• DNA结合 • sequence-specific DNA binding • DNA结合转录因子活性 • DNA-binding transcription activator activity, RNA polymerase II-specific • 转录因子结合 • double-stranded DNA binding • RNA polymerase II cis-regulatory region sequence-specific DNA binding • DNA-binding transcription factor activity, RNA polymerase II-specific
細胞組分
• 細胞內膜結合細胞器 • 细胞核 • 核质
生物學過程
• cellular response to calcium ion • regulation of transcription, DNA-templated • regulation of transcription by RNA polymerase II • response to progesterone • female pregnancy • response to corticosterone • response to mechanical stimulus • negative regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • response to morphine • cellular response to hormone stimulus • response to cAMP • positive regulation of transcription by RNA polymerase II
^原文：hese genes encode leucine zipper proteins that can dimerize with proteins of the JUN（英语：C-jun） family (e.g., c-Jun（英语：c-Jun）, JunD（英语：JunD）), thereby forming the transcription factor complex AP-1.
^原文：As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.
^Siderovski DP, Blum S, Forsdyke RE, Forsdyke DR. A set of human putative lymphocyte G0/G1 switch genes includes genes homologous to rodent cytokine and zinc finger protein-encoding genes. DNA and Cell Biology. Oct 1990, 9 (8): 579–87. PMID 1702972. doi:10.1089/dna.1990.9.579.
^Martin-Gallardo A, McCombie WR, Gocayne JD, FitzGerald MG, Wallace S, Lee BM, Lamerdin J, Trapp S, Kelley JM, Liu LI. Automated DNA sequencing and analysis of 106 kilobases from human chromosome 19q13.3. Nature Genetics. Apr 1992, 1 (1): 34–9. PMID 1301997. doi:10.1038/ng0492-34.
^Sabatakos G, Rowe GC, Kveiborg M, Wu M, Neff L, Chiusaroli R, Philbrick WM, Baron R. Doubly truncated FosB isoform (Delta2DeltaFosB) induces osteosclerosis in transgenic mice and modulates expression and phosphorylation of Smads in osteoblasts independent of intrinsic AP-1 activity. Journal of Bone and Mineral Research. 2008-05, 23 (5): 584–95. PMC 2674536. PMID 18433296. doi:10.1359/jbmr.080110.
^Ruffle JK. Molecular neurobiology of addiction: what's all the (Δ)FosB about?. The American Journal of Drug and Alcohol Abuse. Nov 2014, 40 (6): 428–37. PMID 25083822. doi:10.3109/00952990.2014.933840. ΔFosB as a therapeutic biomarker The strong correlation between chronic drug exposure and ΔFosB provides novel opportunities for targeted therapies in addiction (118), and suggests methods to analyze their efficacy (119). Over the past two decades, research has progressed from identifying ΔFosB induction to investigating its subsequent action (38). It is likely that ΔFosB research will now progress into a new era – the use of ΔFosB as a biomarker. If ΔFosB detection is indicative of chronic drug exposure (and is at least partly responsible for dependence of the substance), then its monitoring for therapeutic efficacy in interventional studies is a suitable biomarker (Figure 2). Examples of therapeutic avenues are discussed herein. ...
Conclusions ΔFosB is an essential transcription factor implicated in the molecular and behavioral pathways of addiction following repeated drug exposure. The formation of ΔFosB in multiple brain regions, and the molecular pathway leading to the formation of AP-1 complexes is well understood. The establishment of a functional purpose for ΔFosB has allowed further determination as to some of the key aspects of its molecular cascades, involving effectors such as GluR2 (87,88), Cdk5 (93) and NFkB (100). Moreover, many of these molecular changes identified are now directly linked to the structural, physiological and behavioral changes observed following chronic drug exposure (60,95,97,102). New frontiers of research investigating the molecular roles of ΔFosB have been opened by epigenetic studies, and recent advances have illustrated the role of ΔFosB acting on DNA and histones, truly as a ‘‘molecular switch’’ (34). As a consequence of our improved understanding of ΔFosB in addiction, it is possible to evaluate the addictive potential of current medications (119), as well as use it as a biomarker for assessing the efficacy of therapeutic interventions (121,122,124). Some of these proposed interventions have limitations (125) or are in their infancy (75). However, it is hoped that some of these preliminary findings may lead to innovative treatments, which are much needed in addiction.
