^Ban C, Ramakrishnan B, Ling KY, Kung C, Sundaralingam M. Structure of the recombinant Paramecium tetraurelia calmodulin at 1.68 A resolution. Acta Crystallogr. D Biol. Crystallogr. January 1994, 50 (Pt 1): 50–63. PMID 15299476. doi:10.1107/S0907444993007991.
延伸阅读
Branden C, Tooze J. Chapter 2: Motifs of protein structure. Introduction to Protein Structure. New York: Garland Pub. 1999: 24–25. ISBN 0-8153-2305-0.
Nakayama S, Kretsinger RH. Evolution of the EF-hand family of proteins. Annu Rev Biophys Biomol Struct. 1994, 23: 473–507. PMID 7919790. doi:10.1146/annurev.bb.23.060194.002353.
Zhou Y, Yang W, Kirberger M, Lee HW, Ayalasomayajula G, Yang JJ. Prediction of EF-hand calcium-binding proteins and analysis of bacterial EF-hand proteins. Proteins. November 2006, 65 (3): 643–55. PMID 16981205. doi:10.1002/prot.21139.
Zhou Y, Frey TK, Yang JJ. Viral calciomics: interplays between Ca2+ and virus. Cell Calcium. July 2009, 46 (1): 1–17. PMID 19535138. doi:10.1016/j.ceca.2009.05.005.
Nakayama S, Moncrief ND, Kretsinger RH. Evolution of EF-hand calcium-modulated proteins. II. Domains of several subfamilies have diverse evolutionary histories. J. Mol. Evol. May 1992, 34 (5): 416–48. PMID 1602495. doi:10.1007/BF00162998.
Hogue CW, MacManus JP, Banville D, Szabo AG. Comparison of terbium (III) luminescence enhancement in mutants of EF hand calcium binding proteins. J. Biol. Chem. July 1992, 267 (19): 13340–7. PMID 1618836.
Bairoch A, Cox JA. EF-hand motifs in inositol phospholipid-specific phospholipase C. FEBS Lett. September 1990, 269 (2): 454–6. PMID 2401372. doi:10.1016/0014-5793(90)81214-9.
Finn BE, Forsén S. The evolving model of calmodulin structure, function and activation. Structure. January 1995, 3 (1): 7–11. PMID 7743133. doi:10.1016/S0969-2126(01)00130-7.
Stathopulos PB, Zheng L, Li GY, Plevin MJ, Ikura M. Structural and mechanistic insights into STIM1-mediated initiation of store-operated calcium entry. Cell. October 2008, 135 (1): 110–22. PMID 18854159. doi:10.1016/j.cell.2008.08.006.
Nelson MR, Thulin E, Fagan PA, Forsén S, Chazin WJ. The EF-hand domain: a globally cooperative structural unit. Protein Sci. February 2002, 11 (2): 198–205. PMC 2373453. PMID 11790829. doi:10.1110/ps.33302.
外部链接
Nelson M, Chazin W. . Vanderbilt University. [2009-08-29]. （原始内容存档于2009-08-25）.
