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维基百科

SUZ12

十二月 05, 2023

多梳蛋白SUZ12是由人类SUZ12 基因所编码的蛋白质[1][2][3][4] 有报导称该锌指基因在子宫内膜基质肉瘤中位于常见染色体易位断裂点上。这些断裂点相互重组导致该基因与JAZF1两者发生融合。该基因编码的蛋白质在编码区域C端包含有一个锌指结构域。目前仍未明确该基因的特异性功能[4]。

Zeste 12同源物（果蝇属）抑制因子
标识
代号 SUZ12; CHET9; JJAZ1
扩展标识 遗传学：606245 鼠基因：1261758 同源基因：32256 GeneCards: SUZ12 Gene
RNA表达模式
更多表达数据
直系同源体
物种 人类 小鼠
Entrez 23512 52615
Ensembl ENSG00000178691 ENSMUSG00000017548
UniProt Q15022 Q80U70
mRNA序列 NM_015355 NM_001163018
蛋白序列 NP_056170 NP_001156490
基因位置 Chr 17:
30.26 – 30.33 Mb		 Chr 11:
79.99 – 80.03 Mb
PubMed查询 [1] [2]

作为多梳抑制复合物2（PRC2）的一部分，SUZ12可能与HOTAIR非编码RNA一起参与到染色质沉默之中，SUZ12利用其锌指结构域与RNA分子进行结合[5]。

参考文献 编辑

  1. ^ Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. DNA Res. Mar 1996, 2 (4): 167–74, 199–210. PMID 8590280. doi:10.1093/dnares/2.4.167. 
  2. ^ Koontz JI, Soreng AL, Nucci M, Kuo FC, Pauwels P, van Den Berghe H, Dal Cin P, Fletcher JA, Sklar J. Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors. Proc Natl Acad Sci U S A. May 2001, 98 (11): 6348–53. PMC 33471  . PMID 11371647. doi:10.1073/pnas.101132598. 
  3. ^ Ross PJ, Ragina NP, Rodriguez RM, Iager AE, Siripattarapravat K, Lopez-Corrales N, Cibelli JB. Polycomb gene expression and histone H3 lysine 27 trimethylation changes during bovine preimplantation development. Reproduction. Dec 2008, 136 (6): 777–85. PMID 18784248. doi:10.1530/REP-08-0045. 
  4. ^ 4.0 4.1 Entrez Gene: SUZ12 suppressor of zeste 12 homolog (Drosophila). （原始内容于2010-03-07）. 
  5. ^ Rinn JL; Kertesz M; Wang JK; et al. Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Non-Coding RNAs. Cell. June 2007, 129 (7): 1311–23 [2010-07-20]. PMC 2084369  . PMID 17604720. doi:10.1016/j.cell.2007.05.022. （原始内容于2019-02-17）.  已忽略未知参数|author-separator= (帮助)