外部連結编辑
ROLE OF ΔFOSB IN THE NUCLEUS ACCUMBENS（页面存档备份，存于互联网档案馆）
KEGG Pathway – human alcohol addiction（页面存档备份，存于互联网档案馆）
KEGG Pathway – human amphetamine addiction（页面存档备份，存于互联网档案馆）
KEGG Pathway – human cocaine addiction（页面存档备份，存于互联网档案馆）
fosb, 此條目可参照英語維基百科相應條目来扩充, 2017年7月10日, 若您熟悉来源语言和主题, 请协助参考外语维基百科扩充条目, 请勿直接提交机械翻译, 也不要翻译不可靠, 低品质内容, 依版权协议, 译文需在编辑摘要注明来源, 或于讨论页顶部标记, href, template, translated, page, html, title, template, translated, page, translated, page, 标签, 此條目翻譯品質不佳, 翻譯者可能不熟悉中文或原文語言, 也可能使用. 此條目可参照英語維基百科相應條目来扩充 2017年7月10日 若您熟悉来源语言和主题 请协助参考外语维基百科扩充条目 请勿直接提交机械翻译 也不要翻译不可靠 低品质内容 依版权协议 译文需在编辑摘要注明来源 或于讨论页顶部标记 a href Template Translated page html title Template Translated page Translated page a 标签 此條目翻譯品質不佳 翻譯者可能不熟悉中文或原文語言 也可能使用了機器翻譯 請協助翻譯本條目或重新編寫 并注意避免翻译腔的问题 明顯拙劣的翻譯請改掛 a href Template D html class mw redirect title Template D d a a href Wikipedia CSD html G13 class mw redirect title Wikipedia CSD G13 a 提交刪除 FBJ murine osteosarcoma viral oncogene homolog B 又名為FOSB 或 FosB 是一個在人體中由FOSB 基因編碼 encoded 的蛋白質 參 1 參 2 參 3 FOS 基因家族由四個成員組成 FOS 英语 C Fos FOSB FOSL1 英语 FOSL1 和FOSL2 英语 FOSL2 這些基因組成 encode 亮氨酸拉链 leucine zipper 蛋白質 這種蛋白質可以與JUN 英语 C jun 這個蛋白質及其家族 e g c Jun 英语 c Jun JunD 英语 JunD 二聚體化 dimerize 然後形成转录因子 transcription factor 綜合區 AP 1转录因子 註 1 FOSB識別號别名FOSB AP 1 G0S3 GOS3 GOSB FosB DFosB FosB proto oncogene AP 1 transcription factor subunit外部IDOMIM 164772 MGI 95575 HomoloGene 31403 GeneCards FOSB基因位置 人类 染色体19號染色體 1 基因座19q13 32起始45 467 995 bp 1 终止45 475 179 bp 1 基因位置 小鼠 染色体小鼠7号染色体 2 基因座7 A3 7 9 56 cM起始19 036 621 bp 2 终止19 043 976 bp 2 RNA表达模式查阅更多表达数据基因本體分子功能 DNA结合 sequence specific DNA binding DNA结合转录因子活性 DNA binding transcription activator activity RNA polymerase II specific 转录因子结合 double stranded DNA binding RNA polymerase II cis regulatory region sequence specific DNA binding DNA binding transcription factor activity RNA polymerase II specific細胞組分 細胞內膜結合細胞器 细胞核 核质生物學過程 cellular response to calcium ion regulation of transcription DNA templated regulation of transcription by RNA polymerase II response to progesterone female pregnancy response to corticosterone response to mechanical stimulus negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II response to morphine cellular response to hormone stimulus response to cAMP positive regulation of transcription by RNA polymerase IISources Amigo QuickGO直系同源物種人類小鼠Entrez235414282EnsemblENSG00000125740ENSMUSG00000003545UniProtP53539P13346mRNA 序列 NM 001114171 NM 006732NM 008036 NM 001347586蛋白序列NP 001107643 NP 006723NP 001334515 NP 032062基因位置 UCSC Chr 19 45 47 45 48 MbChr 7 19 04 19 04 MbPubMed 查找 3 4 維基數據檢視 編輯人類檢視 編輯小鼠维基百科中的醫學内容仅供参考 並不能視作專業意見 如需獲取醫療幫助或意見 请咨询专业人士 詳見醫學聲明 如同這些 FOS蛋白質就被表示成關於細胞增加 細胞差異化 細胞轉型的調節者 註 2 參 1 FosB与其選擇性剪接形成的产物 DFosB 和进一步剪接而成的 D2DFosB 都参与到了骨硬化 英语 osteosclerosis 的过程之中 但 D2DFosB 没有已知的转录活化区域 英语 transactivation domain 无法通过AP 1 复合物影响转录过程 參 4 現已知DFosB之端點銜接處 英语 splice 的變化程度 英语 Variant of uncertain significance 是發展並維持病理行為和神经可塑性的核心因素 充分且必要因素 而病理行為和神经可塑性都參與了行為成癮 與自然酬賞 英语 natural reward 相關 及藥物成癮的形成過程 參 5 目录 1 註解 2 參考資料 3 外部連結 4 相關條目註解 编辑註 原文 hese genes encode leucine zipper proteins that can dimerize with proteins of the JUN 英语 C jun family e g c Jun 英语 c Jun JunD 英语 JunD thereby forming the transcription factor complex AP 1 原文 As such the FOS proteins have been implicated as regulators of cell proliferation differentiation and transformation 參考資料 编辑參 1 0 1 1 Entrez Gene FOSB FBJ murine osteosarcoma viral oncogene homolog B 原始内容存档于2019 10 16 Siderovski DP Blum S Forsdyke RE Forsdyke DR A set of human putative lymphocyte G0 