^Conte C, Ebeling M, Marcuz A, Nef P, Andres-Barquin PJ. Identification and characterization of human taste receptor genes belonging to the TAS2R family. Cytogenet. Genome Res. 2002, 98 (1): 45–53. PMID 12584440. doi:10.1159/000068546.
^Drayna D, Coon H, Kim UK, Elsner T, Cromer K, Otterud B, Baird L, Peiffer AP, Leppert M. Genetic analysis of a complex trait in the Utah Genetic Reference Project: a major locus for PTC taste ability on chromosome 7q and a secondary locus on chromosome 16p. Hum. Genet. 2003, 112 (5-6): 567–72. PMID 12624758. doi:10.1007/s00439-003-0911-y.
^Prodi DA, Drayna D, Forabosco P, Palmas MA, Maestrale GB, Piras D, Pirastu M, Angius A. Bitter taste study in a sardinian genetic isolate supports the association of phenylthiocarbamide sensitivity to the TAS2R38 bitter receptor gene. Chem. Senses. 2004, 29 (8): 697–702. PMID 15466815. doi:10.1093/chemse/bjh074.
^Hayes JE, Bartoshuk LM, Kidd JR, Duffy VB. Supertasting and PROP Bitterness Depends on More Than the TAS2R38 Gene. Chem Senses. 2008, 33 (3): 255–65. PMID 18209019. doi:10.1093/chemse/bjm084.
深入阅读编辑
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tas2r38, 是一种苦味味觉感受器, 该感受器可以尝出苯硫脲, 和丙硫氧嘧啶, 或者相关物质的苦味, 这一点和大多数苦味感受器有所不同, 即该感受器是对某类物质敏感, 而大多数感受器则不会表现出强烈的选择性, 能对多种物质做出响应, 该感受器所能尝出的相应物质大量存在于西兰花, 卷心菜以及其它十字花科植物中, 例如, 葡萄糖异硫氰酸盐, 英语, glucosinolates, 及其相关产物异硫氰酸酯, 目前全球人类中, 约有75, 该感受器相关基因正常, 可以尝出苦味, 而剩下的25, 则无法尝出这类的苦味, . TAS2R38是一种苦味味觉感受器 1 2 该感受器可以尝出苯硫脲 3 和丙硫氧嘧啶 4 或者相关物质的苦味 这一点和大多数苦味感受器有所不同 即该感受器是对某类物质敏感 而大多数感受器则不会表现出强烈的选择性 能对多种物质做出响应 5 该感受器所能尝出的相应物质大量存在于西兰花 卷心菜以及其它十字花科植物中 5 例如 葡萄糖异硫氰酸盐 英语 Glucosinolates 及其相关产物异硫氰酸酯 目前全球人类中 约有75 该感受器相关基因正常 即 可以尝出苦味 而剩下的25 则无法尝出这类的苦味 或者敏感度较低 6 不过目前的研究表明该感受器相关基因的变异与否 并不是决定某个人是否此类苦味物质的超级品尝家 英语 Supertaster 的唯一因素 7 味觉感受器 类型2 成员38标识代号TAS2R38 PTC T2R61扩展标识遗传学 607751 鼠基因 2681306 同源基因 47976 GeneCards TAS2R38 Gene基因本体论描述分子功能 感受器活动 G蛋白耦合受体活动细胞成分 膜 嵌入膜生物过程 信号传导 G蛋白耦合受体蛋白信号传递路径 响应刺激 味觉感受器Sources Amigo QuickGO直系同源体物种人类小鼠Entrez5726387513EnsemblENSG00000183609ENSMUSG00000058250UniProtP59533A0PK79mRNA序列NM 176817NM 001001451蛋白序列NP 789787NP 001001451基因位置Chr 7 141 32 141 32 MbChr 6 40 54 40 54 MbPubMed查询 1 2 目录 1 引用 2 深入阅读 3 参见 4 外部链接引用 编辑 Conte C Ebeling M Marcuz A Nef P Andres Barquin PJ Identification and characterization of human taste receptor genes belonging to the TAS2R family Cytogenet Genome Res 2002 98 1 45 53 PMID 12584440 doi 10 1159 000068546 Drayna D Coon H Kim UK Elsner T Cromer K Otterud B Baird L Peiffer AP Leppert M Genetic analysis of a complex trait in the Utah Genetic Reference Project a major locus for PTC taste ability on chromosome 7q and a secondary locus on chromosome 16p Hum Genet 2003 112 5 6 567 72 PMID 12624758 doi 10 1007 s00439 003 0911 y Prodi DA Drayna D Forabosco P Palmas MA Maestrale GB Piras D Pirastu M Angius A Bitter taste study in a sardinian genetic isolate supports the association of phenylthiocarbamide sensitivity to the TAS2R38 bitter receptor gene Chem Senses 2004 29 8 697 702 PMID 15466815 doi 10 1093 chemse bjh074 Duffy VB Davidson AC Kidd JR Kidd KK Speed WC Pakstis AJ Reed DR Snyder DJ Bartoshuk LM Bitter receptor gene TAS2R38 6 n propylthiouracil PROP bitterness and alcohol intake Alcohol Clin Exp Res 2004 28 11 1629 37 PMC 1397913 nbsp PMID 15547448 doi 10 1097 01 ALC 0000145789 55183 D4 5 0 5 1 味蕾和苦涩说再见 环球科学 电脑报经营有限责任公司与Scientific American合作推出 2006 11 研究称尼安德特人也能 吃苦 科学网 2009 08 18 2010 08 09 原始内容存档于2010 12 28 Hayes JE Bartoshuk LM Kidd JR Duffy VB Supertasting and PROP Bitterness Depends on More Than the TAS2R38 Gene Chem Senses 2008 33 3 255 65 PMID 18209019 doi 10 1093 chemse