Haiech J. EF-hand protein database (EF-handome). European Calcium Society and the Université Libre de Bruxelles. [2009-08-29]. （原始内容于2009-08-09）. upon request to haiech@pharma.u-strasbg.fr
Yang J. . Georgia State University. [2009-08-29]. （原始内容存档于2009-10-12）. prediction server for EF-hand calcium binding proteins
二月 04, 2023
ef手, 英語, hand, 是一种在钙结合蛋白中发现的螺旋, 螺旋结构域或结构基序, 重组的第四双小核草履虫, 英语, paramecium, tetraurelia, 钙调蛋白结构, 鑑定標誌efhandpfampf00036interpro, 英语, interpro, ipr002048prosite, 英语, prosite, pdoc00018scop, 英语, structural, classification, proteins, 1osa, supfamopm, 英语, orientations. EF手 英語 EF hand 是一种在钙结合蛋白中发现的螺旋 环 螺旋结构域或结构基序 EF手重组的第四双小核草履虫 英语 Paramecium tetraurelia 钙调蛋白结构 1 鑑定標誌efhandPfamPF00036InterPro 英语 InterPro IPR002048PROSITE 英语 PROSITE PDOC00018SCOP 英语 Structural Classification of Proteins 1osa SUPFAMOPM 英语 Orientations of Proteins in Membranes database 蛋白1djx現有可用的蛋白結構 Pfam結構 ECODPDBRCSB PDB PDBe PDBjPDBsum 英语 PDBsum 結構概要PDB1s6j A 375 402 1s6i A 375 403 1m39 A 141 169 2a4j A 141 169 1oqp A 138 166 2bbn A 121 148 2bkh B 121 148 1mxe A 121 148 4cln 121 148 2bbm A 121 148 1cdm A 121 146 1lin 121 148 2bki B 121 148 1ooj A 121 148 1osa 121 148 1clm 121 147 1n0y B 121 148 1exr A 121 148 1rfj A 121 149 1ggz A 121 148 1ak8 48 75 1sw8 A 48 76 1j7o A 48 76 1f70 A 48 76 1r2u A 56 84 1r6p A 56 84 1j1e A 56 84EF手包括一个螺旋 环 螺旋拓扑结构 就像人类的手上拇指和食指 而Ca2 离子与其配体就位于环内 这一结构最早在小清蛋白 英语 parvalbumin 中发现 小清蛋白含有三个EF手结构 与钙离子结合而造成的肌肉放松有关 EF手包含两个a螺旋 由一个短的 通常包括12个氨基酸 环状区域连接 常用于结合钙离子 EF手也出现在钙调蛋白的所有结构域和肌肉蛋白质肌钙蛋白C中 目录 1 钙离子结合位点 2 分类 2 1 亚族 2 2 例子 3 另见 4 参考文献 5 延伸阅读 6 外部链接钙离子结合位点 编辑分类 编辑自从EF手结构模体在1973年被描绘以来 迄今为止该家族的蛋白质已扩展到至少66个亚家族 EF手结构基元可以分为Canonical EF hands和Pseudo EF hands 两大类 EF手蛋白家族的系统发育树 亚族 编辑 EPS15 homology EH domain IPR000261例子 编辑 人类基因组中 包含有EF手的蛋白质有 ACTN1 英语 ACTN1 ACTN2 英语 ACTN2 ACTN3 ACTN4 英语 ACTN4 APBA2BP AYTL1 AYTL2 C14orf143 CABP1 CABP2 CABP3 CABP4 CABP5 CABP7 CALB1 CALB2 CALM2 CALM3 CALML3 CALML4 CALML5 CALML6 CALN1 CALU CAPN1 CAPN11 CAPN2 CAPN3 CAPN9 CAPNS1 CAPNS2 CAPS CAPS2 CAPSL CBARA1 CETN1 CETN2 CETN3 CHP CHP2 CIB1 CIB2 CIB3 CIB4 CRNN DGKA DGKB DGKG DST DUOX1 DUOX2 EFCAB1 EFCAB2 EFCAB4A EFCAB4B EFCAB6 EFCBP1 EFCBP2 EFHA1 EFHA2 EFHB EFHC1 EFHD1 EFHD2 EPS15 EPS15L1 FKBP10 FKBP14 FKBP7 FKBP9 FKBP9L FREQ FSTL1 FSTL5 GCA GPD2 GUCA1A GUCA1B GUCA1C hippocalcin HPCAL1 HPCAL4 HZGJ IFPS ITSN1 ITSN2 KCNIP1 KCNIP2 KCNIP3 KCNIP4 KIAA1799 LCP1 MACF1 MRLC2 MRLC3 MST133 MYL1 MYL2 MYL5 MYL6B MYL7 MYL9 MYLC2PL MYLPF NCALD NIN NKD1 NKD2 NLP NOX5 NUCB1 NUCB2 OCM PDCD6 PEF1 PKD2 PLCD1 PLCD4 PLCH1 PLCH2 PLS1 PLS3 PP1187 PPEF1 PPEF2 PPP3R1 PPP3R2 PRKCSH PVALB RAB11FIP3 RASEF RASGRP RASGRP1 RASGRP2 RASGRP3 RCN1 RCN2 RCN3 RCV1 RCVRN REPS1 RHBDL3 RHOT1 RHOT2 RPTN RYR2 RYR3 S100A1 S100A11 S100A12 S100A6 S100A8 S100A9 S100B S100G S100Z SCAMC 2 SCGN SCN5A SDF4 SLC25A12 