G1 switch genes includes genes homologous to rodent cytokine and zinc finger protein encoding genes DNA and Cell Biology Oct 1990 9 8 579 87 PMID 1702972 doi 10 1089 dna 1990 9 579 Martin Gallardo A McCombie WR Gocayne JD FitzGerald MG Wallace S Lee BM Lamerdin J Trapp S Kelley JM Liu LI Automated DNA sequencing and analysis of 106 kilobases from human chromosome 19q13 3 Nature Genetics Apr 1992 1 1 34 9 PMID 1301997 doi 10 1038 ng0492 34 Sabatakos G Rowe GC Kveiborg M Wu M Neff L Chiusaroli R Philbrick WM Baron R Doubly truncated FosB isoform Delta2DeltaFosB induces osteosclerosis in transgenic mice and modulates expression and phosphorylation of Smads in osteoblasts independent of intrinsic AP 1 activity Journal of Bone and Mineral Research 2008 05 23 5 584 95 PMC 2674536 nbsp PMID 18433296 doi 10 1359 jbmr 080110 Ruffle JK Molecular neurobiology of addiction what s all the D FosB about The American Journal of Drug and Alcohol Abuse Nov 2014 40 6 428 37 PMID 25083822 doi 10 3109 00952990 2014 933840 DFosB as a therapeutic biomarkerThe strong correlation between chronic drug exposure and DFosB provides novel opportunities for targeted therapies in addiction 118 and suggests methods to analyze their efficacy 119 Over the past two decades research has progressed from identifying DFosB induction to investigating its subsequent action 38 It is likely that DFosB research will now progress into a new era the use of DFosB as a biomarker If DFosB detection is indicative of chronic drug exposure and is at least partly responsible for dependence of the substance then its monitoring for therapeutic efficacy in interventional studies is a suitable biomarker Figure 2 Examples of therapeutic avenues are discussed herein ConclusionsDFosB is an essential transcription factor implicated in the molecular and behavioral pathways of addiction following repeated drug exposure The formation of DFosB in multiple brain regions and the molecular pathway leading to the formation of AP 1 complexes is well understood The establishment of a functional purpose for DFosB has allowed further determination as to some of the key aspects of its molecular cascades involving effectors such as GluR2 87 88 Cdk5 93 and NFkB 100 Moreover many of these molecular changes identified are now directly linked to the structural physiological and behavioral changes observed following chronic drug exposure 60 95 97 102 New frontiers of research investigating the molecular roles of DFosB have been opened by epigenetic studies and recent advances have illustrated the role of DFosB acting on DNA and histones truly as a molecular switch 34 As a consequence of our improved understanding of DFosB in addiction it is possible to evaluate the addictive potential of current medications 119 as well as use it as a biomarker for assessing the efficacy of therapeutic interventions 121 122 124 Some of these proposed interventions have limitations 125 or are in their infancy 75 However it is hoped that some of these preliminary findings may lead to innovative treatments which are much needed in addiction 外部連結 编辑ROLE OF DFOSB IN THE NUCLEUS ACCUMBENS 页面存档备份 存于互联网档案馆 KEGG Pathway human alcohol addiction 页面存档备份 存于互联网档案馆 KEGG Pathway human amphetamine addiction 页面存档备份 存于互联网档案馆 KEGG Pathway human cocaine addiction 页面存档备份 存于互联网档案馆 相關條目 编辑成癮 安非他命 醫學主題詞表 MeSH FOSB protein human相關主題 nbsp 醫學 nbsp 神經科學 nbsp 生物 nbsp 藥理學FOSB引用了美国国家医学图书馆提供的資料 这些資料属于公共领域 取自 https zh wikipedia org w index php title FOSB amp oldid 73448430, 维基百科，wiki，书籍，书籍，图书馆，