bjm084 深入阅读 编辑Margolskee RF Molecular mechanisms of bitter and sweet taste transduction J Biol Chem 2002 277 1 1 4 PMID 11696554 doi 10 1074 jbc R100054200 Montmayeur JP Matsunami H Receptors for bitter and sweet taste Curr Opin Neurobiol 2002 12 4 366 71 PMID 12139982 doi 10 1016 S0959 4388 02 00345 8 Kim UK Drayna D Genetics of individual differences in bitter taste perception lessons from the PTC gene Clin Genet 2005 67 4 275 80 PMID 15733260 doi 10 1111 j 1399 0004 2004 00361 x Anne Spence M Falk CT Neiswanger K et al Estimating the recombination frequency for the PTC Kell linkage Hum Genet 1984 67 2 183 6 PMID 6745938 doi 10 1007 BF00272997 引文格式1维护 显式使用等标签 link Bufe B Hofmann T Krautwurst D et al The human TAS2R16 receptor mediates bitter taste in response to beta glucopyranosides Nat Genet 2002 32 3 397 401 PMID 12379855 doi 10 1038 ng1014 引文格式1维护 显式使用等标签 link Strausberg RL Feingold EA Grouse LH et al Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 2003 99 26 16899 903 PMC 139241 nbsp PMID 12477932 doi 10 1073 pnas 242603899 引文格式1维护 显式使用等标签 link Zhang Y Hoon MA Chandrashekar J et al Coding of sweet bitter and umami tastes different receptor cells sharing similar signaling pathways Cell 2003 112 3 293 301 PMID 12581520 doi 10 1016 S0092 8674 03 00071 0 引文格式1维护 显式使用等标签 link Conte C Ebeling M Marcuz A et al Identification and characterization of human taste receptor genes belonging to the TAS2R family Cytogenet Genome Res 2003 98 1 45 53 PMID 12584440 doi 10 1159 000068546 引文格式1维护 显式使用等标签 link Kim UK Jorgenson E Coon H et al Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide Science 2003 299 5610 1221 5 PMID 12595690 doi 10 1126 science 1080190 引文格式1维护 显式使用等标签 link Drayna D Coon H Kim UK et al Genetic analysis of a complex trait in the Utah Genetic Reference Project a major locus for PTC taste ability on chromosome 7q and a secondary locus on chromosome 16p Hum Genet 2003 112 5 6 567 72 PMID 12624758 doi 10 1007 s00439 003 0911 y 引文格式1维护 显式使用等标签 link Scherer SW Cheung J MacDonald JR et al Human chromosome 7 DNA sequence and biology Science 2003 300 5620 767 72 PMC 2882961 nbsp PMID 12690205 doi 10 1126 science 1083423 引文格式1维护 显式使用等标签 link Wooding S Kim UK Bamshad MJ et al Natural selection and molecular evolution in PTC a bitter taste receptor gene Am J Hum Genet 2004 74 4 637 46 PMC 1181941 nbsp PMID 14997422 doi 10 1086 383092 引文格式1维护 显式使用等标签 link Pronin AN Tang H Connor J Keung W Identification of ligands for two human bitter T2R receptors Chem Senses 2005 29 7 583 93 PMID 15337684 doi 10 1093 chemse bjh064 Prodi DA Drayna D Forabosco P et al Bitter taste study in a sardinian genetic isolate supports the association of phenylthiocarbamide sensitivity to the TAS2R38 bitter receptor gene Chem Senses 2005 29 8 697 702 PMID 15466815 doi 10 1093 chemse bjh074 引文格式1维护 显式使用等标签 link Gerhard DS Wagner L Feingold EA et al The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 2004 14 10B 2121 7 PMC 528928 nbsp PMID 15489334 doi 10 1101 gr 2596504 引文格式1维护 显式使用等标签 link Fischer A Gilad Y Man O Paabo S Evolution of bitter taste receptors in humans and apes Mol Biol Evol 2005 22 3 432 6 PMID 15496549 doi 10 1093 molbev msi027 Go Y Satta Y Takenaka O Takahata N Lineage specific loss of function of bitter taste receptor genes in humans and nonhuman primates Genetics 2006 170 1 313 26 PMC 1449719 nbsp PMID 15744053 doi 10 1534 genetics 104 037523 参见 编辑苯硫脲 丙硫氧嘧啶 味觉 超级品尝家外部链接 编辑醫學主題詞表 MeSH TAS2R38 protein human 取自 https zh wikipedia org w index php title TAS2R38 amp oldid 71197035, 维基百科，wiki，书籍，书籍，图书馆，