深入阅读 编辑

  • Birve A; Sengupta AK; Beuchle D; et al. Su(z)12, a novel Drosophila Polycomb group gene that is conserved in vertebrates and plants. Development. 2001, 128 (17): 3371–9. PMID 11546753.  已忽略未知参数|author-separator= (帮助)
  • Weinmann AS; Bartley SM; Zhang T; et al. Use of Chromatin Immunoprecipitation To Clone Novel E2F Target Promoters. Mol. Cell. Biol. 2001, 21 (20): 6820–32. PMC 99859  . PMID 11564866. doi:10.1128/MCB.21.20.6820-6832.2001.  已忽略未知参数|author-separator= (帮助)
  • Cao R; Wang L; Wang H; et al. Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science. 2002, 298 (5595): 1039–43. PMID 12351676. doi:10.1126/science.1076997.  已忽略未知参数|author-separator= (帮助)
  • Kuzmichev A; Nishioka K; Erdjument-Bromage H; et al. Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev. 2002, 16 (22): 2893–905. PMC 187479  . PMID 12435631. doi:10.1101/gad.1035902.  已忽略未知参数|author-separator= (帮助)
  • Strausberg RL; Feingold EA; Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241  . PMID 12477932. doi:10.1073/pnas.242603899.  已忽略未知参数|author-separator= (帮助)
  • Petek E; Jenne DE; Smolle J; et al. Mitotic recombination mediated by the JJAZF1 (KIAA0160) gene causing somatic mosaicism and a new type of constitutional NF1 microdeletion in two children of a mosaic female with only few manifestations. J. Med. Genet. 2003, 40 (7): 520–5. PMC 1735521  . PMID 12843325. doi:10.1136/jmg.40.7.520.  已忽略未知参数|author-separator= (帮助)
  • Wang H; An W; Cao R; et al. mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression. Mol. Cell. 2003, 12 (2): 475–87. PMID 14536086. doi:10.1016/j.molcel.2003.08.007.  已忽略未知参数|author-separator= (帮助)
  • Huang HY, Ladanyi M, Soslow RA. Molecular detection of JAZF1-JJAZ1 gene fusion in endometrial stromal neoplasms with classic and variant histology: evidence for genetic heterogeneity. Am. J. Surg. Pathol. 2004, 28 (2): 224–32. PMID 15043312. doi:10.1097/00000478-200402000-00010. 
  • Cao R, Zhang Y. SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex. Mol. Cell. 2004, 15 (1): 57–67. PMID 15225548. doi:10.1016/j.molcel.2004.06.020. 
  • Kehrer-Sawatzki H; Kluwe L; Sandig C; et al. High Frequency of Mosaicism among Patients with Neurofibromatosis Type 1 (NF1) with Microdeletions Caused by Somatic Recombination of the JJAZ1 Gene. Am. J. Hum. Genet. 2004, 75 (3): 410–23. PMC 1182020  . PMID 15257518. doi:10.1086/423624.  已忽略未知参数|author-separator= (帮助)
  • Beausoleil SA; Jedrychowski M; Schwartz D; et al. Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc. Natl. Acad. Sci. U.S.A. 2004, 101 (33): 12130–5. PMC 514446  . PMID 15302935. doi:10.1073/pnas.0404720101.  已忽略未知参数|author-separator= (帮助)
  • Pasini D; Bracken AP; Jensen MR; et al. Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J. 2004, 23 (20): 4061–71. PMC 524339  . PMID 15385962. doi:10.1038/sj.emboj.7600402.  已忽略未知参数|author-separator= (帮助)
  • Gerhard DS; Wagner L; Feingold EA; et al. The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC). Genome Res. 2004, 14 (10B): 2121–7. PMC 528928  . PMID 15489334. doi:10.1101/gr.2596504.  已忽略未知参数|author-separator= (帮助)
  • Cha TL; Zhou BP; Xia W; et al. Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3. Science. 2005, 310 (5746): 306–10. PMID 16224021. doi:10.1126/science.1118947.  已忽略未知参数|author-separator= (帮助)
  • Lee TI; Jenner RG; Boyer LA; et al. Control of developmental regulators by Polycomb in human embryonic stem cells. Cell. 2006, 125 (2): 301–13. PMID 16630818. doi:10.1016/j.cell.2006.02.043.  已忽略未知参数|author-separator= (帮助)
  • Furuno K; Masatsugu T; Sonoda M; et al. Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro. Biochem. Biophys. Res. Commun. 2006, 345 (3): 1051–8. PMID 16712789. doi:10.1016/j.bbrc.2006.05.014.  已忽略未知参数|author-separator= (帮助)
  • Olsen JV; Blagoev B; Gnad F; et al. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006, 127 (3): 635–48. PMID 17081983. doi:10.1016/j.cell.2006.09.026.  已忽略未知参数|author-separator= (帮助)
  • Nucci MR; Harburger D; Koontz J; et al. Molecular analysis of the JAZF1-JJAZ1 gene fusion by RT-PCR and fluorescence in situ hybridization in endometrial stromal neoplasms. Am. J. Surg. Pathol. 2007, 31 (1): 65–70. PMID 17197920. doi:10.1097/01.pas.0000213327.86992.d1.  已忽略未知参数|author-separator= (帮助)