SLC25A13 SLC25A23 SLC25A24 SLC25A25 SPATA21 SPTA1 SPTAN1 SRI TBC1D9 TBC1D9B TCHH TESC TNNC1 TNNC2 USP32 VSNL1 ZZEF1另见 编辑锚定结构域 英语 dockerin domain 另一种由a 螺旋组成的钙结合结构基序 参考文献 编辑 Ban C Ramakrishnan B Ling KY Kung C Sundaralingam M Structure of the recombinant Paramecium tetraurelia calmodulin at 1 68 A resolution Acta Crystallogr D Biol Crystallogr January 1994 50 Pt 1 50 63 PMID 15299476 doi 10 1107 S0907444993007991 延伸阅读 编辑Branden C Tooze J Chapter 2 Motifs of protein structure Introduction to Protein Structure New York Garland Pub 1999 24 25 ISBN 0 8153 2305 0 Nakayama S Kretsinger RH Evolution of the EF hand family of proteins Annu Rev Biophys Biomol Struct 1994 23 473 507 PMID 7919790 doi 10 1146 annurev bb 23 060194 002353 Zhou Y Yang W Kirberger M Lee HW Ayalasomayajula G Yang JJ Prediction of EF hand calcium binding proteins and analysis of bacterial EF hand proteins Proteins November 2006 65 3 643 55 PMID 16981205 doi 10 1002 prot 21139 Zhou Y Frey TK Yang JJ Viral calciomics interplays between Ca2 and virus Cell Calcium July 2009 46 1 1 17 PMID 19535138 doi 10 1016 j ceca 2009 05 005 Nakayama S Moncrief ND Kretsinger RH Evolution of EF hand calcium modulated proteins II Domains of several subfamilies have diverse evolutionary histories J Mol Evol May 1992 34 5 416 48 PMID 1602495 doi 10 1007 BF00162998 Hogue CW MacManus JP Banville D Szabo AG Comparison of terbium III luminescence enhancement in mutants of EF hand calcium binding proteins J Biol Chem July 1992 267 19 13340 7 PMID 1618836 Bairoch A Cox JA EF hand motifs in inositol phospholipid specific phospholipase C FEBS Lett September 1990 269 2 454 6 PMID 2401372 doi 10 1016 0014 5793 90 81214 9 Finn BE Forsen S The evolving model of calmodulin structure function and activation Structure January 1995 3 1 7 11 PMID 7743133 doi 10 1016 S0969 2126 01 00130 7 Stathopulos PB Zheng L Li GY Plevin MJ Ikura M Structural and mechanistic insights into STIM1 mediated initiation of store operated calcium entry Cell October 2008 135 1 110 22 PMID 18854159 doi 10 1016 j cell 2008 08 006 Nelson MR Thulin E Fagan PA Forsen S Chazin WJ The EF hand domain a globally cooperative structural unit Protein Sci February 2002 11 2 198 205 PMC 2373453 PMID 11790829 doi 10 1110 ps 33302 外部链接 编辑Nelson M Chazin W EF Hand Calcium Binding Proteins Data Library Vanderbilt University 2009 08 29 原始内容存档于2009 08 25 Haiech J EF hand protein database EF handome European Calcium Society and the Universite Libre de Bruxelles 2009 08 29 原始内容存档于2009 08 09 upon request to haiech pharma u strasbg fr Yang J Calciomics Georgia State University 2009 08 29 原始内容存档于2009 10 12 prediction server for EF hand calcium binding proteins 取自 https zh wikipedia org w index php title EF手 amp oldid 70198951, 维基百科，wiki，书籍，书籍，图书馆，
