PMID 10595912 doi 10 1016 S0002 9440 10 65501 0 Thiele C Hannah MJ Fahrenholz F Huttner WB Cholesterol binds to synaptophysin and is required for biogenesis of synaptic vesicles Nat Cell Biol 2000 2 1 42 9 PMID 10620806 doi 10 1038 71366 Nag TC Wadhwa S Differential expression of syntaxin 1 and synaptophysin in the developing and adult human retina J Biosci 2001 26 2 179 91 PMID 11426054 doi 10 1007 BF02703642 Bhangu PS Genever PG Spencer GJ Grewal TS Skerry TM Evidence for targeted vesicular glutamate exocytosis in osteoblasts Bone 2001 29 1 16 23 PMID 11472886 doi 10 1016 S8756 3282 01 00482 3 Roudenok V Kuhnel W The development of synaptophysin immunoreactivity in the human sympathetic ganglia Ann Anat 2001 183 4 345 51 PMID 11508360 doi 10 1016 S0940 9602 01 80177 1 Wheeler TC Chin LS Li Y Roudabush FL Li L Regulation of synaptophysin degradation by mammalian homologues of seven in absentia J Biol Chem 2002 277 12 10273 82 PMID 11786535 doi 10 1074 jbc M107857200 Ulfig N Chan WY Expression of a kinase anchoring protein 79 and synaptophysin in the developing human red nucleus Neurosignals 2003 11 2 95 102 PMID 12077483 doi 10 1159 000058546 Yao I Iida J Nishimura W Hata Y Synaptic and nuclear localization of brain enriched guanylate kinase associated protein J Neurosci 2002 22 13 5354 64 PMC 6758191 PMID 12097487 doi 10 1523 JNEUROSCI 22 13 05354 2002 Wistow G Bernstein SL Wyatt MK Ray S Behal A Touchman JW Bouffard G Smith D Peterson K Expressed sequence tag analysis of human retina for the NEIBank Project retbindin an abundant novel retinal cDNA and alternative splicing of other retina preferred gene transcripts Mol Vis 2002 8 196 204 PMID 12107411 外部連結 编辑醫學主題詞表 MeSH SynaptophysinTemplate Tumor markers Template Nerve tissue protein 取自 https zh wikipedia org w index php title 突觸素 amp oldid 72622218, 维基百科，wiki，书籍，书籍，图书馆，
