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维基百科

INF2

逆霍明2(INF2Inverted formin-2)是在人體內由INF2基因編碼的蛋白質[1][2]

INF,FH2及WH2領域包括
标识
代号 INF2; C14orf151; C14orf173; CMTDIE; FSGS5; pp9484
扩展标识 遗传学:610982 鼠基因:1917685 同源基因:82406 GeneCards: INF2 Gene
RNA表达模式
更多表达数据
直系同源体
物种 人类 小鼠
Entrez 64423 70435
Ensembl ENSG00000203485 ENSMUSG00000037679
UniProt Q27J81 Q0GNC1
mRNA序列 NM_001031714 NM_198411
蛋白序列 NP_001026884 NP_940803
基因位置 Chr 14:
105.16 – 105.19 Mb
Chr 12:
112.59 – 112.62 Mb
PubMed查询 [1] [2]

臨床意義

"逆霍明2"與局灶節段性腎小球硬化症有所相關聯。[3]

註釋

  1. ^ Chhabra ES, Higgs HN. INF2 Is a WASP homology 2 motif-containing formin that severs actin filaments and accelerates both polymerization and depolymerization. J Biol Chem. Sep 2006, 281 (36): 26754–67. PMID 16818491. doi:10.1074/jbc.M604666200. 
  2. ^ Entrez Gene: C14orf173 chromosome 14 open reading frame 173. 
  3. ^ Brown EJ, Schlöndorff JS, Becker DJ, Tsukaguchi H, Uscinski AL, Higgs HN, Henderson JM, Pollak MR. Mutations in the formin gene INF2 cause focal segmental glomerulosclerosis. Nature Genetics. Jan 2010, 42 (1): 72–6. PMC 2980844 . PMID 20023659. doi:10.1038/ng.505. 

延伸閱讀

  • Kimura K, Wakamatsu A, Suzuki Y; et al. Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes. Genome Res. 2006, 16 (1): 55–65. PMC 1356129 . PMID 16344560. doi:10.1101/gr.4039406. 
  • Bindschadler M, McGrath JL. Formin' new ideas about actin filament generation. Proc. Natl. Acad. Sci. U.S.A. 2004, 101 (41): 14685–6. PMC 522045 . PMID 15466701. doi:10.1073/pnas.0406317101. 
  • Fu GK, Wang JT, Yang J; et al. Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes. Genomics. 2005, 84 (1): 205–10. PMID 15203218. doi:10.1016/j.ygeno.2004.01.011. 
  • Gevaert K, Goethals M, Martens L; et al. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. Nat. Biotechnol. 2004, 21 (5): 566–9. PMID 12665801. doi:10.1038/nbt810. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899. 
  • Venter JC, Adams MD, Myers EW; et al. The sequence of the human genome. Science. 2001, 291 (5507): 1304–51. PMID 11181995. doi:10.1126/science.1058040. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. Gene. 1997, 200 (1–2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3. 
  • Maruyama K, Sugano S. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. Gene. 1994, 138 (1–2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8. 

inf2, 逆霍明2, inverted, formin, 是在人體內由基因編碼的蛋白質, fh2及wh2領域包括标识代号, c14orf151, c14orf173, cmtdie, fsgs5, pp9484扩展标识遗传学, 610982, 鼠基因, 1917685, 同源基因, 82406, genecards, gene基因本体论描述分子功能, actin, binding, gtpase, binding细胞成分, nucleus, cytoplasm, endoplasmic, reticulum, p. 逆霍明2 INF2 Inverted formin 2 是在人體內由INF2基因編碼的蛋白質 1 2 INF FH2及WH2領域包括标识代号INF2 C14orf151 C14orf173 CMTDIE FSGS5 pp9484扩展标识遗传学 610982 鼠基因 1917685 同源基因 82406 GeneCards INF2 Gene基因本体论描述分子功能 actin binding Rho GTPase binding细胞成分 nucleus cytoplasm endoplasmic reticulum perinuclear region of cytoplasm生物过程 cell death actin cytoskeleton organization regulation of cellular component size regulation of mitochondrial fissionSources Amigo QuickGORNA表达模式更多表达数据直系同源体物种人类小鼠Entrez6442370435EnsemblENSG00000203485ENSMUSG00000037679UniProtQ27J81Q0GNC1mRNA序列NM 001031714NM 198411蛋白序列NP 001026884NP 940803基因位置Chr 14 105 16 105 19 MbChr 12 112 59 112 62 MbPubMed查询 1 2 查论编臨床意義 编辑 逆霍明2 與局灶節段性腎小球硬化症有所相關聯 3 註釋 编辑 Chhabra ES Higgs HN INF2 Is a WASP homology 2 motif containing formin that severs actin filaments and accelerates both polymerization and depolymerization J Biol Chem Sep 2006 281 36 26754 67 PMID 16818491 doi 10 1074 jbc M604666200 Entrez Gene C14orf173 chromosome 14 open reading frame 173 Brown EJ Schlondorff JS Becker DJ Tsukaguchi H Uscinski AL Higgs HN Henderson JM Pollak MR Mutations in the formin gene INF2 cause focal segmental glomerulosclerosis Nature Genetics Jan 2010 42 1 72 6 PMC 2980844 PMID 20023659 doi 10 1038 ng 505 延伸閱讀 编辑Kimura K Wakamatsu A Suzuki Y et al Diversification of transcriptional modulation Large scale identification and characterization of putative alternative promoters of human genes Genome Res 2006 16 1 55 65 PMC 1356129 PMID 16344560 doi 10 1101 gr 4039406 引文格式1维护 显式使用等标签 link Bindschadler M McGrath JL Formin new ideas about actin filament generation Proc Natl Acad Sci U S A 2004 101 41 14685 6 PMC 522045 PMID 15466701 doi 10 1073 pnas 0406317101 Fu GK Wang JT Yang J et al Circular rapid amplification of cDNA ends for high throughput extension cloning of partial genes Genomics 2005 84 1 205 10 PMID 15203218 doi 10 1016 j ygeno 2004 01 011 引文格式1维护 显式使用等标签 link Gevaert K Goethals M Martens L et al Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N terminal peptides Nat Biotechnol 2004 21 5 566 9 PMID 12665801 doi 10 1038 nbt810 引文格式1维护 显式使用等标签 link Strausberg RL Feingold EA Grouse LH et al Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 2003 99 26 16899 903 PMC 139241 PMID 12477932 doi 10 1073 pnas 242603899 引文格式1维护 显式使用等标签 link Venter JC Adams MD Myers EW et al The sequence of the human genome Science 2001 291 5507 1304 51 PMID 11181995 doi 10 1126 science 1058040 引文格式1维护 显式使用等标签 link Suzuki Y Yoshitomo Nakagawa K Maruyama K et al Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 1997 200 1 2 149 56 PMID 9373149 doi 10 1016 S0378 1119 97 00411 3 引文格式1维护 显式使用等标签 link Maruyama K Sugano S Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 1994 138 1 2 171 4 PMID 8125298 doi 10 1016 0378 1119 94 90802 8 取自 https zh wikipedia org w index php title INF2 amp oldid 33112871, 维基百科,wiki,书籍,书籍,图书馆,

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