^ 1.01.11.2Kuhl H. Pharmacokinetics of oestrogens and progestogens. Maturitas. September 1990, 12 (3): 171–97. PMID 2170822. doi:10.1016/0378-5122(90)90003-O.
^ 2.02.12.2Jin Y, Duan L, Chen M, Penning TM, Kloosterboer HJ. Metabolism of the synthetic progestogen norethynodrel by human ketosteroid reductases of the aldo-keto reductase superfamily. J. Steroid Biochem. Mol. Biol. 2012, 129 (3–5): 139–44. PMC 3303946. PMID 22210085. doi:10.1016/j.jsbmb.2011.12.002.
^ 3.03.13.23.33.4Kuhl H. Pharmacology of estrogens and progestogens: influence of different routes of administration (PDF). Climacteric. 2005,. 8 Suppl 1: 3–63 [2019-06-30]. PMID 16112947. doi:10.1080/13697130500148875. (原始内容 (PDF)于2016-08-22).
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一月 28, 2023
异炔诺酮, 英語, noretynodrel, 英語, norethynodrel, 商品名, enovid等, 是一种黄体制剂药物, 过去被用于口服避孕药以及治疗一些妇科疾病, 但现在已不再使用, 和炔诺酮的不同之处在于双键位于5, 号位而非4, 号位, 臨床資料商品名, 英语, drug, nomenclature, enovid, with, mestranol, others其他名稱norethynodrel, noretinodrel, norethinodrel, 4642, 15432, noreth. 异炔诺酮 英語 Noretynodrel 或 英語 norethynodrel 商品名 Enovid等 是一种黄体制剂药物 过去被用于口服避孕药以及治疗一些妇科疾病 但现在已不再使用 3 6 7 8 异炔诺酮和炔诺酮的不同之处在于双键位于5 10 号位而非4 5 号位 异炔诺酮臨床資料商品名 英语 Drug nomenclature Enovid with mestranol others其他名稱Norethynodrel Noretinodrel Norethinodrel NYD SC 4642 NSC 15432 5 10 Norethisterone 17a Ethinyl 19 nor 5 10 testosterone 17a Ethynyl d5 10 19 nortestosterone 17a Ethynylestr 5 10 en 17b ol 3 one 19 Nor 17a pregn 5 10 en 20 yn 17b ol 3 one给药途径口服给药藥物類別 英语 Drug class Progestin Progestogen EstrogenATC碼G03FA09 WHO 藥物動力學數據血漿蛋白結合率Noretynodrel to albumin and not to SHBG or CBG 1 药物代谢Liver intestines hydroxylation isomerization conjugation 1 3 代謝產物 3a Hydroxynoretynodrel 2 3b Hydroxynoretynodrel 2 Norethisterone 2 1 3 Ethinylestradiol 3 4 Conjugates 3 生物半衰期Very short lt 30 minutes 5 排泄途徑Breast milk 1 6 识别信息IUPAC命名法 8R 9S 13S 14S 17R 17 ethynyl 17 hydroxy 13 methyl 1 2 4 6 7 8 9 11 12 14 15 16 dodecahydrocyclopenta a phenanthren 3 oneCAS号68 23 5 PubChem CID6231DrugBankDB09371 ChemSpider5995 UNII88181ACA0MKEGGD05207ChEBICHEBI 34895 ChEMBLChEMBL1387 CompTox Dashboard 英语 CompTox Chemicals Dashboard EPA DTXSID3021069ECHA InfoCard100 000 620化学信息化学式C 20H 26O 2摩尔质量298 419 g mol3D模型 JSmol 英语 JSmol 交互式图像SMILES O C4CCC 1 C CC C H 2 C H 1CC C 3 C H 2CC C 3 C C O C C4InChI InChI 1S C20H26O2 c1 3 20 22 11 9 18 17 6 4 13 12 14 21 5 7 15 13 16 17 8 10 19 18 20 2 h1 16 18 22H 4 12H2 2H3 t16 17 18 19 20 m1 s1 Key ICTXHFFSOAJUMG SLHNCBLASA N 参考文献 编辑 1 0 1 1 1 2 Kuhl H Pharmacokinetics of oestrogens and progestogens Maturitas September 1990 12 3 171 97 PMID 2170822 doi 10 1016 0378 5122 90 90003 O 2 0 2 1 2 2 Jin Y Duan L Chen M Penning TM Kloosterboer HJ Metabolism of the synthetic progestogen norethynodrel by human ketosteroid reductases of the aldo keto reductase superfamily J Steroid Biochem Mol Biol 2012 129 3 5 139 44 PMC 3303946 PMID 22210085 doi 10 1016 j jsbmb 2011 12 002 3 0 3 1 3 2 3 3 3 4 Kuhl H Pharmacology of estrogens and progestogens influence of different routes of administration PDF Climacteric 2005 8 Suppl 1 3 63 2019 06 30 PMID 16112947 doi 10 1080 13697130500148875 原始内容存档 PDF 于2016 08 22 Kuhl H Pharmacology of Progestogens PDF J Reproduktionsmed Endokrinol 2011 8 1 157 177 2019 07 10 原始内容存档 PDF 于2016 10 11 Hammerstein J Prodrugs advantage or disadvantage Am J Obstet Gynecol 1990 163 6 Pt 2 2198 203 PMID 2256526 6 0 6 1 Sweetman Sean C 编 Sex hormones and their modulators Martindale The Complete Drug Reference 36th London Pharmaceutical Press 2009 2120 2121 ISBN 978 0 85369 840 1 Jucker Progress in Drug Research Fortschritte der Arzneimittelforschung Progres des recherches pharmaceutiques Birkhauser 21 December 2013 85 88 2019 06 30 ISBN 978 3 0348 7065 8 原始内容存档于2021 03 14 Lara Marks Sexual Chemistry A History of the Contraceptive Pill Yale University Press 2010 74 75 ISBN 978 0 300 16791 7 取自 https zh wikipedia org w index php title 异炔诺酮 amp oldid 72350502, 维基百科,wiki,书籍,书籍,图书馆,