外部链接 编辑



十二月 05, 2023
suz12, 多梳蛋白是由人类, 基因所编码的蛋白质, 有报导称该锌指基因在子宫内膜基质肉瘤中位于常见染色体易位断裂点上, 这些断裂点相互重组导致该基因与jazf1两者发生融合, 该基因编码的蛋白质在编码区域c端包含有一个锌指结构域, 目前仍未明确该基因的特异性功能, zeste, 12同源物, 果蝇属, 抑制因子标识代号, chet9, jjaz1扩展标识遗传学, 606245, 鼠基因, 1261758, 同源基因, 32256, genecards, gene基因本体论描述分子功能, chromatin, b. 多梳蛋白SUZ12是由人类SUZ12 基因所编码的蛋白质 1 2 3 4 有报导称该锌指基因在子宫内膜基质肉瘤中位于常见染色体易位断裂点上 这些断裂点相互重组导致该基因与JAZF1两者发生融合 该基因编码的蛋白质在编码区域C端包含有一个锌指结构域 目前仍未明确该基因的特异性功能 4 Zeste 12同源物 果蝇属 抑制因子标识代号SUZ12 CHET9 JJAZ1扩展标识遗传学 606245 鼠基因 1261758 同源基因 32256 GeneCards SUZ12 Gene基因本体论描述分子功能 chromatin binding protein binding methylated histone residue binding histone methyltransferase activity sequence specific DNA binding metal ion binding细胞成分 sex chromatin ESC E Z complex生物过程 negative regulation of transcription from RNA polymerase II promoter transcription DNA dependent positive regulation of cell proliferation histone ubiquitination negative regulation of cell differentiationSources Amigo QuickGORNA表达模式更多表达数据直系同源体物种人类小鼠Entrez2351252615EnsemblENSG00000178691ENSMUSG00000017548UniProtQ15022Q80U70mRNA序列NM 015355NM 001163018蛋白序列NP 056170NP 001156490基因位置Chr 17 30 26 30 33 MbChr 11 79 99 80 03 MbPubMed查询 1 2 查论编作为多梳抑制复合物2 PRC2 的一部分 SUZ12可能与HOTAIR非编码RNA一起参与到染色质沉默之中 SUZ12利用其锌指结构域与RNA分子进行结合 5 参考文献 编辑 Nagase T Seki N Tanaka A Ishikawa K Nomura N Prediction of the coding sequences of unidentified human genes IV The coding sequences of 40 new genes KIAA0121 KIAA0160 deduced by analysis of cDNA clones from human cell line KG 1 DNA Res Mar 1996 2 4 167 74 199 210 PMID 8590280 doi 10 1093 dnares 2 4 167 Koontz JI Soreng AL Nucci M Kuo FC Pauwels P van Den Berghe H Dal Cin P Fletcher JA Sklar J Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors Proc Natl Acad Sci U S A May 2001 98 11 6348 53 PMC 33471 nbsp PMID 11371647 doi 10 1073 pnas 101132598 Ross PJ Ragina NP Rodriguez RM Iager AE Siripattarapravat K Lopez Corrales N Cibelli JB Polycomb gene expression and histone H3 lysine 27 trimethylation changes during bovine preimplantation development Reproduction Dec 2008 136 6 777 85 PMID 18784248 doi 10 1530 REP 08 0045 4 0 4 1 Entrez Gene SUZ12 suppressor of zeste 12 homolog Drosophila 原始内容存档于2010 03 07 Rinn JL Kertesz M Wang JK et al Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Non Coding RNAs Cell June 2007 129 7 1311 23 2010 07 20 PMC 2084369 nbsp PMID 17604720 doi 10 1016 j cell 2007 05 022 原始内容存档于2019 02 17 已忽略未知参数 author separator 帮助 深入阅读 编辑Birve A Sengupta AK Beuchle D et al Su z 12 a novel Drosophila Polycomb group gene that is conserved in vertebrates and plants Development 2001 128 17 3371 9 PMID 11546753 已忽略未知参数 author separator 帮助 Weinmann AS Bartley SM Zhang T et al Use of Chromatin Immunoprecipitation To Clone Novel E2F Target Promoters Mol Cell Biol 2001 21 20 6820 32 PMC 99859 nbsp PMID 11564866 doi 10 1128 MCB 21 20 6820 6832 2001 已忽略未知参数 author separator 帮助 Cao R Wang L Wang H et al Role of histone H3 lysine 27 methylation in Polycomb group silencing Science 2002 298 5595 1039 43 PMID 12351676 doi 10 1126 science 1076997 已忽略未知参数 author separator 帮助 Kuzmichev A Nishioka K Erdjument Bromage H et al Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein Genes Dev 2002 16 22 2893 905 PMC 187479 nbsp PMID 12435631 doi 10 1101 gad 1035902 已忽略未知参数 author separator 帮助 Strausberg RL Feingold EA Grouse LH et al Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 2003 99 26 16899 903 PMC 139241 nbsp PMID 12477932 doi 10 1073 pnas 242603899 已忽略未知参数 author separator 帮助 Petek E Jenne DE Smolle J et al Mitotic recombination mediated by the JJAZF1 KIAA0160 gene causing somatic mosaicism and a new type of constitutional NF1 microdeletion in two children of a mosaic female with only few manifestations J Med Genet 2003 40 7 520 5 PMC 1735521 nbsp PMID 12843325 doi 10 1136 jmg 40 7 520 已忽略未知参数 author separator 帮助 Wang H An W Cao R et al mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression Mol Cell 2003 12 2 475 87 PMID 14536086 doi 10 1016 j molcel 2003 08 007 已忽略未知参数 author separator 帮助 Huang HY Ladanyi M Soslow RA Molecular detection of JAZF1 JJAZ1 gene fusion in endometrial stromal neoplasms with classic and variant histology evidence for genetic heterogeneity Am J Surg Pathol 2004 28 2 224 32 PMID 15043312 doi 10 1097 00000478 200402000 00010 Cao R Zhang Y SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED EZH2 complex Mol Cell 2004 15 1 57 67 PMID 15225548 doi 10 1016 j molcel 2004 06 020 Kehrer Sawatzki H Kluwe L Sandig C et al High Frequency of Mosaicism among Patients with Neurofibromatosis Type 1 NF1 with Microdeletions Caused by Somatic Recombination of the JJAZ1 Gene Am J Hum Genet 2004 75 3 410 23 PMC 1182020 nbsp PMID 15257518 doi 10 1086 423624 已忽略未知参数 author separator 帮助 Beausoleil SA Jedrychowski M Schwartz D et al Large scale characterization of HeLa cell nuclear phosphoproteins Proc Natl Acad Sci U S A 2004 101 33 12130 5 PMC 514446 nbsp PMID 15302935 doi 10 1073 pnas 0404720101 已忽略未知参数 author separator 帮助 Pasini D Bracken AP Jensen MR et al Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity EMBO J 2004 23 20 4061 71 PMC 524339 nbsp PMID 15385962 doi 10 1038 sj emboj 7600402 已忽略未知参数 author separator 帮助 Gerhard DS Wagner L Feingold EA et al The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 2004 14 10B 2121 7 PMC 528928 nbsp PMID 15489334 doi 10 1101 gr 2596504 已忽略未知参数 author separator 帮助 Cha TL Zhou BP Xia W et al Akt mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3 Science 2005 310 5746 306 10 PMID 16224021 doi 10 1126 science 1118947 已忽略未知参数 author separator 帮助 Lee TI Jenner RG Boyer LA et al Control of developmental regulators by Polycomb in human embryonic stem cells Cell 2006 125 2 301 13 PMID 16630818 doi 10 1016 j cell 2006 02 043 已忽略未知参数 author separator 帮助 Furuno K Masatsugu T Sonoda M et al Association of Polycomb group SUZ12 with WD repeat protein MEP50 that binds to histone H2A selectively in vitro Biochem Biophys Res Commun 2006 345 3 1051 8 PMID 16712789 doi 10 1016 j bbrc 2006 05 014 已忽略未知参数 author separator 帮助 Olsen JV Blagoev B Gnad F et al Global in vivo and site specific phosphorylation dynamics in signaling networks Cell 2006 127 3 635 48 PMID 17081983 doi 10 1016 j cell 2006 09 026 已忽略未知参数 author separator 帮助 Nucci MR Harburger D Koontz J et al Molecular analysis of the JAZF1 JJAZ1 gene fusion by RT PCR and fluorescence in situ hybridization in endometrial stromal neoplasms Am J Surg Pathol 2007 31 1 65 70 PMID 17197920 doi 10 1097 01 pas 0000213327 86992 d1 已忽略未知参数 author separator 帮助 外部链接 编辑FactorBook SUZ12 取自 https zh wikipedia org w index php title SUZ12 amp oldid 69717674, 维基百科，wiki，书籍，书籍，图书馆，

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